aVLFA0721c Pharmacology I - practice

Faculty of Medicine
autumn 2018
Extent and Intensity
0/3/0. 1 credit(s). Type of Completion: z (credit).
Teacher(s)
doc. MUDr. Regina Demlová, Ph.D. (seminar tutor)
doc. PharmDr. Jan Juřica, Ph.D. (seminar tutor)
Mgr. Petra Amchová, Ph.D. (seminar tutor)
doc. RNDr. Ladislava Bartošová, Ph.D. (seminar tutor)
Mgr. Jana Kubátová, Ph.D. (seminar tutor)
doc. Mgr. MVDr. Leoš Landa, Ph.D. (seminar tutor)
Mgr. Kristýna Nosková, Ph.D. (seminar tutor)
MUDr. Jana Nováková, Ph.D. (seminar tutor)
PharmDr. Adriána Papiež, Ph.D. (seminar tutor)
MUDr. Jana Pistovčáková, Ph.D. (seminar tutor)
doc. PharmDr. Jana Rudá, Ph.D. (seminar tutor)
PharmDr. Jitka Rychlíčková, Ph.D. (seminar tutor)
Mgr. Barbora Říhová, Ph.D. (seminar tutor)
PharmDr. Lenka Součková, Ph.D. (seminar tutor)
MUDr. Filip Šiška (seminar tutor)
doc. PharmDr. Ondřej Zendulka, Ph.D. (seminar tutor)
Renata Bláblová (assistant)
Mgr. Kateřina Nebeská (alternate examiner)
Guaranteed by
doc. MUDr. Regina Demlová, Ph.D.
Department of Pharmacology – Theoretical Departments – Faculty of Medicine
Contact Person: Renata Bláblová
Supplier department: Department of Pharmacology – Theoretical Departments – Faculty of Medicine
Timetable of Seminar Groups
aVLFA0721c/30: Mon 24. 9. to Fri 11. 1. Tue 13:00–15:30 A19/326
aVLFA0721c/31: Mon 24. 9. to Fri 11. 1. Thu 14:00–16:30 A19/231
aVLFA0721c/32: Mon 24. 9. to Fri 11. 1. Tue 13:00–15:30 A19/231
aVLFA0721c/33: Mon 24. 9. to Fri 11. 1. Thu 14:00–16:30 A19/326
aVLFA0721c/34: Mon 24. 9. to Fri 11. 1. Thu 14:00–16:30 A19/229
aVLFA0721c/35: Mon 24. 9. to Fri 11. 1. Mon 16:00–18:30 A19/326
Prerequisites (in Czech)
aVLPF0622c Pathological Phys. II - prac. && aVLPA0622c Pathology II - practice
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The aims of the course are:
to recognize the basic pharmacological terminology and legislation related to the use of drugs and thei prescription
to understand to differences between single drug dosage forms
to understand to the prescription of drugs
to understand to the basics of pharmacokinetics
to understand to the basic facts about the discussed drugs
Learning outcomes
At the end of the course the student knows:
single pharmacoterapeutical drug classes
single drug dosage forms
the modes of action, adverse reactions and basic indications of single drugs of discussed drugs
how to prescribe selected medical preparation or a drug in particular drug dosage form
Syllabus

