LF:aVLBC0321c Biochemistry I - pract.

aVLBC0321c Biochemistry I - practice

Faculty of Medicine
Autumn 2016

Extent and Intensity

0/2/0. 3 credit(s). Type of Completion: z (credit).

Teacher(s)

Guaranteed by

prof. RNDr. Eva Táborská, CSc.
Department of Biochemistry – Theoretical Departments – Faculty of Medicine
Supplier department: Department of Biochemistry – Theoretical Departments – Faculty of Medicine

Timetable of Seminar Groups

aVLBC0321c/30: Fri 14:45–16:25 A16/213, H. Paulová
aVLBC0321c/31: Thu 14:00–15:40 A16/212, J. Dostál
aVLBC0321c/32: Thu 14:00–15:40 A16/216, J. Dostál
aVLBC0321c/33: Wed 14:00–15:40 A16/216
aVLBC0321c/34: Fri 14:40–16:25 A16/216, H. Paulová
aVLBC0321c/35: Thu 16:00–17:40 A16/216, J. Tomandl
aVLBC0321c/36: Thu 16:00–17:40 A16/213, J. Tomandl
aVLBC0321c/37: Wed 14:00–15:40 A16/212

Prerequisites (in Czech)

aVLBI0222c Biology II - pract. && aVLBF011c Biophysics - pract.

Course Enrolment Limitations

The course is only offered to the students of the study fields the course is directly associated with.

fields of study / plans the course is directly associated with

General Medicine (eng.) (programme LF, M-VL)
General Medicine (programme LF, M-VL)

Course objectives

The aim of the course is to obtain knowledge on essential metabolic processes on the cell level. Understanding of these proceses is a base for comprihension of metabolism on the tissue and organ level. In the introductory lessons are summarized basic terms from chemistry needed for understanding of body structure a physico-chemical processes occuring in it ((chemical composition of the body, survay of biologically important elements,water, elektrolytes, non-elektrolytes, osmotic pressure, acid-base, redox and precipitation reactions), the following lectures are focused on biochemichal pathways in cells. The graduate is acquainted with principles of acid-base, precipitation and redox reactions, role of macro- and micro elements in the body, properties and function of enzymes, is oriented in catabolic and anabolic pathways of metabolism of saccharides, lipids and proteins and their consequences.Understands the principles of cell bioenegetics.Become familiar with the funcion of cell membranes, principle of cell compartmentation and membrane transport.Has knowledge on proteosynthesis including processes replication,transcription, translation and posttranslantion modifications.Understands the relation between the structure and function of proteins. Is acquinted with function of hemoglobine in oxygen transport.Molecular bases of some diseases are introduced. The course provides the essential knowledge for future understanding of metabolism on organe and inter-organe level and its disturbances.

Syllabus

Introduction into the metabolism of cells (differences between prokatyotic and eukaryotic cell, compartmentation of metabolic processes, non-covalent interactions). Structure of haemoglobin and its relationship to the function. Hb types in the blood of healthy subjects, HbCO and MetHb, abnormal Hb types. Enzymes - reaction rate, progress curve, the Michaelis plot and Km, enzyme inhibition. Coenzymes, their relationship to vitamins. Written test I (Biochemical methods, haemoglobin, enzymology, coenzymes.) Membrane structure and assembly. Transport across membranes. Metabolism of glucose: Glycolysis under anaerobic and aerobic conditions and the oxidation of pyruvate. Gluconeogenesis. Glycogenesis and glycogenolysis. Metabolism of proteins. Common features of amino acid conversion. The synthesis of urea. Nitrogen balance. Important reactions in amino acid catabolism. Written test II (Membranes, transport across membranes, metabolism of saccharides and amino acids.) Biosynthesis and desaturation of fatty acids. The sources of essential fatty acids. Metabolism of triacylglycerols. Metabolism of phospholipids. Biosynthesis of eicosanoids. Peroxidation of lipids. Written test III (Metabolism of lipids.) The citric acid cycle. The respiratory chain and oxidative phosphorylation. Replication, transcription, proteosynthesis.

Teaching methods

Course is based on group discusion to the given topics. The outlines of discusion are in the recommended textbook. Complementary materials are available in section Study materials.

Language of instruction

English

Further Comments

The course is taught annually.

The course is also listed under the following terms Autumn 2017, autumn 2018, autumn 2019, autumn 2020.

Enrolment Statistics (Autumn 2016, recent)
Permalink: https://is.muni.cz/course/med/autumn2016/aVLBC0321c

LF:aVLBC0321c Biochemistry I - pract. - Course Information

aVLBC0321c Biochemistry I - practice

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