IBA » Jiří Jarkovsky, Adam Svobodnik nalys MU IBA IM) _L_L_L^J 1_L L111 uiD£Jííi N£j n ü£j tLQL ri-ii ly>]H>] iüy '^J^'^J History Structure Collaboration Institute of Biostatatistic and Analyses: History b Since 2001 group of scientists interested in analysis of ical and clinical data Centre of Biostatistics and analyses 0 2006 ■* Institute of Biostatistics and Analyses ■* 45 employees and PhD students ■* 40 students in pregraduate study of Computational Biology Autor: Název © Institute of Biostatistics and analyses IBA Institute of Biostatatistic and Analyses: Internal Structure 0 Nowadays IBA has the following structure: l^ S^^ľ**j»^^ Masaryk university <£ í Ü J • Faculty of Medicine ^J^lj i Ľ • Faculty of Science in jn ^4*A ** Department of Clinical Trials Department of Data Analysis SIBA\ Department of Environmental Tnformatic° ^ j J v ♦a DSC Services RECETOX TOCOEN Autor: Název © Institute of Biostatistics and analyses IBA (Mí) Institute of Biostatatistic and Analyses: Collaboration Close mutual collaboration Faculty of Medicine (MU in Brno) Faculty of Informatics (MU in Brno) Faculty of Science (MU in Brno) Research Centre for Environmental Chemistry and Ecotoxicology (MU in Brno) Department of Mathematics (MU in Brno) Czech Environmental Information Agency National and Regional Centre for Persistent Organic Pollutants in Middle and East Europe Masaryk Memorial Hospital Czech Statistical Office Czech National Cancer Registry Committee for Breast Cancer Screening (Ministry of Health) Czech Oncology Society Standard professional collaboration More than 100 independent health care providers and hospitals, research institutions, environmental agencies, ministries etc. Autor: Název © Institute of Biostatistics and analyses IBA (Mí) Institute of Biostatatistic and Analyses: Areas of interests 0 There are five main areas of interest Analysis and scientific research of clinical and other biological data Analysis and scientific research of nvironmental data Software development \ Educational activities Clinical trials and registries ^ Autor: Název © Institute of Biostatistics and analyses IBA (Mí) MU IBA IM) Basic and advanced courses of data analysis Computational Biology Conferences Background of educational and scientific activities Basic and advanced courses of data analysis 0 18 courses for Faculty of Medicine and Faculty of Science 0 Both undergraduate and postgraduate courses with 450 students per year * Analysis of biological and clinical data ť- s Ä7 Catalogue of Courses is.muni.cz ■ ■ ■ MY MAIL . . ■ TEACHER ■ ■ ■ ■ P lification: LF, PřF LF: LF: LF: LF: ■Ä:: credit. O-m-d dar»™*™ (Autumn 2006) rické obory (Spring 2006) j Biostatistics □ Stochastic modelling j Multivariate data analysis □ Experimental design j Data mining j Etc. Clinical trials ________________ j Design and analyses of clinical trials □ Data management in clinical trials Courses of visiting professors: International collaboration in teaching rfCompletion:: ■ LF: LF: ofComplstion:: c. LF: ,<1 analyses of h„:„_d„„,,..,«,, - o ,„« i.. WM -> Free access to many databases e^____ 0 Software equipment 1^===== MU IBA IM) Important projects in Vlľ Dli J Jl bil till j Dl Dl Ü ?i ÍJlii íili íl £ piíi híiiii üi Ü y.y ľ bD bíiľ {Sll Environmental research Epidemiology Various biological research TRITON project 0 Project with Agricultural Water Management