LF:VLFA07212c Pharmacology I - Course Information

VLFA07212c Pharmacology I - practice

Faculty of Medicine
autumn 2018

Extent and Intensity

0/3/0. 2 credit(s). Type of Completion: z (credit).

Teacher(s)

Guaranteed by

doc. MUDr. Regina Demlová, Ph.D.
Department of Pharmacology – Theoretical Departments – Faculty of Medicine
Contact Person: doc. PharmDr. Ondřej Zendulka, Ph.D.
Supplier department: Department of Pharmacology – Theoretical Departments – Faculty of Medicine

Timetable of Seminar Groups

VLFA07212c/01: Mon 24. 9. to Sun 20. 1. Mon 13:00–15:30 A19/231
VLFA07212c/02: Mon 24. 9. to Sun 20. 1. Mon 16:00–18:30 A19/231
VLFA07212c/03: Mon 24. 9. to Sun 20. 1. Fri 13:00–15:30 A19/231
VLFA07212c/04: Mon 24. 9. to Sun 20. 1. Fri 13:00–15:30 A19/231
VLFA07212c/05: Mon 24. 9. to Sun 20. 1. Mon 13:00–15:30 A19/231
VLFA07212c/06: Mon 24. 9. to Sun 20. 1. Mon 16:00–18:30 A19/231
VLFA07212c/07: Mon 24. 9. to Sun 20. 1. Wed 13:00–15:30 A19/231
VLFA07212c/09: Mon 24. 9. to Sun 20. 1. Wed 16:00–18:30 A19/231
VLFA07212c/10: Mon 24. 9. to Sun 20. 1. Wed 13:00–15:30 A19/231
VLFA07212c/11: Mon 24. 9. to Sun 20. 1. Wed 16:00–18:30 A19/231
VLFA07212c/12: Mon 24. 9. to Sun 20. 1. Wed 13:00–15:30 A19/231
VLFA07212c/15: Mon 24. 9. to Sun 20. 1. Wed 16:00–18:30 A19/231
VLFA07212c/16: Mon 24. 9. to Sun 20. 1. Mon 13:00–15:30 A19/231

Prerequisites (in Czech)

VLPF0622p Pathophysiol. II - lect. && VLPA0622c Pathology - practice

Course Enrolment Limitations

The course is only offered to the students of the study fields the course is directly associated with.

fields of study / plans the course is directly associated with

General Medicine (programme LF, M-VL)

Course objectives

The aims of the course are:
to recognize the basic pharmacological terminology and legislation related to the use of drugs and thei prescription
to understand to differences between single drug dosage forms
to understand to the prescription of drugs
to understand to the basics of pharmacokinetics
to understand to the basic facts about the discussed drugs

Learning outcomes

At the end of the course the student knows:
single pharmacoterapeutical drug clases
single drug dosage forms
the modes of action, adverse reactions and basic indications of single drugs of discussed drugs
how to prescribe selected medical preparation or a drug in particular drug dosage form

