aVLFA0721c Pharmacology I - practice

Faculty of Medicine
autumn 2020
Extent and Intensity
0/3/0. 1 credit(s). Type of Completion: z (credit).
Teacher(s)
doc. MUDr. Regina Demlová, Ph.D. (seminar tutor)
doc. PharmDr. Jan Juřica, Ph.D. (seminar tutor)
doc. Mgr. MVDr. Leoš Landa, Ph.D. (lecturer)
Mgr. Petra Amchová, Ph.D. (seminar tutor)
doc. RNDr. Ladislava Bartošová, Ph.D. (seminar tutor)
Mgr. Jana Kubátová, Ph.D. (seminar tutor)
Mgr. Kristýna Nosková, Ph.D. (seminar tutor)
MUDr. Jana Nováková, Ph.D. (seminar tutor)
MUDr. Jana Pistovčáková, Ph.D. (seminar tutor)
PharmDr. Jitka Rychlíčková, Ph.D. (seminar tutor)
Mgr. Barbora Říhová, Ph.D. (seminar tutor)
PharmDr. Lenka Součková, Ph.D. (seminar tutor)
doc. PharmDr. Ondřej Zendulka, Ph.D. (seminar tutor)
Renata Bláblová (assistant)
Květoslava Sedlářová (assistant)
Guaranteed by
doc. MUDr. Regina Demlová, Ph.D.
Department of Pharmacology – Theoretical Departments – Faculty of Medicine
Contact Person: doc. Mgr. MVDr. Leoš Landa, Ph.D.
Supplier department: Department of Pharmacology – Theoretical Departments – Faculty of Medicine
Timetable of Seminar Groups
aVLFA0721c/30: Thu 15. 10. 16:00–18:30 A19/229, Thu 22. 10. 16:00–18:30 A19/229, Thu 29. 10. 16:00–18:30 A19/229, Thu 5. 11. 16:00–18:30 A19/229, Thu 12. 11. 16:00–18:30 A19/229, Thu 19. 11. 16:00–18:30 A19/229, Thu 26. 11. 16:00–18:30 A19/229, Thu 3. 12. 16:00–18:30 A19/229, Thu 10. 12. 16:00–18:30 A19/229, Thu 17. 12. 16:00–18:30 A19/229, Thu 7. 1. 16:00–18:30 A19/229, Thu 14. 1. 16:00–18:30 A19/229, Thu 21. 1. 16:00–18:30 A19/229, Thu 28. 1. 16:00–18:30 A19/229, Thu 4. 2. 16:00–18:30 A19/229, J. Pistovčáková
aVLFA0721c/31: Wed 14. 10. 13:00–15:30 A19/229, Wed 21. 10. 13:00–15:30 A19/229, Wed 4. 11. 13:00–15:30 A19/229, Wed 11. 11. 13:00–15:30 A19/229, Wed 18. 11. 13:00–15:30 A19/229, Wed 25. 11. 13:00–15:30 A19/229, Wed 2. 12. 13:00–15:30 A19/229, Wed 9. 12. 13:00–15:30 A19/229, Wed 16. 12. 13:00–15:30 A19/229, Wed 6. 1. 13:00–15:30 A19/229, Wed 13. 1. 13:00–15:30 A19/229, Wed 20. 1. 13:00–15:30 A19/229, Wed 27. 1. 13:00–15:30 A19/229, Wed 3. 2. 13:00–15:30 A19/229, J. Rychlíčková
aVLFA0721c/32: Fri 16. 10. 13:00–15:30 A19/229, Fri 23. 10. 13:00–15:30 A19/229, Fri 30. 10. 13:00–15:30 A19/229, Fri 6. 11. 13:00–15:30 A19/229, Fri 13. 11. 13:00–15:30 A19/229, Fri 20. 11. 13:00–15:30 A19/229, Fri 27. 11. 13:00–15:30 A19/229, Fri 4. 12. 13:00–15:30 A19/229, Fri 11. 12. 13:00–15:30 A19/229, Fri 18. 12. 13:00–15:30 A19/229, Fri 8. 1. 13:00–15:30 A19/229, Fri 15. 1. 13:00–15:30 A19/229, Fri 22. 1. 13:00–15:30 A19/229, Fri 29. 1. 13:00–15:30 A19/229, Fri 5. 2. 13:00–15:30 A19/229, J. Pistovčáková
aVLFA0721c/33: Mon 12. 10. 16:00–18:30 A19/229, Mon 19. 10. 16:00–18:30 A19/229, Mon 26. 10. 16:00–18:30 A19/229, Mon 2. 11. 16:00–18:30 A19/229, Mon 9. 11. 16:00–18:30 A19/229, Mon 16. 11. 16:00–18:30 A19/229, Mon 23. 11. 16:00–18:30 A19/229, Mon 30. 11. 16:00–18:30 A19/229, Mon 7. 12. 16:00–18:30 A19/229, Mon 14. 12. 16:00–18:30 A19/229, Mon 4. 1. 16:00–18:30 A19/229, Mon 11. 1. 16:00–18:30 A19/229, Mon 18. 1. 16:00–18:30 A19/229, Mon 25. 1. 16:00–18:30 A19/229, Mon 1. 2. 16:00–18:30 A19/229, L. Součková
aVLFA0721c/34: Tue 13. 10. 16:00–18:30 A19/326, Tue 20. 10. 16:00–18:30 A19/326, Tue 27. 10. 16:00–18:30 A19/326, Tue 3. 11. 16:00–18:30 A19/326, Tue 10. 11. 16:00–18:30 A19/326, Tue 24. 11. 16:00–18:30 A19/326, Tue 1. 12. 16:00–18:30 A19/326, Tue 8. 12. 16:00–18:30 A19/326, Tue 15. 12. 16:00–18:30 A19/326, Tue 5. 1. 16:00–18:30 A19/326, Tue 12. 1. 16:00–18:30 A19/326, Tue 19. 1. 16:00–18:30 A19/326, Tue 26. 1. 16:00–18:30 A19/326, Tue 2. 2. 16:00–18:30 A19/326, L. Landa
aVLFA0721c/35: Tue 13. 10. 16:00–18:30 A19/229, Tue 20. 10. 16:00–18:30 A19/229, Tue 27. 10. 16:00–18:30 A19/229, Tue 3. 11. 16:00–18:30 A19/229, Tue 10. 11. 16:00–18:30 A19/229, Tue 24. 11. 16:00–18:30 A19/229, Tue 1. 12. 16:00–18:30 A19/229, Tue 8. 12. 16:00–18:30 A19/229, Tue 15. 12. 16:00–18:30 A19/229, Tue 5. 1. 16:00–18:30 A19/229, Tue 12. 1. 16:00–18:30 A19/229, Tue 19. 1. 16:00–18:30 A19/229, Tue 26. 1. 16:00–18:30 A19/229, Tue 2. 2. 16:00–18:30 A19/229, J. Juřica
Prerequisites (in Czech)
aVLPF0622c Pathological Phys. II - prac. && aVLPA0622c Pathology II - practice
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The aims of the course are:
to recognize the basic pharmacological terminology and legislation related to the use of drugs and thei prescription
to understand to differences between single drug dosage forms
to understand to the prescription of drugs
to understand to the basics of pharmacokinetics
to understand to the basic facts about the discussed drugs
Learning outcomes
At the end of the course the student knows:
single pharmacoterapeutical drug classes
single drug dosage forms
the modes of action, adverse reactions and basic indications of single drugs of discussed drugs
how to prescribe selected medical preparation or a drug in particular drug dosage form
Syllabus

