FaF:F1LF1_13 Theory of Dosage Forms - Course Information
F1LF1_13 Theory of Dosage Forms
Faculty of PharmacyAutumn 2021
- Extent and Intensity
- 2/1/0. 4 credit(s). Type of Completion: zk (examination).
Taught in person. - Teacher(s)
- prof. PharmDr. Mgr. David Vetchý, Ph.D. (lecturer)
doc. PharmDr. Jan Gajdziok, Ph.D. (lecturer)
PharmDr. Jan Elbl, Ph.D. (lecturer)
doc. Mgr. Jan Muselík, Ph.D. (seminar tutor)
PharmDr. Jiří Zeman, Ph.D. (seminar tutor)
Mgr. Sylvie Pavloková, Ph.D. (seminar tutor)
PharmDr. Jan Elbl, Ph.D. (seminar tutor)
Mgr. Jan Macků (seminar tutor)
PharmDr. Tomáš Bílik (seminar tutor) - Guaranteed by
- prof. PharmDr. Mgr. David Vetchý, Ph.D.
Department of Pharmaceutical Technology – Departments – Faculty of Pharmacy
Supplier department: Department of Pharmaceutical Technology – Departments – Faculty of Pharmacy - Timetable
- Mon 9:45–11:25 posluchárna, -056
- Timetable of Seminar Groups:
F1LF1_13/02: Mon 20. 9. 15:35–16:25 posluchárna, 122, 16:25–18:55 laboratoř, 138, Mon 11. 10. 15:35–16:25 posluchárna, 122, 16:25–18:55 laboratoř, 138, Mon 1. 11. 15:35–16:25 posluchárna, 122, 16:25–18:55 laboratoř, 138, Mon 22. 11. 15:35–17:15 laboratoř, 138, J. Zeman
F1LF1_13/03: Mon 27. 9. 15:35–16:25 posluchárna, 122, 16:25–18:55 laboratoř, 138, Mon 18. 10. 15:35–16:25 posluchárna, 122, 16:25–18:55 laboratoř, 138, Mon 8. 11. 15:35–16:25 posluchárna, 122, 16:25–18:55 laboratoř, 138, Mon 29. 11. 15:35–17:15 laboratoř, 138, J. Elbl
F1LF1_13/04: Thu 16. 9. 7:00–7:50 posluchárna, 122, 7:50–10:20 laboratoř, 138, Thu 7. 10. 7:00–7:50 posluchárna, 122, 7:50–10:20 laboratoř, 138, Thu 4. 11. 7:00–7:50 posluchárna, 122, 7:50–10:20 laboratoř, 138, Thu 25. 11. 7:00–8:40 laboratoř, 138, S. Pavloková
F1LF1_13/05: Thu 23. 9. 7:00–7:50 posluchárna, 122, 7:50–10:20 laboratoř, 138, Thu 14. 10. 7:00–7:50 posluchárna, 122, 7:50–10:20 laboratoř, 138, Thu 11. 11. 7:00–7:50 posluchárna, 122, 7:50–10:20 laboratoř, 138, Thu 2. 12. 7:00–8:40 laboratoř, 138
F1LF1_13/06: Thu 30. 9. 7:00–7:50 posluchárna, 122, 7:50–10:20 laboratoř, 138, Thu 21. 10. 7:00–7:50 posluchárna, 122, 7:50–10:20 laboratoř, 138, Thu 18. 11. 7:00–7:50 posluchárna, 122, 7:50–10:20 laboratoř, 138, Thu 9. 12. 7:00–8:40 laboratoř, 138, J. Macků - Prerequisites (in Czech)
- FAKULTA ( FaF ) || OBOR ( MUSFaF )
- Course Enrolment Limitations
- The course is only offered to the students of the study fields the course is directly associated with.
- fields of study / plans the course is directly associated with
- Pharmacy (programme FaF, M-FARM)
- Multidisciplinary studies at Faculty of Pharmacy (programme CST, KOS)
- Course objectives
- The aim of the course is to acquaint students with the basics and principles of drug formulation, methods and processes used in the design and development of dosage forms and stability studies.
- Learning outcomes
- After completing the course, the student will be able to:
– identify and classify the dosage form into one of the three generations according to the nature of the drug release;
– describe procedures leading to increased bioavailability of drugs;
– describe the production and evaluation of mucoadhesive systems, ion exchangers and biological dosage forms;
– describe the principles of 3D printing for the preparation of dosage forms;
– describe in vitro – in vivo models in drug development. - Syllabus
- LECTURES:
- Introduction to the field of pharmaceutical technology. Drug (active substance), dosage forms, medicine. The importance of biopharmacy and pharmacokinetics in the formulation and development of pharmaceuticals. Generation of dosage forms. Dosage forms of the first generation.
- Dosage forms of the second and the third generation.
- Physico-chemical factors influencing the effect of the drug.
- Biological factors influencing the effect of the drug.
- Preformulation studies, drug formulation, drug validation.
- Increasing bioavailability of poorly water soluble drugs by their modification.
- Increasing bioavailability of poorly water soluble drugs by technological methods facilitating drug dissolution.
- Lipophilic formulations for increasing bioavailability of poorly water-soluble drugs.
- Liquid-solid systems and their application in pharmacy. Dosage forms based on these systems.
- Mucoadhesive systems and their application in pharmacy. Dosage forms based on these systems.
- 3D printing and its application in pharmacy. Dosage forms based on this technology.
- Ion exchangers and their application in pharmacy. Dosage forms based on ion exchangers. Production of biological dosage forms.
- In vitro – in vivo models in drug development.
LABORATORY EXERCISES: - Preparation and evaluation of mucoadhesive oral films (MOF).
- Surface tension measurement by stalagmometric method.
- Evaluation of aggregate state of suspension.
- Literature
- required literature
- www.chemicke-listy.cz. Chem. Listy 104, 21-26 (2010). Chem. Listy 105, 34-40 (2011), Chem. Listy 106, 3-9 (2012). info
- Sinko, P.T., Singh, Y. Martin's Physical Pharmacy 2011. info
- Komárek, P., Rabišková, M. Technologie léků. Galén Praha, 2006. info
- Komárek, P., Rabišková, M. Technologie léků. Galén, Praha. ISBN 80-7262-423-7. 2006. info
- Teaching methods
- lectures, laboratory exercises
- Assessment methods
- credit, oral exam
- Language of instruction
- Czech
- Further comments (probably available only in Czech)
- The course can also be completed outside the examination period.
- Teacher's information
- Lectures recommended due to lack of suitable literature. Participate in exercises in the full range given by the syllabus and properly prepare protocols from laboratory exercises. Demonstrate ongoing knowledge in the preparation for laboratory exercices. The condition for participation in the exam is to obtain a credit.
- Enrolment Statistics (Autumn 2021, recent)
- Permalink: https://is.muni.cz/course/pharm/autumn2021/F1LF1_13