aVLFA0721c Pharmacology I - practice

Faculty of Medicine
autumn 2021
Extent and Intensity
0/3/0. 1 credit(s). Type of Completion: z (credit).
Taught in person.
Teacher(s)
doc. MUDr. Regina Demlová, Ph.D. (seminar tutor)
doc. PharmDr. Jan Juřica, Ph.D. (seminar tutor)
doc. Mgr. MVDr. Leoš Landa, Ph.D. (lecturer)
Mgr. Petra Amchová, Ph.D. (seminar tutor)
doc. RNDr. Ladislava Bartošová, Ph.D. (seminar tutor)
Mgr. Jana Kubátová, Ph.D. (seminar tutor)
MUDr. Alena Máchalová, Ph.D. (seminar tutor)
Mgr. Kristýna Nosková, Ph.D. (seminar tutor)
MUDr. Jana Nováková, Ph.D. (seminar tutor)
MUDr. Jana Pistovčáková, Ph.D. (seminar tutor)
PharmDr. Jitka Rychlíčková, Ph.D. (seminar tutor)
Mgr. Barbora Říhová, Ph.D. (seminar tutor)
PharmDr. Lenka Součková, Ph.D. (seminar tutor)
doc. PharmDr. Ondřej Zendulka, Ph.D. (seminar tutor)
Renata Bláblová (assistant)
Květoslava Sedlářová (assistant)
Guaranteed by
doc. MUDr. Regina Demlová, Ph.D.
Department of Pharmacology – Theoretical Departments – Faculty of Medicine
Contact Person: doc. Mgr. MVDr. Leoš Landa, Ph.D.
Supplier department: Department of Pharmacology – Theoretical Departments – Faculty of Medicine
Timetable of Seminar Groups
aVLFA0721c/30: Wed 22. 9. 13:00–15:30 A19/229, Wed 29. 9. 13:00–15:30 A19/229, Wed 6. 10. 13:00–15:30 A19/229, Wed 13. 10. 13:00–15:30 A19/229, Wed 20. 10. 13:00–15:30 A19/229, Wed 27. 10. 13:00–15:30 A19/229, Wed 3. 11. 13:00–15:30 A19/229, Wed 10. 11. 13:00–15:30 A19/229, Wed 24. 11. 13:00–15:30 A19/229, Wed 1. 12. 13:00–15:30 A19/229, Wed 8. 12. 13:00–15:30 A19/229, Wed 15. 12. 13:00–15:30 A19/229, Wed 5. 1. 13:00–15:30 A19/229, Wed 12. 1. 13:00–15:30 A19/229, O. Zendulka
aVLFA0721c/31: Mon 20. 9. 13:00–15:30 A19/229, Mon 27. 9. 13:00–15:30 A19/229, Mon 4. 10. 13:00–15:30 A19/229, Mon 11. 10. 13:00–15:30 A19/229, Mon 18. 10. 13:00–15:30 A19/229, Mon 25. 10. 13:00–15:30 A19/229, Mon 1. 11. 13:00–15:30 A19/229, Mon 8. 11. 13:00–15:30 A19/229, Mon 15. 11. 13:00–15:30 A19/229, Mon 22. 11. 13:00–15:30 A19/229, Mon 29. 11. 13:00–15:30 A19/229, Mon 6. 12. 13:00–15:30 A19/229, Mon 13. 12. 13:00–15:30 A19/229, Mon 3. 1. 13:00–15:30 A19/229, Mon 10. 1. 13:00–15:30 A19/229, P. Amchová, J. Pistovčáková, J. Rychlíčková
aVLFA0721c/32: Fri 24. 9. 13:00–15:30 A19/229, Fri 1. 10. 13:00–15:30 A19/229, Fri 8. 10. 13:00–15:30 A19/229, Fri 15. 10. 13:00–15:30 A19/229, Fri 22. 10. 13:00–15:30 A19/229, Fri 29. 10. 13:00–15:30 A19/229, Fri 5. 11. 13:00–15:30 A19/229, Fri 12. 11. 13:00–15:30 A19/229, Fri 19. 11. 13:00–15:30 A19/229, Fri 26. 11. 13:00–15:30 A19/229, Fri 3. 12. 13:00–15:30 A19/229, Fri 10. 12. 13:00–15:30 A19/229, Fri 17. 12. 13:00–15:30 A19/229, Fri 7. 1. 13:00–15:30 A19/229, Fri 14. 1. 13:00–15:30 A19/229, J. Pistovčáková
