aZLGE061p Genetics in Dentistry - lecture

Faculty of Medicine
Spring 2018
Extent and Intensity
0/0.5/0. 1 credit(s). Type of Completion: k (colloquium).
Teacher(s)
prof. MUDr. Anna Vašků, CSc. (lecturer)
prof. RNDr. Monika Pávková Goldbergová, Ph.D. (lecturer)
Věra Ježková (assistant)
Mgr. Jolana Lipková, Ph.D. (assistant)
Guaranteed by
prof. MUDr. Anna Vašků, CSc.
Department of Pathophysiology – Theoretical Departments – Faculty of Medicine
Contact Person: prof. MUDr. Anna Vašků, CSc.
Supplier department: Department of Pathophysiology – Theoretical Departments – Faculty of Medicine
Timetable
Wed 21. 2. 8:00–11:45 A18/108, Wed 14. 3. 8:00–11:45 A18/108
Prerequisites (in Czech)
aZLLM0522p Medical Microbiology II-lect. && aZLIM051p Immunology in Dent. - lecture && ( aZLBC041p Biochemistry II -lec. || ZLBC041p Biochemistry II -lec. ) && aZLPF0521c Pathophysiol.I - practice
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
Genome structure and its reactions on environmental effects. Mutations in exons, intrones and promoters. Monogenic and multigenic diseases. Relations of multigenic diseases and environment. Molecular biology methods – PCR, RFLP, sequencing. Functional genomics, proteomics. Gene therapy and pharmacogenetics. Genetics of developmental defects of enamel and dentine. Genetics of craniofacial malformations. Genetic analysis of oral pathogens. Genetics of periodontal diseases and tooth caries. Genes involved in pathogenesis of diseases manifested in oral cavity.
Learning outcomes
Student will be able to:
- summarize the basic methods used in molecular biology and genetics
- acquire the basics of work in the molecular-biological laboratory
- identify the monogenic and multigenic basis of defects from the point of view of the dentist
- describe the influence of genetics on the development of oral cavity disease
- evaluate the effect of epigenetic factors
Syllabus
  • 1.week Structure of genome and its interaction with environmental factors. Epigenetics. Exon, intron and promoter mutations. Monogenic and polygenic diseases. Functional genomics. Gene therapy and pharmacogenetics. 2.week Molecular-biological methods (PCR, RFLP, sequencing). Relation between polygenic diseases and environment. The role of genes in the pathogenesis of disease manifestations in the oral cavity. Effect of tissue development on abnormalities of the oral cavity. 4.week Genetics of dentin and enamel anomalies. Genetics of craniofacial malformations. Molecular-genetic analysis of oral bacteria. Genetics of periodontal diseases and dental caries.
Literature
  • NUSSBAUM, Robert L., Roderick R. MCINNES, Huntington F. WILLARD, James THOMPSON and Margaret Wilson THOMPSON. Klinická genetika : Thompson & Thompson. Translated by Petr Goetz. Vyd. 1. Praha: Triton, 2004, 426, lix. ISBN 8072544756. info
  • Essential genetics :a genomics perspective. Edited by Daniel L. Hartl - Elizabeth W. Jones. 3rd ed. Boston: Jones and Bartlett Publishers, 2002, xxv, 612 s. ISBN 0-7637-1852-1. info
Teaching methods
Lecture.
Assessment methods
Oral exam - colloquium. Student respond to 2 questions - one from general and second from special genetics.
Language of instruction
English
Further comments (probably available only in Czech)
The course is taught annually.
Listed among pre-requisites of other courses
The course is also listed under the following terms spring 2019, spring 2020, spring 2021, spring 2022, spring 2023, spring 2024.
  • Enrolment Statistics (Spring 2018, recent)
  • Permalink: https://is.muni.cz/course/med/spring2018/aZLGE061p