C8570 Early Molecular Evolution

Přírodovědecká fakulta
jaro 2015
Rozsah
2/0. 2 kr. (příf plus uk plus > 4). Doporučované ukončení: k. Jiná možná ukončení: zk.
Vyučující
prof. Ing. Eduard Nikolajevič Trifonov, Ph.D. (přednášející), prof. RNDr. Jiří Fajkus, CSc. (zástupce)
Mgr. Lucie Crhák Khaitová, Ph.D. (pomocník)
Garance
prof. RNDr. Jiří Fajkus, CSc.
Národní centrum pro výzkum biomolekul – Přírodovědecká fakulta
Kontaktní osoba: prof. RNDr. Jiří Fajkus, CSc.
Dodavatelské pracoviště: Národní centrum pro výzkum biomolekul – Přírodovědecká fakulta
Předpoklady
Basic knowledge of molecular biology.
Omezení zápisu do předmětu
Předmět je nabízen i studentům mimo mateřské obory.
Předmět si smí zapsat nejvýše 30 stud.
Momentální stav registrace a zápisu: zapsáno: 0/30, pouze zareg.: 0/30, pouze zareg. s předností (mateřské obory): 0/30
Mateřské obory/plány
Cíle předmětu
At the end of the course, the students will be able to: Understand evolutionary chart of codons; Understand the theory of omnipresent protein sequence motifs; Understand standard structural modules of modern proteins; Understand construction of protein sequence space.
Osnova
  • Four fundamentally novel, recent developments make a basis for the Theory of Early Molecular Evolution. The theory outlines the molecular events from the onset of the triplet code to the formation of the earliest sequence/structure/function modules of proteins. These developments are: 1) Reconstruction of the evolutionary chart of codons (1, 2); 2) Discovery of omnipresent protein sequence motifs, conserved since the last common ancestor (3, 4); 3) Discovery of closed loops - standard structural modules of modern proteins (5-7); 4) Construction of protein sequence space of module size fragments, with evolutionary implications (8, 9). The theory generates numerous predictions, confirmed by massive nucleotide and protein sequence analyses, such as existence of two distinct classes of amino acids, and their periodical distribution along the sequences . The emerging picture of the earliest molecular evolutionary events is outlined - consecutive engagement of codons, formation of the earliest short peptides, and growth of the polypeptide chains to the size of loop closure, 25-30 residues. Repertoire of the very first protein activities is outlined. The earliest closed loop modules are found to be associated with ATP synthesis and utilization. Ref. (10) is an extended summary of the course. 1. Trifonov, E. N., Gene 261, 139-151 (2000) 2. Trifonov, E. N., J Biomol Str Dyn 22, 1-11 (2004) 3. Sobolevsky, Y., Trifonov, E. N., J Mol Evol 61, 591-596 (2005) 4. Sobolevsky, Y., Trifonov, E. N., J Mol Evol 63, 622-634 (2006) 5. Berezovsky, I. N., Grosberg, A. Y., Trifonov, E. N., FEBS Letters 466, 283-286 (2000) 6. Berezovsky, I. N., Protein Engineering 16, 161-167 (2003) 7. Berezovsky, I. N., Kirzhner, A., Kirzhner, V. M., Trifonov, E. N., J. Biomol Str Dyn. 21, 327-339 (2003) 8. Frenkel, Z. M., Trifonov, E. N., J Theor Biol 244, 77-80 (2007) 9. Frenkel, Z. M., Trifonov, E. N., Proteins Str Function Bioinf, in press 10. Trifonov, E. N., Early molecular evolution, Isr J Ecol Evol in press 1) Reconstruction of the evolutionary chart of codons (1, 2); 2) Discovery of omnipresent protein sequence motifs, conserved since the last common ancestor (3, 4); 3) Discovery of closed loops - standard structural modules of modern proteins (5-7); 4) Construction of protein sequence space of module size fragments, with evolutionary implications (8, 9).
Literatura
  • 3. Sobolevsky, Y., Trifonov, E. N., J Mol Evol 61, 591-596 (2005)
  • 8. Frenkel, Z. M., Trifonov, E. N., J Theor Biol 244, 77-80 (2007)
  • TRIFONOV, Eduard Nikolajevič a Zakharia M FRENKEL. Origin and evolution of genes and genomes. Crucial role of triplet expansions. J. Biomol. Struct. Dynamics 12. Philadelphia: Taylor&Francis Inc., 2012, roč. 30, č. 2, s. 201-210. ISSN 0739-1102. Dostupné z: https://dx.doi.org/10.1080/07391102.2012.677771. URL info
  • PINO, Samanta, Eduard TRIFONOV a Di Ernesto MAURO. On the Observable Transition to Living Matter. Genomics, Proteomics & Bioinformatics. Elsevier Ltd., 2011, roč. 9, 1-2, s. 7-14. ISSN 1672-0229. Dostupné z: https://dx.doi.org/10.1016/S1672-0229(11)60002-8. info
  • KOREN, Zohar a Eduard TRIFONOV. Role of Everlasting Triplet Expansions in Protein Evolution. Journal of molecular evolution. New York: Springer, 2011, roč. 72, č. 2, s. 232-239. ISSN 0022-2844. Dostupné z: https://dx.doi.org/10.1007/s00239-010-9425-0. info
  • TRIFONOV, Edward a Zakharia FRENKEL. Evolution of protein modularity. Current Opinion in Structural Biology. London: Elsevier Science Ltd., 2009, roč. 19, č. 3, s. 335-340. ISSN 0959-440X. info
  • TRIFONOV, Edward. The origin of the genetic code and of the earliest oligopeptides. Research in Microbiology. Netherlands: Elsevier Science BV, 2009, roč. 160, č. 7, s. 481-486. ISSN 0923-2508. info
Výukové metody
přednášky
Metody hodnocení
Lectures will be given in English within a period of 14 working days (2-4 lessons per day). The course will be concluded by colloquium after the last lesson. To pass the colloquium, active participation in the concluding session and correct answering of >50% of questions is required. Colloquium may be replaced by oral exam if preferred by a student.
Vyučovací jazyk
Angličtina
Navazující předměty
Informace učitele
Lectures will be given in English within a period of two weeks (2-4 lessons per day) between Feb 17 and Feb 25, 2014. The course will be concluded by colloquium after the last lesson. Schedule for spring 2014: Thu Feb 20: 13.00-15.00 Fri Feb 21: 10.00-12.00 Mo Feb 24: 15.00-17.00 Tue Feb 25: 11.00-13.00, 15.00-17.00 (plus colloquium or exam)
Další komentáře
Předmět je vyučován každoročně.
Výuka probíhá blokově.
The course will be tought in spring term 2015 in ca. 5 day block, exact dates will be provided later.
Předmět je zařazen také v obdobích jaro 2013, jaro 2014.
  • Statistika zápisu (nejnovější)
  • Permalink: https://is.muni.cz/predmet/sci/jaro2015/C8570