EMPF0521c Patologická fyziologie I - cvičení

Faculty of Medicine
autumn 2022
Extent and Intensity
0/3/0. 2 credit(s). Type of Completion: z (credit).
Teacher(s)
RNDr. Jan Balvan, Ph.D. (seminar tutor)
prof. MUDr. Julie Dobrovolná, Ph.D. (seminar tutor)
MUDr. Kamil Ďuriš, Ph.D. (seminar tutor)
doc. MUDr. Jaromír Gumulec, Ph.D. (seminar tutor)
MUDr. Michal Jurajda, Ph.D. (seminar tutor)
MUDr. Jan Máchal, Ph.D. (seminar tutor)
prof. MUDr. Anna Vašků, CSc. (seminar tutor)
Věra Ježková (assistant)
Guaranteed by
prof. MUDr. Anna Vašků, CSc.
Department of Pathophysiology – Theoretical Departments – Faculty of Medicine
Supplier department: Department of Pathophysiology – Theoretical Departments – Faculty of Medicine
Timetable
Thu 13:00–15:30 A18/208
Prerequisites
EMBC0422c Biochemistry II - practice && EMBC0422s Biochemistry II - seminar && EMBC0422p Biochemistry II - lecture && EMFY0422c Fyziologie II - cvičení && EMFY0422p Fyziologie II - přednáška
Physiology, biochemistry
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The student will be trained for assuming these knowledge and skills:
Principles and ethics of experimental use of laboratory animals, basic surgical skills, general principles of work with lab. animals - explorative laparotomy
Experimental arrhythmias in experimental animal
Spirometry examination in lung diseases with ventilation/perfusion disturbances
Experimentally induced renal ischemia - renin production in kidney
Experimentally induced acute renal insufficiency in laboratory animal - GFR evaluation using inulin excretion by kidneys
Experimentally induced renal failure - peritoneal dialysis in experimental animal
Experimentally induced blood flow disturbances in splanchnic region of experimental animal
Learning outcomes
Student applies basic ethical principles of work with laboratory animals
Student is able to perform basic surgical technics dosung work with laboratory animal;
Student demonstrates the basic static and dynamic parameters surveyed during the spirometric examination and their relationship to pulmonary diseased
Student will describe the development of renal ischemia in experimental animal model
Student will explain the determination of the glomerular filtration rate, depending on the curve of concentration of inulin excretion by the kidneys, while discussing the use of clearance of other substances (creatinine, PAH)
Student demonstrates the emergence of renovascular hypertension in the Goldblatt´s model, renal artery stenosis, the difference between unilateral and bilateral stenosis, the role of the RAAS and the expansion of the volume due to hypertension diagnosis
Syllabus
  • Introduction, health & safety in the lab, principles and ethics of experimental use of laboratory animals, basic surgical skills, general principles of work with lab. animals & explorative laparotomy
  • Experimentally induce arrhythmias. Pathophysiology of ventilation disorders and pulmonary gas exchange – spirometry
  • Exp. induced renal ischemia – detection of renal renin expression
  • Exp. induced acute renal insufficiency in lab. animal – measurement of GFR based on kinetics of renal inulin excretion
  • Exp. induced renal failure - peritoneal dialysis in lab. animal
Literature
Teaching methods
Practical exercises in labs, discussion to the given topics, video with comments. Practical training (about 20 % of the total volume of teaching) is complemented by a comprehensive range of simulation teaching methods on virtual patients.
Assessment methods
Practicals are compulsory. The only permited reason for not attending is a student's sick leave. Student can - with tutor's approval - substitute the particular practical in a given week with another group in case he/she has a justifiable reason for it. Student's participation in the practicals throughout the term is certified by a credit. The protocols must be presented. Students can be given written tests or individual home work by tutor's throughout the term. Students have to be wearing lab coats during the practicals.
Language of instruction
Czech
Further comments (probably available only in Czech)
Study Materials
Information on the extent and intensity of the course: 45.
Listed among pre-requisites of other courses
The course is also listed under the following terms autumn 2023.
  • Enrolment Statistics (autumn 2022, recent)
  • Permalink: https://is.muni.cz/course/med/autumn2022/EMPF0521c