CLINICALCLINICAL SESSIONSSESSIONS 20102010 'Handbook of Clinical Procedures' Compiled and led by Shan Keshri Manuals created by: Shan Keshri, Devangna Bhatia, Bhavin Doshi, Shilpa Nelapatla, Nathan Golban, Dave Utulu, Richard Dolan, Arjun Keshri, Sada Chatzialis, Joae de Oliveira, Amit Kaushal, Pooja Mithani, Diogo Forjaz, Mubarak Al-Rasheedi Kumaran Thanabalasingham, Nikos Lymberopoulos, Michalis Ploumidis Teaching Room courtesy of: MIMSA Clinical Sessions was a 6 week course (09.03.10 – 13.04.10) run ‘by the students, for the students’ at the Faculty of Medicine, Masaryk University, Brno. As promised in the first session introduction, this is the ‘Handbook of Clinical Procedures’. It is the result of the efforts of the students. Sincere thanks to everyone who took part, be it by preparing and presenting a topic, or by attending. I believe it was a huge success, and feel these notes are an invaluable reference source. As this is the efforts of fellow students, please be understanding if you find any mistakes. Do however, be assured all efforts were made to make the information as accurate and as up-to-date as we could manage. Once again thanks to all that took part, Good Luck, Shan Keshri Preface Pooja Sada Michalis Richard Mubarak Nikos Bhav Shan Devangna Joae Dave Shilpa Nathan Amit Arjun Diogo Kumaran SESSION 1 (Blood & Urine procedures) 1) Taking a Patient History Devangna Bhatia 2) Phlebotomy (taking blood) Shan Keshri 3) Interpreting Blood Results (Heamatology, Biochemistry, Lipids, Enzymes) Shan Keshri & Amit Kaushal 4) Urine Collection, Urinalysis Shan Keshri 5) Cathethers and Cannulas (IV situations) Bhavin Doshi 6) Common Drugs used to treat common respiratory disorders Shan Keshri SESSION 2 (Obs / Gynae) 1) Arterial Blood Sampling Nathan Golban 2) Obs n Gynae Intro, Breast examination Arjun Keshri & Sada Chatzialis 3) Pregnancy Test Arjun Keshri & Sada Chatzialis 4) IM & SC injections. Insulin injection techniques Pooja Mithani 5) Pelvic examination & Cervical Pap Smear Shan Keshri SESSION 3 (GIT) 1) Abdominal examination Amit Kaushal & Kumeran Thanabalasingham 2) Nasogastric tube insertion Shan Keshri 3) First Aid overview Devangna Bhatia 4) Central Venous Catheterisation Shilpa Nelapatla 5) Sutures Joae de Oliviera SESSION 4 1) Rectal examination Nikos Lymberopoulos 2) Otoscopy & Opthalmoscopy Shan Keshri 3) Urethral Catheterisation (male & female) Diogo Forjaz 4) GALS (gait, arm, leg, spine) & joint exam Dave Utulu SESSION 5 (Neuro, Cardiac) 1) Neurological examination (cerebellar, cranial nv, reflexs) Shan Keshri 2) CSF Examination Michalis Ploumidis 3) Drainage Tubes (application and removal) Devangna Bhatia 4) Normal chest xray (things to check) Mubarak Alrasheedi 5) ECG (signs of heart disease) Dave Utulu SESSION 6 (Resp) 1) Respiratory Function Tests (peak flow, spirometry, manual ventilation) Dave Utulu 2) Airway Intubation (inc. simple adjuncts e.g. Guedal airway/ laryngeal masks) Joae de Oliviera 3) Administration of oxygen therapy (via a face mask or other equipment) Richard Dolan 4) Using a Nebuliser / Inhaler correctly Richard Dolan *Due to technical problems, CSF Examination and Chest X-Ray Manuals are not included. WELCOME TOWELCOME TO CLINICAL SESSIONSCLINICAL SESSIONS AIMAIM –– Quick reference guidesQuick reference guides  Resource ofResource of ‘‘clinical manualsclinical manuals’’ = quick reference to= quick reference to know step by step method and core principlesknow step by step method and core principles  NonNon--practical topics = train our minds to thinkpractical topics = train our minds to think differential diagnoses and treatmentsdifferential diagnoses and treatments  Results of urinalysis show low urea level. What could thisResults of urinalysis show low urea level. What could this indicate?indicate?  Patients suffers from heart failure. What is the first linePatients suffers from heart failure. What is the first line drugs classes; what are some names of preferred Bdrugs classes; what are some names of preferred B-- Blockers used in hospitals / UK today?Blockers used in hospitals / UK today?  Learn or revise via weekly interactive presentationsLearn or revise via weekly interactive presentations  Q&A discussions, videos, roleQ&A discussions, videos, role--play, props, anything toplay, props, anything to illustrate the conceptsillustrate the concepts Why is it important to know theseWhy is it important to know these things now?things now?  