Bi_IB8 Genetic codes

Faculty of Science
Spring 2007
Extent and Intensity
0/0. 2 credit(s). Type of Completion: z (credit).
Teacher(s)
prof. E. N. Trifonov (lecturer)
Guaranteed by
prof. RNDr. Jiří Fajkus, CSc.
Department of Experimental Biology – Biology Section – Faculty of Science
Contact Person: prof. RNDr. Jiří Fajkus, CSc.
Course Enrolment Limitations
The course is offered to students of any study field.
Course objectives
In addition to protein-coding message the nucleotide sequences carry instructions for DNA folding, transcription, translation framing, gene splicing, fast adaptation code, and many more (1, 2). Every sequence element belongs simultaneously to several different messages superimposed on one another. The codes of protein sequences are of this nature as well. Most prominent examples of the code overlapping and interaction will be considered. The course is based largely on the most recent publications. This includes the latest developments on the chromatin code and its interactions with other codes (3, 4). Ref. (2) is an extended summary of the course. 1. Trifonov, E. N., Sequence codes. In: "Encyclopedia of Molecular Biology", T. E. Creighton, Ed., John Wiley & Sons, Inc., New York, 1999, p. 2324-2326 2. Trifonov, E. N., Codes of biosequences. In: The Codes of Life. The Rules of Macroevolution. Barbieri, M. (ed.). Springer. New York, in press 3. Trifonov, E. N., Kogan, S., Cohanim, A. B. Latest on the nucleosome positioning sequence patterns. In "DNA Structure, Chromatin and Gene Expression" (Eds. R. Kiyama, M. Shimizu), Transworld Research Network, Trivandrum (India), pp 43-54 (2006) 4. F. Salih, B. Salih, E. N. Trifonov, Sequence-directed mapping of nucleosome positions, JBSD in press
Language of instruction
English
Further Comments
Study Materials
The course is taught only once.
The course is taught: in blocks.
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