  • aVLFA0721c - Pharmacology I - practical lessons

    General medicine

    Autumn semester 2018

  • 1st week
  • Topic: INFORMATION ON DRUGS
  • Course content: Organisation of practical courses and lectures, system of evaluation. Repetition of basic pharmacologic terminology. Sub-branches of pharmacology. Sources of information concerning drugs and recommended textbooks. Work with relevant databases (Brevíř, SÚKL, EMA, AISLP), ATC classification.
  • Self-studying preparation for practical lessons: Lecture No. 1. Preparation for the next practical lesson: Principles of drug prescription in different countries, examples.
  • 2nd week
  • Topic: PRESCRIPTION OF MEDICAL PRODUCTS I
  • Course content: Principles of prescription in different countries, general rules of drug prescription, basic Latin terminology, essentials of individually prepared preparations prescription, introduction to prescription of ready-made drug products, databases EMA and Drugs.com, video Manufacturing of tablets.
  • Self-studying preparation for practical lessons: Latin terminology (+ abbreviations), Drug dosage forms from the textbook.
  • 3rd week
  • Topic: PRESCRIPTION OF MEDICAL PRODUCTS II, ROUTES OF DRUG ADMINISTRATION
  • Course content: Brief characteristics of the individual drug dosage forms. Prescription of ready-made drug products. Clinical significance of the way of drug administration.
  • Self-studying preparation for practical lessons: Materials for the Lecture No. 3, EMA and Drugs.com databases.
  • 4th week
  • Topic: PRINCIPLES OF PHARMACOKINETICS
  • Course content: Pharmacokinetic processes, parameters and calculations.
  • Self-studying preparation for practical lessons: Materials for the Lecture No. 4.
  • 5th week
  • Topic: PRINCIPLES OF APPLIED PHARMACOKINETICS
  • Course content: Pharmacokinetic case reports, simulation of plasma concentrations course, dosage optimalization and use of software tools, factors affecting course and value of drug´s plasma concentrations.
  • Self-studying preparation for practical lessons: Materials for the Lectures No. 4 and 5.
  • 6th week
  • Topic: PHARMACODYNAMICS
  • Course content: MULTIPLE-CHOICE TEST (1st - 5th week). Mechanisms of drug effects - classification, examples. Dose-response curves.
  • Self-studying preparation for practical lessons: Materials for the Lecture No. 6.
  • 7th week
  • Topic: ADVERSE DRUG REACTIONS
  • Course content: Classification and characteristics of adverse drug effects. Pharmacovigilance in clinical practice, sources of current information on drug safety. Databases of drug interactions. Pharmaceutical interactions (case reports).
  • Self-studying preparation for practical lessons: Materials for the Lecture No. 7, case report (drug incompatibility) materials in IS.
  • 8th week
  • Topic: FACTORS AFFECTING DRUG EFFECTS
  • Course content: Pharmacotherapy in childhood, in pregnancy, in breastfeeding women, in elderly. Pharmacogenetics.
  • Self-studying preparation for practical lessons: Materials for the Lecture No. 8. Pharmacogenetics - materials in IS.
  • 9th week
  • Topic: PHARMACOLOGY OF SYMPATHETIC NERVOUS SYSTEM
  • Course content: Drugs affecting sympathetic nervous system - classification, basic pharmacological characteristics.
  • Self-studying preparation for practical lessons: Materials for the Lecture No. 9. Pathophysiological bases - ANS, neurotransmitters (their synthesis and degradation), receptors of the sympathetic nervous system (alpha, beta) and parasympathetic nervous system (nicotinic, muscarinic) and their subtypes and organ distribution. Systems of second messengers. Pharmacodynamics, both direct and indirect mechanisms of action.
  • 10th week
  • Topic: PHARMACOLOGY OF PARASYMPATHETIC NERVOUS SYSTEM
  • Course content: Drugs affecting parasympathetic nervous system - classification, basic pharmacological characteristics. Spasmolytic drugs.
  • Self-studying preparation for practical lessons: Materials for the Lectures No. 9. Spasmolytic drugs.
  • 11th week
  • Topic: GLUCOCORTICOIDS, DRUGS OF ABUSE
  • Course content: MULTIPLE-CHOICE TEST (6th - 10th week). Repetition of basic pharmacological characteristics of glucocorticoids. Problems of drug abuse, doping and falsification of medical products.
  • Self-studying preparation for practical lessons: Materials for the Lecture No. 11, preparation of oral presentation should be uploaded to IS at least 24 hours prior to the practical lesson.
  • 12th week
  • Topic: PHARMACOTHERAPY OF DIABETES MELLITUS
  • Course content: Repetition of anti-diabetic drugs - basic pharmacological characteristics. Drugs used in therapy of specific and acute conditions in diabetology. Combinations of insulins, insulin regimens.
  • Self-studying preparation for practical lessons: Materials for the Lecture No. 12, preparation of oral presentation - presentation should be uploaded to IS at least 24 hours prior to the practical lesson.
  • 13th week
  • Topic: SEX HORMONES
  • Course content: Endocrine therapy, hormone replacement therapy, hormonal contraceptive drugs.
  • Self-studying preparation for practical lessons: Uterotonics and tocolytics.
  • 14th week
  • Topic: ANALGESIC DRUGS
  • Course content: MULTIPLE-CHOICE TEST (11th - 13th week). Basic pharmacological characteristics of opioid and non-opioid analgesic drugs, antirheumatoid drugs and drugs used in gout.
  • Self-studying preparation for practical lessons: Materials for the Lecture No. 14. Drugs used in gout.
  • 15th week
  • Topic: ANAESTHETIC DRUGS
  • Course content: PRESCRIPTION TEST. Basic pharmacological characteristics of general and local anaesthetic drugs. Premedication prior to general anaesthesia.
  • Self-studying preparation for practical lessons: Materials for the Lecture No. 15. Skeletal muscle relaxants.
Literature
    required literature
  • Practicals in Pharmacology, 2009, Náhradní obsah: http://portal.med.muni.cz/article-491-practicals-in-pharmacology.html
  • http://search.ebscohost.com/login.aspx?direct=true&db=nlebk&AN=1160493&lang=cs&site=ehost-live
  • RANG, H. P., James RITTER, R. J. FLOWER and Graeme HENDERSON. Rang & Dale's pharmacology. Eighth edition. [Edinburgh]: Churchill Livingstone. xv, 760. ISBN 9780702053627. 2016. info
    recommended literature
  • WHALEN, Karen. Pharmacology. Edited by Richard Finkel - Thomas A. Panavelil. 6th ed. Philadelphia, Pa.: Lippincott Williams & Wilkins. xi, 664. ISBN 9781451191776. 2015. info
    not specified
  • Pharmaceutical practice. Edited by Judith A. Rees - Ian Smith - Jennie Watson. 5th ed. Edinburgh: Churchill Livingstone Elsevier. xvii, 552. ISBN 9780702051432. 2014. info
  • Waller, Derek - Renwick, Andrew G. - Hillier, Keith. Medical pharmacology and therapeutics. 3rd ed. New York : Elsevier Saunders, 2009. ix, 744 p. ISBN 0-7020-2991-2.
  • Ritter, James M. - Lewis, Lionel D. - Mant, Timothy G.K. - Ferro, Albert. A Textbook of Clinical Pharmacology and Therapeutics, 5th Ed., Hodder Arnold, 2008. 465 s. ISBN 978-0-340-90046-8
  • LÜLLMANN, Heinz, Lutz HEIN and Klaus MOHR. Color atlas of pharmacology. Translated by Detlef Bierger, Illustrated by Jürgen Wirth. 4th ed. Stuttgart: Thieme. x, 393. ISBN 9783137817048. 2011. info
  • Pharmacology. Edited by Michelle Alexia Clark. 5th ed. Baltimore: Wolters Kluwer Health/Lippincott Williams & Wilkins. xii, 612. ISBN 9781451113143. 2012. info
Bookmarks
https://is.muni.cz/ln/tag/LF:aVLFA0721c!
Teaching methods
practicals, class discussion

