aVLFA0721c Farmakologie I - cvičení

Lékařská fakulta
podzim 2018
Rozsah
0/3/0. 45. 1 kr. Ukončení: z.
Vyučující
doc. MUDr. Regina Demlová, Ph.D. (cvičící)
doc. PharmDr. Jan Juřica, Ph.D. (cvičící)
Mgr. Petra Amchová, Ph.D. (cvičící)
doc. RNDr. Ladislava Bartošová, Ph.D. (cvičící)
Mgr. Jana Kubátová, Ph.D. (cvičící)
doc. Mgr. MVDr. Leoš Landa, Ph.D. (cvičící)
Mgr. Kristýna Nosková, Ph.D. (cvičící)
MUDr. Jana Nováková, Ph.D. (cvičící)
PharmDr. Adriána Papiež, Ph.D. (cvičící)
MUDr. Jana Pistovčáková, Ph.D. (cvičící)
doc. PharmDr. Jana Rudá, Ph.D. (cvičící)
PharmDr. Jitka Rychlíčková, Ph.D. (cvičící)
Mgr. Barbora Říhová, Ph.D. (cvičící)
PharmDr. Lenka Součková, Ph.D. (cvičící)
MUDr. Filip Šiška (cvičící)
doc. PharmDr. Ondřej Zendulka, Ph.D. (cvičící)
Renata Bláblová (pomocník)
Mgr. Kateřina Nebeská (náhr. zkoušející)
Garance
doc. MUDr. Regina Demlová, Ph.D.
Farmakologický ústav – Teoretická pracoviště – Lékařská fakulta
Kontaktní osoba: Renata Bláblová
Dodavatelské pracoviště: Farmakologický ústav – Teoretická pracoviště – Lékařská fakulta
Rozvrh seminárních/paralelních skupin
aVLFA0721c/30: Po 24. 9. až Pá 11. 1. Út 13:00–15:30 A19/326
aVLFA0721c/31: Po 24. 9. až Pá 11. 1. Čt 14:00–16:30 A19/231
aVLFA0721c/32: Po 24. 9. až Pá 11. 1. Út 13:00–15:30 A19/231
aVLFA0721c/33: Po 24. 9. až Pá 11. 1. Čt 14:00–16:30 A19/326
aVLFA0721c/34: Po 24. 9. až Pá 11. 1. Čt 14:00–16:30 A19/229
aVLFA0721c/35: Po 24. 9. až Pá 11. 1. Po 16:00–18:30 A19/326
Předpoklady
aVLPF0622c Patologická fyziol. II - cv && aVLPA0622c Patologie II - cv.
Omezení zápisu do předmětu
Předmět je určen pouze studentům mateřských oborů.
Mateřské obory/plány
Cíle předmětu
The aims of the course are:
to recognize the basic pharmacological terminology and legislation related to the use of drugs and thei prescription
to understand to differences between single drug dosage forms
to understand to the prescription of drugs
to understand to the basics of pharmacokinetics
to understand to the basic facts about the discussed drugs
Výstupy z učení
At the end of the course the student knows:
single pharmacoterapeutical drug clases
single drug dosage forms
the modes of action, adverse reactions and basic indications of single drugs of discussed drugs
how to prescribe selected medical preparation or a drug in particular drug dosage form
Osnova

