LF:VLFA0621p Pharmacology - lect. - Course Information
VLFA0621p Pharmacology - lectures
Faculty of MedicineSpring 2011
- Extent and Intensity
- 2/0/0. 0 credit(s). Type of Completion: -.
- Teacher(s)
- prof. MUDr. Alexandra Šulcová, CSc. (lecturer)
Ing. Pavel Musil (lecturer)
MUDr. Jana Nováková, Ph.D. (seminar tutor)
MUDr. Jana Pistovčáková, Ph.D. (seminar tutor)
doc. PharmDr. Jan Juřica, Ph.D. (seminar tutor)
doc. PharmDr. Ondřej Zendulka, Ph.D. (seminar tutor)
doc. PharmDr. Jana Rudá, Ph.D. (seminar tutor)
Mgr. Barbora Říhová, Ph.D. (seminar tutor)
MUDr. Alena Máchalová, Ph.D. (seminar tutor)
Renata Bláblová (assistant)
MUDr. Mgr. Karel Šlais, Ph.D. (alternate examiner) - Guaranteed by
- prof. MUDr. Alexandra Šulcová, CSc.
Department of Pharmacology – Theoretical Departments – Faculty of Medicine
Contact Person: prof. MUDr. Alexandra Šulcová, CSc. - Timetable
- Mon 28. 2. to Fri 3. 6. Tue 13:45–15:25 B22/116 aula
- Timetable of Seminar Groups:
VLFA0621p/30: Fri 13:30–15:10 B11/234 - Prerequisites (in Czech)
- VSPF0521c Pathophysiol. I - practice. && VSPA0521c Pathology - practicals
- Course Enrolment Limitations
- The course is only offered to the students of the study fields the course is directly associated with.
- fields of study / plans the course is directly associated with
- General Medicine (eng.) (programme LF, M-VL)
- General Medicine (programme LF, M-VL)
- Course objectives
- At the end of the course student should be able to understand integration in the field of biomedical sciences such as chemistry, physiology, molecular biology, pathology and pathological physiology clarifying mechanisms of xenobiotic (including drugs) effects and under which conditions they and their combinations may elicit therapeutic, adverse, and toxic effects, and what is the relation to the dose given, administration route, status of the organism (differences in pediatrics and geriatrics). They will be familiar with the requirements of "Good Clinical Practice" for development of new drugs, and duties of physicians in cooperation with the pharmaceutical industry and principles of pharmacovigilance.
- Syllabus
- LECTURES ON PHARMACOLOGY - Spring Semester
- 1+2: Introduction to pharmacology. Basic pharmacological terms, definitions. Types of pharmacotherapy and drug effects. Therapeutic Index. Teratogenic drug effects. Quantitative and qualitative deviations in drug effects, hypo-, and hyperergic reactions, allergy.
- 3: Purposeful pharmacotherapy. Importance of the pharmacological anamnesis, monitoring of drug pharmacotherapy, risk of pharmacotherapy.
- 4: Drug delivery approaches, routes of administration, prolonged release preparations. Novel pharmaceutical drug dosage forms.
- 5: Mechanisms of drug action, non-specific, specific. Classical receptors and ligand binding. Receptor subtypes, autoreceptors, heteroreceptors.
- 6: Concentration-response relationship. Pharmacokinetic principles. Drug absorption, distribution, metabolism and elimination.
- 7: Physiological and pathological factors influencing drug effects. Changes of drug effects after the repeated administration.
- 8: Pharmacogenetics, pharmacogenomics. Combined drug effects. Drug interactions.
- 9: Adverse drug effects. Toxic responses.
- 10: The management of poisoning.
- 11: Drug therapy in children, general principles, pharmacokinetic and pharmacodynamic peculiaritis. Pharmacotherapy in neonates.
- 12: Pharmacotherapy in geriatry.
- 13: Drug discovery and development, preclinical and clinical examination and evaluation. Regulation and guidelines for "Good Clinical Practice". Collaboration of experimental and clinical pharmacologists.
- 14: Principles of pharmacovigilance, duties of physicians and pharmaceutical companies, general rules in drug promotion.
- Literature
- required literature
- LINCOVÁ, Dagmar and Hassan FARGHALI. Základní a aplikovaná farmakologie. 2., dopl. a přeprac. vyd. Praha: Galén. xxiv, 672. ISBN 9788072623730. 2007. info
- http://portal.med.muni.cz/clanek-461-farmakovigilance-a-propagace-leciv.html
- https://is.muni.cz/auth/el/1411/podzim2008/ZLFA0722p/um/Zasady_antibioticke_ lecby.pdf?fakulta=1411;obdobi=4343;kod=ZLFA0722p
- recommended literature
- DOSTÁLEK, Miroslav, Jan JUŘICA, Eva JANOŠTÍKOVÁ and Lucia ZAHRADNÍKOVÁ. Farmakokinetika (Pharmacokinetics). ČR: Grada. 220 pp. Farmacie a farmakologie. ISBN 80-247-1464-7. 2006. info
- http://portal.med.muni.cz/modules.php?name=News&file=article&sid=367
- RANG, H. P. Rang and Dale's pharmacology. 6th ed. [S.l.]: Churchill Livingstone. xiii, 829. ISBN 9780443069116. 2007. info
- Ritter, James M. - Lewis, Lionel D. - Mant, Timothy G.K. - Ferro, Albert. A Textbook of Clinical Pharmacology and Therapeutics, 5th Ed., Hodder Arnold, 2008. 465 s. ISBN 978-0-340-90046-8
- Pharmaceutical Practice, 3rd Ed. Winfield, A.J. & Richards, R.M.E., eds. Churchill Livingstone, 2004, ISBN 0443 07206 X
- HOWLAND, Richard D. and Mary Julia MYCEK. Pharmacology. 3rd ed. Philadelphia: Lippincott Williams & Wilkins. vii, 552. ISBN 0781741181. 2006. info
- Waller, Derek - Renwick, Andrew G. - Hillier, Keith. Medical pharmacology and therapeutics. 3rd ed. New York : Elsevier Saunders, 2009. ix, 744 p. ISBN 0-7020-2991-2.
- https://is.muni.cz/auth/el/1411/jaro2009/VLFA0621c/um/Practicals_in_Pharmacology_ENGL.pdf?fakulta=1411;obdobi=4504;kod=VLFA0621c
- Teaching methods
- According to schedule given students are expected to attend lectures read by habilitated pharmacology teacher.
- Assessment methods
- There is no testing of knowledge in this part of study as students are expected to continue pharmacological course in the subsequent semester.
- Language of instruction
- Czech
- Further comments (probably available only in Czech)
- Study Materials
The course is taught annually.
- Enrolment Statistics (Spring 2011, recent)
- Permalink: https://is.muni.cz/course/med/spring2011/VLFA0621p