FaF:FAAL1_15 Analysis of Drugs - Course Information

FAAL1_15 Analysis of Drugs

Extent and Intensity

2/3/0. 8 credit(s). Type of Completion: zk (examination).

Teacher(s)

doc. PharmDr. Ing. Radka Opatřilová, Ph.D., MBA (lecturer)
Ing. Klára Odehnalová, Ph.D. (seminar tutor)
doc. PharmDr. Ing. Radka Opatřilová, Ph.D., MBA (seminar tutor)
Mgr. Hana Pížová, Ph.D. (seminar tutor)

Guaranteed by

doc. PharmDr. Ing. Radka Opatřilová, Ph.D., MBA
Department of Chemical Drugs – Departments – Faculty of Pharmacy

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

• Pharmacy (programme FaF, M-FARMA)

Course objectives

Drug Analysis course aims to teach students to work methods and procedures used in the control practices for providing efficient, reliable and safe medicines.
The subject is the interpretation of the principles of analysis - chemical and physico-chemical methods used in assessing individual indicators of quality (identity, purity, content, stability) of single chemically active substances, excipients and medicinal products.

Syllabus

• LECTURES
  Basic: Pharmacopeia
  Purity and stability of drugs
  Pharmacopoeial detection of impurities with the use of chemical reactions by means of physicochemical methods
  Stability of drugs, processes of decomposition, factors influencing stability
  Drug Identification
  * Detection of drugs by means of chemical reactions
  * Group and selective reactions of pharmacotherapeutic groups
  * Detection of drugs on the basis of physical constants (melting point, distillation range, density, refractive index, optical rotation)
  * Use of physicochemical methods for the detection of drugs (spectral, separational, electrochemical methods)
  Drug Assay
  * Volumetric methods used in drugs analysis
  * Acid-base titrations of drugs (acidimetry, alkalimetry in aqueous and nonaqueous media)
  * Oxidoreduction titrations of drugs (iodometry, bromatometry, manganometry, cerimetry)
  * Complexometric titrations of drugs (chelatometry, mercurimetry)
  * Determination of drugs by means of precipitation titrations
  Spectrophotometric determination of drugs
  Polarimetric determination of drugs
  Determination of drugs with the use of electroanalytical methods
  Determination of drugs by chromatographic and electrophoretic methods
  
  PRACTICAL TRAINING
  - Control-analytical evaluation of drugs according to the Pharmacopoeia
  - Test for purity of drugs (chemical detection of impurities)
  - Test for purity of drugs (detection of impurities, or degradation products by chromatographic and spectral methods)
  - Identification of drugs by means of chemical reactions, physical constants, physicochemical methods
  - Determination of drug content (pharmacopoeial methods of quantitative evaluation of drugs)
  - Control-analytical evaluation of pharmaceutical preparations
  - Control of extemporaneously prepared pharmaceutical preparations according to the pharamacopoeia and control-analytical procedures used in drug control laboratories
  - Control of mass-produced pharmaceutical preparations according to factory standards (control- analytical methods used in outlet control in pharmaceutical industry)
  Instrumental methods (use of UV spectrometry in drug control, control, analysis of drugs on the basis of specific optical rotation, analysis of drugs by means of HPLC and TLC)
  

Literature

recommended literature
• European Pharmacopoeia, 9th Edition. 2017. info

Language of instruction

English

Further comments (probably available only in Czech)

Study Materials
The course can also be completed outside the examination period.

Teacher's information

To gain credits, a student must take part in ALL the laboratory
exercises and pass all written exercise tests

• Enrolment Statistics (Spring 2020, recent)
  
• Permalink: https://is.muni.cz/course/pharm/spring2020/FAAL1_15