FaF:FATO1_14 Toxicology - Course Information
FATO1_14 ToxicologyFaculty of Pharmacy
- Extent and Intensity
- 2/1/0. 4 credit(s). Recommended Type of Completion: zk (examination). Other types of completion: z (credit).
Taught in person.
- MUDr. Marta Chalupová, Ph.D. (lecturer)
doc. PharmDr. Peter Kollár, Ph.D. (lecturer)
MUDr. Tomáš Parák, Ph.D. (lecturer)
prof. PharmDr. Karel Šmejkal, Ph.D. (lecturer)
MUDr. Marta Chalupová, Ph.D. (seminar tutor)
PharmDr. Tereza Kauerová, Ph.D. (seminar tutor)
doc. PharmDr. Peter Kollár, Ph.D. (seminar tutor)
PharmDr. Mgr. Alžběta Kružicová (seminar tutor)
MUDr. Tomáš Parák, Ph.D. (seminar tutor)
PharmDr. Lenka Paráková, Ph.D. (seminar tutor)
- Guaranteed by
- doc. MVDr. Pavel Suchý, Ph.D.
Department of Pharmacology and Toxicology - Departments - Faculty of Pharmacy
- Tue 9:55–11:35 Učebna botaniky, 221
- Timetable of Seminar Groups:
- Prerequisites (in Czech)
- FAKULTA ( FaF ) || OBOR ( MUSFaF )
- Course Enrolment Limitations
- The course is only offered to the students of the study fields the course is directly associated with.
- fields of study / plans the course is directly associated with
- Course objectives
- The aim of this subject is to provide students basic knowledge in the area of toxicology. Modern toxicology is an interdisciplinary scientific discipline focused on interactions of xenobiotics with living systems, which lead to their damage or death. The subject incorporates with various disciplines, which are taught in previous years (biology, morphology, physiology and human pathophysiology).
- Learning outcomes
- After completing the course the student is able to define the course Toxicology and have knowledge of basic toxicological terms. The student is able to describe in general the dangerous characteristics of substances, the mechanisms of their toxic effect and kinetics. The student has a comprehensive overview of the hazards of toxicologically important inorganic, organic and natural substances and a basic overview of the toxicity of selected pesticides, radionuclides and drugs. He orients himself in related legal regulations and has an overview of methods for testing the hazardous properties of substances.
1. Toxicology, definition and history, general terminology, classification of toxins
2. Relationship between the substance, dose and toxic effect, toxicokinetics
3. Mechanisms of toxic effect, factors influencing the toxic effect
4. Toxicologically important inorganic substances
5. Toxicologically important organic substances (I)
6. Toxicologically important organic substances (II)
7. Pesticides and their residues in food, ecotoxicology
8. Toxicologically important natural substances I (herbal toxins, toxins in algae and cyanobacteria, mycotoxins)
9. Toxicologically important natural substances II (bacterial toxins and animal toxins)
10. Toxicology of medicinal drugs, most common medicinal drug poisonings
11. Chemical warfare agents, radiotoxicology
12. Drug abuse, toxicological view on newly synthesized drugs
13. Intoxication therapy, general rules
14. Final lesson - consultations
1. Organisation of lessons
Introduction into the experimental evaluation of toxicity
2. In silico evaluation of toxicity
The READ Across method, alternative methods for the assessment of toxicity, QSAR Tool Box, constructing valid QSAR models, the use of predictive models
3. In vitro evaluation of toxicity
Toxicity mechanisms on cellular level and their evaluation, tests of cytotoxicity and genotoxicity, determining EC50
4. In vivo evaluation of toxicity
Determining systemic toxicity and toxicity after repeated administering, testing local effect (dermal irritability, sensibilisation, eye irritation, implantation), pyrogenicity tests, carcinogenicity and reproduction toxicity
Circulation of pollutants in the environment, biomonitoring, effect on organisms, degradability, absorption/desorption. Drug residues in the environment.
5. Guided visit of a toxicological laboratory
Good laboratory practice, interpreting results of tests, most common findings ? case studies
6. Credit and classification test
- required literature
- Reichl, F.X. - Ritter, L. Illustrated Handbook of Toxicology. Thiemme Stuttgart, 2011. ISBN 978-3-13-126921-8. info
- recommended literature
- Mulder, Gerard J, Dencker, Lennart. Pharmaceutical Toxicology. 2006. ISBN 978 0 85369 593 6. info
- Phillip L. Williams. PRINCIPLES OF TOXICOLOGY. 2000. ISBN 0-471-29321-0. URL info
- Ted A. Loomis, M.D., Ph.D., and A. Wallace Hayes, Ph.D. Loomis's Essentials of Toxicology. 1996. ISBN 978-0-12-455625-6. URL info
- Teaching methods
- lectures, seminars
- Assessment methods
- Classification test at the end of the semester. or test questions, the student always chooses one correct answer from the options offered, for which 1 point is added. No points will be deducted for an unfilled or incorrectly answered question. The condition for passing the credit test is to achieve at least 50% of the maximum possible number of points.
- Language of instruction
- Further comments (probably available only in Czech)
- Study Materials
The course can also be completed outside the examination period.
- Teacher's information
- In accordance with study and examining order of credit system of MUNI Brno.
- Enrolment Statistics (recent)
- Permalink: https://is.muni.cz/course/pharm/autumn2021/FATO1_14