  • aVLFA0721c - Pharmacology I - practical lessons

    General medicine

    Autumn semester 2020

  • 12. 10. – 16. 10. 2020
  • Topic 1: INFORMATION ON DRUGS
  • Course content: Organisation of practical courses and lectures, system of evaluation. Repetition of basic pharmacologic terminology. Sub-branches of pharmacology. Sources of information concerning drugs and recommended textbooks. Work with relevant databases (Brevíř, SÚKL, EMA, AISLP), ATC classification.
  • Self-studying preparation for practical lessons: Materials for the Lecture No. 1. Exam questions outlines.
  • 19. 10. – 23. 10. 2020
  • Topic 2: ROUTES OF DRUG ADMINISTRATION, DRUG DOSAGE FORMS
  • Course content: Brief characteristics of the individual drug dosage forms. Clinical significance of the way of drug administration.
  • Self-studying preparation for practical lessons: Materials for the Lecture No. 2. Exam questions outlines. Information in drug databases - SÚKL (www.sukl.cz), EMA and Drugs.com.
  • 26. 10. – 30. 10. 2020
  • Topic 3: PRESCRIPTION OF MEDICAL PRODUCTS
  • Course content: General rules of drug prescription. Prescription of the ready-made preparations, drug dosage forms.
  • Self-studying preparation for practical lessons: Materials for the Lectures No. 2 and 3. Exam question outlines. Drug dosage forms from the textbook. Legislation of the Czech Republic related to drugs and their prescription (selected section of the Act No. 378/2007 Coll., on Pharmaceuticals and on Amendments to Some Related Acts).
  • 2. 11. – 6.11. 2020
  • Topic 4: PHARMACOKINETICS I
  • Course content: Pharmacokinetic processes, parameters and calculations.
  • Self-studying preparation for practical lessons: Materials for the Lecture No. 4. Exam questions outlines.
  • 9. 11. – 13. 11. 2020
  • Topic 5: PHARMACOKINETICS II
  • Course content: Pharmacokinetic case reports, simulation of plasma concentrations course, dosage optimalization and use of software tools, factors affecting course and value of drug´s plasma concentrations.
  • Self-studying preparation for practical lessons: Materials for the Lectures No. 4 and 5. Exam questions outlines.
  • 16. 11. – 20. 11. 2020
  • Topic 6: PHARMACODYNAMICS
  • MULTIPLE-CHOICE TEST 1(Topics 1-5).
  • Course content: Mechanisms of drug effects - classification, examples. Dose-response curves.
  • Self-studying preparation for practical lessons: Materials for the Lecture No. 6. Exam questions outlines.
  • 23. 11. – 27. 11. 2020
  • Topic 7: FACTORS AFFECTING DRUG EFFECTS
  • Course content: Pharmacotherapy in childhood, in pregnancy, in breastfeeding women, in elderly. Beer's list, STOPP-START, FORTA. Pharmacogenetics.
  • Self-studying preparation for practical lessons: Materials for the Lecture No. 7. Exam questions outlines. Pharmacogenetics - materials in IS.
  • 30. 11. – 4. 12. 2020
  • Topic 8: PHARMACOVIGILANCE, ADVERSE DRUG REACTIONS
  • PRESCRIPTION TEST
  • Course content: Classification and characteristics of adverse drug effects. Pharmacovigilance in clinical practice, sources of current information on drug safety.
  • Self-studying preparation for practical lessons: Materials for the Lecture No. 8. Exam questions outlines.
  • 7. 12. – 11. 12. 2020
  • Topic 9: PHARMACOLOGY OF SYMPATHETIC NERVOUS SYSTEM
  • Course content: Drugs affecting sympathetic nervous system - classification, basic pharmacological characteristics.
  • Self-studying preparation for practical lessons: Materials for the Lecture No. 9. Exam question outlines. Pathophysiological bases - ANS, neurotransmitters (their synthesis and degradation), receptors of the sympathetic nervous system (alpha, beta) and parasympathetic nervous system (nicotinic, muscarinic) and their subtypes and organ distribution. Systems of second messengers. Pharmacodynamics, both direct and indirect mechanisms of action.
  • 14. 12. – 18. 12. 2020
