Bi8099 Fundamentals of antimicrobial therapy

Faculty of Science
Spring 2008 - for the purpose of the accreditation
Extent and Intensity
2/0. 2 credit(s) (plus extra credits for completion). Type of Completion: zk (examination).
Teacher(s)
Lucie Pokludová (lecturer), doc. RNDr. Miroslav Němec, CSc. (deputy)
Guaranteed by
prof. RNDr. Zdeněk Hubálek, DrSc.
Department of Experimental Biology – Biology Section – Faculty of Science
Contact Person: doc. RNDr. Miroslav Němec, CSc.
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives (in Czech)
CĂlem pedmtu je seznĂĄmit studenty s terapiĂ lĂŠivy obsahujĂcĂmi antimikrobnĂ lĂĄtky. Pednåška zahrnuje nejprve teoretickĂĄ vĂchodiska zabĂvajĂcĂ se strukturou antimikrobnĂch lĂĄtek a podstatou mechanism Ăşinku na mikroorganismy, mechanism penosu rezistence z hlediska molekulĂĄrn biologickĂŠho a genetickĂŠho. NĂĄsledujĂ kapitoly tĂkajĂcĂ se laboratornĂ kontroly, kterou se stanovuje citlivost a rezistence na antimikrobnĂ lĂĄtky a to metodami kvalitativnĂmi a kvantitativnĂmi, kultivanĂmi i molekulĂĄrn biologickĂmi. Vpednåšce je obsažena klasifikace antibiotik podle pĂslušnosti do farmakologickĂch skupin, piemž u každĂŠ skupiny je charakterizovĂĄno spektrum psobenĂ, mechanismus Ăşinku, rezistence, kinetika, použitĂ-indikace,toxicita, kontraindikace a interakce. NĂĄhled na problematiku vkontextu klinickĂŠ praxe je podĂĄn vĂĄsti vnujĂcĂ se zĂĄsadĂĄm použitĂ antibiotik sohledem na infekce vkomunit a vnemocnici, na zvlĂĄdĂĄnĂ nozokomiĂĄlnĂch infekcĂ multirezistentnĂmi mikroorganismy, na danou problematiku ve sfĂŠe humĂĄnnĂ i veterinĂĄrnĂ. NedĂlnou souĂĄstĂ je takĂŠ vysvtlenĂ princip antibiotickĂŠ politiky vrĂĄmci R. NĂĄležitĂĄ pozornost je rovnž vnovĂĄna specifickĂŠ problematice použitĂ antimikrobnĂch lĂĄtek u thotnĂch žen, u novorozenc a u dtĂ a u rznĂch typ infekcĂ. AktuĂĄlnĂ stav a novĂŠ perspektivy oboru jsou podĂĄny vkapitolĂĄch zabĂvajĂcĂch se zkoušenĂm antimikrobnĂch lĂŠiv, registracĂ lĂŠiv vR a vĂvojem novĂch preparĂĄt. SouĂĄstĂ pednåšky jsou odkazy na aktuĂĄlnĂ zdroje informacĂ na internetovĂch strĂĄnkĂĄch, nejnovjšà literaturu voboru ve svt, pĂklady kasuistik infekcĂ, kterĂŠ je možno terapeuticky zvlĂĄdnout antibiotiky a takĂŠ pvodnĂ webovĂĄ strĂĄnka vnovanĂĄ tĂŠto problematice a obsahujĂcĂ odpednåšenou lĂĄtku.
Syllabus
  • 1)The history of the chemotherapy and use of antibiotics 2)The mechanisms of efficacy of antimicrobial substances 3)The resistance to antimicrobials mechanisms 4)The resistance to antimicrobials genetics and resistance transfers 5)The resistance from the aspect of therapy in human medicine communities and hospitals 6)The resistance from the aspect of therapy in veterinary medicine 7)The laboratory checking of the antimicrobial therapy 8)Specifics of laboratory checking regarding to the species of microorganisms 9)The survey of antimicrobials according to pharmacologic groups and aspects of use of antimicrobial products in human and veterinary medicine 10)The principles of antimicrobial therapy, specific of pregnant women and children use of antibiotics 11)The human antibiotic health care policy in the Czech Republic 12)The veterinary health care strategy in the Czech Republic 13)Adverse reactions in use of antimicrobial drugs 14)The development of new antimicrobials, marketing authorization of medicinale products for human and veterinary use 15)Aspects of checking of veterinary antimicrobials
Literature
  • Antibiotika, sulfonamidy a chinolony ve veterinární medicíně, J. Šimůnek,J.Smola, LAST, 1998
  • Antibiotika vsoučasné lékařské praxi C.Simon, W Stille, Grada Publishing, 1998
Language of instruction
Czech
The course is also listed under the following terms Spring 2011 - only for the accreditation, Spring 2003, Spring 2004, Spring 2005, Spring 2006, Spring 2007, Spring 2008, Spring 2009, Spring 2010, Spring 2011, Spring 2012, spring 2012 - acreditation, Spring 2013, Spring 2014, Spring 2015, Spring 2016, Spring 2017, spring 2018, Spring 2019, Spring 2020, Spring 2021, Spring 2022, Spring 2023, Spring 2024, Spring 2025.