aVLFA0721c/33: Tue 21. 9. 13:00–15:30 A19/229, Tue 5. 10. 13:00–15:30 A19/229, Tue 12. 10. 13:00–15:30 A19/229, Tue 19. 10. 13:00–15:30 A19/229, Tue 26. 10. 13:00–15:30 A19/229, Tue 2. 11. 13:00–15:30 A19/229, Tue 9. 11. 13:00–15:30 A19/229, Tue 16. 11. 13:00–15:30 A19/229, Tue 23. 11. 13:00–15:30 A19/229, Tue 30. 11. 13:00–15:30 A19/229, Tue 7. 12. 13:00–15:30 A19/229, Tue 14. 12. 13:00–15:30 A19/229, Tue 4. 1. 13:00–15:30 A19/229, Tue 11. 1. 13:00–15:30 A19/229, L. Landa
aVLFA0721c/34: Thu 23. 9. 13:00–15:30 A19/229, Thu 30. 9. 13:00–15:30 A19/229, Thu 7. 10. 13:00–15:30 A19/229, Thu 14. 10. 13:00–15:30 A19/229, Thu 21. 10. 13:00–15:30 A19/229, Thu 4. 11. 13:00–15:30 A19/229, Thu 11. 11. 13:00–15:30 A19/229, Thu 18. 11. 13:00–15:30 A19/229, Thu 25. 11. 13:00–15:30 A19/229, Thu 2. 12. 13:00–15:30 A19/229, Thu 9. 12. 13:00–15:30 A19/229, Thu 16. 12. 13:00–15:30 A19/229, Thu 6. 1. 13:00–15:30 A19/229, Thu 13. 1. 13:00–15:30 A19/229, L. Součková
aVLFA0721c/35: Thu 23. 9. 16:00–18:30 A19/229, Thu 30. 9. 16:00–18:30 A19/229, Thu 7. 10. 16:00–18:30 A19/229, Thu 14. 10. 16:00–18:30 A19/229, Thu 21. 10. 16:00–18:30 A19/229, Thu 4. 11. 16:00–18:30 A19/229, Thu 11. 11. 16:00–18:30 A19/229, Thu 18. 11. 16:00–18:30 A19/229, Thu 25. 11. 16:00–18:30 A19/229, Thu 2. 12. 16:00–18:30 A19/229, Thu 9. 12. 16:00–18:30 A19/229, Thu 16. 12. 16:00–18:30 A19/229, Thu 6. 1. 16:00–18:30 A19/229, Thu 13. 1. 16:00–18:30 A19/229, J. Juřica
Prerequisites (in Czech)
aVLPF0622p Pathophysiology II - lecture && aVLPA0622c Pathology II - practice
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The aims of the course are:
to recognize the basic pharmacological terminology and legislation related to the use of drugs and thei prescription
to understand to differences between single drug dosage forms
to understand to the prescription of drugs
to understand to the basics of pharmacokinetics
to understand to the basic facts about the discussed drugs
Learning outcomes
At the end of the course the student knows:
single pharmacoterapeutical drug classes
single drug dosage forms
the modes of action, adverse reactions and basic indications of single drugs of discussed drugs
how to prescribe selected medical preparation or a drug in particular drug dosage form
Syllabus

