aVLBC0321p Biochemistry I - lecture

Lékařská fakulta
podzim 2023
Rozsah
3/0/0. 45. 3 kr. Ukončení: z.
Vyučováno prezenčně.
Vyučující
doc. RNDr. Jiří Dostál, CSc. (přednášející)
prof. RNDr. Eva Táborská, CSc. (přednášející)
doc. RNDr. Josef Tomandl, Ph.D. (přednášející)
MUDr. Michaela Králíková, Ph.D. (pomocník)
RNDr. Hana Paulová, CSc. (pomocník)
Mgr. Jiří Slanina, Ph.D. (pomocník)
Mgr. Marie Tomandlová, Ph.D. (pomocník)
Garance
doc. RNDr. Josef Tomandl, Ph.D.
Biochemický ústav – Teoretická pracoviště – Lékařská fakulta
Dodavatelské pracoviště: Biochemický ústav – Teoretická pracoviště – Lékařská fakulta
Rozvrh
Po 18. 9. až Pá 6. 10. St 12:00–12:50 B11/114, Po 16. 10. až Pá 27. 10. St 12:00–12:50 B11/114, Po 30. 10. až Pá 22. 12. Út 12:00–13:50 B22/116 aula, Po 6. 11. až Pá 22. 12. St 12:00–12:50 B11/114, Po 18. 9. až Pá 20. 10. Út 12:00–13:50 B22/116 aula; a St 11. 10. 12:00–12:50 B11/334, Út 24. 10. 12:00–13:50 Kinosál N02901, St 1. 11. 12:00–12:50 B11/234
Předpoklady
aVLBI0222p Lékařská biologie II - před. && aVLBF011p Biophysics - lecture
Omezení zápisu do předmětu
Předmět je určen pouze studentům mateřských oborů.
Mateřské obory/plány
Cíle předmětu
The aim of the course is to gain knowledge about the basic metabolic processes and pathways taking place at the cellular level.
Understanding these processes is the basis for understanding metabolism at the tissue and organ level, which is the focus of the follow-up course Biochemistry II.
Výstupy z učení
At the end of the course, students will:
  • understand the meaning of basic chemical concepts and can apply this knowledge to describe biochemical processes in the body and the properties of body fluids.
    - discuss the properties and function of enzymes.
    - describe basic catabolic and anabolic pathways of carbohydrate, lipid and protein metabolism and their relationships.
    - understand the principles of energy production, utilization and deposition at the cellular level.
    - explain the function of cell membranes and the principle of compartmentalization at the cellular level, and the transport processes on the membrane.
    - describe protein synthesis, starting with the replication and transcription, translation and post-translational modifications.
    - understand the relationship between protein structure and function.
    - explain the function of hemoglobin in oxygen transport and maintaining acid-base balance.
    - discuss the principles of some diseases at the molecular level.
    • Osnova
    • Electrolytes, ion activity. Weak acids/bases. Buffers. Bioenergetics, Gibbs energy, high-energy compounds. Redox reaction.
    • Enzymes. Characteristic features of biocatalysis. Cofactors.
    • Metabolism of nutrients. Citrate cycle. Respiratory chain. Oxidative phosphorylation.
    • Carbohydrates in nutrition. Carbohydrate digestion. Basic features of glucose metabolism. Glucose transport into cells. Glycolysis. Gluconeogenesis.
    • Glycogen. Metabolism of fructose, galactose, lactose. The pentose phosphate pathway. Glycosaminoglycans, proteoglycans.
    • Lipids and fatty acids. Surfactants. Lipophilic vitamins. Lipids in nutrition. Lipid digestion. Fatty acid metabolism. PUFA synthesis. Metabolism of ketone bodies.
    • Metabolism of triacylglycerols, glycerophospholipids, sphingolipids. Lipoperoxidation. Biosynthesis and importance of eicosanoids.
    • Metabolism of cholesterol, bile acids. Biosynthesis of calciols.
    • Amino acids. Peptides. Structure of proteins, myosin, collagen, immunoglobulins. Hemoglobin, myoglobin. Hemoglobinopathies.
    • Digestion and intracellular degradation of proteins. General features in catabolism of amino acids. Ammonia metabolism and toxicity.
    • Catabolism of amino acids, congenital disorders of amino acid metabolism. Synthesis of non-essential amino acids.
    • Conversions of amino acids into low molecular weight products. Heme synthesis, porphyria.
    • Metabolism of purine/pyrimidine nucleotides.
    • Structure of DNA, RNA. Replication and corrections. Transcription and its regulation, post-transcriptional modifications.
    • Protein synthesis. Folding, transport and sorting of proteins in the cell. Post-translational modification.
    • Biosynthesis of collagen, elastin.
    Literatura
      povinná literatura
    • RODWELL, Victor W., David A. BENDER, Kathleen M. BOTHAM, Peter J. KENNELLY a P. Anthony WEIL. Harper's illustrated biochemistry. Thirty-first edition. New York: McGraw-Hill, 2018, x, 789. ISBN 9781260288421. info
      doporučená literatura
    • Essentials of Medical Chemistry and Biochemistry (Ed. Dostál J.). Download: https://portal.med.muni.cz/article-623-essentials-of-medical-chemistry-and-biochemistry.html
    • LIEBERMAN, Michael a Alisa PEET. Marks' basic medical biochemistry : a clinical approach. Illustrated by Matthew Chansky. 5th edition. Philadelphia: Wolters Kluwer, 2018, xii, 1051. ISBN 9781496387721. info
    • VASUDEVAN, D. M., S. SREEKUMARI a Kannan VAIDYANATHAN. Textbook of biochemistry for medical students. Eighth edition. New Delhi: Jaypee The Health Sciences Publisher, 2016, xvi, 718. ISBN 9789385999741. info
    • KOOLMAN, Jan a Klaus-Heinrich ROEHM. Color Atlas of Biochemistry. 3rd ed. Georg Thieme Verlag, 2013. ISBN 978-3-13-100373-7. info
    Výukové metody
    Lectures.
    Metody hodnocení
    Students pass to continuing education in the next (spring) semester without their knowledge being verified in the current (autumn) semester.
    Vyučovací jazyk
    Angličtina
    Další komentáře
    Předmět je vyučován každoročně.
    Nachází se v prerekvizitách jiných předmětů
    Předmět je zařazen také v obdobích podzim 2016, podzim 2017, podzim 2018, podzim 2019, podzim 2020, podzim 2021, podzim 2022.
    • Statistika zápisu (nejnovější)
    • Permalink: https://is.muni.cz/predmet/med/podzim2023/aVLBC0321p