F1FG2_12 Pharmacognosy II

Faculty of Pharmacy
Spring 2020
Extent and Intensity
2/5/0. 10 credit(s). Type of Completion: zk (examination).
Teacher(s)
doc. PharmDr. Renata Kubínová, Ph.D. (lecturer)
prof. RNDr. Václav Suchý, DrSc., dr. h.c. (lecturer)
prof. PharmDr. Karel Šmejkal, Ph.D. (lecturer)
PharmDr. Marie Čulenová, Ph.D. (seminar tutor)
PharmDr. Ivana Daňková, Ph.D. (seminar tutor)
PharmDr. Margita Dvorská, Ph.D. (seminar tutor)
PharmDr. Markéta Gazdová, Ph.D. (seminar tutor)
PharmDr. Dagmar Jankovská, Ph.D. (seminar tutor)
PharmDr. Petra Kaucká, Ph.D. (seminar tutor)
doc. PharmDr. Renata Kubínová, Ph.D. (seminar tutor)
PharmDr. Alice Sychrová, Ph.D. (seminar tutor)
prof. PharmDr. Karel Šmejkal, Ph.D. (seminar tutor)
Mgr. Ing. Jiří Václavík, Ph.D. (seminar tutor)
Guaranteed by
Department of Natural Drugs – Departments – Faculty of Pharmacy
Prerequisites
The students should have passed basic subject touching organic chemistry, analytical chemistry, biology, botany, and physiology.
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
Objectives of Pharmacognosy are to impart knowledges of those drugs of biological origin and their constituents that are of value for their therapeutic, profylactic and diagnostic use in the human and veterinary medicine.
Its scope includes the study of the physical, chemical, biochemical and biological properties of drugs, drug substances, or potential drugs or drug substances of natural origin as well as the search for new drugs from natural sources. Research problems in pharmacognosy include studies in the areas of phytochemistry, microbial chemistry, biosynthesis, biotransformation, chemotaxonomy, and other biological and chemical sciences.
Pharmacognosy represents a highly interdisciplinary science which is one of five major areas of pharmaceutical education.

Learning outcomes
The student must be able to microscopically and macroscopically identify selected drugs, know their main content substances, use, basic biosynthetic reactions, basal classes of secondary metabolites. Know the main plants used in the pharmacy. Chemical characteristics of secondary metabolites, basic knowledge of structure-activity relationships, basic knowledge of adverse effects and interactions.
Syllabus
  • Syllabus of lectures
    " Drugs affecting the central and peripheral nervous system
    " Drugs affecting vegetative nervous system
    " Drugs affecting the cardiovascular system
    " Drugs affecting hemocoagulation, fibrinolysis and used as the substitution of blood plasma
    " Drugs affecting water balance of the organism
    " Drugs affecting the respiratory system
    " Drugs affecting the digestive system
    " Uterotonics, antiuratics, antiphlogistics
    " Dietetics, roborants, geriatrics, sources of vitamins, supporting therapy of diabetes mellitus
