The course is also offered to the students of the fields other than those the course is directly associated with.
Fields of study the course is directly associated with
there are 17 fields of study the course is directly associated with, display
The course covers the basic fields of biochemistry from the chemical point of view. Most important properties and structure of natural substances(aminoacids and proteins, carbohydrates, lipids) are described here. The general description of chemical reactions in the cell includes enzymes and coenzymes, their properties and structure, active site, thermodynamics, enzyme kinetics, inhibition, allostery and regulation of enzyme acitivity. Special chapters describe most important metabolism of carbohydrates and lipids with emphasis on energetic features of metabolism.
The goal of this course in to equip students with the basic knowledge about chemical principles of metabolism.
The goal of this course in to equip students with the basic knowledge about chemical principles of metabolism of saccharides and lipids, cellular bioenergetics, structure and function of proteins and enzyme catalysis.
1. Aminoacids, properties, determination, chromatography
2. Peptides, peptide bond, primary, secondary, terciary, quaternary structure
3. Non-repetitive structures, colagene, hydropathy, properties of proteins
4. Glycides, properties, reactions, anomers, hemiacetals, anomers. conformation
5. Glycosides, oligosaccharides, polysaccharides (starch, glycogen, chitin), heteropolysaccharides.
6. Lipids, acylglycerols, phospholipids, plasmalogens, sphingolipids, steroids
7. Nucleic acids, nucleosides, nucleotides, primary structure
8. DNA, RNA, double-helix, superhelix, denaturation, hybrid structure, methods for determination of primary structure
9. Thermodynamics in biochemistry, macroergic bond, reaction kinetics, enzymes, their active site, prosthetic groups, coenzymes, mechanism of enzyme catalysis
10. Coenzymes and vitamins, nicotinamide and NAD, flavins, ATP. AMO, cAMO, biotin, thiamin, coenzyme A, lipoic acid, folic acid
11. Pyridoxalphosphate, B12, metaloporphyrins, iron-sulfur proteins, vitamin C, lipophilic vitamins
12. Michaelis-Menten equation, Km, VL, turnover number, enzyme activity
13. Anabolism, catabolism, their regulation, anaerobic glycolysis
14. Gluconeogenesis, synthesis of PEP, glycogenolysis, synthesis of glycogen, Cori cycle