Curriculum vitae

Person Identification

• Assoc. Prof. Markéta Bébarová, MD, PhD, born on 23th September 1976 in Hodonín (Czech Republic)

Workplace

• Department of Physiology
  Faculty of Medicine
  Masaryk University
  Kamenice 5
  625 00 Brno
  Czech Republic

Employment Position

• Associate Professor

Education and Academic Qualifications

• 2014 - Assoc. Prof.: Medical Physiology, Masaryk University, Brno; title: „Analysis of electrical properties of cardiac cells: changes induced by drugs, ethanol and sodium channel mutation (the patch clamp technique)“
• 2005 - PhD: Physiology and Pathological Physiology, Masaryk University, Brno; theses: "Effect of antiarrhythmic drug ajmaline on electrophysiological properties of working cardiomyocyte"; supervisor: Doc. RNDr. Ing. Jiří Šimurda, CSc.
• 2001 - MD: General Medicine, Masaryk University, Brno

Employment

• February 2014 - present: Associate Professor, Department of Physiology, Faculty of Medicine, Masaryk University, Brno (Czech Republic)
• September 2006 - January 2014: Lecturer, Department of Physiology, Faculty of Medicine, Masaryk University, Brno (Czech Republic)
• April 2005 - August 2006: Postdoctoral Research Fellow, Department of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht (The Netherlands)
• October 2004 - April 2005: Assistant, Department of Physiology, Faculty of Medicine, Masaryk University, Brno (Czech Republic)

Pedagogical Activities

• Physiology - practicals, tutorials, lectures

Scientific and Research Activities

• Areas of interest:
  Effect of drugs on ionic currents in ventricular myocytes
  Ionic currents in the course of action potential
  Biophysical characterization of wild-type and mutant channels in hereditary cardiovacular diseases (Brugada syndrome, Long QT syndrome type 1) and myotonia congenita
  
• Main Research Projects:
  Clinical significance and electrophysiological evaluation of KCNQ1 gene mutation c.926CT (p.T309I) as a possible long QT syndrome founder mutation (16-30571A; 2016-2019; as the co-investigator)
  Effect of ethanol and its principle metabolite acetaldehyde on cardiac inward rectifier potassium currents: a link to atrial fibrillation related to alcohol consumption? (NT14301-3/2013; 2013-2015; as the principal investigator)
  Effects of ajmaline on membrane currents in cardiomyocytes (FRVS/492/2003; 2003; as the principal investigator)
  Institutional Projects: MUNI/A/1365/2015 (2016; MU), MUNI/A/1326/2014 (2015; MU), MSM0021622402 (2005-2011; MŠMT), J07/98: 141100004 (2000-2004; MŠMT)
  
• Publication Activity - Summary:
  43 peer-review papers including 28 in journals with IF
  over 70 contributions presented at scientific conferences
  188 sum of times cited according to Web of Science (without self-citations); h-index: 9
  
• Membership in Scientific Societies:
  since 2011: member of the European Working Group on Cardiac Cellular Electrophysiology 2012-2016 and 2020-present – the nucleus member)
  since 2002: member of the Czech Physiological Society

Academical Stays

• April 2005 - August 2006: Postdoctoral Research Fellow, Department of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht (The Netherlands)

Appreciation of Science Community

• 2012-2016 and 2020-present: nucleus member of the European Working Group on Cardiac Cellular Electrophysiology (European Society of Cardiology)
• June 2007 - the second prize at Prix de Pharmacie 2007 (Ambassade de France and Sanofi-Aventis)
• November 2003 - the first prize at the conference of Czech postgradual students MediForum, Brno
• February 2003 - one of the four prizes at 79th Physiological Days (conference of Czech and Slovak Physiological Societies)
• November 2002 - the first prize at the conference of Czech postgradual students MediForum, Brno