Syllabus

VLFA07212c - Pharmacology I - practical lessons

General medicine

Autumn semester 2018
1^st week
Topic: INFORMATION ON DRUGS
Course content: Organisation of practical courses and lectures, system of evaluation. Repetition of basic pharmacologic terminology. Sub-branches of pharmacology. Sources of information concerning drugs and recommended textbooks. Work with relevant databases (Brevíř, SÚKL, EMA, AISLP), ATC classification.
Self-studying preparation for practical lessons: Materials for the Lecture No. 1 and the Chapter 1.1 in the textbook Nováková J. et al. 2010 - Latin terminology, Pharmacological calculations with the use of the textbook for Practical lessons.
2^nd week
Topic: PRESCRIPTION OF MEDICAL PRODUCTS I
Course content: General rules of drug prescription. Prescription of the individually-made solid, liquid and semi-solid pharmaceutical dosage forms.
Self-studying preparation for practical lessons: Materials for the Lecture No. 2. Drug dosage forms from the textbook. Legislation of the Czech Republic related to drugs and their prescription (selected section of the Act No. 378/2007 Coll., on Pharmaceuticals and on Amendments to Some Related Acts).
3^rd week
Topic: PRESCRIPTION OF MEDICAL PRODUCTS II, ROUTES OF DRUG ADMINISTRATION
Course content: Brief characteristics of the individual drug dosage forms. Prescription of ready-made drug products. Clinical significance of the way of drug administration.
Self-studying preparation for practical lessons: Materials for the Lecture No. 3. Information in drug databases - SÚKL (www.sukl.cz), EMA and Drugs.com.
4^th week
Topic: PRINCIPLES OF PHARMACOKINETICS
Course content: Pharmacokinetic processes, parameters and calculations.
Self-studying preparation for practical lessons: Materials for the Lecture No. 4.
5^th week
Topic: PRINCIPLES OF APPLIED PHARMACOKINETICS
Course content: Pharmacokinetic case reports, simulation of plasma concentrations course, dosage optimalization and use of software tools, factors affecting course and value of drug´s plasma concentrations.
Self-studying preparation for practical lessons: Materials for the Lectures No. 4 and 5.
6^th week
Topic: PHARMACODYNAMICS
Course content: MULTIPLE-CHOICE TEST (1^st - 5^th week). Mechanisms of drug effects - classification, examples. Dose-response curves.
Self-studying preparation for practical lessons: Materials for the Lecture No. 6.
7^th week
Topic: ADVERSE DRUG REACTIONS
Course content: Classification and characteristics of adverse drug effects. Pharmacovigilance in clinical practice, sources of current information on drug safety. Databases of drug interactions. Pharmaceutical interactions (case reports).
Self-studying preparation for practical lessons: Materials for the Lecture No. 7, case report (drug incompatibility) materials in IS.
8^th week
Topic: FACTORS AFFECTING DRUG EFFECTS
Course content: Pharmacotherapy in childhood, in pregnancy, in breastfeeding women, in elderly. Pharmacogenetics.
Self-studying preparation for practical lessons: Materials for the Lecture No. 8. Pharmacogenetics - materials in IS.
9^th week
Topic: PHARMACOLOGY OF SYMPATHETIC NERVOUS SYSTEM
Course content: Drugs affecting sympathetic nervous system - classification, basic pharmacological characteristics.
Self-studying preparation for practical lessons: Materials for the Lecture No. 9. Pathophysiological bases - ANS, neurotransmitters (their synthesis and degradation), receptors of the sympathetic nervous system (alpha, beta) and parasympathetic nervous system (nicotinic, muscarinic) and their subtypes and organ distribution. Systems of second messengers. Pharmacodynamics, both direct and indirect mechanisms of action.
10^th week
Topic: PHARMACOLOGY OF PARASYMPATHETIC NERVOUS SYSTEM
Course content: Drugs affecting parasympathetic nervous system - classification, basic pharmacological characteristics. Spasmolytic drugs.
Self-studying preparation for practical lessons: Materials for the Lectures No. 9. Spasmolytic drugs.
11^th week
Topic: GLUCOCORTICOIDS, DRUGS OF ABUSE
Course content: MULTIPLE-CHOICE TEST (6^th - 10^th week). Repetition of basic pharmacological characteristics of glucocorticoids. Problems of drug abuse, doping and falsification of medical products.
Self-studying preparation for practical lessons: Materials for the Lecture No. 11, preparation of oral presentation should be uploaded to IS at least 24 hours prior to the practical lesson.
12^th week
Topic: PHARMACOTHERAPY OF DIABETES MELLITUS
Course content: Repetition of anti-diabetic drugs - basic pharmacological characteristics. Drugs used in therapy of specific and acute conditions in diabetology. Combinations of insulins, insulin regimens.
Self-studying preparation for practical lessons: Materials for the Lecture No. 12, preparation of oral presentation - presentation should be uploaded to IS at least 24 hours prior to the practical lesson.
13^th week
Topic: SEX HORMONES
Course content: Endocrine therapy, hormone replacement therapy, hormonal contraceptive drugs.
Self-studying preparation for practical lessons: Materials for the Lecture No. 13. Uterotonics and tocolytics.
14^th week
Topic: ANALGESIC DRUGS
Course content: MULTIPLE-CHOICE TEST (11^th - 13^th week). Basic pharmacological characteristics of opioid and non-opioid analgesic drugs, antirheumatoid drugs and drugs used in gout.
Self-studying preparation for practical lessons: Materials for the seminar No. 14. Antirheumatoid drugs and Drugs used in gout).
15^th week
Topic: ANAESTHETIC DRUGS
Course content: PRESCRIPTION TEST. Basic pharmacological characteristics of general and local anaesthetic drugs. Premedication prior to general anaesthesia.
Self-studying preparation for practical lessons: Materials for the Lecture No. 15. Muscle relaxants.

Literature

required literature

RANG, H. P., James RITTER, R. J. FLOWER and Graeme HENDERSON. Rang & Dale's pharmacology. Eighth edition. [Edinburgh]: Churchill Livingstone. xv, 760. ISBN 9780702053627. 2016. info
Základy speciální receptury léčivých přípravků, Juřica a kol., 2013, http://portal.med.muni.cz/clanek-611-zaklady-specialni-receptury-lecivych-pripravku.html
Základy receptury léčivých přípravků. Nováková a kol., 2010, http://portal.med.muni.cz/clanek-553-zaklady-receptury-lecivych-pripravku.html

