FDCME_FAF Molecular Biology

Faculty of Pharmacy
Autumn 2024
Extent and Intensity
1/1/0. 25 credit(s). Type of Completion: zk (examination).
Teacher(s)
Mgr. Marie Brázdová, Ph.D. (lecturer)
Guaranteed by
Mgr. Marie Brázdová, Ph.D.
Faculty of Pharmacy
Prerequisites
FAKULTA(FaF)
The subject is realized through consultations and self-study, assumes the mastering of the study literature and the understanding of the context.
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
Molecular biology for DSP as a discipline which aims to study cellular biological processes at their molecular level. Learning outcomes of the course unit aim to acquaint the student with current trends and methods, especially for testing the bioactivity of natural substances at the molecular level.
Learning outcomes
Knowledge of molecular biology forming the basis for follow-up subjects Methods of molecular biology, Biotechnology of drugs, Exercises from drug biotechnology, Pharmacogenomics, Structure and evolution of genomes. After completing the course, the student will be able to: - identify and summarize important features on the structure of proteins and nucleic acids and the functions and relationships of information macromolecules in the transmission of genetic information; - describe the structure of prokaryotic and eukaryotic genomes, with mechanisms of replication, transcription, translation and regulation of gene expression; - describe the molecular mechanisms of mutagenesis, recombination and transposition, repair mechanisms and the molecular nature of carcinogenesis;
Syllabus
  • 1) Molecular biology and its position in biological sciences, milestones, personalities, central dogma of molecular biology
    2) Information macromolecules, their structure, function and interaction in gene expression, genetic code.
    3) Structure of prokaryotic genome, replication and gene expression in prokaryotes.
    4) Structure of eukaryotic genome, replication and gene expression in eukaryotes.
    5) Regulation of gene expression, molecular signalling.
    6) RNA interference
    7) Molecular biology of viruses, replication, expression of bacterial and animal virus's genes.
    8) Mutagenesis, spontaneous and induced mutation and reversion.
    9) Molecular basis of recombination, recombinantion in genetics.
    10) Transposons, mechanisms of transposition, retroelements, retroviruses.
    11) Reparation and excision mechanisms.
    12) Molecular basis of cancerogenesis, protooncogenes and oncogenes, suppressor genes, oncoviruses.
    13) Cell cycle and apoptosis
Literature
    required literature
  • D. Peter Snustad Michael J. Simmons. Genetika. Brno, 2017. ISBN 9788021086135. info
  • BARTOŠ, M., BARTOŠOVÁ, L. Základy molekulární biologie pro farmaceuty. FaF VFU Brno, 2006. info
  • ROSYPAL, S. et al. Úvod do molekulární biologie. Vydavatel prof. RNDR. Stanislav Rosypal, DrSc. B, 2002. info
    not specified
  • RUSSELL, P.J. iGenetics, A molecular Approach. Pearson, Benjamin Cummings. New York, U.S.A., 2006. info
  • WATSON, D.J. et al. Molecular biology of the gene. Cold Spring Harbor Laboratory Press, Pearson, Be, 2004. info
  • ROSYPAL, S. et al. Terminologie molekulární biologie. Vydavatel prof. RNDr. Stanislav Rosypal, DrSc.,, 2001. info
Teaching methods
Methods of working with text (textbook, book)
Assessment methods
Orealand written examination, Written exam, 30 questions, mostly supplemented, evaluation of 60 points, to successfully complete the need to master 60%,
Language of instruction
Czech
Further comments (probably available only in Czech)
The course can also be completed outside the examination period.
The course is taught each semester.
Teacher's information
Requirements for the student
Successful completion of the subject by written and oral examination. The mark is based mainly on the part of the test. To pass the course, you must pass the test at 60%.
The course is also listed under the following terms Spring 2020, Autumn 2020, Spring 2021, Autumn 2021, Spring 2022, Autumn 2022, Spring 2023, Autumn 2023, Spring 2024, Spring 2025.
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