FaF:FDCFB_FAF Medicinal Chemistry - Course Information

FDCFB_FAF Medicinal Chemistry

Extent and Intensity

1/1/0. 30 credit(s). Type of Completion: zk (examination).

Teacher(s)

prof. RNDr. Jozef Csöllei, CSc. (lecturer)
doc. PharmDr. Oldřich Farsa, Ph.D. (lecturer)

Guaranteed by

prof. RNDr. Jozef Csöllei, CSc.
Faculty of Pharmacy

Prerequisites (in Czech)

FAKULTA(FaF)

Course Enrolment Limitations

The course is only offered to the students of the study fields the course is directly associated with.

fields of study / plans the course is directly associated with

• Medicinal Chemistry (programme FaF, D-FCH) (2)

Course objectives

The subject serves to broaden and deepen the knowledge of biologically active substances according to their classification into individual pharmacotherapeutic groups or according to the classification of the drug in terms of its effect at the molecular level (in terms of its mechanism of action at the level of receptor, enzyme, ion channel, etc.). It also deals with methods of molecular design, study of chemical structure relations and biological activity of pharmaceuticals in relation to physicochemical properties and studies the biological activity of the drug in relation to its spatial arrangement, including the influence of chirality on its efficiency and biotransformation.

Learning outcomes

The knowledge of the topics of the discipline in the range which will be preliminarily agreed among the guarantor, Ph.D. student and his/her tutor.

Syllabus

• General knowledge:
  - nonspecific and specific action of drugs - the importance of physicochemical properties, the binding of the drug to the target endogenous structure
  - quantitative relationships between chemical structure and biological activity and molecular modeling in drug development
  - drug metabolism - 1st and 2nd phase of biotransformation
  Therapeutic drug groups:
  - substances affecting the peripheral nervous system
  - substances affecting the central nervous system
  - substances affecting the cardiovascular and renal system
  - drugs that affect blood clotting
  - drugs that affect the nociceptive system and the therapy of the locomotory system
  - antihistamines, antiallergics, prostanoids, leukotrienes, antiserotoninergics and migraine prophylaxis
  - digestive and excretory drugs
  - therapy of respiratory diseases
  - medicines with an effect on the function of the internal secretion glands
  - chemotherapeutics - microbial, viral, parasitic and cancerous diseases
  

Literature

recommended literature
• M. Wolff. Burger´s Medicinal Chemistry I. - V. díl, V. vydání , Wiley Interscience, N. York, Chichester, Brisbane, Toronto, Singapore 1995?1998. info
• Auterhoff H., Knabe H. J., Höltje H. D. Lehrbuch der Pharmazeutischen Chemie. Stuttgart, 1999. info

not specified
• Bultinck,P., De Winter, H., Langenaeker, W., Tollenare, J. P.:. Computational medicinal chemistry for drug discovery, Taylor and Francis, 2003, ISBN: 0824747747. info
• Cairns, D.:. Essentials of pharmaceutical chemistry, Deutscher Apotheker Verlag, 2003, ISBN: 3769234006. info
• Wiliams D. A., Lemke T L.:. Foye´s Principles of Medicinal Chemistry, Fifth Edition, Lippincot Williams and Wilkins Philadelphia, Baltimore 2002. info
• Reddy, I. K., Mehvar, R.:. Chirality in drug design and development, Marcel Dekker, Inc., 2004, ISBN: 0824750624. info
• Wermuth, C. G.:. The praktice of medicinal chemistry, Elsevier - Harcourt, 2008, ISBN: 012374194. info

Teaching methods

Self-study of resources recommended by the subject guarantor in agreement with the DSP student's tutor.

Assessment methods

With a mark
Oral exam.

Language of instruction

Czech

Further Comments

The course can also be completed outside the examination period.
The course is taught each semester.

• Enrolment Statistics (Autumn 2020, recent)
  
• Permalink: https://is.muni.cz/course/pharm/autumn2020/FDCFB_FAF