FaF:FABL1_16 Biotechnology of Drugs - Informace o předmětu

FABL1_16 Biotechnology of Drugs

Rozsah

3/0/0. 3 kr. Ukončení: zk.
Vyučováno online.

Vyučující

Mgr. Marie Brázdová, Ph.D. (přednášející)
prof. Ing. René Kizek, DrSc., MBA (přednášející)

Garance

prof. Ing. René Kizek, DrSc., MBA
Ústav molekulární farmacie – Ústavy – Farmaceutická fakulta

Rozvrh

Čt 13:00–15:15 45-224

• Rozvrh seminárních/paralelních skupin:

FABL1_16/01: Rozvrh nebyl do ISu vložen.

Předpoklady

The knowledge of subject in range of lectures

Omezení zápisu do předmětu

Předmět je určen pouze studentům mateřských oborů.

Předmět si smí zapsat nejvýše 24 stud.
Momentální stav registrace a zápisu: zapsáno: 0/24, pouze zareg.: 0/24

Mateřské obory/plány

• Multidisciplinární studia na farmaceutické fakultě (program CST, KOS)
• Pharmacy (program FaF, M-FARMA)

Cíle předmětu

The course is demonstration of Pharmaceutical Biotechnology - scientific discipline focusing on all technologies required for the production, manufacturing and registration of biotechnological drugs. Students will be introduced to processes which are used by organisms or their parts to production or modification of drugs. The methods used for breeding of animals, plants and microorganisms usable in medicine and pharmacy will be discussed. The main focus is done for recombinant techniques, gene and protein engineering and gene therapy. Products of industrial biotechnology as antibiotics, vitamins, organic acids, amino acids and alkaloids, will be presented.

Výstupy z učení

Basic knowledge from cytology, gene engineering and industrial microbiology usable in recombinant drugs design, development and production. View to biotechnological production of antibiotics, vitamins, organic acids, amino acids and alkaloids.

Osnova

• 1) Introduction to pharmaceutical biotechnology, definition, milestones
  2) The cell as a tool of biotechnology, function of endoplasmic reticulum, Golgi komplex, posttranslational processes, chaperones
  3) The basics of gene engineering I - the principles, how to prepare recombinant gene, vectors
  4) The basics of gene engineering II - preparation of genes for cloning, host cells, transformation, selection and transformants identification
  5) Expression of recombinant proteins in prokaryotic cells and yeasts
  6) Expression of recombinant proteins in eukaryotic cells - insect cells and baculoviruses, mammalian cells and adenoviruses
  7) The classical biotechnological processes in pharmacology
  8) The process of biotechnology - definition, the phases of biotechnological process, basic materials, fermentors and bioreactors, methods of biotechnological products purification
  9) Examples of classical and recombinant biotechnology products in pharmacy, cytokines, hormones, enzymes, antibodies and their derivates
  10) Gene engineering of plants - structure of plant genome, vectors, expression cassettes
  11) Plant biotechnology - methods of transformation and transgene identification, molecular pharming
  12) Application of gene engineering and plant biotechnology in pharmacy, medicine, and food industry, rules for genetically modified organisms manipulation
  13) Gene and cell therapy, tissue engineering, genomics and proteomics in pharmacy
  14) New trends in biopharmaceutical products development
  

Literatura

povinná literatura
• Brown, T.A. (2010). Gene cloning and DNA analysis, an introduction. 6th edition, Wiley-Blackwell. info
• Alberts et al. (1998). Molecular Biology of the Cell, 5th edition, GS Garland Science. info
• Walsh, G. (2007). Pharmaceutical Biotechnology, John Wiley and sons. info
• HO, R. J. Y. , GIBALDI, M. Biotechnology and Biopharmaceuticals. Transforming proteins and genes into drugs. John Willey and Sons, Hobokey, New Jersey, U.S.A, 2003. info
• SLATER, A., SCOTT, N., FOWLER, M. Plant biotechnology. The genetic manipulation of plants. Oxford University Press. Oxford, New York, U.S.A, 2003. info

doporučená literatura
• Alberts et al. Essential cell biology. Garland Science, Taylor and Francis Group. ISBN 0-8153-3481-8. info

neurčeno
• KAYSER, O., MÜLLER, R.H. Pharmaceutical Biotechnology. Wiley-VCH Verlag GmbH and Co. KGaA, Weinheim, Ge, 2004. info

Výukové metody

Monologic (reading, lecture, briefing)

Metody hodnocení

Oral exam
Written exam

Vyučovací jazyk

Angličtina

Informace učitele

Credits from practical course
Test: at least 50 % of credits
Oral examination

Activity	Difficulty [h]
Domácí příprava na výuku	12
Příprava na zkoušku	24
Účast na výuce	36
Summary	72

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• Statistika zápisu (jaro 2021, nejnovější)
  
• Permalink: https://is.muni.cz/predmet/pharm/jaro2021/FABL1_16