  • aVLFA0721c - Pharmacology I - practical lessons

    General medicine

    Autumn semester 2018

  • 1st week
  • Topic: INFORMATION ON DRUGS
  • Course content: Organisation of practical courses and lectures, system of evaluation. Repetition of basic pharmacologic terminology. Sub-branches of pharmacology. Sources of information concerning drugs and recommended textbooks. Work with relevant databases (Brevíř, SÚKL, EMA, AISLP), ATC classification.
  • Self-studying preparation for practical lessons: Lecture No. 1. Preparation for the next practical lesson: Principles of drug prescription in different countries, examples.
  • 2nd week
  • Topic: PRESCRIPTION OF MEDICAL PRODUCTS I
  • Course content: Principles of prescription in different countries, general rules of drug prescription, basic Latin terminology, essentials of individually prepared preparations prescription, introduction to prescription of ready-made drug products, databases EMA and Drugs.com, video Manufacturing of tablets.
  • Self-studying preparation for practical lessons: Latin terminology (+ abbreviations), Drug dosage forms from the textbook.
  • 3rd week
  • Topic: PRESCRIPTION OF MEDICAL PRODUCTS II, ROUTES OF DRUG ADMINISTRATION
  • Course content: Brief characteristics of the individual drug dosage forms. Prescription of ready-made drug products. Clinical significance of the way of drug administration.
  • Self-studying preparation for practical lessons: Materials for the Lecture No. 3, EMA and Drugs.com databases.
  • 4th week
  • Topic: PRINCIPLES OF PHARMACOKINETICS
  • Course content: Pharmacokinetic processes, parameters and calculations.
  • Self-studying preparation for practical lessons: Materials for the Lecture No. 4.
  • 5th week
  • Topic: PRINCIPLES OF APPLIED PHARMACOKINETICS
  • Course content: Pharmacokinetic case reports, simulation of plasma concentrations course, dosage optimalization and use of software tools, factors affecting course and value of drug´s plasma concentrations.
  • Self-studying preparation for practical lessons: Materials for the Lectures No. 4 and 5.
  • 6th week
  • Topic: PHARMACODYNAMICS
  • Course content: MULTIPLE-CHOICE TEST (1st - 5th week). Mechanisms of drug effects - classification, examples. Dose-response curves.
  • Self-studying preparation for practical lessons: Materials for the Lecture No. 6.
  • 7th week
  • Topic: ADVERSE DRUG REACTIONS
  • Course content: Classification and characteristics of adverse drug effects. Pharmacovigilance in clinical practice, sources of current information on drug safety. Databases of drug interactions. Pharmaceutical interactions (case reports).
  • Self-studying preparation for practical lessons: Materials for the Lecture No. 7, case report (drug incompatibility) materials in IS.
  • 8th week
  • Topic: FACTORS AFFECTING DRUG EFFECTS
  • Course content: Pharmacotherapy in childhood, in pregnancy, in breastfeeding women, in elderly. Pharmacogenetics.
  • Self-studying preparation for practical lessons: Materials for the Lecture No. 8. Pharmacogenetics - materials in IS.
  • 9th week
  • Topic: PHARMACOLOGY OF SYMPATHETIC NERVOUS SYSTEM
  • Course content: Drugs affecting sympathetic nervous system - classification, basic pharmacological characteristics.
  • Self-studying preparation for practical lessons: Materials for the Lecture No. 9. Pathophysiological bases - ANS, neurotransmitters (their synthesis and degradation), receptors of the sympathetic nervous system (alpha, beta) and parasympathetic nervous system (nicotinic, muscarinic) and their subtypes and organ distribution. Systems of second messengers. Pharmacodynamics, both direct and indirect mechanisms of action.
  • 10th week
  • Topic: PHARMACOLOGY OF PARASYMPATHETIC NERVOUS SYSTEM
  • Course content: Drugs affecting parasympathetic nervous system - classification, basic pharmacological characteristics. Spasmolytic drugs.
  • Self-studying preparation for practical lessons: Materials for the Lectures No. 9. Spasmolytic drugs.
  • 11th week
  • Topic: GLUCOCORTICOIDS, DRUGS OF ABUSE
  • Course content: MULTIPLE-CHOICE TEST (6th - 10th week). Repetition of basic pharmacological characteristics of glucocorticoids. Problems of drug abuse, doping and falsification of medical products.
  • Self-studying preparation for practical lessons: Materials for the Lecture No. 11, preparation of oral presentation should be uploaded to IS at least 24 hours prior to the practical lesson.
  • 12th week
  • Topic: PHARMACOTHERAPY OF DIABETES MELLITUS
  • Course content: Repetition of anti-diabetic drugs - basic pharmacological characteristics. Drugs used in therapy of specific and acute conditions in diabetology. Combinations of insulins, insulin regimens.
  • Self-studying preparation for practical lessons: Materials for the Lecture No. 12, preparation of oral presentation - presentation should be uploaded to IS at least 24 hours prior to the practical lesson.
  • 13th week
  • Topic: SEX HORMONES
  • Course content: Endocrine therapy, hormone replacement therapy, hormonal contraceptive drugs.
  • Self-studying preparation for practical lessons: Uterotonics and tocolytics.
  • 14th week
  • Topic: ANALGESIC DRUGS
  • Course content: MULTIPLE-CHOICE TEST (11th - 13th week). Basic pharmacological characteristics of opioid and non-opioid analgesic drugs, antirheumatoid drugs and drugs used in gout.
  • Self-studying preparation for practical lessons: Materials for the Lecture No. 14. Drugs used in gout.
  • 15th week
  • Topic: ANAESTHETIC DRUGS
  • Course content: PRESCRIPTION TEST. Basic pharmacological characteristics of general and local anaesthetic drugs. Premedication prior to general anaesthesia.
  • Self-studying preparation for practical lessons: Materials for the Lecture No. 15. Skeletal muscle relaxants.
Literatura
    povinná literatura
  • Practicals in Pharmacology, 2009, Náhradní obsah: http://portal.med.muni.cz/article-491-practicals-in-pharmacology.html
  • http://search.ebscohost.com/login.aspx?direct=true&db=nlebk&AN=1160493&lang=cs&site=ehost-live
  • RANG, H. P., James RITTER, R. J. FLOWER a Graeme HENDERSON. Rang & Dale's pharmacology. Eighth edition. [Edinburgh]: Churchill Livingstone, 2016, xv, 760. ISBN 9780702053627. info
    doporučená literatura
  • WHALEN, Karen. Pharmacology. Edited by Richard Finkel - Thomas A. Panavelil. 6th ed. Philadelphia, Pa.: Lippincott Williams & Wilkins, 2015, xi, 664. ISBN 9781451191776. info
    neurčeno
  • Pharmaceutical practice. Edited by Judith A. Rees - Ian Smith - Jennie Watson. 5th ed. Edinburgh: Churchill Livingstone Elsevier, 2014, xvii, 552. ISBN 9780702051432. info
  • Waller, Derek - Renwick, Andrew G. - Hillier, Keith. Medical pharmacology and therapeutics. 3rd ed. New York : Elsevier Saunders, 2009. ix, 744 p. ISBN 0-7020-2991-2.
  • Ritter, James M. - Lewis, Lionel D. - Mant, Timothy G.K. - Ferro, Albert. A Textbook of Clinical Pharmacology and Therapeutics, 5th Ed., Hodder Arnold, 2008. 465 s. ISBN 978-0-340-90046-8
  • LÜLLMANN, Heinz, Lutz HEIN a Klaus MOHR. Color atlas of pharmacology. Translated by Detlef Bierger, Illustrated by Jürgen Wirth. 4th ed. Stuttgart: Thieme, 2011, x, 393. ISBN 9783137817048. info
  • Pharmacology. Edited by Michelle Alexia Clark. 5th ed. Baltimore: Wolters Kluwer Health/Lippincott Williams & Wilkins, 2012, xii, 612. ISBN 9781451113143. info
Záložky
https://is.muni.cz/ln/tag/LF:aVLFA0721c!
Výukové metody
practicals, class discussion

