aZLPA0521p Pathology I - lecture

Faculty of Medicine
autumn 2021
Extent and Intensity
2/0/0. 1 credit(s). Type of Completion: z (credit).
Taught online.
prof. MUDr. Markéta Hermanová, Ph.D. (lecturer)
MUDr. Víta Žampachová (lecturer)
MUDr. Iva Staniczková Zambo, Ph.D. (lecturer)
Markéta Grozertová (assistant)
Mgr. Iva Holušová (assistant)
Guaranteed by
prof. MUDr. Markéta Hermanová, Ph.D.
First Department of Pathology - Institutions shared with St. Anne's Faculty Hospital - Faculty of Medicine
Supplier department: First Department of Pathology - Institutions shared with St. Anne's Faculty Hospital - Faculty of Medicine
aZLFY0422c Physiology II - practice && aZLFY0422s Physiology II - seminar && aZLBC041c Biochemistry II - pract. && aZLBC041s Biochemistry II sem && ( aZLAN0222p Anatomy II - lecture || aZLAN0333p Anatomy III - lect. )&& aZLHE0322p Histology and Embryol.II -lect && aZLLT0222s Bas.Med.Terminology II -sem.
aZLFY0422c && aZLBC041c && aZLAN0333p && aZLHE0322p && (aZLLT0222s || ZLLT0222s) && aZLET021p && aZC041
Course Enrolment Limitations
The course is only offered to the students of the study fields the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The main aims of the course include:
understanding the basic pathologic processes (regressive and progressive changes, inflammation, pathologic immune reactions, oncogenesis, genetic background of disease)
knowledge of basic classifications of non-neoplastic and neoplastic disorders
application of this knowledge in individual organ systems with focus on morphological substrate od individual disorders from both microscopis and macroscopic point of view
introduction of the role of pathology in clinical practice, of methods of tissue processing, methods of molecular pathology; demonstration of pathological anatomical autopsies and thier evaluation.
Learning outcomes
Completing the course, the student will be able:
- to understand basic pathologic processes (regressive and progressive changes, inflammation, pathologic immune reactions, oncogenesis, genetic background of disease)
- to know basic classifications of both nonneoplastic and neoplastic disorders
- to apply the knowledge of general pathology to individual organ systems: to know basic etiopathogenesis, both macroscopic and microscopic correlates, basic clinical symptoms and complications of diseases in individual organ systems
- to know the role of pathology in clinical practive and main methods of examination in pathology.
  • Introductory information. Basic nomenclature: autopsy, histological necroptic and bioptical examination, the importance of autopsies. Death and postmortal changes. Necrosis: types and appearance, causes and further evolution. Apoptosis, maceration.
  • Atrophy, hypertrophy, hyperplasia, metaplasia.
  • Inflammation (acute, chronic); gross and macroscopic appearance Phagocytosis, cells engaged in inflammation. Chemical mediators of inflammation.
  • Inflammation: types and their characteristics (superficial, deep, serous, fibrinous...). Macroscopic & microscopic changes Fever, sepsis, pyemia Healing and reparation Specific inflammation (tuberculosis, lues, lepra, sarkoidosis); granulomatous inflam-mation.
  • Immune system and its function Immune reactions, their classification and pathology. Autoimmune diseases. Rejection.
  • Immunodeficiency diseases (inborn and acquired). HIV. Infections in immunocompromised patients Infectious diseases.
  • Hemodynamic disorders od perfusion (central and peripheral). Shock, fluid loss and overload Local disorders of circulation (infarction, embolism, edema), DIC, eclampsy.
  • General oncology; Benign and malignant tumors and their classification.Cancerogenesis. Epithelial tumors, choriocarcinoma, mesothelioma.
  • Leukemia. Lymphomas (WHO classification)
  • Mesenchymal tumors. Tumors of peripheral nervous system Pigmented skin lesions. Neuroectodermal tumors of CNS.
  • Cardiovascular pathology: congenital heart disease, inflammatory heart disease, ischemic heart disease, cardiomyopathy.
  • Cardiovascular pathology: blood vessels (degenerative changes, vasculitis), myocardial biopsy.
  • The respiratory systém.
  • Autopsy, biopsy. Tissue fixation, sampling and processing. Frozen sections.Light, fluorescent, electron microscopy. Cytology (smears, fine needle aspirations). Routine and special staining, histochemistry, immunohistochemistry Molecular biology techniques.
    required literature
  • Underwood's pathology : a clinical approach. Edited by Simon S. Cross. 6th ed. Edinburgh: Churchill Livingstone, 2013. xviii, 769. ISBN 9780702046735. info
    recommended literature
  • KUMAR, Vinay. Robbins and Cotran pathologic basis of disease. Illustrated by James A. Perkins. 8th ed. Philadelphia: Saunders, 2010. xiv, 1450. ISBN 9781416031215. info
Teaching methods
Pathology course consists of lectures and practical classes. Practical classes include two parts: histopathological practices (with demonstration of microscopic and macroscopic findings of bioptic and auroptic samples) and autoptical practices (with demonstration of pathological anatomical autopsies).
Assessment methods
The course of pathology is closed by oral exam covering three sets of topics: general pathology, systemic pathology and oncology. The list of these topics is available to the students in advance. Attendance is compulsory, knowledge of the students is periodically tested during the practical classes. Testing is oral or by written tests.
Language of instruction
Further comments (probably available only in Czech)
The course can also be completed outside the examination period.
The course is taught annually.
The course is taught: every week.
Information on the extent and intensity of the course: 30.
The course is also listed under the following terms Autumn 2017, autumn 2018, autumn 2019, autumn 2020.
  • Enrolment Statistics (autumn 2021, recent)
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