Selected Publications

• BÉBAROVÁ, Markéta. Electrophysiological cellular effects of sex hormones. In Marek Malik. Sex and Cardiac Electrophysiology: Differences in Cardiac Electrical Disorders Between Men and Women. 1st edition. Neuveden: Academic Press, 2020, p. 201-210. ISBN 978-0-12-817728-0. Available from: https://dx.doi.org/10.1016/B978-0-12-817728-0.00017-6. URL info
• SUTANTO, Henry, Matthijs J.M. CLUITMANS, Dobromir DOBREV, Paul G.A. VOLDERS, Markéta BÉBAROVÁ and Jordi HEIJMAN. Acute effects of alcohol on cardiac electrophysiology and arrhythmogenesis: Insights from multiscale in silico analyses. Journal of Molecular and Cellular Cardiology. Oxford: Elsevier, 2020, vol. 146, September 2020, p. 69-83. ISSN 0022-2828. Available from: https://dx.doi.org/10.1016/j.yjmcc.2020.07.007. URL info
• BÉBAROVÁ, Markéta, Zuzana HOŘÁKOVÁ and Roman KULA. Addictive drugs, arrhythmias, and cardiac inward rectifiers. Europace. Oxford: Oxford University Press, 2017, vol. 19, No 3, p. 346-355. ISSN 1099-5129. Available from: https://dx.doi.org/10.1093/europace/euw071. info
• RADASZKIEWICZ, Katarzyna Anna, Dominika SÝKOROVÁ, Lucia BINÓ, Jana KUDOVÁ, Markéta BÉBAROVÁ, Jiřina PROCHÁZKOVÁ, Hana KOTASOVÁ, Lukáš KUBALA and Jiří PACHERNÍK. The acceleration of cardiomyogenesis in embryonic stem cells in vitro by serum depletion does not increase the number of developed cardiomyocytes. Plos ONE. San Francisco: Public Library of Science, 2017, vol. 12, No 3, p. nestránkováno, 17 pp. ISSN 1932-6203. Available from: https://dx.doi.org/10.1371/journal.pone.0173140. URL info
• BÉBAROVÁ, Markéta, Peter MATEJOVIČ, Olga ŠVECOVÁ, Roman KULA, Milena ŠIMURDOVÁ and Jiří ŠIMURDA. Nicotine at clinically relevant concentrations affects atrial inward rectifier potassium current sensitive to acetylcholine. Naunyn-Schmiedeberg's Archives of Pharmacology. New York: Springer, 2017, vol. 390, No 5, p. 471-481. ISSN 0028-1298. Available from: https://dx.doi.org/10.1007/s00210-017-1341-z. info
• BÉBAROVÁ, Markéta, Peter MATEJOVIČ, Michal PÁSEK, Zuzana HOŘÁKOVÁ, Jan HOŠEK, Milena ŠIMURDOVÁ and Jiří ŠIMURDA. Effect of ethanol at clinically relevant concentrations on atrial inward rectifier potassium current sensitive to acetylcholine. Naunyn-Schmiedeberg's Archives of Pharmacology. New York: Springer, 2016, vol. 389, No 10, p. 1049-1058. ISSN 0028-1298. Available from: https://dx.doi.org/10.1007/s00210-016-1265-z. info
• HOŘÁKOVÁ, Zuzana, Peter MATEJOVIČ, Michal PÁSEK, Jan HOŠEK, Milena ŠIMURDOVÁ, Jiří ŠIMURDA and Markéta BÉBAROVÁ. Effect of ethanol and acetaldehyde at clinically relevant concentrations on atrial inward rectifier potassium current I-K1: Separate and combined effect. Journal of Physiology and Pharmacology. Krakow: Polish Physiological Society, 2016, vol. 67, No 3, p. 339-351. ISSN 0867-5910. info
• PÁSEK, Michal, Markéta BÉBAROVÁ, Georges CHRISTÉ, Milena ŠIMURDOVÁ and Jiří ŠIMURDA. Acute effects of ethanol on action potential and intracellular Ca2+ transient in cardiac ventricular cells: a simulation study. Medical & Biological Engineering & Computing. Heidelberg: Springer Heidelberg, 2016, vol. 54, No 5, p. 753-762. ISSN 0140-0118. Available from: https://dx.doi.org/10.1007/s11517-015-1366-8. info
