LF:aZLIM051p Immunology in Dent. - lecture - Course Information
aZLIM051p Immunology in Dentistry - lectureFaculty of Medicine
- Extent and Intensity
- 0.5/0/0. 2 credit(s). Type of Completion: zk (examination).
- prof. MUDr. Vojtěch Thon, Ph.D. (lecturer)
prof. MUDr. Jiří Litzman, CSc. (lecturer)
prof. MUDr. Jindřich Lokaj, CSc. (lecturer)
Miroslava Bučková (assistant)
- Guaranteed by
- prof. MUDr. Vojtěch Thon, Ph.D.
Department of Clinical Immunology and Allergology - Institutions shared with St. Anne's Faculty Hospital - Faculty of Medicine
Contact Person: prof. MUDr. Vojtěch Thon, Ph.D.
Supplier department: Department of Clinical Immunology and Allergology - Institutions shared with St. Anne's Faculty Hospital - Faculty of Medicine
- Mon 25. 9. to Fri 8. 12. Wed 16:30–19:10 N02303; and Wed 20. 9. 16:30–19:10 N01001
- Prerequisites (in Czech)
- aZLBC0221p Biochemistry I - lecture && aZLFY0422c Physiology II - practice && aZLFY0422s Physiology II - seminar && aZLLM0421c Med.Oral Microbiol.I-pract. && aZC041 Handling chemical substances
- Course Enrolment Limitations
- The course is only offered to the students of the study fields the course is directly associated with.
- fields of study / plans the course is directly associated with
- Course objectives
- The course covers basic aspects of the structure and function of the immune system in humans. Topics include mechanisms of non- specific immunity with main emphasis on the inflammatory process, such as humoral and cellular branches of the specific immune response. It includes mainly mechanisms of activation of the immune response and its regulation. Special emphasis is given to mucosal immunity and immune response to microbes and immunoprophylaxis to infectious and non-infectious diseases in the orofacial area. After finishing the course the students will understand the mechanisms of the immune response in physiology, and the knowledge will enable them to understand the immune system disturbances leading to immunopathological diseases.
- Learning outcomes
- - The student will understand basic mechanisms of functioning of the immune system, functional characteristics of specific and non-specific immune response, and the interrelationship of these reactions;
- The student will understand the importance of the immune system in defense against microbes, as well as the principles of active and passive artificial immunization;
- The student will become acquainted with the regional specificity of the individual compartments of the immune system with an emphasis on the mucosal immune system and the immune system of the orofacial region;
- Immunology in medicine. Medical subject allergology and clinical immunology. Physiology and pathology of the immune system. Immunological concept of “own”, “foreign”, “dangerous”. Anatomy and cellular elements of the immune system. Immune mechanisms. Innate and acquired immunity. Innate or natural immunity: phagocytosis, NK cells, cytotoxicity, interferon system, complement system, acute phase reaction, inflammation. B lymphocytes and immunoglobulins. Genetic basis of immunoglobulin heterogeneity. Biological properties of antibodies. Monoclonal antibodies as diagnostic and therapeutic tools. T-lymphocytes, their development and effector functions. Polarisation of T-lymphocytes (Th1, Th2, Th17). Cytotoxicity. Cytokines. Major histocompatibility complex: structure, function. Activation of T and B cells by antigen. Interactions between antigen-presenting cells and T- and B-lymphocytes. Regulation of the immune reaction. Mucosal immunity. Immunity against infectious agents. Microbial antigens. Active and passive immunisation.
- ABBAS, Abul K., Andrew H. LICHTMAN and Shiv PILLAI. Basic immunology : functions and disorders of the immune system. Fifth edition. St. Louis: Elsevier, 2016. x, 335. ISBN 9780323390828. info
- Teaching methods
- Lecture. To get the creditactive participation in discussions is required. The knowledge is continuously checked by oral questions.
- Assessment methods
- Oral exam
- Language of instruction
- Further comments (probably available only in Czech)
- Study Materials
The course is taught annually.
- Listed among pre-requisites of other courses