They are based on theThey are based on the ‘‘basic learning outcomes of medicalbasic learning outcomes of medical schoolschool’’, set out by the GMC UK., set out by the GMC UK.  When applying for your 1When applying for your 1stst job, thejob, the ‘‘Clinical SkillsClinical Skills’’ section ofsection of form asks: Can you confidently do the following proceduresform asks: Can you confidently do the following procedures Yes or No?Yes or No? DonDon’’t only concentrate on the coret only concentrate on the core principles!principles!  UK students have OSCE practical exams. If theyUK students have OSCE practical exams. If they forget to wash their hands or forget to checkforget to wash their hands or forget to check patient identity before even touching the patientpatient identity before even touching the patient they lose marks!!they lose marks!!  So to maintain this standard, Safety, infectionSo to maintain this standard, Safety, infection control and communication reminders will also becontrol and communication reminders will also be included in the presentations .included in the presentations .  We only have time to study the clinical side ofWe only have time to study the clinical side of things.things.  With regards to the textbook science, we canWith regards to the textbook science, we can make references to the key words, to give you amake references to the key words, to give you a starting point needed to read further.starting point needed to read further. Any questions before we getAny questions before we get started?started? HISTORY TAKINGHISTORY TAKING Devangna Bhatia INTRO • A.k.a anamnesis • An accurate history is the biggest step in making  the correct diagnosis. • The main aim of history taking is to find out what  caused the patient to come to the surgery and  seek help.  • Then it is our job, as doctors, to use this  information and formulate a diagnosis and  provide the medical care needed. • The more detail you can get, the better and  easier it will be for you to come up with a  diagnosis. Before taking a history… • Put the patient at ease – developing a good  relationship with the patient will help • Shake hands, introduce yourself • Check whether the patient is comfortable • Have a conversational tone rather than an  interrogative one – it will make the patient feel  more comfortable and that (s)he can tell you more  information While taking the history, keep in mind… • Don’t interrupt the patient while (s)he is talking,  let them finish and then ask the questions… • Show that you are paying attention even while  writing – nodding, occasionally looking up and  making eye contact, or the occasional “yes, ok” • Don’t forget to write the date (& time)! • If you ask about any malignancies in the family,  you need to be tactful! • Keep in mind the religion of the patient and be  tactful, so as you don’t look ignorant when  asking some questions Taking the history… 1) Start with general questions : name, age,  DOB, occupation, martial status 2) Presenting Complaint (PC): “What has been  the trouble recently?” This is the complaint that caused them to seek  medical help. Use the patient’s wording, when noting it down,  rather than medical terms… 3) History of Presenting complaint (HPC): “When  did it begin? What was the first thing you  noticed? Have you had it before?” Site Onset – gradual or sudden Character – sharp, dull, thumping, constant… Radiation Associations (sweating, nausea…) Timing of pain/duration/frequency Exacerbating and alleviating factors Severity (scale of 1 to 10, or comparing it to child  birth) 4) Direct questioning (DQ): specific questions  about the diagnosis you have in mind (+ its risk  factors), e.g. if you suspect the patient may have  malaria, ask them about their travel history,  what they may have consumed… 5) Past Medical History (PMH): ever been in  hospital? Illnesses, especially childhood ones.  Operations? Diabetes, asthma, bronchitis, TB,  jaundice, hypertension, rheumatic fever, heart  disease, epilepsy, stroke, peptic ulcer,  anaesthetic problems. Also, ask here about allergies – penicillin, dogs,  cats, hay fever, dust… 6) Drug History (DH): taking any tablets,  injections? “off the shelf” drugs, e.g. cough  syrup? The pill, herbal remedies?  7) Social History (SH): martial status? Live alone?  