• BÉBAROVÁ, Markéta, Peter MATEJOVIČ, Milena ŠIMURDOVÁ and Jiří ŠIMURDA. Acetaldehyde at Clinically Relevant Concentrations Inhibits Inward Rectifier Potassium Current I-K1 in Rat Ventricular Myocytes. Physiological Research. Praha: Fyziologický ústav AV ČR, 2015, vol. 64, No 6, p. 939-943. ISSN 0862-8408. info
• BÉBAROVÁ, Markéta, Peter MATEJOVIČ, Michal PÁSEK, Milena ŠIMURDOVÁ and Jiří ŠIMURDA. Dual effect of ethanol on inward rectifier potassium current Ik1 in rat ventricular myocytes. Journal of Physiology and Pharmacology. Kraków: Polish Physiological Society, 2014, vol. 65, No 4, p. 497-509. ISSN 0867-5910. info
• SPÄTJENS, Roel L.H.M.G., Markéta BÉBAROVÁ, Sandrine R.M. SEYEN, Viola LENTINK, Roselie J. JONGBLOED, Yvonne H.J.M. ARENS, Jordi HEIJMAN and Paul G.A. VOLDERS. Long-QT mutation p.K557E-Kv7.1: dominant-negative suppression of I-Ks, but preserved cAMP-dependent up-regulation (Long-QT mutation p.K557E-Kv7.1: dominant-negative suppression of IKs, but preserved cAMP-dependent up-regulation). Cardiovascular Research. Netherlands: Elsevier Science B.V., 2014, vol. 104, No 1, p. 216-225. ISSN 0008-6363. Available from: https://dx.doi.org/10.1093/cvr/cvu191. info
• ANDRŠOVÁ, Irena, Markéta BÉBAROVÁ, Roman A. GEBAUER, Jan JANOUŠEK, Peter KUBUŠ, Tomáš NOVOTNÝ, Michal PROCHÁZKA, Jiří RADVANSKÝ, Kryštof SLABÝ, Viktor TOMEK and Pavel VÍT. EKG a dysrytmie v dětském věku (ECG and arrhythmias in childhood). 3., přeprac. a dopl. vyd. Praha: Grada, 2014, 272 pp. ISBN 978-80-247-5006-4. info
• BÉBAROVÁ, Markéta. Arrhythmogenesis in Brugada syndrome: Impact and constrains of current concepts. International Journal of Cardiology. Amsterdam: Elsevier, 2013, vol. 167, No 5, p. 1760-1771. ISSN 0167-5273. Available from: https://dx.doi.org/10.1016/j.ijcard.2012.12.019. info
• BÉBAROVÁ, Markéta. Advances in patch clamp technique: towards higher quality and quantity. General physiology and biophysics. GENERAL PHYSIOL AND BIOPHYSICS, 2012, vol. 31, No 2, p. 131-140. ISSN 0231-5882. Available from: https://dx.doi.org/10.4149/gpb_2012_016. info
• KILIANOVÁ, Anna, Markéta BÉBAROVÁ, Klára BERÁNKOVÁ, Radka OPATŘILOVÁ, Michal PÁSEK and Ladislava BARTOŠOVÁ. Effect of Newly Synthesized Compounds 44Bu and 444 on QRS-Complex Width and Fast Sodium Current: Differences between Isomers. Acta Veterinaria Brno. Brno, 2010, vol. 79, No 1, p. 41-49. ISSN 0001-7213. Available from: https://dx.doi.org/10.2754/avb201079010041. info
• BÉBAROVÁ, Markéta, Peter MATEJOVIČ, Michal PÁSEK, Dana OHLÍDALOVÁ, Dagmar JANSOVÁ, Milena ŠIMURDOVÁ and Jiří ŠIMURDA. Effect of ethanol on action potential and ionic membrane currents in rat ventricular myocytes. Acta Physiologica. Oxford: Blackwell Publishing, 2010, vol. 200, No 4, p. 301-314. ISSN 1748-1708. Available from: https://dx.doi.org/10.1111/j.1748-1716.2010.02162.x. info
• BÉBAROVÁ, Markéta, Peter MATEJOVIČ, Michal PÁSEK, Dagmar JANSOVÁ, Milena ŠIMURDOVÁ, Marie NOVÁKOVÁ and Jiří ŠIMURDA. Effect of antipsychotic drug perphenazine on fast sodium current and transient outward potassium current in rat ventricular myocytes. Naunyn-Schmiedebergs Archives of Pharmacology. Německo: Springer, 2009, vol. 380, No 2, p. 125-133. ISSN 0028-1298. info