recommended literature

ŠVIHOVEC, Jan a kol. Farmakologie, Praha: Grada, 2018. ISBN 978-80-247-5558-8. www.grada.cz/farmakologie-(1)-8687
http://elportal.cz/publikace/kazuistiky-farmakologie
Životní cyklus léčiv, Demlová a kol., 2014, http://portal.med.muni.cz/clanek-621-zivotni-cyklus-leciv-klinicke-hodnoceni-a-registrace-lecivych-pripravku-farmakovigilance-a-stanovovani-cen-a-uhrad-leciv.html
Atlas léčivých rostlin, https://is.muni.cz/auth/do/med/el/lecive_rostliny/atlas.html
Základy farmakoekonomiky, Říhová a kol, 2016, http://portal.med.muni.cz/clanek-649-zaklady-farmakoekonomiky.html
LINCOVÁ, Dagmar and Hassan FARGHALI. Základní a aplikovaná farmakologie. 2., dopl. a přeprac. vyd. Praha: Galén. xxiv, 672. ISBN 9788072623730. 2007. info

not specified

Pharmaceutical practice. Edited by Judith A. Rees - Ian Smith - Jennie Watson. 5th ed. Edinburgh: Churchill Livingstone Elsevier. xvii, 552. ISBN 9780702051432. 2014. info
WHALEN, Karen. Pharmacology. Edited by Richard Finkel - Thomas A. Panavelil. 6th ed. Philadelphia, Pa.: Lippincott Williams & Wilkins. xi, 664. ISBN 9781451191776. 2015. info
DOSTÁLEK, Miroslav, Jan JUŘICA, Eva JANOŠTÍKOVÁ and Lucia ZAHRADNÍKOVÁ. Farmakokinetika (Pharmacokinetics). ČR: Grada. 220 pp. Farmacie a farmakologie. ISBN 80-247-1464-7. 2006. info
Waller, Derek - Renwick, Andrew G. - Hillier, Keith. Medical pharmacology and therapeutics. 3rd ed. New York : Elsevier Saunders, 2009. ix, 744 p. ISBN 0-7020-2991-2.
Ritter, James M. - Lewis, Lionel D. - Mant, Timothy G.K. - Ferro, Albert. A Textbook of Clinical Pharmacology and Therapeutics, 5th Ed., Hodder Arnold, 2008. 465 s. ISBN 978-0-340-90046-8
Farmakologie pro studenty bakalářských oborů na LF MU, Máchalová a kol., 2015, http://portal.med.muni.cz/clanek-644-farmakologie-pro-studenty-bakalarskych-oboru-na-lf-mu.html
Výzkum nových léčiv od zrodu k registraci, Starobová a kol., 2006, http://portal.med.muni.cz/clanek-367-vyzkum-novych-leciv-od-zrodu-k-registraci.html
http://portal.med.muni.cz/clanek-652-behavioralni-metody-v-neuropsychofarmakologii.html
Farmakovigilance a propagace léčiv, Vršková a kol., 2007 http://portal.med.muni.cz/clanek-461-farmakovigilance-a-propagace-leciv.html
For English speaking students: Practicals in Pharmacology http://portal.med.muni.cz/discipline-13-pharmacology

Teaching methods

practicals, class discussion

Only 1 absence from practical lessons is possible.

Assessment methods

3 continuous multiple-choice tests (time limit: 15 min)and 1 prescription test in a paper form. MCQ tests will not be repeated. The prescription test can be repeated only twice.

Each multiple-choice test contains 15 questions. The number of correct answers is given. Student gets 1 point for each completely correct answer, i.e. maximum 15 points for each multiple-choice test; total 45 points for all three MCQ tests.

The prescription test consists of individually-made and a read-made preparations. For the individually-made preparation the Pharmacopoeial name of the main active substance, its single-therapeutic dose and the drug dosage form will be given. For the ready-made preparation the drug dosage form and the number of original packages to be prescribed will be listed. The prescription handbook will be available for the test.

To obtain credits, the student has to pass the prescription test successfully and also get at least 6 points from each single multiple-choice test and at least 20 points (minimum) from all three MCQ tests.

Note: Together with the new accreditation of the Pharmacology subject for students of General Medicine, a system of continuous assessment of the student was introduced, when the results achieved in multiple-choice tests in practical lessons and colloquium will be taken into account and included in the final mark of the subject.

Language of instruction

Czech

Further comments (probably available only in Czech)

Study Materials
The course is taught annually.
Information on the extent and intensity of the course: 45.

Listed among pre-requisites of other courses

VLAL081 Anaesthesiology and Treatment of Pain I
VLFA07212c
VLPM081 Palliative Medicine
VLFA07212c && VLPF0622p && (rocnik(5) || rocnik(4))

The course is also listed under the following terms Autumn 2017, autumn 2019, autumn 2020, autumn 2021, autumn 2022, autumn 2023.

Enrolment Statistics (autumn 2018, recent)
Permalink: https://is.muni.cz/course/med/autumn2018/VLFA07212c

LF:VLFA07212c Pharmacology I - Course Information

VLFA07212c Pharmacology I - practice

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