    " Hormones, enzymes
    " Anti-infectious and anti-invasive drugs
    " Drugs used for their local anesthetic activity
    " Biogenic additives
    " Natural substances inspirational for synthesis
    SYLABUS OF PRACTICAL CLASSES FROM PHARMACOGNOSY II
    1. Drugs containing carbohydrates
    Identification assays
    Purity assays
    2. Drugs containing polysaccharides and mucilages
    Identification assays
    Determination of number of swelling
    3. Drugs containing phenolics glycosides
    Identification assays
    Chromatographic proof of hydroquinones and arbutin
    Determination of arbutin content by titration
    4. Drugs containing cardioglycosides (test no. 1)
    Identification assays
    Chromatographic proof
    Colorimetric determination
    5. Drugs containing the anthracene derivatives
    Identification assays
    Chromatographic proof of anthraquinone derivatives
    Quantification of hypericin
    6. Drugs containing flavonoid glycosides
    Identification assays
    Colorimetric quantification of flavonoids
    Chromatographic proof
    7. Drugs containing saponins (test no. 2)
    Identification assays
    Determination of hemolytic activity using blood agar
    Determination of foaming power according to Kofler
    Quantification of glycyrrhizinic acid
    8. Drugs containing tannins
    Identification assays color, precipitation
    Chromatographic proof
    Quantification of tannins in drug quantification of total phenolics
    9. Drugs containing essential oils
    Identification assays
    Chromatographic proof
    Quantification of essential oils
    10. Drugs containing alkaloids I. (test no. 3)
    Precipitation and color reaction of alkaloids
    Quantification of tropane alkaloids using titration
    11. Drugs containing alkaloids II.
    Precipitation and color reaction of alkaloids
    Gravimetric quantification of purine alkaloids
    Thin layer chromatography of opium alkaloids
    12. Drugs containing bitter substances
    Identification assays
    Determination of number of bitterness
    13. Drugs containing thioglycosides of Brassicaceae
    Identification assays and purity
    14. Drugs containing coumarins, anthocyanins ( test no. 4)
    Chromatographic proof
Literature
    required literature
  • Šmejkal, K., Kubínová, R., Suchý, V. Farmakognozie část obecná. ISBN 978-80-7305-785-5. 2016. info
  • Kubínová R., Jankovská D. Obrazový atlas farmaceuticky významných drog. Brno. ISBN 978-80-7305-667-4. 2013. info
  • Suchý V. a kol. Praktická cvičení z farmakognosie. Brno. ISBN 978-80-7305-659-9. 2013. info
  • Tomko, J. a kol. Farmakognózia. Osveta, 1999. info
  • Suchý, V. Farmakognosie, část všeobecná, část speciální I. UK Bratislava, 1994. info
    recommended literature
  • Český lékopis 2017. ISBN 859-404-924-045-6. 2017. info
  • Nagy, M., Mučaji, P., Grančai, D. Farmakognózia. ISBN 9788089631643. 2017. info
  • Samuelsson G., Bohlin L. Drugs of Natural Origin. A Treatise of Pharmacognosy. 7th revised edition. 2015. info
  • Grančai, D., Nagy, M., Mučaji, P. Farmakognózia - Biogenéza prírodných látok. ISBN 978-80-8063-368-4. 2015. info
  • Suchý V. Fytofarmaka. In Kuchař M. ed. Farmaceutický encyklopedický slovník. Praha, 2014. info
  • Wichtl M. Herbal Drugs and Phytopharmaceuticals. 2002. info
  • Dewick P.M. Medicinal Natural Products. 2002. info
  • Bruneton J. Pharmacognosy, Phytochemistry, Medicinal Plants. 1999. info
  • Bučková, A. a kol. Praktické cvičenia z farmakognózie, chemická časť. UK Bratislava, 1993. info
  • Mika, K. Fytoterapia. Osveta, 1988. info
  • Kindl, H., Vöber, B. Biochemie rostlin. Academia Praha, 1981. info
Teaching methods (in Czech)
Dialogická (diskuze, rozhovor, brainstorming)
Metody písemných akcí (např. u souborných zkoušek, klauzur)
Demonstrace
Nácvik pohybových a pracovních dovedností
Laborování
Assessment methods (in Czech)
Známkou
Písemná zkouška
Rozhovor
Language of instruction
Czech
Further comments (probably available only in Czech)
Study Materials
The course can also be completed outside the examination period.
Teacher's information
100% of attendance of practical classes.
To pass all tests with a minimum of 60 %.
Prior to the theoretical examination to pass the practical examination (10 macroscopic and 3 microscopic preparations) to show the knowledge of drugs, their content compounds, usage and common identification methods.
Knowledge of Pharmacognosiy within the range of syllabus.
The course is also listed under the following terms Spring 2021, Spring 2022, Spring 2023, Spring 2024.
  • Enrolment Statistics (Spring 2020, recent)
  • Permalink: https://is.muni.cz/course/pharm/spring2020/F1FG2_12