Bi8678 Applied survival analysis

Faculty of Science
Autumn 2016
Extent and Intensity
2/0/0. 2 credit(s) (fasci plus compl plus > 4). Type of Completion: graded credit.
Teacher(s)
doc. Mgr. Zdeněk Valenta, M.Sc., M. S., Ph.D. (lecturer)
RNDr. Tomáš Pavlík, Ph.D. (lecturer)
Guaranteed by
prof. RNDr. Ladislav Dušek, Ph.D.
RECETOX – Faculty of Science
Contact Person: RNDr. Tomáš Pavlík, Ph.D.
Supplier department: RECETOX – Faculty of Science
Timetable
Mon 19. 9. to Sun 18. 12. Wed 12:00–15:50 F01B1/709
Prerequisites
Bi5045 Biostatistics for Computational Biology
Course Enrolment Limitations
The course is offered to students of any study field.
Course objectives
After completion of the course, student:
-knows the principles of censoring;
-can define survival function, hazard function, and cumulative hazard function;
-understands the difference between median and mean survival time and life expectancy;
-is able to construct Kaplan-Meier estimate of the survival function;
-is able to construct life-table estimate of the survival function;
-is able to construct Nelson-Aalen estimate of the cumulative hazard function;
-can add confidence interval to the nonparametric estimates;
-understands the principles of maximum likelihood estimation in survival analysis;
-is able to construct the likelihood function for survival data;
-can assess the assumption of exponential or Weibull probability distribution;
-can define proportionality of hazard functions;
-is able to apply Mantel-Haenszel logrank test;
-knows an alternative test in the case of nonproportionality of hazards;
-is able to use test for more than two groups of subjects;
-understands the relationship between overall, expected, and relative survival;
-knows the most used methods for expected survival estimation;
-understands the principles of statistical cure;
-is able to detect statistical cure using interval-specific relative survival;
-is able to explain the meaning of regression methods in survival analysis;
-can define hazard ratio and baseline hazard;
-is able to formulate proportional hazards model for survival data;
-is able to formulate accelerated failure time model for survival data;
-is able to formulate Cox proportional hazards model;
-understands the meaning of regression coefficients in survival model;
-knows maximum likelihood estimation of the regression coefficients;
-knows methods for nonparametric estimation of the baseline hazard.
- is able to formulate, explain and apply Aalen' additive model
- is able to formulate, explain and apply Grays' flexible model with time-varying regression coefficients
Syllabus
  • Basic terms in survival analysis
  • Nonparametric estimates
  • Parametric estimates
  • Methods for comparing survival functions
  • Relative survival
  • Regression models in survival analysis
  • Cox proportional hazards model
  • Aalen's additive model
  • Gray's flexible time-varying coefficients model
Literature
  • KLEIN, John P. and Melvin L. MOESCHBERGER. Survival analysis : techniques for censored and truncated data. New York: Springer, 1997, xiv, 502. ISBN 0387948295. info
  • MARUBINI, Ettore and Maria Grazia VALSECCHI. Analysing survival data from clinical trials and observational studies. Chichester: John Wiley & Sons, 1995, xvi, 414. ISBN 0471939870. info
Teaching methods
lectures, class discussion, group project
Assessment methods
one written test (30 questions, each contributing 1 point, 25 points needed to pass), final (group) project, oral examination in case of failing the written test.
Language of instruction
Czech
Further comments (probably available only in Czech)
Study Materials
Information on the extent and intensity of the course: výuka bude 1 x za 2 týdny, první výuka proběhne 5.10.2016.
The course is also listed under the following terms Autumn 2014, Autumn 2015, autumn 2017, Autumn 2018, Autumn 2019, Autumn 2020, autumn 2021.
  • Enrolment Statistics (Autumn 2016, recent)
  • Permalink: https://is.muni.cz/course/sci/autumn2016/Bi8678