FAIA1_13 Instrumental Analytical Methods in Pharmaceutical Technology

Faculty of Pharmacy
Autumn 2024

The course is not taught in Autumn 2024

Extent and Intensity
1/1/0. 3 credit(s). Type of Completion: zk (examination).
In-person direct teaching
Teacher(s)
doc. Mgr. Jan Muselík, Ph.D. (lecturer)
doc. Mgr. Jan Muselík, Ph.D. (seminar tutor)
Guaranteed by
doc. Mgr. Jan Muselík, Ph.D.
Department of Pharmaceutical Technology – Departments – Faculty of Pharmacy
Prerequisites (in Czech)
FAKULTA(FaF) || OBOR(MUSFaF)
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The subject named "Instrumental analytical methods in the pharmaceutical technology" is dealing with modern instrumental methods useful in the field of the pharmaceutical technology, development and industry. The main aim of this subject is to create a comprehensive overview of methods used for the evaluation, analysis and quality control of pharmaceutical dosage forms. Main topics: Near and middle infrared spectroscopy, dissolution tests and drug content analysis (UV/VIS spectrophotometry, HPLC), light and electron microscopy, laser diffraction analysis, X-ray diffraction analysis, thermal analysis. The theoretical principles of selected methods are discussed and their practical applications are demonstrated.
Syllabus
  • 1 Middle and near infrared spectroscopy, principles, instrumentation, measurement techniques.
    Lecturer: Mgr. Jan Muselík, Ph.D.
    2 Applications of infrared spectroscopy, evaluation of spectra
    Lecturer: Mgr. Jan Muselík, Ph.D.
    3 Dissolution test, methods of determination of active compound content (UV/VIS spectrophotometry).
    Lecturer: Mgr. Jan Muselík, Ph.D.
    4 Methods of determination of active compound content (HPLC).
    Lecturer: Mgr. Jan Muselík, Ph.D
    5 Light microscopy.
    Lecturer: PharmDr. Martina Bajerová
    6 Scanning, transmission and environmental electron microscopy.
    Lecturer: PharmDr. Martina Bajerová
    7 Scanning probe microscopy.
    Lecturer: PharmDr. Martina Bajerová
    8 Methods of particle size determination (light microscopy, sedimentation analysis, sieve analysis, Coulter counter).
    Lecturer: PharmDr. Martina Bajerová
    9 Methods of particle size determination - laser diffraction
    Lecturer: PharmDr. Martina Bajerová
    10 X-ray analysis, instrumentation and applications in pharmaceutical technology.
    Lecturer: Mgr. Jan Muselík, Ph.D.
    11 Methods of thermal analysis (differential thermal analysis - DTA, thermogravimetry - TGA).
    Lecturer: Mgr. Jan Muselík, Ph.D.
    12 Methods of thermal analysis (differential scanning calorimetry - DSC).
    Lecturer: Mgr. Jan Muselík, Ph.D.
    13 Tutorial giving

    SYLABUS OF LABORATORY PRACTISE
    1.-3. FT-NIR (analysis of model samples, evaluation of spectra by chemometric methods).
    4.-6. Optimization of chromatographic conditions, dissolution test of dosage form, chromatographic determination of active compound content.
    7.-8. Light microscopy - image analysis (analysis of model sample, e.g. pellets, microparticles, powders).
    9. Evaluation of DSC, TGA a XRPD spectra. Calculations.
    10. Evaluation of effects of processing factors on dissolution profile.
    11.-13. Excursion to the laboratory of scanning electron microscopy.
Literature
    recommended literature
  • Brown M. E. 1. Introduction to Thermal Analysis: Techniques and Applications. New York, 2004. ISBN 1-4020-0472-9. info
  • Ciurczak E. W. Pharmaceutical and Medical Applications of Near-Infrared Spectroscopy. New York, 2002. ISBN 0-8247-9453-2. info
Language of instruction
English
Further Comments
The course can also be completed outside the examination period.
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