AMOLp Introduction into molecular biology and genetics

Faculty of Medicine
Spring 2009
Extent and Intensity
2/2. 3 credit(s). Type of Completion: zk (examination).
Teacher(s)
prof. Ing. Petr Dvořák, CSc. (lecturer)
doc. MVDr. Aleš Hampl, CSc. (lecturer)
prof. MUDr. Augustin Svoboda, CSc., dr. h.c. (lecturer)
prof. MUDr. David Šmajs, Ph.D. (lecturer)
Debora Ledahudcová (assistant)
Mgr. Petra Pospíšilová, Ph.D. (assistant)
Ing. Lucia Ráheľová (assistant)
RNDr. Markéta Unucková, Ph.D. (assistant)
Guaranteed by
prof. Ing. Petr Dvořák, CSc.
Department of Biology – Theoretical Departments – Faculty of Medicine
Timetable
Tue 11:10–12:50 Kinosál N02901
Prerequisites
Grammar school or similar type with biology education
Course Enrolment Limitations
The course is offered to students of any study field.
Course objectives
The subject should provide an overview of basic knowledge from molecular and cell biology and human genetics. At the end of the course students should be able to: understand and explain basic terms of molecular biology, cell biology and human genetics - biopolymers, transcription and translation of genetic information, DNA replication, cell organelles, biomembranes and transport of solutes, cell cycle, mitosis and meiosis, secretion pathway and endocytosis, cell differentiation, stem cells, oncogenic transformation, genotype a fenotype, alelles, Mendel laws, dominant and recessive inheritance, autosomal and sex-linked traits, molecular diagnostics of hereditary diseases; use of the new knowledge for solving problems in practical classes; use of the new knowledge for easier understanding of other subjects -biochemistry, physiology, histology and pathology; understand more new trends in molecular medicine
Syllabus
  • Cellular organization of living systems. Biopolymers. Cell memory. Genetic information. DNA replication. Expression of genetic information and its regulation. Translation and protein metabolism.
  • Biomembranes and energy transformation. Membrane transport. Organization of cell nucleus.Cytoskeleton. Motor proteins. Cell cycle and its control. Mitosis and cytokinesis. Cell interactions and signalling. Stem cells and strategy of cell therapy. Cell differentiation.
  • Neoplastic transformation of cells. From gene to trait: Mendel rules of heredity. Hereditary diseases. Genetic counselling. Human genome. Gene cloning. Genetic engineering. Molecular disgnostics of hereditary diseases. Gene therapy.
Literature
    recommended literature
  • CAMPBELL, Neil A. Biologie. Edited by Jane B. Reece. Vyd. 1. Brno: Computer Press, 2006, xxxiv, 133. ISBN 8025111784. info
  • NEČAS, Oldřich, Augustin SVOBODA, Milan HEJTMÁNEK, Roman JANISCH, Miroslav ČERVINKA, Karel LENHART and Zdeněk KOLÁŘ. Obecná biologie pro lékařské fakulty (General Biology for Medical Faculties). 3. přepracované, v H+H 1. Jinočany: H+H, 2000, 554 pp. ISBN 80-86022-46-3. info
  • ALBERTS, Bruce. Základy buněčné biologie :úvod do molekulární biologie buňky. 1. vyd. Ústí nad Labem: Espero, 1999, xxvi, 630. ISBN 80-902906-0-4. info
Teaching methods
lectures, practical classes: microscopy of living and fixed cells, exercises from genetic counseling, basic techniques of molecular genetics
Assessment methods
Written and oral examination, lecture attendance is mandatory.
Language of instruction
Czech
Further Comments
Study Materials
The course is taught annually.
Teacher's information
http://www.med.muni.cz/biologie/Edu-under.htm
The course is also listed under the following terms Spring 2008, Spring 2010, Spring 2011, Spring 2012, Spring 2013, Spring 2014, Spring 2015, Spring 2016, Spring 2017, Spring 2018, spring 2019, spring 2020, spring 2021, spring 2022, spring 2023, spring 2024, spring 2025.
  • Enrolment Statistics (Spring 2009, recent)
  • Permalink: https://is.muni.cz/course/med/spring2009/AMOLp