C8432 Heterocyclic Compounds

Faculty of Science
Spring 2009
Extent and Intensity
2/0/0. 2 credit(s) (fasci plus compl plus > 4). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).
Teacher(s)
prof. RNDr. Milan Potáček, CSc. (lecturer)
Guaranteed by
prof. RNDr. Milan Potáček, CSc.
Department of Chemistry – Chemistry Section – Faculty of Science
Timetable
Wed 10:00–11:50 A08/309
Prerequisites
Konowledge of Organic Chemistry
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
there are 23 fields of study the course is directly associated with, display
Course objectives
Six membered heterocyclic compounds with one heteroatom (nitrogen, oxygen)and their benzoderivatives. Diazines. Fused heterocyclic compounds (purines, pterines). Reactivity and their synthesis. Representatives of all the mentiones classes in nature and life and applied chemistry. At the end of the course the students are supposed to understand diferences in the behaviour of the heterocycles above with respect to structure and reactivity relationship and will be able to propose their posible syntheses.
Syllabus
  • 1.Six-membered heterocycles with one heteroatom. Pyridine, its structure and methods of its preparation.Chemical properties in reactions with electrofiles, nucleofiles and radicals. 2. Main representatives of pyridine derivatives. N-Pyridinium oxide and its properties. 3.Quinoline, methods of its synthesis, chemical properties (comparison with pyridine), derivatives of quinoline. 4. Isoquinolin, methods of its synthesis, chemical properties, derivatives. 5. Pyrrylium salts, structure and reactivity, comparison with pyridine. 6. Pyrones and their behaviour. Cumarine, chromone, flavones, their properties. 7.Benzopyrylium salts, flavylium salts and plants dyes.8. Diazines (pyrimidine, pyrazine, pyridazine), their methods of synthesis and chemical properties. 9. Hydroxy a amino derivatives of pyrimidine a their tautomeric behaviour, function in nucleic acids. 10. Fused heterocycles. Purines, hydroxy a amino derivatives, their chemical properties. 11. Pterines, characterization and derivatives. 12., 13., 14. Inovation.
Literature
  • KOVÁČ, Jaroslav, Alžbeta KRUTOŠÍKOVÁ and Rudolf KADA. Chémia heterocyklických zlúčenin. 1. vyd. Bratislava: VEDA vydavatel'stvo Slovenskej akadémie vied, 1982, 515 s. info
  • GILCHRIST, Thomas L. Heterocyclic chemistry. 3rd ed. Essex: Longman, 1997, xvii, 414. ISBN 0582278430. info
  • JOULE, J. A., K. MILLS and G. F. SMITH. Heterocyclic chemistry [Joule, 1995]. 3rd ed. London: Chapman & Hall, 1995, 516 s. ISBN 0-412-41340-X. info
  • ČERVINKA, Otakar. Chemie organických sloučenin. Vyd. 1. Praha: Státní nakladatelství technické literatury, 1987, 1052 s. info
  • POZHARSKII, Alexander F., Anatoly SOLADATENKOV and Alan R. KATRITZKY. Heterocycles in life and society : an introduction to heterocyclic chemistry and biochemistry and the role of heterocycles in science, technology, medicine and agriculture. Chichester: John Wiley & Sons, 1996, viii, 301. ISBN 0-471-96034-9. info
Assessment methods
The course is closed by a written examination accompanied with oral discussion.
Language of instruction
Czech
Further comments (probably available only in Czech)
The course is taught annually.
The course is also listed under the following terms Spring 2008 - for the purpose of the accreditation, Spring 2000, Spring 2001, Spring 2002, Spring 2003, Spring 2004, Spring 2005, Spring 2006, Spring 2007, Spring 2008.
  • Enrolment Statistics (recent)
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