Information System of Masaryk University 

Course Information

Bi6930 Immunotoxicology

Faculty of Science
Spring 2003

Extent and Intensity

2/0/0. 2 credit(s) (plus extra credits for completion). Type of Completion: zk (examination).

Teacher(s)

doc. RNDr. Luděk Bláha, Ph.D. (lecturer)

Supervisor

doc. RNDr. Luděk Bláha, Ph.D.
Research Centre for Toxic Compounds in the Environment (RECETOX) - Chemistry Section - Faculty of Science
Contact Person: doc. RNDr. Luděk Bláha, Ph.D.

Course Enrollment Limitations

The course is also offered to the students of the fields other than those the course is directly associated with.

Fields of study the course is directly associated with

• Ecotoxicology (programme PřF, M-BI)

Course objectives

Immunotoxicology - research branch studying effects of stressors (mainly chemical compounds) on immune system and the importance of immune system changes for organism health.. Immune system - components, function, communication. Experimental design in immunotoxicology. Tiered approach. Laboratory methods in immunotoxicology. Factors affecting immune system. Special immunotoxicology - drugs, pollutants. Ecological immunotoxicology - invertebrates, fish, amphibians. Risk assessment in immunotoxicology.

Syllabus

• 1. Immunotoxicology. Introduction, history, aims and scopes, human immunotoxicology, ecological immunotoxicology. 2. Immune system. Components of immune system, function, communication, immune system as a target of xenobiotics. Immune system as a part of an organism - interactions, controls, homeostasis, (xeno-)estrogens. 3. Experimental design in immunotoxicology. Exposure, response. "Tier I" and "Tier II" methods. Animal models in immunotoxicology, batteries of immunotoxicology tests. 4. Laboratory methods in immunotoxicology. Assays of immunocompetence, macrophage function assays, host resistance, antitumor immunity, hypersensitivity, autoimmunity. 5. Special immunotoxicology 1 - introduction. Factors affecting immune system (climate, geography, biorhythms, stress, social habits, chemicals, irradiation and other physico-chemical factors). 6. Special immunotoxicology 2 - immunotoxicology of drugs (antibiotics, important pharamceuticals, immunosuppressives a immunomodulators, antitumor therapy). 7. Special immunotoxicology 3 - immunotoxicology of pollutants (metals, pesticides, industrial chemicals - PCBs, PAHs, PCDD(F)s, other organic pollutants, azbestosis, silikosis). 8. Ecological immunotoxicology. Animal immune system and interactions with xenobiotics. Invertebrates, fish, amphibians, birds, mammals. Markers of immune system alterations, ecological consequences. Case studies. 9. Risk assessment. Immunotoxicology as a branch of general toxicology, hazard identification, uncertainities.

Literature

• Immunotoxicology and immunopharmacology. Edited by Jack H. Dean. 2nd ed. New York: Raven Press, 1994. xxi, 761 s. ISBN 0-7817-0219-4. info
• Wagner, V., Wagnerová, M. Ekoimunologie, Avicenum, 1988, Praha
• Ferenčík, M. Immunochémia, Alfa, 1989, Bratislava

Further Comments

The course is taught annually.
The course is taught: every week.

Listed among pre-requisites of other courses

• Bi9901 Free radicals in animal physiology
  Bi3030 && (Bi5220 || Bi6930)  

The course is also listed under the following terms Spring 2008 - for the purpose of the accreditation, Spring 2011 - only for the accreditation, Spring 2004, Spring 2005, Spring 2006, Spring 2007, Spring 2008, Spring 2009, Spring 2010, Spring 2011, spring 2012, spring 2012 - acreditation, spring 2013, spring 2014.

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• Enrollment Statistics (Spring 2003, recent)
  
• Permalink: https://is.muni.cz/course/sci/spring2003/Bi6930

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