C4460 Organic Chemistry - laboratory course

Faculty of Science
Spring 2008 - for the purpose of the accreditation
Extent and Intensity
0/0/5. 5 credit(s). Type of Completion: graded credit.
Teacher(s)
RNDr. Slávka Janků, Ph.D. (seminar tutor), Ing. Alena Pálková (deputy)
Guaranteed by
prof. RNDr. Milan Potáček, CSc.
Department of Chemistry – Chemistry Section – Faculty of Science
Prerequisites
C2021 Organic Chemistry I
C1080. You have to pass tests of your knowledge. Information to the practical training is at http://koch.chemi.cz/
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
Fundamental laboratory methods of organic chemistry for synthesis (heating, stirring, cooling, introduction of gases, working with decrease of pressure, drying) and separation of organic compounds (filtering, crzstallization, distillation, extraction). The methods are trained on important types of organic compounds syntheses. The products are characterized by melting point, thin-layer chromathography, refractive index, and infra-red spectroscopy.
Syllabus
  • 1. a) Ethyl bromide (SN2 mechanism, distillation) b) tert-Butyl chloride (SN1 mechanism, distillation) 2. Substitution nucleophilic on aromatic system Aminolysis of 1-chloro-2,4-dinitrobenzene (recrystalization) 3. Ethyl-acetate (esterifikation, distillation) 4. Ethyl 3-oxobutanoate ethylenacetale(AN mechanism to C=O, azeotropic and vacuum distillation, work with rotary evaporator) 5. 3-Nitroacetophenone (SEAr mechanism , recrystallization, IR spectroscopy) 6. 1-(3-Nitrophenyl)ethanol (selective reduction, extraction, recrystallization, IR spectroscopy) 3-Aminoacetophenone (selective reduction, recrystallization, IR spectroscopy) 7. 2-Hydroxy-5-methyl-2'-nitroazobenzene (diazotization and diazonium coupling, recrystallization, TLC) 8. Phenole nitration(SEAr mechanism , steam distillation , recrystallization) 9. Anthranilic acid (Hofmannovo odbourávání amide, recrystallization) 10. Extraction of plant dyes on Soxhlet extractor (TLC, work with rotary evaporator) 2-chlorbenzoic acide (diazotisation a Sandmayer reakction, recrystallization) 11. Pinacol (metal reduction in anhydrous non-polar solvents, work with rotary evaporator) 12. Benzoic acid(AN to C=O, work with anhydrous solvents, extraction, sublimation) 13. Acetylsalicylic acid (using of karboxyacid anhydride for estere preparation, recrystallization) Azobenzene (electrochemical reduction, recrystallization, TLC)
Literature
  • NOVÁČEK, Eduard and Milan POTÁČEK. Laboratorní technika ke cvičení z metod organické chemie. Edited by Slávka Janků. 1. vyd. Brno: Masarykova univerzita, 1997, 91 s. ISBN 8021015004. info
Assessment methods (in Czech)
Předmět je vyučován každoročně. Vyučují učitelé katedry organické chemie. Předmět je ukončen klasifikovaným zápočtem. Podmínky pro udělení zápočtu: 1. Odevzdání produktů a řádné doplnění všech údajů v laboratorních protokolech, 2. Ústní pohovor, 3. Zaplacení skla
Language of instruction
Czech
Further comments (probably available only in Czech)
The course is taught annually.
The course is taught: every week.
General note: Vyučují učitelé katedry organické chemie.
Teacher's information
http://koch.chemi.muni.cz/laboratore/index.html
The course is also listed under the following terms Spring 2011 - only for the accreditation, Spring 2000, Spring 2001, Spring 2002, Spring 2003, Spring 2004, Spring 2005, Spring 2006, Spring 2007, Spring 2008, Spring 2009, Spring 2010, Spring 2011.