Bi7575 Stem Cell Physiology

Faculty of Science
Autumn 2008
Extent and Intensity
1/0. 1 credit(s) (fasci plus compl plus > 4). Type of Completion: zk (examination).
Teacher(s)
Mgr. Jiří Pacherník, Ph.D. (lecturer)
Guaranteed by
Mgr. Jiří Pacherník, Ph.D.
Department of Experimental Biology – Biology Section – Faculty of Science
Contact Person: Mgr. Jiří Pacherník, Ph.D.
Timetable
Tue 9:00–9:50 BR1
Prerequisites (in Czech)
Bi3030 Animal physiology && Bi4020 Molecular biology
Předmět je vhodný pro studenty třetích a vyších ročníků biologických a lékařských oborů.
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
  • General Biology (programme PřF, M-BI, specialization Physiology of Animals)
Course objectives
Stem cells are primal undifferentiated cells that retain the ability to divide and differentiate into other cell types. Serving as a sort of repair system for the body, they can theoretically divide without limit to replenish other cells as long as the organism is still alive. When a stem cell divides, each new cell has the potential to either remain a stem cell or become another type of cell with a more specialized function, such as progenitors of muscle cell, blood cell, or a brain cell. The some aspects of mammalian stem cells biology, and their utilisation in biology and medicine will present here. At the end of this course, students should be able to: understand and be able to explain some problems of stem cell biology.
Syllabus
  • 1. Stem cells, totipotency, pluripotency, multipotency; 2.Self-renewal, proliferation, differentiation, redifferentiation, selection and apoptosis; 3. Embryonic stem cells; 4. Germ cells; 5. Somatic stem cells; 6. Carcinoma stem cells; 7. Neural stem cells; 8. Hematopoietic stem cells; 9. Epidermis and colon stem cells; 10. Mesenchymal and bone marow stem cells; 11. Stem cells and cell therapy; 12. Stem cells differentiation in vitro; 13. Application of stem cells in toxicology; 14. Therapeutic cloning; 15. Embryonic stem cells and gene modify organism. Recommended literature Essentials of Stem Cell Biology, First Edition (Hardcover) by Robert Lanza, E. Donnall Thomas, James Thomson, Roger Pedersen, John Gearhart (Editor), Brigid Hogan (Editor), Douglas Melton (Editor), Michael West (Editor) ISBN: 0120884429 Handbook of Stem Cells, Two-Volume Set with CD-ROM, Volume 1-2, First Edition : Volume 1-Embryonic Stem Cells; Volume 2-Adult & Fetal Stem Cells (Hardcover) by Robert Lanza, Irving Weissman, James Thomson, Roger Pedersen, Brigid Hogan (Editor), John Gearhart (Editor), Helen Blau (Editor), Douglas Melton (Editor), Malcolm Moore (Editor), Catherine Verfaillie (Editor), E. Donnall Thomas (Editor), Michael West (Editor) ISBN: 0124366430 Stem Cells Handbook (Hardcover) by Stewart Sell (Editor) ISBN: 1588291138
Literature
  • Essentials of stem cell biology. Edited by R. P. Lanza. Amsterdam: Elsevier Academic Press, 2006, xxxi, 548. ISBN 0120884429. info
  • Stem cells handbook. Edited by Stewart Sell. Totowa, N.J.: Humana Press, 2004, xiii, 509. ISBN 1588291138. info
Assessment methods
Written test.
Language of instruction
Czech
Further Comments
Study Materials
The course is taught annually.
The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 2010 - only for the accreditation, Autumn 2006, Autumn 2007, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2016, Autumn 2018, Autumn 2020, Autumn 2022, Autumn 2023, Autumn 2024.
  • Enrolment Statistics (Autumn 2008, recent)
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