BLBC0211s Biochemistry - seminar

Faculty of Medicine
spring 2023
Extent and Intensity
0/2/0. 1 credit(s). Type of Completion: z (credit).
Taught in person.
Teacher(s)
Mgr. Marie Tomandlová, Ph.D. (assistant)
Mgr. Jindra Smutná, Ph.D. (assistant)
Mgr. David Galuška (seminar tutor)
doc. PharmDr. Jiří Kos, Ph.D. (seminar tutor)
doc. RNDr. Jiří Dostál, CSc. (assistant)
MUDr. Michaela Králíková, Ph.D. (assistant)
RNDr. Hana Paulová, CSc. (assistant)
Mgr. Jiří Slanina, Ph.D. (assistant)
Bc. Ivana Ševčíková (assistant)
prof. RNDr. Eva Táborská, CSc. (assistant)
doc. RNDr. Josef Tomandl, Ph.D. (assistant)
Guaranteed by
doc. RNDr. Josef Tomandl, Ph.D.
Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Contact Person: Mgr. Marie Tomandlová, Ph.D.
Supplier department: Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Timetable
Tue 14. 2. 8:45–10:25 A16/215, Tue 21. 2. 8:45–10:25 A16/215, Tue 28. 2. 8:45–10:25 A16/215, Tue 7. 3. 8:45–10:25 A16/215, Tue 14. 3. 8:45–10:25 A16/215, Tue 21. 3. 8:45–10:25 A16/215, Tue 28. 3. 8:45–10:25 A16/215, Tue 4. 4. 8:45–10:25 A16/215, Tue 11. 4. 8:45–10:25 A16/215, Tue 18. 4. 8:45–10:25 A16/215, Tue 25. 4. 8:45–10:25 A16/215, Tue 2. 5. 8:45–10:25 A16/215, Tue 9. 5. 8:45–10:25 A16/215, Tue 16. 5. 8:45–10:25 A16/215, Tue 23. 5. 8:45–10:25 A16/215
Prerequisites (in Czech)
BLLC0111s Medical Chemistry - seminar && BLLC0111c Medical Chemistry - practice
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The aim of the course is to practice the basic metabolic processes taking place at the cellular level.
Learning outcomes
In the end of the course will students:
- understand the properties and function of enzymes
- describes basic catabolic and anabolic pathways of carbohydrate, lipid and protein metabolism
- understand the principles of energy production, utilization and deposition at the cellular level
- explain the function of cell membranes and the transport processes on the membrane
- describe protein synthesis, understand the relationship between protein structure and function
- explain the function of hemoglobin in oxygen transport and maintaining acid-base balance
Syllabus
  • Introduction to cell metabolism. The structure of biomembranes. Membrane transport.
  • Kinetics of enzyme reactions.
  • Enzyme cofactors.
  • Three phases of nutrient catabolism. Citrate cycle.
  • Respiratory chain. Oxidative phosphorylation. Reactive oxygen species.
  • Carbohydrate digestion. Glucose metabolism. Glycogen metabolism. Metabolism of fructose and galactose.
  • Digestion and intracellular degradation of proteins. Elimination of α-carboxyl and α-amino nitrogen from amino acids. Ammonia detoxification.
  • Significant reactions in amino acid transformations.
  • Lipid digestion. Synthesis and breakdown of fatty acids. Synthesis of triacylglycerols, phospholipids, cholesterol and bile acids. Lipoperoxidation. Eicosanoids.
  • Heme biosynthesis and degradation. Hemoglobin.
  • Metabolism of purine and pyrimidine nucleotides. Uric acid.
Literature
    required literature
  • Studijní podklady a materiály k předmětu dostupné v IS MUNI.
  • LEDVINA, Miroslav, Alena STOKLASOVÁ and Jaroslav CERMAN. Biochemie pro studující medicíny. 3. vydání. Praha: Univerzita Karlova, nakladatelství Karolinum, 2020, 269 stran. ISBN 9788024647487. info
    recommended literature
  • FERRIER, Denise R. Biochemistry. Seventh edition. Philadelphia: Wolters Kluwer, 2017, viii, 567. ISBN 9781496363541. info
  • KOOLMAN, Jan and Klaus-Heinrich RÖHM. Barevný atlas biochemie. 1st ed. Praha: Grada, 2012, 498 pp. ISBN 978-80-247-2977-0. info
  • MATOUŠ, Bohuslav. Základy lékařské chemie a biochemie. 1. vyd. Praha: Galén, 2010, xv, 540. ISBN 9788072627028. info
Teaching methods
Seminary course. Class discussions on assigned topics.
Assessment methods
Course-unit credit.
Conditions for giving the course-unit credit (all conditions should be met):
  • completion of all lessons,
  • minimal success rate of 70 % from all revision tests or minimal success rate of 50 % from the credit test. The resit credit test can be taken only once.
    The detailed conditions are posted in IS MUNI (Study materials – Course-related instructions).
    • Language of instruction
    Czech
    Further comments (probably available only in Czech)
    The course is taught annually.
    General note: Úspěšné ukončení předmětu je předpokladem pro přistoupení ke zkoušce v předmětu BLBC0211p.
    Information on the extent and intensity of the course: 30.
    Listed among pre-requisites of other courses
    Teacher's information
    https://is.muni.cz/auth/el/1411/jaro2024/BLBC0211s/
    Information to seminars, the conditions for giving the course-unit credit and the syllabus are available in the IS MUNI in the Course-related instructions. The syllabus is also posted on the notice board of the Department of Biochemistry.
    Consultations are possible after a personal arrangement with the teacher.
    The course is also listed under the following terms Spring 2006, Spring 2007, Spring 2008, Spring 2009, Spring 2010, Spring 2011, Spring 2012, Spring 2013, Spring 2014, Spring 2015, Spring 2016, Spring 2017, Spring 2018, spring 2019, spring 2020, spring 2021, spring 2022, spring 2024.
    • Enrolment Statistics (spring 2023, recent)
    • Permalink: https://is.muni.cz/course/med/spring2023/BLBC0211s