  • Topic 10: PHARMACOLOGY OF PARASYMPATHETIC NERVOUS SYSTEM, SPASMOLYTIC DRUGS
  • Course content: Drugs affecting parasympathetic nervous system - classification, basic pharmacological characteristics. Spasmolytic drugs.
  • Self-studying preparation for practical lessons: Materials for the Lectures No. 9. Spasmolytic drugs. Exam questions outlines.
  • 4. 1. – 8. 1. 2021
  • Topic 11: ANAESTHETIC DRUGS
  • MULTIPLE-CHOICE TEST 2 (Topics 6-10).
  • Course content: Basic pharmacological characteristics of general and local anaesthetic drugs. Premedication prior to general anaesthesia.
  • Self-studying preparation for practical lessons: Materials for the Lecture No. 11. Exam questions outlines. Muscle relaxants (IS).
  • 11. 1. – 15. 1. 2021
  • Topic 12: ANALGESICS
  • Course content: Basic pharmacological characteristics of opioid and non-opioid analgesic drugs, antirheumatoid drugs and drugs used in gout.
  • Self-studying preparation for practical lessons: Materials for the Lectures No. 12, Exam questions outlines. Anti-gout medications - study material in IS.
  • 18. 1. – 22. 1. 2021
  • Topic 13: PHARMACOTHERAPY OF DIABETES MELLITUS
  • Course content: Repetition of anti-diabetic drugs - basic pharmacological characteristics. Drugs used in therapy of specific and acute conditions in diabetology. Combinations of insulins, insulin regimens.
  • Self-studying preparation for practical lessons: Materials for the Lecture No. 13. Exam questions outlines.
  • 25. 1. – 29. 1. 2021
  • Topic 14: SEX HORMONES
  • Course content: Endocrine therapy, hormone replacement therapy, hormonal contraceptive drugs.
  • Self-studying preparation for practical lessons: Materials for the seminar No. 14. Exam questions outlines. Uterotonics and tocolytics.
  • 1. 2. – 5. 2. 2021
  • Topic 15: GLUCOCORTICOIDS, THYROID HORMONES
  • MULTIPLE-CHOICE TEST 3 (Topics 11-14).
  • Course content: Repetition of basic pharmacological characteristics of glucocorticoids and thyroid hormones.
  • Self-studying preparation for practical lessons: Materials for the Lecture No. 15. Exam questions outlines.
Literature
    required literature
  • Practicals in Pharmacology, 2009, Náhradní obsah: http://portal.med.muni.cz/article-491-practicals-in-pharmacology.html
  • http://search.ebscohost.com/login.aspx?direct=true&db=nlebk&AN=1160493&lang=cs&site=ehost-live
  • RANG, H. P., James RITTER, R. J. FLOWER and Graeme HENDERSON. Rang & Dale's pharmacology. Eighth edition. [Edinburgh]: Churchill Livingstone, 2016, xv, 760. ISBN 9780702053627. info
    recommended literature
  • WHALEN, Karen. Pharmacology. Edited by Richard Finkel - Thomas A. Panavelil. 6th ed. Philadelphia, Pa.: Lippincott Williams & Wilkins, 2015, xi, 664. ISBN 9781451191776. info
    not specified
  • Pharmaceutical practice. Edited by Judith A. Rees - Ian Smith - Jennie Watson. 5th ed. Edinburgh: Churchill Livingstone Elsevier, 2014, xvii, 552. ISBN 9780702051432. info
  • Waller, Derek - Renwick, Andrew G. - Hillier, Keith. Medical pharmacology and therapeutics. 3rd ed. New York : Elsevier Saunders, 2009. ix, 744 p. ISBN 0-7020-2991-2.
  • Ritter, James M. - Lewis, Lionel D. - Mant, Timothy G.K. - Ferro, Albert. A Textbook of Clinical Pharmacology and Therapeutics, 5th Ed., Hodder Arnold, 2008. 465 s. ISBN 978-0-340-90046-8
  • LÜLLMANN, Heinz, Lutz HEIN and Klaus MOHR. Color atlas of pharmacology. Translated by Detlef Bierger, Illustrated by Jürgen Wirth. 4th ed. Stuttgart: Thieme, 2011, x, 393. ISBN 9783137817048. info
  • Pharmacology. Edited by Michelle Alexia Clark. 5th ed. Baltimore: Wolters Kluwer Health/Lippincott Williams & Wilkins, 2012, xii, 612. ISBN 9781451113143. info
Bookmarks
https://is.muni.cz/ln/tag/LF:aVLFA0721c!
Teaching methods
Classes take place periodically in the afternoon. The lectures are followed by practical exercises with discussion.

