C3181 Biochemistry I

Faculty of Science
autumn 2017
Extent and Intensity
2/0/0. 2 credit(s) (fasci plus compl plus > 4). Type of Completion: zk (examination).
Teacher(s)
doc. RNDr. Petr Skládal, CSc. (lecturer)
Supervisor
prof. RNDr. Zdeněk Glatz, CSc.
Department of Biochemistry - Chemistry Section - Faculty of Science
Contact Person: doc. RNDr. Petr Skládal, CSc.
Supplier department: Department of Biochemistry - Chemistry Section - Faculty of Science
Timetable
Mon 18. 9. to Fri 15. 12. Tue 9:00–10:50 A11/205
Prerequisites
C2021 Organic Chemistry I || C2700 Basic Organic Chemistry
Basic knowledge of organic and general chemistry, biology
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
Fields of study the course is directly associated with
there are 17 fields of study the course is directly associated with, display
Course objectives
The course covers the basic fields of biochemistry from the chemical point of view. Most important properties and structure of natural substances(aminoacids and proteins, carbohydrates, lipids) are described here. The general description of chemical reactions in the cell includes enzymes and coenzymes, their properties and structure, active site, thermodynamics, enzyme kinetics, inhibition, allostery and regulation of enzyme acitivity. Special chapters describe most important metabolism of carbohydrates and lipids with emphasis on energetic features of metabolism.
The goal of this course in to equip students with the basic knowledge about chemical principles of metabolism.
Learning outcomes
The goal of this course in to equip students with the basic knowledge about chemical principles of metabolism of saccharides and lipids, cellular bioenergetics, structure and function of proteins and enzyme catalysis.
Syllabus
  • 1. Aminoacids, properties, determination, chromatography 2. Peptides, peptide bond, primary, secondary, terciary, quaternary structure 3. Non-repetitive structures, colagene, hydropathy, properties of proteins 4. Glycides, properties, reactions, anomers, hemiacetals, anomers. conformation 5. Glycosides, oligosaccharides, polysaccharides (starch, glycogen, chitin), heteropolysaccharides. 6. Lipids, acylglycerols, phospholipids, plasmalogens, sphingolipids, steroids 7. Nucleic acids, nucleosides, nucleotides, primary structure 8. DNA, RNA, double-helix, superhelix, denaturation, hybrid structure, methods for determination of primary structure 9. Thermodynamics in biochemistry, macroergic bond, reaction kinetics, enzymes, their active site, prosthetic groups, coenzymes, mechanism of enzyme catalysis 10. Coenzymes and vitamins, nicotinamide and NAD, flavins, ATP. AMO, cAMO, biotin, thiamin, coenzyme A, lipoic acid, folic acid 11. Pyridoxalphosphate, B12, metaloporphyrins, iron-sulfur proteins, vitamin C, lipophilic vitamins 12. Michaelis-Menten equation, Km, VL, turnover number, enzyme activity 13. Anabolism, catabolism, their regulation, anaerobic glycolysis 14. Gluconeogenesis, synthesis of PEP, glycogenolysis, synthesis of glycogen, Cori cycle
Literature
  • Vodážka - Biochemie
  • Voet, Voetová - Biochemie; Zubay, Parson, Vance - Principles of Biochemistry
  • Mikeš - Základní pojmy z biochemie II
Teaching methods
Theoretical lecture.
Assessment methods
Lecture 2 hr. Written examination.
Language of instruction
Czech
Follow-Up Courses
Further comments (probably available only v češtině)
Study Materials
The course can also be completed outside the examination period.
The course is taught annually.
Listed among pre-requisites of other courses
The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Autumn 1999, Autumn 2010 - only for the accreditation, Autumn 2000, Autumn 2001, Autumn 2002, Autumn 2003, Autumn 2004, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2015, Autumn 2016.
  • Enrolment Statistics (recent)
  • Permalink: https://is.muni.cz/course/sci/autumn2017/C3181

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