FATO1_14 Toxicology

Faculty of Pharmacy
Spring 2020
Extent and Intensity
2/1/0. 4 credit(s). Type of Completion: zk (examination).
Teacher(s)
MUDr. Marta Chalupová, Ph.D. (lecturer)
doc. PharmDr. Peter Kollár, Ph.D. (lecturer)
MUDr. Tomáš Parák, Ph.D. (lecturer)
prof. PharmDr. Karel Šmejkal, Ph.D. (lecturer)
MUDr. Marta Chalupová, Ph.D. (seminar tutor)
PharmDr. Tereza Kauerová, Ph.D. (seminar tutor)
doc. PharmDr. Peter Kollár, Ph.D. (seminar tutor)
PharmDr. Mgr. Alžběta Kružicová (seminar tutor)
MUDr. Tomáš Parák, Ph.D. (seminar tutor)
PharmDr. Lenka Paráková, Ph.D. (seminar tutor)
Guaranteed by
Department of Pharmacology and Toxicology - Departments - Faculty of Pharmacy
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The aim of this subject is to provide students basic knowledge in the area of toxicology. Modern toxicology is an interdisciplinary scientific discipline focused on interactions of xenobiotics with living systems, which lead to their damage or death. The subject incorporates with various disciplines, which are taught in previous years (biology, morphology, physiology and human pathophysiology).
Syllabus
  • Lectures

    1. Toxicology, definition and history, general terminology, classification of toxins

    2. Relationship between the substance, dose and toxic effect, toxicokinetics

    3. Mechanisms of toxic effect, factors influencing the toxic effect

    4. Toxicologically important inorganic substances

    5. Toxicologically important organic substances (I)

    6. Toxicologically important organic substances (II)

    7. Pesticides and their residues in food, ecotoxicology

    8. Toxicologically important natural substances I (herbal toxins, toxins in algae and cyanobacteria, mycotoxins)

    9. Toxicologically important natural substances II (bacterial toxins and animal toxins)

    10. Toxicology of medicinal drugs, most common medicinal drug poisonings

    11. Chemical warfare agents, radiotoxicology

    12. Drug abuse, toxicological view on newly synthesized drugs

    13. Intoxication therapy, general rules

    14. Final lesson - consultations


    Exercises

    1. Organisation of lessons
    Introduction into the experimental evaluation of toxicity

    2. In silico evaluation of toxicity
    The READ Across method, alternative methods for the assessment of toxicity, QSAR Tool Box, constructing valid QSAR models, the use of predictive models

    3. In vitro evaluation of toxicity
    Toxicity mechanisms on cellular level and their evaluation, tests of cytotoxicity and genotoxicity, determining EC50

    4. In vivo evaluation of toxicity
    Determining systemic toxicity and toxicity after repeated administering, testing local effect (dermal irritability, sensibilisation, eye irritation, implantation), pyrogenicity tests, carcinogenicity and reproduction toxicity

    5. Ecotoxicology
    Circulation of pollutants in the environment, biomonitoring, effect on organisms, degradability, absorption/desorption. Drug residues in the environment.

    5. Guided visit of a toxicological laboratory
    Good laboratory practice, interpreting results of tests, most common findings ? case studies

    6. Credit and classification test

    7. Classification
Literature
    required literature
  • Reichl, F.X. - Ritter, L. Illustrated Handbook of Toxicology. Thiemme Stuttgart, 2011. ISBN 978-3-13-126921-8. info
    recommended literature
  • Mulder, Gerard J, Dencker, Lennart. Pharmaceutical Toxicology. 2006. ISBN 978 0 85369 593 6. info
  • Phillip L. Williams. PRINCIPLES OF TOXICOLOGY. 2000. ISBN 0-471-29321-0. URL info
  • Ted A. Loomis, M.D., Ph.D., and A. Wallace Hayes, Ph.D. Loomis's Essentials of Toxicology. 1996. ISBN 978-0-12-455625-6. URL info
Teaching methods (in Czech)
Monologická (výklad, přednáška, instruktáž)
Assessment methods (in Czech)
Známkou
Language of instruction
English
Further comments (probably available only in Czech)
The course can also be completed outside the examination period.
Teacher's information
In accordance with study and examining order of credit system of University of Veterinary and Pharmaceutical Sciences Brno.
The course is also listed under the following terms Autumn 2020, Autumn 2021.
  • Enrolment Statistics (Spring 2020, recent)
  • Permalink: https://is.muni.cz/course/pharm/spring2020/FATO1_14