FASU1_13 Physical Chemistry

Farmaceutická fakulta
jaro 2025
Rozsah
2/2/0. 6 kr. Ukončení: zk.
Vyučováno kontaktně
Vyučující
doc. Mgr. Jan Muselík, Ph.D. (přednášející)
prof. PharmDr. Mgr. David Vetchý, Ph.D. (přednášející)
doc. Mgr. Jan Muselík, Ph.D. (cvičící)
PharmDr. Jiří Zeman, Ph.D. (cvičící)
Garance
prof. PharmDr. Mgr. David Vetchý, Ph.D.
Ústav farmaceutické technologie – Ústavy – Farmaceutická fakulta
Omezení zápisu do předmětu
Předmět je určen pouze studentům mateřských oborů.

Předmět si smí zapsat nejvýše 24 stud.
Momentální stav registrace a zápisu: zapsáno: 0/24, pouze zareg.: 0/24
Mateřské obory/plány
Cíle předmětu
The course aims to acquaint students with basic knowledge of physical chemistry, which forms part of the theoretical basis necessary for understanding the processes delivered within disciplines in further stages of the study. Lectures are divided according to the basic part of physical and colloid chemistry, such as thermodynamics, kinetics of chemical reactions, the behavior of solutions, electrochemistry, phase equilibria, the behavior of phase interfaces, rheology, and colloidal systems. In laboratory exercises, students will learn the experimental techniques of physical chemistry. In seminars, students will get acquainted with physicochemical calculations, which are integral parts of the knowledge required in the discipline.
Výstupy z učení
After completing the course, the student will be able to:
– describe the thermodynamic nature of a number of pharmaceutical processes;
– describe the factors that influence the solubility and dissolution of substances;
– determine and describe kinetic parameters in pharmaceutical processes;
– identify and summarize important features of electrochemical and phase phenomena;
– apply rheological principles to a practical problem;
– identify and summarize important characteristics of colloidal systems.
Osnova
  • LECTURES:
  • Thermodynamics.
  • Solubility: solubility gas/liquid, liquid/liquid, solid/liquid. Solubility of salts, poor soluble electrolytes, weak electrolytes and their salts.
  • Electrochemistry.
  • Phase equilibria.
  • Phase interfaces.
  • Diffusion, dissolution and their importance in drug development.
  • Kinetics: rates and orders of reactions. Influence of temperature and other factors on reaction rates. The importance of kinetics in formulation and development of pharmaceuticals.
  • Rheology: Newtonian systems, non-Newtonian systems, thixotropy, determination of rheologic properties, viscoelasticity, application in pharmacy.
  • Colloids.

  • SEMINARS:
  • States of matter and thermodynamics – calculations.
  • Phase equilibria, chemical kinetics and electrochemistry – calculations.
  • Written test – calculations.

  • LABORATORY EXERCISES:
  • Density determination by pycnometric method.
  • Partitioning of succinic acid in the system butanol-water.
  • Determination of upper critical dissolution temperature of the mixture phenol-water.
  • Written test – theory from laboratory exercises.
Literatura
    doporučená literatura
  • Atkins, P.W. Physical Chemistry. Oxford Univ.Press, Oxford, 1997. info
  • Kišová, L. , Trnková, L. Příklady z fyzikální chemie. PřF MU Brno, 1993. info
  • Fischer, O. a kol. Fyzikální chemie. SPN Praha, 1983. info
  • Vodrážka, Z. Fyzikální chemie pro biologické vědy. Academia, Praha, 1983. info
  • Moore, W.J. Fyzikální chemie. SNTL, Praha, 1979. info
  • Brdička, R., Dvořák, J. Základy fyzikální chemie. Academia, 1977. info
Výukové metody
lectures, seminars, laboratory exercises
Metody hodnocení
2 written tests (1 test for calculations from seminars, you need to get at least 50 % of points to pass; and 1 test for theory from laboratory exercises; you need to get at least 60 % of points to pass), written exam
Vyučovací jazyk
Angličtina
Informace učitele
Conditions of participation in the exam:
Participate in seminars and laboratory exercises in the full range given by the syllabus, properly write protocols from laboratory exercises. Demonstrate ongoing knowledge during seminars and laboratory exercises. Successfully pass a written test on calculations (min. 50 % of points) and a written test on the knowledge acquired in the laboratory exercises (min. 60 % of points). If any of the above conditions are not met, the student cannot participate in the final exam.

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Předmět je dovoleno ukončit i mimo zkouškové období.
Předmět je zařazen také v obdobích jaro 2020, jaro 2021, jaro 2022, jaro 2023, jaro 2024.