Only 1 absence from practical lessons is possible.
Metody hodnocení
3 continuous multiple-choice tests (time limit: 15 min) and 1 prescription test in a paper form. MCQ tests will not be repeated. The prescription test can be repeated only twice.

Each multiple-choice test contains 15 questions. The number of correct answers is given. Student gets 1 point for each completely correct answer, i.e. maximum 15 points for each multiple-choice test; total 45 points for all three MCQ tests.

The prescription test consists of two read-made preparations. For both preparations, the active substance, the drug dosage form and the number of original packages to be prescribed will be listed. The prescription handbook will be available for the test.

To obtain credits, the student has to pass the prescription test successfully and also get at least 6 points from each single multiple-choice test and at least 20 points (minimum) from all three MCQ tests.

Note: Together with the new accreditation of the Pharmacology subject for students of General Medicine, a system of continuous assessment of the student was introduced, when the results achieved in multiple-choice tests in practical lessons and colloquium will be taken into account and included in the final mark from the subject.
Vyučovací jazyk
Angličtina
Informace učitele
Course Contents:

INTRODUCTION, TERMINOLOGY, DOSES, PHARMACOLOGICAL CALCULATIONS
GENERAL RULES OF THE DRUG PRESCRIPTION
FLUID DRUG DOSAGE FORMS FOR THE EXTERNAL USE, ORAL AND PARENTERAL USE. GASEOUS DRUG DOSAGE FORMS
SOLID DRUG DOSAGE FORMS. SOFT AND MELTING DRUG DOSAGE FORMS
ROUTES OF DRUG ADMINISTRATION
INTRODUCTION TO PHARMACOKINETICS, PRINCIPLES, PARAMETERS
PHARMACOKINETIC INTERACTIONS. THERAPEUTIC DRUG MONITORING
PHARMACODYNAMICS
ADVERSE DRUG REACTIONS
FACTORS AFFECTING DRUG EFFECTS
PHARMACOLOGY OF THE SYMPATHETIC NERVOUS SYSTEM SYMPATHOMIMETICS, SYMPATHOLYTICS
PHARMACOLOGY OF THE PARASYMPATHETIC NERVOUS SYSTEM CHOLINERGIC DRUGS, SPASMOLYTICS
PHARMACOLOGY OF ENDOCRINE SYSTEM
GLUCOCORTICOIDS
ANTI-DIABETIC DRUGS
SEX HORMONES, UTEROTONICS, TOCOLYTICS
ANALGESIC DRUGS
ANTIRHEUMATOID DRUGS
DRUGS USED IN GOUT
ANAESTHETIC DRUGS
MUSCLE RELAXANTS
Další komentáře
Studijní materiály
Předmět je vyučován každoročně.
Předmět je zařazen také v obdobích podzim 2017, podzim 2019, podzim 2020, podzim 2021, podzim 2022, podzim 2023.