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Masaryk University

Faculty of Science

Master's degree programme/field of study:
Biology/Molecular Biology and Genetics

Bc. Lucie Bačáková

The role of the central domain in the regulation of Mdm2 oncoprotein function

Úloha centrální domény onkoproteinu Mdm2 v regulaci jeho funkce

Abstract: Mdm2 je hlavní negativní regulátor nádorového supresoru p53, který aktivuje expresi proteinů indukujících apoptózu, zástavu buněčného cyklu nebo se podílí na opravě DNA. Mdm2 funguje jako E3 ubiquitin ligáza pro p53 a zprostředkovává jeho ubiquitinylaci a následnou proteazomální degradaci.Ve této práci jsem se zaměřila na identifikaci role různých úseků kyselé domény Mdm2 v procesu ubiquitinylace a …more

Abstract: Mdm2 is the main negative regulator of tumour suppressor p53, which p53 induces expression of proteins responsible for the induction of apoptosis, cell cycle arrest or activation of DNA repair. Mdm2 mediates p53 ubiquitinylation and subsequent proteasomal degradation. In this work I aimed to determine the role of different regions in the Mdm2 acidic domain in ubiquitinylation and degradation of p53 …more

Mdm2 p53 acidic domain of Mdm2 kyselá doména Mdm2 phosphorylation of serines fosforylace serinů

Language used: English

  • Entered/Edited 22. 6. 2010 13:45, Romana Němcová
  • Record made 20. 1. 2009 11:34, Eva Nebolová
  • Accessible from: 17. 5. 2010 15:09, Romana Němcová
  • Thesis/dissertation received 17. 5. 2010 15:09, Romana Němcová

Master's thesis defence

  • Took place 15. 6. 2010, the thesis was defended successfully.

Supervisor:

  • Mgr. Stjepan Uldrijan, CSc., BiologÚ Teorie LF MU, Department of Genome Research - Biology Section - Faculty of Science
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Thesis check

The thesis has been checked: 27. 5. 2010 11:32, Mgr. Stjepan Uldrijan, CSc.


Složka /th/  Závěrečné práce /th/
Složka /th/151097/  Bc. Lucie Bačáková /151097/
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