Immunotoxicology - research branch studying effects of stressors (mainly chemical compounds) on immune system and the importance of immune system changes for organism health.. Immune system - components, function, communication. Experimental design in immunotoxicology. Tiered approach. Laboratory methods in immunotoxicology. Factors affecting immune system. Special immunotoxicology - drugs, pollutants. Ecological immunotoxicology - invertebrates, fish, amphibians. Risk assessment in immunotoxicology.
1. Immunotoxicology. Introduction, history, aims and scopes, human immunotoxicology, ecological immunotoxicology. 2. Immune system. Components of immune system, function, communication, immune system as a target of xenobiotics. Immune system as a part of an organism - interactions, controls, homeostasis, (xeno-)estrogens. 3. Experimental design in immunotoxicology. Exposure, response. "Tier I" and "Tier II" methods. Animal models in immunotoxicology, batteries of immunotoxicology tests. 4. Laboratory methods in immunotoxicology. Assays of immunocompetence, macrophage function assays, host resistance, antitumor immunity, hypersensitivity, autoimmunity. 5. Special immunotoxicology 1 - introduction. Factors affecting immune system (climate, geography, biorhythms, stress, social habits, chemicals, irradiation and other physico-chemical factors). 6. Special immunotoxicology 2 - immunotoxicology of drugs (antibiotics, important pharamceuticals, immunosuppressives a immunomodulators, antitumor therapy). 7. Special immunotoxicology 3 - immunotoxicology of pollutants (metals, pesticides, industrial chemicals - PCBs, PAHs, PCDD(F)s, other organic pollutants, azbestosis, silikosis). 8. Ecological immunotoxicology. Animal immune system and interactions with xenobiotics. Invertebrates, fish, amphibians, birds, mammals. Markers of immune system alterations, ecological consequences. Case studies. 9. Risk assessment. Immunotoxicology as a branch of general toxicology, hazard identification, uncertainities.
Immunotoxicology and immunopharmacology. Edited by Jack H. Dean. 2nd ed. New York: Raven Press, 1994. xxi, 761 s. ISBN 0-7817-0219-4. info
Wagner, V., Wagnerová, M. Ekoimunologie, Avicenum, 1988, Praha
Ferenčík, M. Immunochémia, Alfa, 1989, Bratislava
The course is taught annually.
The course is taught: every week.