PřF:B8540 Mutagenesis - Course Information

B8540 Mutagenesis

Extent and Intensity

2/1/0. 4 credit(s). Type of Completion: zk (examination).

Teacher(s)

doc. RNDr. Petr Kuglík, CSc. (lecturer)
doc. RNDr. Petr Kuglík, CSc. (seminar tutor)

Guaranteed by

doc. RNDr. Petr Kuglík, CSc.
Department of Experimental Biology – Biology Section – Faculty of Science
Contact Person: doc. RNDr. Petr Kuglík, CSc.

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

• Cellular and Molecular Diagnostics (programme PřF, B-BI)
• Molecular Biology and Genetics (programme PřF, M-BI)
• Molecular Biology and Genetics (programme PřF, N-BI)
• General Biology (programme PřF, M-BI, specialization Microbiology)
• General Biology (programme PřF, N-BI, specialization Microbiology)

Course objectives

History of mutagenesis, types of mutations. Origin of spontaneous mutation. Tautomerization, deamination of DNA bases. Role of DNA repair, replication, and recombination. Induced mutations. Radiation-induced mutations. Biological effects of UV radiation. Consequences of thinning of ozone layer. Biological effects of ionizing radiation. Sources and types of ionizing radiation. Radiation-induced DNA damage. Factor controlling biological effects of radiation. Biological effects of magnetic field. Chemical mutagenesis and chemical mutagens. Classification of chemical mutagens. Molecular basis of mutagenesis induced by physical and chemical mutagens. Promutagens. Metabolic activation of promutagens, plant promutagens, animal promutagens. Pharmacological polymorphisms. DNA damage and repair mechanisms (fotoreactivation, excision repair, postreplication repair, SOS repair). Error prone and error free DNA repair, adaptive repair. Antimutagens. Classification of antimutagenic compound. Mechanisms of antimutagenenesis. Environmental mutagens and carcinogens. Method for genetic risk assessment. Identification of mutagens among potentially hazardous chemicals. Monitoring environmental genotoxicant. Principles of mutation tests.

Language of instruction

Czech

Further Comments

The course can also be completed outside the examination period.
The course is taught annually.
The course is taught: every week.

• Enrolment Statistics (Autumn 2000, recent)
  
• Permalink: https://is.muni.cz/course/sci/autumn2000/B8540