• BÉBAROVÁ, Markéta, Tom 0´HARA, Jan GEELEN, Roselie JONGBLOED, Carl TIMMERMANS, Yvonne ARENS, Luz-Maria RODRIGUEZ, Yoram RUDY and Paul VOLDERS. Subepicardial phase 0 block and discontinuous transmural conduction underlie right precordial ST-segment elevation by a SCN5A loss-of-function mutation. American Journal of Physiology - Heart and Circulatory Physiology. 2008, vol. 295, No 1, p. H48-H58, 10 pp. ISSN 0363-6135. info
• BARTOŠOVÁ, Ladislava, Filip NOVÁK, Markéta BÉBAROVÁ, Marek FRYDRYCH, Vít BRUNCLÍK, Radka OPATŘILOVÁ, Jana KOLEVSKÁ, Petr MOKRÝ, Peter KOLLÁR, Věra STRNADOVÁ and Pavel SUCHÝ. Antiarrhythmic effect of newly synthesized compound 44Bu on model of aconitine-induced arrhythmia - Compared to lidocaine. European Journal of Pharmacology. Amsterdam, The Netherlands: Elsevier Science B.V., 2007, vol. 575, 1-3, p. 127-133. ISSN 0014-2999. info
• BÉBAROVÁ, Markéta, Peter MATEJOVIČ, Michal PÁSEK and Marie NOVÁKOVÁ. Effect of haloperidol on transient outward potassium current in rat ventricular myocytes. European Journal of Pharmacology. Amsterdam, The Netherlands: Elsevier Science B.V., 2006, vol. 550, 1-3, p. 15-23. ISSN 0014-2999. info
• BARTOŠOVÁ, Ladislava, Marek FRYDRYCH, G. VACULOVÁ, K. BERÁNKOVÁ, Markéta BÉBAROVÁ, R. OPATŘILOVÁ, V. STRNADOVÁ, P. MOKRÝ, V. BRUNCLÍK, J. KOLEVSKÁ, J. KRČMÁŘ, L. BARTOŠÍKOVÁ, T. FLORIAN and J. NEČAS. Ultrashort Bradycardic Effect of Newly Synthetized Compounds. Acta Veterinaria Brunensis. Brno, 2006, vol. 75, No 2, p. 183-196. ISSN 0001-7213. info
• BÉBAROVÁ, Markéta, Peter MATEJOVIČ, Michal PÁSEK, Milena ŠIMURDOVÁ and Jiří ŠIMURDA. Effect of ajmaline on transient outward current Ito in rat ventricular myocytes. General Physiology and Biophysics. Bratislava: Slovak Academy of Sciences, 2005, vol. 24, No 1, p. 27-45. ISSN 0231-5882. info
• BÉBAROVÁ, Markéta, Peter MATEJOVIČ, Michal PÁSEK, Milena ŠIMURDOVÁ and Jiří ŠIMURDA. Effect of ajmaline on action potential and ionic currents in rat ventricular myocytes. General Physiology and Biophysics. 2005, vol. 24, No 3, p. 311-325. ISSN 0231-5882. info
• BARTOŠOVÁ, L., Marek FRYDRYCH, G. HULÁKOVÁ, K. BERÁNKOVÁ, V. STRNADOVÁ, P. MOKRÝ, V. BRUNCLÍK, J. KOLEVSKÁ and Markéta BÉBAROVÁ. Efficacy of newly synthesized 44Bu ultrashort-acting beta-adrenergic antagonist to isoprenaline-induced tachycardia - comparison with esmolol. Acta Veterinaria Brunensis. Brno, 2004, vol. 73, No 2, p. 171-179. ISSN 0001-7213. info
• BAHNÍKOVÁ, Markéta, Peter MATEJOVIČ, Michal PÁSEK, Milena ŠIMURDOVÁ and Jiří ŠIMURDA. Ajmaline-induced block of sodium current in rat ventricular myocytes. Scripta medica. Brno, 2002, vol. 75, No 4, p. 169-177. ISSN 1211-3395. info
• BAHNÍKOVÁ, Markéta, Milena ŠIMURDOVÁ and Jiří ŠIMURDA. Effects of antiarrhythmics on potassium current sensitive to ATP: comparison of propafenone and trimecaine. Scripta medica. Brno: Lékařská fakulta Brno, 1999, vol. 72, No 7, p. 299-306. ISSN 1211-3395. info

2021/01/27