FASU1_13 Physical Chemistry

Faculty of Pharmacy
Spring 2021
Extent and Intensity
2/2/0. 6 credit(s). Type of Completion: zk (examination).
Taught partially online.
Teacher(s)
doc. Mgr. Jan Muselík, Ph.D. (lecturer)
prof. PharmDr. Mgr. David Vetchý, Ph.D. (lecturer)
doc. Mgr. Jan Muselík, Ph.D. (seminar tutor)
prof. PharmDr. Mgr. David Vetchý, Ph.D. (seminar tutor)
PharmDr. Jiří Zeman, Ph.D. (seminar tutor)
Guaranteed by
prof. PharmDr. Mgr. David Vetchý, Ph.D.
Department of Pharmaceutical Technology – Departments – Faculty of Pharmacy
Timetable
Thu 14:00–15:30 18-122
  • Timetable of Seminar Groups:
FASU1_13/01: Fri 12. 3. to Fri 26. 3. each even Friday 13:45–16:45 18-122, Fri 9. 4. to Fri 7. 5. each even Friday 13:45–14:30 18-122, each even Friday 14:30–16:45 18-138, Fri 21. 5. each even Friday 13:45–16:45 18-122, J. Muselík, J. Zeman
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.

The capacity limit for the course is 12 student(s).
Current registration and enrolment status: enrolled: 3/12, only registered: 0/12
fields of study / plans the course is directly associated with
Course objectives
The aim of the discipline is to make students familiar with basic knowledge of the physical chemistry, which constitutes part of the theoretical basis, necessary for understanding of processes delivered within disciplines in further stages of the study. Lectures are divided according to basic part of physical and colloid chemistry such as thermodynamics, kinetics of chemical reactions, behaviour of solutions, electrochemistry, phase balances, behaviour of phase interfaces, rheology and behaviour of colloid systems. In laboratories students learn the experimental technique of physical chemistry while in seminars students will get acquaintance with physical chemistry calculations, which are integral parts of knowledge required in the discipline.
Learning outcomes
After completing the course, the student will be able to:
- describe the thermodynamic nature of a number of pharmaceutical processes;
- describe the factors that influence the solubility and dissolution of substances;
- determine and describe kinetic parameters in pharmaceutical processes;
- identify and summarize important features of electrochemical and phase phenomena;
- apply rheological principles to a practical problem;
- identify and summarize important characteristics of colloidal systems
Syllabus
  • LECTURES:
  • Thermodynamics.
  • Solubility: solubility gas/liquid, liquid/liquid, solid/liquid. Solubility of salts, poor soluble electrolytes, weak electrolytes and their salts.
  • Electrochemistry.
  • Phase equilibrium.
  • Phase interfaces.
  • Diffusion, dissolution and their importance in drug development.
  • Kinetics: rates and orders of reactions. Influence of temperature and other factors on reaction rates. The importance of kinetics in formulation and development of pharmaceuticals.
  • Rheology: Newtonian systems, non-Newtonian systems, thixotropy, determination of rheologic properties, viscoelasticity, application in pharmacy.
  • Colloids.

    PRACTICAL TRAINING:
  • States of matter and thermodynamics - calculations
  • Phase equilibria, chemical kinetics and electrochemistry - calculations
  • Density determination by pycnometric method
  • Partitioning of succinic acid in the system butanol-water
  • Determination of upper critical dissolution temperature of the mixture phenol-water
Literature
    recommended literature
  • Atkins, P.W. Physical Chemistry. Oxford Univ.Press, Oxford, 1997. info
  • Kišová, L. , Trnková, L. Příklady z fyzikální chemie. PřF MU Brno, 1993. info
  • Fischer, O. a kol. Fyzikální chemie. SPN Praha, 1983. info
  • Vodrážka, Z. Fyzikální chemie pro biologické vědy. Academia, Praha, 1983. info
  • Moore, W.J. Fyzikální chemie. SNTL, Praha, 1979. info
  • Brdička, R., Dvořák, J. Základy fyzikální chemie. Academia, 1977. info
Teaching methods
lectures, seminars, laboratory exercises
Assessment methods
credit, written exam
Language of instruction
English
Further comments (probably available only in Czech)
The course can also be completed outside the examination period.
Teacher's information
Participate in exercises and seminars in the full range given by the syllabus, properly write protocols from laboratory exercises. Demonstrate ongoing knowledge during seminars and exercises. Part of the credit is a written test for calculations and a test of knowledge of the content of practical training.
The course is also listed under the following terms Spring 2020, Spring 2022, Spring 2023, Spring 2024, Spring 2025.
  • Enrolment Statistics (Spring 2021, recent)
  • Permalink: https://is.muni.cz/course/pharm/spring2021/FASU1_13