Only 1 absence from practical lessons is possible.
Assessment methods
3 continuous multiple-choice tests (time limit: 15 min) and 1 prescription test in a paper form. MCQ tests will not be repeated. The prescription test can be repeated only twice.

Each multiple-choice test contains 15 questions. The number of correct answers is given. Student gets 1 point for each completely correct answer, i.e. maximum 15 points for each multiple-choice test; total 45 points for all three MCQ tests.

The prescription test consists of two read-made preparations. For both preparations, the active substance, the drug dosage form and the number of original packages to be prescribed will be listed. The prescription handbook will be available for the test.

To obtain credits, the student has to pass the prescription test successfully and also get at least 6 points from each single multiple-choice test and at least 20 points (minimum) from all three MCQ tests.

Note: Together with the new accreditation of the Pharmacology subject for students of General Medicine, a system of continuous assessment of the student was introduced, when the results achieved in multiple-choice tests in practical lessons and colloquium will be taken into account and included in the final mark from the subject.
Language of instruction
English
Further comments (probably available only in Czech)
Study Materials
The course is taught annually.
Information on the extent and intensity of the course: 45.
The course is also listed under the following terms Autumn 2017, autumn 2019, autumn 2020, autumn 2021, autumn 2022, autumn 2023.
  • Enrolment Statistics (autumn 2018, recent)
  • Permalink: https://is.muni.cz/course/med/autumn2018/aVLFA0721c