F1IF1_14 Immunopharmacology

Faculty of Pharmacy
Autumn 2021
Extent and Intensity
2/1/0. 4 credit(s). Type of Completion: zk (examination).
Taught in person.
Teacher(s)
MUDr. PharmDr. Marek Frydrych, Ph.D. (lecturer)
MUDr. PharmDr. Marek Frydrych, Ph.D. (seminar tutor)
Guaranteed by
MUDr. PharmDr. Marek Frydrych, Ph.D.
Department of Pharmacology and Toxicology – Departments – Faculty of Pharmacy
Timetable
Thu 17:25–19:05 44-037
  • Timetable of Seminar Groups:
F1IF1_14/01: Thu 19:05–19:55 44-037
Prerequisites (in Czech)
FAKULTA ( FaF ) || OBOR ( MUSFaF )
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.

The capacity limit for the course is 20 student(s).
Current registration and enrolment status: enrolled: 1/20, only registered: 0/20
fields of study / plans the course is directly associated with
Course objectives
Aims: Basic aim of education in Immunopharmacology is to gain knowledge of basic interactions between immune system function and feasibilities of pharmacointervention.
Contentual focus: Main objective is study of compounds, which suppress unfavourable organism immune response (immunosuppressive drugs) and compounds, which on the contrary enhance organism immune response (immunostimulants).
Learning outcomes
After completing the course, the student will be able to: - summarize the basic links between the function of the immune system and the possibility of influencing it by pharmacointerventions, - describe the basic principles of therapy with immunosuppressants and immunostimulatory substances, - describe the basic principles and action of monoclonal antibodies, including their mechanism of action and indications
Syllabus
  • Syllabus of Lectures and Tutorials: 1. Introduction to Immunopharmacology, Overview of the Immune Response, Hematopoiesis Including Lymphocyte Development and Maturation, T and B Cell Mediated Immunity, Cytokines, Innate and Acquired Immunity. Tutorial: Inflammatory Mediators, Hypersensitivity and Autoimmunity, Cancer Immunity 2. Cytokines I. Role of Cytokines, IL-1, IL-2, IL-4, IL-5, IL-6, IL-9, IL-10, IL-11, IL-13, IL-18, Therapeutic Use of IL-1,2,11. Tutorial: Clinical Case Reports Related to the Topic 3. Cytokines II. Interferons – Division and Clinical Applications, Colony Stimulating Factors – G-CSF, GM-CSF, TNF-Α, Etanercept. Tutorial: Clinical Case Reports Related to the Topic 4. Immunosuppressive Drugs I. Glucocorticoids – Mechanism of Action, Absorption, Distribution and Excretion, Side Effects, Clinical Uses. Tutorial: Clinical Case Reports Related to the Topic 5. Immunosuppressive Drugs II. Cytotoxic Agents – Methotraxate, Cyclophosphamide, Azathioprine. Tutorial: Clinical Case Reports Related to the Topic 6. Immunosupressive Drugs III. Cyclosporine, Tacrolimus, Sirolimus, Everolimus, Mycophenolate Mofetil, Fingolimod Tutorial: Clinical Case Reports Related to the Topic 7. Immunostimmulants: Isoprinosine, Bacterial Extracts, Vaccines Tutorial: Clinical Case Reports Related to the Topic 8. Monoclonal Antibodies as Therapeutic Agents in Tissue Transplantation, in The Treatment of Psoriasis, Rheumatoid Arthritis, Thrombosis, Treatment of Cancer. Tutorial: Clinical Case Reports Related to the Topic 9. Anti-Allergic Drugs: Chromones, Histamine Receptors Antagonists, Anti-Ige. Tutorial: Clinical Case Reports Related to the Topic 10. Drugs For The Treatment of Asthma And COPD: Bronchodilators (Β2-Agonists, Theophylline, Anticholinergics), Controller Drugs (Corticosteriods, Cromones, Mediator Antagonists: Anti-Histamines, Anti-Leukotrienes, Anti-IgE). Tutorial: Clinical Case Reports Related to the Topic 11. Disease Modifying Anti-Rheumatic Drugs: Antimalarial Drugs, Sulphasalazine, Gold Complexes, Leflunomide, Monoclonal Antibodies in the Treatment of Rheumatiod Diseases. Tutorial: Clinical Case Reports Related to the Topic 12. Drugs For The Treatment of Inflammatory Bowel Diseases: Therapeutic Strategy, Aminosalicylates, Corticosteroids, Antibiotics, Immunosuppressive Agents, Anti-Cytokines. Tutorial: Clinical Case Reports Related to the Topic 13. Tissue Transplantation: Types of Organ Rejection (Hyperacute, Acute, Chronic), GvHD, Clinical Transplantation (Kidney, Liver, Pancreas, Heart, Lung, Bone Marrow).Tutorial: Clinical Case Reports Related to the Topic 14. Acquired Immune Deficiency Syndrome: HIV Disease, Clinical Strategy for the Treatment of AIDS - Reverse Transcriptase Inhibitors, Protease Inhibitors, Drugs Inhibiting Viral Binding, Drugs Stimulating Immune Response. Tutorial: Clinical Case Reports Related to the Topic
Literature
    required literature
  • Nijkamp F.P., Parnham M.J. Principles of Immunopharmacology: 2nd revised and extended edition (Paperback). info
  • Manzoor M. Khan. Immunopharmacology. Springer Science, 2008. ISBN 978-0-387-77975-1. info
Teaching methods
Homework for topics according to the syllabus.
Assessment methods
Compulsory attendance at classes, oral exam.
Language of instruction
Czech
Further Comments
Study Materials
The course can also be completed outside the examination period.
The course is also listed under the following terms Autumn 2020.
  • Enrolment Statistics (recent)
  • Permalink: https://is.muni.cz/course/pharm/autumn2021/F1IF1_14