  • aVLFA0721c - Pharmacology I - practical lessons

    General medicine

    Autumn semester 2021

  • 20. 9. – 24. 9. 2021
  • Topic 1: INFORMATION ON DRUGS
  • Organisation of practical courses and lectures, system of evaluation. Repetition of basic pharmacologic terminology. Sub-branches of pharmacology. Sources of information concerning drugs and recommended textbooks. Work with relevant databases (Brevíř, SÚKL, EMA, AISLP), ATC classification.
  • 27. 9. – 1. 10. 2021
  • Topic 2: ROUTES OF DRUG ADMINISTRATION, DRUG DOSAGE FORMS
  • Brief characteristics of the individual drug dosage forms. Clinical significance of the way of drug administration.
  • 4. 10. – 8. 10. 2021
  • Topic 3: PRESCRIPTION OF MEDICAL PRODUCTS
  • General rules of drug prescription. Prescription of the ready-made preparations, drug dosage forms.
  • 11. 10. – 15.10. 2021
  • Topic 4: PHARMACOKINETICS I
  • Pharmacokinetic processes, parameters and calculations.
  • 18. 10. – 22. 10. 2021
  • Topic 5: PHARMACOKINETICS II
  • Pharmacokinetic case reports, simulation of plasma concentrations course, dosage optimalization and use of software tools, factors affecting course and value of drug´s plasma concentrations.
  • 25. 10. – 29. 10. 2021
  • Topic 6: PHARMACODYNAMICS
  • MULTIPLE-CHOICE TEST 1 (Topics 1-5).
  • Mechanisms of drug effects - classification, examples. Dose-response curves.
  • 1. 11. – 5. 11. 2021
  • Topic 7: FACTORS AFFECTING DRUG EFFECTS
  • Pharmacotherapy in childhood, in pregnancy, in breastfeeding women, in elderly. Beer's list, STOPP-START, FORTA. Pharmacogenetics.
  • 8. 11. – 12. 11. 2021
  • Topic 8: PHARMACOVIGILANCE, ADVERSE DRUG REACTIONS
  • PRESCRIPTION TEST
  • Classification and characteristics of adverse drug effects. Pharmacovigilance in clinical practice, sources of current information on drug safety.
  • 15. 11. – 19. 11. 2021
  • Topic 9: PHARMACOLOGY OF SYMPATHETIC NERVOUS SYSTEM
  • Receptors of the sympathetic nervous system (alpha, beta) and their subtypes and organ distribution. Classification and basic pharmacological characteristics of drugs influencing sympathetic nervous system (pharmacodynamics - both direct and indirect mechanisms of drug action, systems of second messengers).
  • 22. 11. – 26. 11. 2021
  • Topic 10: PHARMACOLOGY OF PARASYMPATHETIC NERVOUS SYSTEM, SPASMOLYTIC DRUGS
  • Drugs affecting parasympathetic nervous system - classification, basic pharmacological characteristics. Spasmolytic drugs.
  • 29. 11. – 3. 12. 2021
  • Topic 11: ANAESTHETIC DRUGS
  • MULTIPLE-CHOICE TEST 2 (Topics 6-10).
  • Basic pharmacological characteristics of general and local anaesthetic drugs and muscle relaxants. Premedication prior to general anaesthesia.
  • 6. 12. – 10. 12. 2021
  • Topic 12: ANALGESICS
  • Basic pharmacological characteristics of opioid and non-opioid analgesic drugs, antirheumatoid drugs and drugs used in gout.
  • 13. 12. – 17. 12. 2021
  • Topic 13: PHARMACOTHERAPY OF DIABETES MELLITUS
  • Anti-diabetic drugs - basic pharmacological characteristics. Drugs used in therapy of specific and acute conditions in diabetology. Combinations of insulins, insulin regimens.
  • 3. 1. – 7. 1. 2022
  • Topic 14: SEX HORMONES
  • Endocrine therapy, hormone replacement therapy, hormonal contraceptive drugs. Uterotonics and tocolytics.
  • 10. 1. – 14. 1. 2022
  • Topic 15: GLUCOCORTICOIDS, THYROID HORMONES
  • MULTIPLE-CHOICE TEST 3 (Topics 11-14).
  • Repetition of basic pharmacological characteristics of glucocorticoids and thyroid hormones.
Literature
    required literature
  • Practicals in Pharmacology, 2009, Náhradní obsah: http://portal.med.muni.cz/article-491-practicals-in-pharmacology.html
  • http://search.ebscohost.com/login.aspx?direct=true&db=nlebk&AN=1160493&lang=cs&site=ehost-live
  • RANG, H. P., James RITTER, R. J. FLOWER and Graeme HENDERSON. Rang & Dale's pharmacology. Eighth edition. [Edinburgh]: Churchill Livingstone, 2016, xv, 760. ISBN 9780702053627. info
    not specified
  • Pharmaceutical practice. Edited by Judith A. Rees - Ian Smith - Jennie Watson. 5th ed. Edinburgh: Churchill Livingstone Elsevier, 2014, xvii, 552. ISBN 9780702051432. info
  • Waller, Derek - Renwick, Andrew G. - Hillier, Keith. Medical pharmacology and therapeutics. 3rd ed. New York : Elsevier Saunders, 2009. ix, 744 p. ISBN 0-7020-2991-2.
  • Ritter, James M. - Lewis, Lionel D. - Mant, Timothy G.K. - Ferro, Albert. A Textbook of Clinical Pharmacology and Therapeutics, 5th Ed., Hodder Arnold, 2008. 465 s. ISBN 978-0-340-90046-8
  • LÜLLMANN, Heinz, Lutz HEIN and Klaus MOHR. Color atlas of pharmacology. Translated by Detlef Bierger, Illustrated by Jürgen Wirth. 4th ed. Stuttgart: Thieme, 2011, x, 393. ISBN 9783137817048. info
  • Pharmacology. Edited by Michelle Alexia Clark. 5th ed. Baltimore: Wolters Kluwer Health/Lippincott Williams & Wilkins, 2012, xii, 612. ISBN 9781451113143. info
Bookmarks
https://is.muni.cz/ln/tag/LF:aVLFA0721c!
Teaching methods
Classes take place periodically in the afternoon. The lectures are followed by practical exercises with discussion.

