Bi6881 Biochemistry of Xenobiotics

Faculty of Science
Spring 2003
Extent and Intensity
2/0/0. 2 credit(s) (plus extra credits for completion). Type of Completion: zk (examination).
Teacher(s)
RNDr. Miroslav Machala, CSc. (lecturer)
prof. RNDr. Jakub Hofman, Ph.D. (assistant)
Guaranteed by
RNDr. Miroslav Machala, CSc.
RECETOX – Faculty of Science
Contact Person: prof. RNDr. Ladislav Dušek, Ph.D.
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
Classification of xenobiotics. Mechanisms of regulation, effects of xenobiotics. Metabolism of xenobiotics: monooxygenases, conjugating enzymes, MDR. Modes of action of toxicants: receptor-mediated mechanisms, metabolic activation of xenobitics, oxidative stress, inhibition of mitochondrial functions, neurotoxicity, modulation of cytokinetics, disruption of metabolism of endogeneous compounds. Chemical carcinogenesis, chemoprotective compounds.
Literature
  • Cytochrome P450 Protocols (ed. I.R. Phillips, E.A. Shephard). In: Methods in Molecular Biology, Vol. 107, Humana Press, New Jersey, 1998.
  • VOET, Donald and Judith G. VOET. Biochemie. Translated by Arnošt Kotyk. 1. vyd. Praha: Victoria Publishing, 1995, S. II-XIV,. ISBN 80-85605-44-9. info
  • TIMBRELL, John A. Principles of biochemical toxicology. 2nd ed. London: Taylor & Francis, 1991, 415 s. ISBN 0-85066-832-8. info
Language of instruction
Czech
Further Comments
The course is taught annually.
The course is taught: every week.
  • Enrolment Statistics (recent)
  • Permalink: https://is.muni.cz/course/sci/spring2003/Bi6881