The course is also offered to the students of the fields other than those the course is directly associated with.
Fields of study the course is directly associated with
there are 14 fields of study the course is directly associated with, display
The course will provide introduction to modern NMR techniques which can be applied to extract structural information for small and mid-size biological macromolecules - peptides, proteins, DNA and RNA oligonucleotides. Experimental procedures and computational protocols for determination of three-dimensional structures and dynamics based on NMR data will be discussed.
1. NMR as a tool for structure biology
2. Basic NMR Experiments
3. Key to biomolecular NMR: Idea of correlation
4. First step in NMR of proteins
5. Second step in determination of protein structure
6. From spectra to structure
7. Special features of nucleic acid NMR
8. Nucleic acid structure by NMR
9. Molecules are not rigid
10. From relaxation to molecular motions
11. Molecules are not alone
12. Beyond small soluble biomolecules
CAVANAGH, John and Wayne J. FAIRBROTHER. Protein NMR Spectroscopy. Principles and Practice. San Diego: Academic Press, 1996. 587 pp. ISBN 0-12-164490-1. info
Assessment methods (in Czech)
Oral examination based on discussion of a project solved by the student.