aVLBC0422s Biochemie II - seminář

Lékařská fakulta
jaro 2021
Rozsah
0/3/0. 45. 2 kr. Ukončení: z.
Vyučováno online.
Vyučující
doc. RNDr. Jiří Dostál, CSc. (cvičící)
MUDr. Michaela Králíková, Ph.D. (cvičící)
RNDr. Hana Paulová, CSc. (cvičící)
Mgr. Jiří Slanina, Ph.D. (cvičící)
prof. RNDr. Eva Táborská, CSc. (cvičící)
doc. RNDr. Josef Tomandl, Ph.D. (cvičící)
Mgr. Marie Tomandlová, Ph.D. (cvičící)
MUDr. Miroslava Hlaváčová, Ph.D. (pomocník)
Garance
prof. RNDr. Eva Táborská, CSc.
Biochemický ústav – Teoretická pracoviště – Lékařská fakulta
Dodavatelské pracoviště: Biochemický ústav – Teoretická pracoviště – Lékařská fakulta
Rozvrh seminárních/paralelních skupin
aVLBC0422s/30: Čt 15:00–17:30 A16/215, J. Tomandl
aVLBC0422s/31: Čt 15:00–17:30 A16/215, J. Tomandl
aVLBC0422s/32: Čt 12:00–14:30 A16/213, E. Táborská, J. Tomandl
aVLBC0422s/33: Čt 12:00–14:30 A16/213, E. Táborská, J. Tomandl
aVLBC0422s/34: Po 8:00–10:30 A16/215, E. Táborská, J. Tomandl
aVLBC0422s/35: Po 8:00–10:30 A16/215, E. Táborská, J. Tomandl
aVLBC0422s/36: Út 11:00–13:30 A16/215, E. Táborská, J. Tomandl
aVLBC0422s/37: Út 11:00–13:30 A16/215, E. Táborská, J. Tomandl
aVLBC0422s/38: Čt 12:00–14:30 A16/215, J. Dostál
aVLBC0422s/39: Čt 12:00–14:30 A16/215, J. Dostál
Předpoklady
aVLBI0222p Lékařská biologie II - př && aVLBF011p Biophysics - lecture && aVLBC0321s Biochemie I - sem. && aVLBC0321c Biochemie I - cvičení && aVLFY0321c Fyziologie I - cv. && aVLFY0321s Fyziologie I - sem.
Omezení zápisu do předmětu
Předmět je určen pouze studentům mateřských oborů.
Mateřské obory/plány
Cíle předmětu
Seminars are complementary to Biochemistry II lecture (aVLBC0422p). At the end of the course students undestand principles of intermediary metabolism, characteristic features of metabolism of individual organs and tissues and metabolism at various conditions of organism (well fed state, fasting, starvation, metabolic stress, obesity, metabolic syndrome).
Výstupy z učení
The student is able:
- to explain the interrelationship between the metabolism of nutrients under different states of the organism.
- to describe the metabolic characteristics of major organs and tissues and major disorders, discusses their association with diseases.
- to understand and discuss principles of maintaining homeostasis and acid-base balance in the organism, including modeling situations
- to discuss the composition of body fluids and their disorders in connection with the principles of homeostasis.
- to explain the principles of metabolism regulation at all levels.
Osnova
  • Enzyme assays in clinical diagnostics. Methods in clinical biochemistry (photometry, electrophoretic methods). • Plasma lipoproteins, interconversions of lipoproteins. Cholesterol transport, balance of cholesterol intake and excretion. • Blood glucose (sources, consumption, regulation). Diabetes mellitus. • Proteins in nutrition. Absorption of amino acids, utilization of amino acids in tissues, blood transport of ammonia, the glutamine cycle. Hormonal regulation. • Integration of metabolism of nutrients: relationships among the major metabolic pathways in the fed state, post-absorptive state, prolonged starvation, obesity. • The liver functions – the role in metabolism of nutrients. Catabolism of haemoglobin, urobilinoids, the types of hyperbilirubinemia. • The liver functions – the role in metabolism of hormones, and vitamins. Metabolism of Fe. Biotransformation of xenobiotics. Metabolism of ethanol. • Water and mineral metabolism. Sodium and water homeostasis, osmolality and volume of water, regulation, disorders. Blood acid-base parameters. Transport of O2 a CO2. Metabolic processes producing and consuming H+. Buffer bases. Acid base disorders. • Major functions of the kidney. Glomerular filtration. • Tubular resorption and secretion. • Neurotransmitters and hormone receptors. The most common signal pathways. • Metabolism of Ca, Mg, P, F, I. Hormones important for their metabolism. • Metabolism of connective tissue. Extracellular matrix. Mineralisation of bone tissue, regulation. Biochemical markers of bone metabolism. Cartilage and skin. • Biochemistry of muscle work (skeletal, cardiac, smooth). Effect of NO.Energetics of muscle work.
Literatura
    povinná literatura
  • Seminar texts available in Information system
Výukové metody
Course is based on group discusion to the given topics. The outlines of discusion are in the recommended textbook. Complementary materials are available in section Study materials.
Metody hodnocení
Conditions of giving the credits • Submission of all completed protocols with answers to the Homework Vaults in relevant dates. • Required attendance in seminars. • All absences must be made up according to teacher instructions. • Obtaining 52 points or more from continuous revision tests or • Obtaining 14 points from the credit test
Vyučovací jazyk
Angličtina
Informace učitele
Teaching in seminars will be realized in a contactless form, as online meetings in MS Teams environment, similarly as in the Autumn semester. The seminars will take place on the dates and times specified in the schedule. Online seminars will be teacher-moderated discussions to the given topic according to the syllabus of the course. The control questions of the given seminar topic intended for self-study and preparation for the discussion will be saved in the Study materials of the course. Attendance at online classes is mandatory, absences must be excused in IS MUNI. Maximally one unexcused absence per semester is tolerated. Like in previous semester, the up-load of a completed protocol to IS Homework Vault before the seminar date will be required. The deadline for submission is always the Sunday 24:00 for the seminar in the following week. Protocols must be provided for all seminar topics, even in case of absence from the seminar. In the 4th, 9th and 12th week, on Fridays, continuous revision online tests will be opened in the IS MUNI application at the same time for all students. These tests must be taken by all students. If students obtain at least 52/75 points from three continuous tests, they are awarded a credit without the obligation to write a credit test. (Excused absence from continuous tests can be made up in the credit week). The other students must take a credit test in the 15th week. The credit test covers the topics of all seminars and has 30 questions. The condition for giving the credit is to obtain 14 points. The credit test can be written after all absences are made up. Students who do not meet the conditions of the credit test in the credit week have the opportunity to repeat it once.
Další komentáře
Předmět je vyučován každoročně.
Nachází se v prerekvizitách jiných předmětů
Předmět je zařazen také v obdobích jaro 2017, jaro 2018, jaro 2019, jaro 2020, jaro 2022, jaro 2023, jaro 2024.