PřF:B8540p Mutageneze - předn.

B8540p Mutageneze - přednáška

Faculty of Science
Autumn 1999

Extent and Intensity

2/0/0. 0 credit(s). Type of Completion: zk (examination).

Teacher(s)

Guaranteed by

Prerequisites (in Czech)

B3060 Basic genetics && ( B4020 Molecular biology || B6130 Molecular biology || B4030 Molecular biology )

Course Enrolment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

fields of study / plans the course is directly associated with

Syllabus

History of mutagenesis, types of mutations. Origin of spontaneous mutation. Tautomerization, deamination of DNA bases. Role of DNA repair, replication, and recombination. Induced mutations. Radiation-induced mutations. Biological effects of UV radiation. Consequences of thinning of ozone layer. Biological effects of ionizing radiation. Sources and types of ionizing radiation. Radiation-induced DNA damage. Factor controlling biological effects of radiation. Biological effects of magnetic field. Chemical mutagenesis and chemical mutagens. Classification of chemical mutagens. Molecular basis of mutagenesis induced by physical and chemical mutagens. Promutagens. Metabolic activation of promutagens, plant promutagens, animal promutagens. Pharmacological polymorphisms. DNA damage and repair mechanisms (fotoreactivation, excision repair, postreplication repair, SOS repair). Error prone and error free DNA repair, adaptive repair. Antimutagens. Classification of antimutagenic compound. Mechanisms of antimutagenenesis. Environmental mutagens and carcinogens. Method for genetic risk assessment. Identification of mutagens among potentially hazardous chemicals. Monitoring environmental genotoxicant. Principles of mutation tests.