The lectures discuss the basic issues of the subject. This knowledge is further deepened via specific practical tasks in exercises.

Materials for self-study and preparation for exercises will be available in the interactive syllabus/study materials for each topic, including references to the relevant chapters in the textbook.

2 absences from practical lessons are possible.
Assessment methods
3 continuous multiple-choice tests (time limit: 15 min) and 1 prescription test in a paper form. MCQ tests will not be repeated. The prescription test can be repeated only twice.

Each multiple-choice test contains 15 questions. The number of correct answers is given. Student gets 1 point for each completely correct answer, i.e. maximum 15 points for each multiple-choice test; total 45 points for all three MCQ tests.

The prescription test consists of two read-made preparations. For both preparations, the active substance, the drug dosage form and the number of original packages to be prescribed will be listed. The prescription handbook will be available for the test.

To obtain credits, the student has to pass the prescription test successfully and also get at least 6 points from each single multiple-choice test and at least 20 points (minimum) from all three MCQ tests.

Note: Together with the new accreditation of the Pharmacology subject for students of General Medicine, a system of continuous assessment of the student was introduced, when the results achieved in multiple-choice tests in practical lessons and colloquium will be taken into account and included in the final mark from the subject.
Language of instruction
English
Further comments (probably available only in Czech)
The course is taught annually.
Information on the extent and intensity of the course: 45.
Teacher's information
Course Contents:

INTRODUCTION, TERMINOLOGY, DOSES, PHARMACOLOGICAL CALCULATIONS

GENERAL RULES OF THE DRUG PRESCRIPTION

FLUID DRUG DOSAGE FORMS FOR THE EXTERNAL USE, ORAL AND PARENTERAL USE. GASEOUS DRUG DOSAGE FORMS

SOLID DRUG DOSAGE FORMS. SOFT AND MELTING DRUG DOSAGE FORMS

ROUTES OF DRUG ADMINISTRATION

INTRODUCTION TO PHARMACOKINETICS, PRINCIPLES, PARAMETERS

PHARMACOKINETIC INTERACTIONS. THERAPEUTIC DRUG MONITORING

PHARMACODYNAMICS

ADVERSE DRUG REACTIONS

FACTORS AFFECTING DRUG EFFECTS

PHARMACOLOGY OF THE SYMPATHETIC NERVOUS SYSTEM SYMPATHOMIMETICS, SYMPATHOLYTICS

PHARMACOLOGY OF THE PARASYMPATHETIC NERVOUS SYSTEM CHOLINERGIC DRUGS, SPASMOLYTICS

PHARMACOLOGY OF ENDOCRINE SYSTEM

GLUCOCORTICOIDS

ANTI-DIABETIC DRUGS

SEX HORMONES, UTEROTONICS, TOCOLYTICS

ANALGESIC DRUGS

ANTIRHEUMATOID DRUGS

DRUGS USED IN GOUT

ANAESTHETIC DRUGS

MUSCLE RELAXANTS

The course is also listed under the following terms Autumn 2017, autumn 2018, autumn 2019, autumn 2020, autumn 2022, autumn 2023.
  • Enrolment Statistics (autumn 2021, recent)
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