C2720 Organic Chemistry - laboratory course

Faculty of Science
Autumn 2023
Extent and Intensity
0/0/6. 6 credit(s) (plus extra credits for completion). Type of Completion: z (credit).
Taught in person.
Teacher(s)
RNDr. Slávka Janků, Ph.D. (seminar tutor)
Mgr. Jaromír Literák, Ph.D. (seminar tutor)
Guaranteed by
RNDr. Slávka Janků, Ph.D.
Department of Chemistry – Chemistry Section – Faculty of Science
Supplier department: Department of Chemistry – Chemistry Section – Faculty of Science
Prerequisites (in Czech)
C4221 Biochemical Lab Technique || C1100 Introductory Chemistry Lab || C1600 Laboratory in Chemistry
Course Enrolment Limitations
The course is offered to students of any study field.
Course objectives
The course represents an elementary laboratory course of preparatory chemistry in bachelor’s studies and aims for deepening and adopting fundamental as well as complementary techniques used in synthetic organic chemistry (e.g. vacuum distillation, work under lowered temperatures, column chromatography, synthesis in waterless environment, …) including selected physico-chemical methods for identification of products (determining melting point and refractive index, gas chromatography, NMR,IR spectroscopy). Exercises are chosen carefully to cover the most common and important types of chemical reactions, which are discussed in lectures on organic chemistry, allowing the students to apply their theoretical knowledge in practice.
Learning outcomes
By the end of this course, students: • - will have mastered elementary and complementary techniques commonly used in chemical laboratory. • - will be capable of handling laboratory equipment necessary for analysis of purity and identification of prepared solutions with ease (gas chromatograph, IR spectrometer,NMR spectroscopy, refractometer, melting point apparatus and others). • - will have built self-confidence and gained manual skillfulness essential for work in chemical laboratory. • - will be able to explain chemical nature of selected preparatory techniques. Exercises were chosen carefully to cover the most common and important types of chemical reactions, which are discussed in lectures on organic chemistry, allowing the students to apply their theoretical knowledge in practice. • - will have learnt to report thoroughly on outcomes of their work and will have mastered basic chemical calculations needed for their laboratory praxis.
Syllabus
  • 1. Introduction, safety rules. Practical introduction to instrumental techniques used to identify organic substances. 2. Preparation of ethyl formate. 3. Preparation of paracetamol. 4. Diastereoselective reduction of benzoin. 5. Extraction using Soxhlet extractor and isolation of natural substances. 6. Preparation of ethyl 3-oxobutanoate ethylenacetal. 7. Preparation of 4-methylumbelliferon. 8. Preparation of penta-O-acetyl-d-glucopyranose. 9. Substitution of hemiacetal-OH group penta-O-acetyl-d-glucopyranose – preparation of glycoside and bromide. 10. Aldol condensation of alcohol and acetone. 11. Preparation of chromophore analogous to k GFP – dependence of absorption spectrum on nature of substituent. 12. Preparation of benzoic acid.
Literature
    recommended literature
  • PŘÍHODA, Jiří, Miloš ČERNÍK, Slávka JANKŮ and Jaromír LITERÁK. Laboratorní technika. Příručka pro začínajícího chemika (Laboratory technique. Handbook for young chemist). 1. vydání. Brno: Masarykova univerzita, 2012, 221 pp. ISBN 978-80-210-5820-0. info
  • KLIKORKA, Jiří. Úvod do preparativní anorganické chemie. 3. vyd. Praha: SNTL - Nakladatelství technické literatury, 1974, 373 s. info
Teaching methods
The education is realized as a laboratory course, which takes place once a week and the laboratory course covers basic laboratory operations, which are practised on the real organic syntheses. In the end the students have to work out the laboratory reports.
Assessment methods
Continuous tests at the beginning of each laboratory course and final credit test. The conditions for granting the credit are: 1. submission of all preparations in  sufficient quantity and purity, complete and careful entries in  laboratory diary about performed reactions and experiments, including calculations. 2. Recognition of protocols from all tasks. 3. Success rate in  continuous and credit tests of at least 60 %.
Language of instruction
Czech
Further Comments
The course is taught annually.
The course is taught: every week.
The course is also listed under the following terms Spring 2008 - for the purpose of the accreditation, Spring 2011 - only for the accreditation, Autumn 2010 - only for the accreditation, Spring 2001, Spring 2002, Spring 2003, Spring 2004, Spring 2005, Spring 2006, Spring 2007, Spring 2008, Spring 2009, Spring 2010, Autumn 2010, Spring 2011, Autumn 2011 - acreditation, Autumn 2024.
  • Enrolment Statistics (recent)
  • Permalink: https://is.muni.cz/course/sci/autumn2023/C2720