C8840 Chemistry of macrocyclic compounds

Faculty of Science
Autumn 2018
Extent and Intensity
2/0/0. 2 credit(s) (plus extra credits for completion). Recommended Type of Completion: zk (examination). Other types of completion: k (colloquium).
Teacher(s)
prof. RNDr. Přemysl Lubal, Ph.D. (lecturer)
Guaranteed by
prof. RNDr. Přemysl Lubal, Ph.D.
Department of Chemistry – Chemistry Section – Faculty of Science
Contact Person: prof. RNDr. Přemysl Lubal, Ph.D.
Supplier department: Department of Chemistry – Chemistry Section – Faculty of Science
Prerequisites
The main prerequisites to attend this lecture is passing of basic courses Inorganic chemistry I (C1061), Inorganic chemistry II (C2062), Organic chemistry I (C2021), Organic chemistry II (C3022), Analytical chemistry I (C3100) and Analytical chemistry II (C4050). It also suitable to visit course C8885 Supramolecular chemistry (it is not required).
Course Enrolment Limitations
The course is also offered to the students of the fields other than those the course is directly associated with.
fields of study / plans the course is directly associated with
Course objectives
The lecture is focused on the understanding and explanation of reactivity and properties of macrocylic compounds and it is accompanied by examples taken from literature or from experimental experiences of lecturer. In addition, the potential application of macrocyclic complexes in practice is mentioned.
Syllabus
  • 1. Introduction into macrocylic chemistry (nomenclature, natural macrocyles, importance).
  • 2. Types of macrocylic ligands and their complexes, cyclic polyamines and porphyrines, cyclic polyethers (crowns, polyethers, cryptands, cavitands, calixarens), cyclic ligands with other donor atoms than O or N, polycore and polymer macrocycles, catenans and catenands, macrocyclic sugars, robust macrocycles, stereoisomerism of macrocycles, "hole-size" concept.
  • 3. Aspects of macrocycle synthesis. Free ligands - non-template synthesis, reaction of ring formation (synthesis under high and low dilution).
  • 4. Complexes - non-template synthesis, template synthesis (influence of physical and chemical conditions on kind and yield of reaction - kinds of template effects), in situ reactions. Derivatization of macrocycles - introduction of functional groups into cyclic skeleton and protection of cyclic skeleton.
  • 5. Chelate and macrocyclic effect - origin and quantification. Experimental techniques suitable for study of reactivity of macrocyclic compounds.
  • 6. Thermodynamic aspect - selectivity for ions. Kinetic aspect - formation and dissociation kinetics.
  • 7. Reactivity of complexes and their redox properties. Stabilisation of less common oxidation states - "metal-centered", "ligand-centered" oxidation and reduction. Substitution reactions in axial site, reaction of coordinated macrocyclic ligand, demetallic reactions and ionic exchange reactions.
  • 8. Macrocyclic systems. Complexation of metal ions (cyclic polyethers, polyamines and polyimines; cryptands, calixarenes, etc.).
  • 9. "Host-guest" chemistry - complexation of organic cations.
  • 10. Complexation of organic anions.
  • 11. Complexation of neutral compounds cyclodextrines.
  • 12. The use of macrocyclic ligands and their complexes in chemistry, biology, medicine - examples.
Literature
  • Constable, Edwin C., Coordination Chemistry of Macrocyclic Compounds, Oxford University Press, Oxford 1999.
  • MARTELL, Arthur E. and Robert D. HANCOCK. Metal complexes in aqueous solutions. New York: Plenum Press, 1996, x, 253 s. ISBN 0-306-45248-0. info
  • Lindoy L.F., The Chemistry of Macrocylic Ligand Complexes, Cambridge University Press, Cambridge 1989.
Teaching methods
lectures
Assessment methods
The lecture is presented during term or in block according to agreement with lecturer. The knowledge of students is verified by oral exam.
Language of instruction
English
Further Comments
The course is taught once in two years.
The course is taught: every week.
The course is also listed under the following terms Autumn 2007 - for the purpose of the accreditation, Spring 2000, Autumn 2010 - only for the accreditation, Spring 2001, Spring 2002, Autumn 2002, Autumn 2003, Autumn 2005, Autumn 2006, Autumn 2007, Autumn 2008, Autumn 2009, Autumn 2010, Autumn 2011, Autumn 2011 - acreditation, Autumn 2012, Autumn 2013, Autumn 2014, Autumn 2016, Autumn 2020, Autumn 2022, Autumn 2024.
  • Enrolment Statistics (Autumn 2018, recent)
  • Permalink: https://is.muni.cz/course/sci/autumn2018/C8840