Authority 0 Software and statistical methodology of data analysis in biomonitoring networks ■* Visualisation of data Statistical analysis of time trends, biodiversity etc. © Institute of Biostatistics and analyses IBA ARROW project 0 0 Part of implementation of Water Framework Directive EU in the Czech Republic IBA tasks Development of methodology and scientific research in analysis, typology and prediction of ecological state of localities -> Software implementation of analytical methodology fj|jij.iiaiiiii..ij.iii.i,i.ii,jij.ijjij,i.iiii.ii.i.iijj.i.i.i.iii.iii.i.ii.l.i.iiiii.liii. 5oubor Úpravy Zobrazit Proiľt Záložky ScrapBook Nástroje Nápověda http: I f-n WN. c b a. muni. r_ z jat row/ e ng/ index. htm Centi ála Firefoxu Přehled zpráv Merriam-Webster Online .-.-■ Masarykova univerzita 5eznarr, ■ ' Verejné služby iní-j:.., TIE5 2006 ijjb Masarykova univerzita ^ IBA; Institut biostatistiky a ... I fh Unknown site ______,________ __________I Primary data, reference models Biological community I X Biological community II Evaluation of ecological state (D(x), IPwd(x; I Environmental parameters, biotic indices Evaluation of ecological state (D(x), IPwd(x) ... I Evaluation of ecological state (D(x), IPwd(x) ... I J I II J ( III ) I IV J I V Final categories of evaluation Autor: Název © Institute of Biostatistics and analyses IBA (Mí) INCHEMBIOL project 0 0 Source of contamination Environmental characteristics J INTERACTIONS AMONG THE CHEMICALS, ENVIRONMENT AND BIOLOGICAL SYSTEMS AND THEIR CONSEQUENCES N THE GLOBAL, REGIONAL AND LOCAL SCALES Long term projects (7 years) including * Experimental work * Data analysis □ Modelling of POPs distribution and transport j Dose-response analysis □ Biodiversity analysis j Analysis of data of biomonitoring networks □ Environmental risk assessment J GIS Compounds of interest d« 5 6 8' E^CI, SITUATION PLAN Pilot tests (screening) Zatopené oblasti Železnice /w Hranice povodí Dřevnice /\y Přítoky Dřevnice ^B Jezera /\y Řeka Dřevnice /\y Řeka Morava /\/ Silnice I------1 Sídla Autor: Název © Institute of Biostatistics and analyses IBA CimjD INCHEMBIOL: Evironmental risk assessment 0 kUnc< Uncertainty analysis C RISK CHARACTERIZATION ±±±± Bioindicators í c ,. Modelling Sampling a ö Expert Biota judgement EXPOSURE ASSESSMENT Bio-tests Biomonitoring Benchmarking Probability estimation EFFECTS CONCEPTUAL MODEL & SCENARIO 1444444444444444^ Data processing Modelling Multivariate analyses Model of area ofinterest Experimental design Problem definition Hazard identification JQ Retrospective problem Actual / urgent situation Autor: Název Data gathering Data aggregation Information services Optimization & Processing in information systems & Communication Prospective evaluation © Institute of Biostatistics and analyses IBA CimjD SVOD project: description 0 SVOD = EXPERT SYSTEM FOR ANALYSIS AND PRESENTATION OF EPIDEMIOLOGICAL DATA IN ONCOLOGY 0 0 Data of National Cancer Institute: population database of cancer epidemiology since 1970 Data includes incidence and mortality rates, time profiles, distribution of clinical stages, regional heterogeneity and more... II. TUMOURS OF DIGESTIVE ORGANS Mi i.|- w f.- .|. i if ■ ■ - ■ ■ | .1 i».| M a I iqnant neoplasm of stom ach .n ■■....... .u ■■ . .