The lectures discuss the basic issues of the subject. This knowledge is further deepened via specific practical tasks in exercises.

Materials for self-study and preparation for exercises will be available in the interactive syllabus/study materials for each topic, including references to the relevant chapters in the textbook.

2 absences from practical lessons are possible.
Assessment methods
3 continuous multiple-choice tests (time limit: 15 min) and 1 prescription test in a paper form. MCQ tests will not be repeated. The prescription test can be repeated only twice.

Each multiple-choice test contains 15 questions. The number of correct answers is given. Student gets 1 point for each completely correct answer, i.e. maximum 15 points for each multiple-choice test; total 45 points for all three MCQ tests.

The prescription test consists of two read-made preparations. For both preparations, the active substance, the drug dosage form and the number of original packages to be prescribed will be listed. The prescription handbook will be available for the test.

To obtain credits, the student has to pass the prescription test successfully and also get at least 6 points from each single multiple-choice test and at least 20 points (minimum) from all three MCQ tests.

Note: Together with the new accreditation of the Pharmacology subject for students of General Medicine, a system of continuous assessment of the student was introduced, when the results achieved in multiple-choice tests in practical lessons and colloquium will be taken into account and included in the final mark from the subject.
Language of instruction
English
Further comments (probably available only in Czech)
Study Materials
The course is taught annually.
Information on the extent and intensity of the course: 45.
The course is also listed under the following terms Autumn 2017, autumn 2018, autumn 2019, autumn 2021, autumn 2022, autumn 2023, autumn 2024.
  • Enrolment Statistics (autumn 2020, recent)
  • Permalink: https://is.muni.cz/course/med/autumn2020/aVLFA0721c