F1LF1_13 Theory of Dosage Forms

Faculty of Pharmacy
Autumn 2022
Extent and Intensity
2/1/0. 4 credit(s). Type of Completion: zk (examination).
Teacher(s)
prof. PharmDr. Mgr. David Vetchý, Ph.D. (lecturer)
doc. PharmDr. Jan Gajdziok, Ph.D. (lecturer)
PharmDr. Jan Elbl, Ph.D. (lecturer)
doc. Mgr. Jan Muselík, Ph.D. (seminar tutor)
PharmDr. Jiří Zeman, Ph.D. (seminar tutor)
Mgr. Sylvie Pavloková, Ph.D. (seminar tutor)
PharmDr. Jan Elbl, Ph.D. (seminar tutor)
Mgr. Jan Macků (seminar tutor)
Guaranteed by
prof. PharmDr. Mgr. David Vetchý, Ph.D.
Department of Pharmaceutical Technology – Departments – Faculty of Pharmacy
Supplier department: Department of Pharmaceutical Technology – Departments – Faculty of Pharmacy
Timetable
Mon 9:55–11:35 44-056
  • Timetable of Seminar Groups:
F1LF1_13/01: Mon 12. 9. 15:35–16:25 18-122, 16:25–18:55 18-138, Mon 3. 10. 15:35–16:25 18-122, 16:25–18:55 18-138, Mon 24. 10. 15:35–16:25 18-122, 16:25–18:55 18-138, Mon 14. 11. 15:35–17:15 18-122, J. Muselík
F1LF1_13/02: Mon 19. 9. 15:35–16:25 18-122, 16:25–18:55 18-138, Mon 10. 10. 15:35–16:25 18-122, 16:25–18:55 18-138, Mon 31. 10. 15:35–16:25 18-122, 16:25–18:55 18-138, Mon 21. 11. 15:35–17:15 18-122, J. Elbl
F1LF1_13/03: Mon 26. 9. 15:35–16:25 18-122, 16:25–18:55 18-138, Mon 17. 10. 15:35–16:25 18-122, 16:25–18:55 18-138, Mon 7. 11. 15:35–16:25 18-122, 16:25–18:55 18-138, Mon 28. 11. 15:35–17:15 18-122, J. Macků
F1LF1_13/04: Thu 15. 9. 7:00–7:50 18-122, 7:50–10:20 18-138, Thu 6. 10. 7:00–7:50 18-122, 7:50–10:20 18-138, Thu 27. 10. 7:00–7:50 18-122, 7:50–10:20 18-138, Thu 10. 11. 7:00–8:40 18-122, S. Pavloková
F1LF1_13/05: Thu 22. 9. 7:00–7:50 18-122, 7:50–10:20 18-138, Thu 13. 10. 7:00–7:50 18-122, 7:50–10:20 18-138, Thu 3. 11. 7:00–7:50 18-122, 7:50–10:20 18-138, Thu 24. 11. 7:00–8:40 18-122, J. Zeman
Prerequisites (in Czech)
FAKULTA(FaF) || OBOR(MUSFaF)
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The aim of the course is to acquaint students with the basics and principles of drug formulation, methods and processes used in the design and development of dosage forms and stability studies.
Learning outcomes
After completing the course, the student will be able to:
– identify and classify the dosage form into one of the three generations according to the nature of the drug release;
– describe procedures leading to increased bioavailability of drugs;
– describe the production and evaluation of mucoadhesive systems, ion exchangers and biological dosage forms;
– describe the principles of 3D printing for the preparation of dosage forms;
– describe in vitro – in vivo models in drug development.
Syllabus
  • LECTURES:
  • Introduction to the field of pharmaceutical technology. Drug (active substance), dosage forms, medicine. The importance of biopharmacy and pharmacokinetics in the formulation and development of pharmaceuticals. Generation of dosage forms. Dosage forms of the first generation.
  • Dosage forms of the second and the third generation.
  • Physico-chemical factors influencing the effect of the drug.
  • Biological factors influencing the effect of the drug.
  • Preformulation studies, drug formulation, drug validation.
  • Increasing bioavailability of poorly water soluble drugs by their modification.
  • Increasing bioavailability of poorly water soluble drugs by technological methods facilitating drug dissolution.
  • Lipophilic formulations for increasing bioavailability of poorly water-soluble drugs.
  • Liquid-solid systems and their application in pharmacy. Dosage forms based on these systems.
  • Mucoadhesive systems and their application in pharmacy. Dosage forms based on these systems.
  • 3D printing and its application in pharmacy. Dosage forms based on this technology.
  • Ion exchangers and their application in pharmacy. Dosage forms based on ion exchangers. Production of biological dosage forms.
  • In vitro – in vivo models in drug development.

    LABORATORY EXERCISES:
  • Preparation and evaluation of mucoadhesive oral films (MOF).
  • Surface tension measurement by stalagmometric method.
  • Evaluation of aggregate state of suspension.
  • Written test.
Literature
    required literature
  • www.chemicke-listy.cz. Chem. Listy 104, 21-26 (2010). Chem. Listy 105, 34-40 (2011), Chem. Listy 106, 3-9 (2012). info
  • Sinko, P.T., Singh, Y. Martin's Physical Pharmacy 2011. info
  • Komárek, P., Rabišková, M. Technologie léků. Galén Praha, 2006. info
  • Komárek, P., Rabišková, M. Technologie léků. Galén, Praha, 2006. ISBN 80-7262-423-7. info
    not specified
  • Česká a slovenská farmacie. info
  • Zathurecký, L., Chalabala, M., Janků, I., Modr., Z. Biofarmácia a farmakokinetika. Osveta Martin, 1989. ISBN 80-217-0068-8. info
  • Chalabala, M., Heinrich, J. Základy výroby a tvorby liekov. Osveta Martin, 1988. info
Teaching methods
lectures, laboratory exercises
Assessment methods
written test (content of laboratory exercises; to participate in exam, you need to get at least 60 % of points), oral exam
Language of instruction
Czech
Further comments (probably available only in Czech)
The course can also be completed outside the examination period.
Teacher's information
Lectures recommended due to lack of suitable literature.

Conditions of participation in the exam:

Participate in exercises in the full range given by the syllabus, demonstrate ongoing knowledge in the preparation for laboratory exercices, properly prepare protocols from laboratory exercises and successfully pass written test (min. 60 % of points). If any of the above conditions are not met, the student cannot participate in the final exam.

The course is also listed under the following terms Autumn 2020, Autumn 2021, Autumn 2023, Autumn 2024.
  • Enrolment Statistics (Autumn 2022, recent)
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