■■ ■" ■■■ ■. .1 ■■ . M SME &LÍ. IjĚMISSirLQlSill 2Ii .Msi ig n at neoĽ iM!Il JiL^^Q^^Oiá jun GS i on Maiicipart r^Ľ/frlaŕm of rer.tLiff - Mal kin.irft neoplasm of arius an d anal canal ■Cíl ■■ Mgiicjrant necnlasTí of c:fcn ar-d rentair: Malignant neogjasís. of jv er.ana.jriĽaÍLSäi' 1&M~ ďucts i-JLL^ L"!§Jfrinsnt neúslasii of tas iibjsciöer H*ľ4- Malinnanr nespijf.rn c;T ĹJľ*Bľ snu u;\ň(ifc\:\f-M carf-s ci i.i 1,1 i i i ■i ii ■■.........|-.......i !■■■ ■..... . i ■■ CľF ■ Mslirinspí nespim of STinrrE-ap C26 - Malignant neoplasm of or he r and sil-def!n& ddj a e stive organs http:tfw .svöd.cs/analy5e.php?nodul=regionprehled# Patient group selection K$ Sex, age Stage Period TNM classification Other parameters Other analyses for selected diagnose and group of patients™ 050,005 - Breast tumours, uonen growth index of incidence to year 1977 Analysed data: N-107294 Other outputs ng Cüanged-agnose Analysis setups Datable Display report Autor: Název © Institute of Biostatistics and analyses IBA (Mí) 5991 SVOD project: aims 0 Project aims H ■* Scientific research of epidemiology data □ General epidemiological and socio-economical analyses. □ Load of population by malignant tumours, population risks. □ Analysis of health care heterogeneity □ Approximate evaluation of the health care effectiveness according to therapeutic results. Software development □ Desktop software □ Web visualization of epidemiology data - public access http://www.svod.cz/ Soubor Úpravy Zobrazit Pře; t Záložky ScrapBook Nástroje Nápověda K'p - [§? ľ http:/Mww.svod.cz/?sec=aktualili-8Jang=en _____________________ v © Přejit \%.____________ Centrála Firefoxu Přehled zpráv Me r riam-Webster Online Ijjjjj Masarykova univerzita 5eznam 'Jeřrjné služby Infoi.,, Google Calendai TIES 2006 | |JhH|J Masarykova univerzita | ft IBA: Ins stiky... CENIA || U SVOD EPIDEMIOLOGY OF MALIGNANT TUMORS V & IN THE CZECH REPUBLIC ABOUT PROJECT SOFTWARE SVOD EPIDEMIOLOGICAL ANALYSES ANALYS ES WIZARD 1\ Scientific events WWW Mi iks II I !■■■ |l <■ II ............ I llll ■ <....... I E|iiilriiiiůlin|i.:,il ,iii.. (?) i'ljiri .in.-ilv&Ěa j .- !■■■.. 28.06.2006 MliKiliZ.loe iklIIIURľ.lUtl-. ?00í období 1977-2003. í 0. í 0.2005 Vjŕb«i COS sdiwililouboiiiouiiidu projektu SVOD Vrado odborných garantů projektu j;ouzastoupeni představitelé yšech významných směrů současné onkológie a odborní zástupci spolupracujících institucí. Q4.i0.200o Probíhající lípravy portálu Autor: Název © Institute of Biostatistics and analyses IBA ílMJi INFORMATION AND ANALYTIC SEVICES OF THE SYSTEM SVOD 1 UJ.IJ!J.I,,I.IUJ,lťJJiia4.LIJ,[.ll|.l,lJ,[.lWIJU.WI,lJ,,ll„[.|.l,LlJ!JI« Soubor Nastavení Zobrazit Expertní služby Nápověda J S JB\ %>[äS 1 P H 1 Q o- érf S SVOD - System for Viewing of Oricologi 'Jill D'AÍ'J. redefined user controlled analytic tools 5114465 Microarrays and analysis of their data 0 0 0 Promising technique of molecular biology, nevertheless with lots of problems on the field of data analysis Analysis of expression and CGH microarrays data Project in cooperation with Masaryk Memorial Hospital -> Genomic profiling in prediction of response of radiochemotherapeutic treatment in colorectal carcinoma (a) Sporadic Weasi tumours patents unsupervised cluster analysis • supervised classification • validation of predictive classifier • analysis of u ncharacterised samples drop jenes «PROJ.sample merge by Sno PROJ_test_results I Sample Autor: Název ■ 3 © Institute of Biostatistics and analyses IBA (Mí)