The course provides an overview of the current knowledge of molecular biology, genetics and human genetics in the context of other theoretical branches of the Faculty of Medicine. Recent and modern concepts of developmental biology, cell signaling, structural and epigenetic changes in the DNA, gene therapy and bioinformatics are discussed. In addition, an introduction to tumor biology is included. The subject matter presented in this course will help to better understand other subjects including physiology, pathology and human and clinical genetics.
Syllabus
1st week: 20. – 24.2.2012
Lecture: Introduction to developmental biology
2nd week: 27.2. – 2.3.2012
Lecture: Basic principles and molecular mechanisms regulating early
development of mammals – physiology and pathology
3rd week: 5. – 9.3.2012
Lecture: Biology and use of stem cells in disease modelling and cell therapy
4th week: 12. – 16.3.2012
Lecture: Growth factors and signal transduction in development and disease
5th week: 19. – 23.3.2012
Lecture: Genome Instability- from molecular mechanisms of damage and DNA repair to clinical implications
6th week: 26. – 30.3.2012
Lecture: Molecular principle of genetic diseases
7th week: 2. – 6.4.2012
Lecture: Introduction to cancer biology
8th week: 9. – 13.4.2012
Lecture: Oncogenes and oncoviruses in cancer transformation
9th week: 16. – 20.4.2012
Lecture: Tumour supressor genes – implications for diagnostics and therapy
10th week: 22. – 26.4.2012
Lecture: Paradigm of cancer stem cells
11th week: 30.4. – 4.5.2012
Lecture: Objectives and strategies of molecular therapy
12th week: 7. – 11.5.2012
Lecture: Bioinformatics in medicine – from molecules to populations
13th week: 14. – 18.5.2012
Lecture: Milestones in biological sciences in context with advances in clinical medicine
14th week: 21. – 25.5.2012
Lecture: Advances in molecular, cell or developmental biology with regard to biomedicine - „Breakthrough of the Year 2011“
Literature
recommended literature
ALBERTS, Bruce. Základy buněčné biologie :úvod do molekulární biologie buňky. Translated by Arnošt Kotyk. 2. vyd. Ústí nad Labem: Espero Publishing, 2006. xxvi, 630. ISBN 80-902906-2-0. info
ALBERTS, Bruce. Essential cell biology : an introduction to the molecular biology of the cell. New York: Garland Publishing, 1998. xxii, 630. ISBN 0-8153-2045-0. info
Essential cell biology. Edited by Bruce Alberts. 3rd ed. New York: Garland Science, 2009. 1 v. (vari. ISBN 978-0-8153-4130. info
CAMPBELL, Neil A. and Jane B. REECE. Biologie. Vyd. 1. Brno: Computer Press, 2006. xxxiv, 133. ISBN 80-251-1178-4. info
CAMPBELL, Neil A. and Jane B. REECE. Biology. 7th ed. San Francisco: Pearson/Benjamin Cummings, 2005. xl, 1231 s. ISBN 0-8053-7146-X. info
PRITCHARD Dorian J. a B. R. KORF: Základy lékařské genetiky, 1. české vydání, Galén 2007. ISBN 978-80-7262-449-2
SNUSTAD D. Peter a Michael D. SIMMONS: Principles of Genetics, 5th edition, Wiley&Sons 2009. ISBN-13: 978-0-470-38825-9
JANISCH, Roman. Overview of General Biology (Overview of General Biology). 2. rozšířené. Brno: Masarykova univerzita, 2010. 91 pp. ISBN 978-80-210-5187-4. info
LODISH, Harvey F. Molecular cell biology. 6th ed. New York, N.Y.: W.H. Freeman and Company, 2008. xxxvii, 11. ISBN 978-0-7167-7601. info
Pollard, Thomas D., Earnshaw, William C.: Cell Biology, 2nd edition, Saunders 2007. ISBN: 978-1-4160-2255-8
Principles of development. Edited by Lewis Wolpert. 2nd ed. Oxford: Oxford University Press, 2002. xxv, 542 s. ISBN 0-19-879291-3. info
Teaching methods
lecture
Assessment methods
written test, the valid ICIS card is required to prove personal identity