Any help at home? House or apartment? What  does the illness prevent the patient from doing?  Occupation? Sexual history – their attitude  towards it… 8) Family History (FH): age, health and cause of  death of parents, siblings and children. Diseases  such as hypertension, diabetes, or malignancies  in the family 9) Alcohol, Recreational drugs, tobacco: How much?  How often? When did you begin? When did you  stop? Express cigarettes in pack‐years: 20 cigarettes  smoked per day for 1 year = 1 pack‐year We all like to present ourselves in the good light, so  be ready to double the stated quantities by the  patient!  The CAGE questionnaire can be used as a screening  test for alcoholism (later on) General problems ‐ weight loss, night sweats, any  lumps, appetite, fever, recent trauma Cardio‐respiratory symptoms – cough, sputum,  wheeze, haemoptysis, oedema, chest pain,  dyspnoea, orthopnoea Gut symptoms – abdominal pain, haematemesis  swallowing, ingestion, nausea/vomiting, bowel  habit, stool – colour, consistency, blood Functional enquiry: to uncover un‐declared  symptoms… Genitourinary Symptoms – incontinence, dysuria,  haematuria, nocturia, frequency, polyuria,  hesistancy FEMALES: vaginal discharge, menses: freq,  regularity, painful, heavy/light, first day of last  menstrual period (LMP), menarche, menopause,  no. of pregnancies, any chance of pregnancy  right now? Neurological Symptoms – special senses – sight,  hearing, taste & smell; seizures, faints, poor  balance, headaches, weakness, “pins and needles”,  speech problems, sphincter problems Important thing to do, is assess function: what can  and can’t the patient do at home, work etc. Musculoskeletal symptoms – pain, stiffness, swelling  of joints; functional deficit; diurnal variation in  symptoms (i.e. with time of day) CAGE Questionnaire Been used for a long time, as a screening test for  alcoholism 2 or more positive answers = alcohol problem C: have you ever felt you should cut down on your  drinking? A: have you ever been annoyed at others’ concerns  about your drinking? G: have you ever felt guilty about drinking? E: have you ever had alcohol as an eye‐opener in  the morning? Definitions • Haemoptysis ‐ coughing up blood • Dyspnoea – breathlessness • Orthopnoea ‐ breathlessness while lying flat • Haematemesis ‐ vomiting blood • Incontinence – stress or urge • Dysuria – painful micturition • Haematuria – bloody micurition • Nocturia – needing to micturate at night • Polyuria – passing excessive amounts of urine • Hesitancy – difficulty starting micurition • Menarche – the first menstrual period, usually occurring  during puberty • Menopause ‐ the period of permanent cessation of  menstruation, usually occurring between the ages of 45 and  55.  VENEPUNCTURE:VENEPUNCTURE: PHLEBOTOMYPHLEBOTOMY SHAN KESHRISHAN KESHRI Clinical Sessions 2010Clinical Sessions 2010 akaaka BLOOD COLLECTIONBLOOD COLLECTION INDICATIONSINDICATIONS DiagnosticDiagnostic:: •• Obtain blood sample for analysis.Obtain blood sample for analysis. (e.g. systemic problems(e.g. systemic problems –– Fe anemia, glucose DM,Fe anemia, glucose DM, INR,INR, infections, cholesterol, immunology, liver enzymes/ function)infections, cholesterol, immunology, liver enzymes/ function) INDICATIONSINDICATIONS TherepeuticTherepeutic:: •• treat Polycythemia Veratreat Polycythemia Vera (elevated RBC volume(elevated RBC volume aka hematocrit)aka hematocrit) •• treat hemochromatosistreat hemochromatosis (dangerously high iron(dangerously high iron levels)levels) •• Donation for transfusionDonation for transfusion CONTRAINDICATIONSCONTRAINDICATIONS  Low oxygen levels in bloodLow oxygen levels in blood (hypoxemia)(hypoxemia) RISKSRISKS  InfectionInfection  negligible if sterile environment, propernegligible if sterile environment, proper use/disposal of needles, and proper management ofuse/disposal of needles, and proper management of samples.samples.  Hitting a nerve or arteryHitting a nerve or artery (arterial stab)(arterial stab)  remove needle and apply pressureremove needle and apply pressure SIDE EFFECTSSIDE EFFECTS  Some pain, possible bruisingSome pain, possible bruising  Fainting and light headed (Fainting and light headed (vasovaso--vagalvagal))  Excessive bleedingExcessive bleeding  HaematomaHaematoma (blood acc. under skin)(blood acc. under skin)  Iron deficiency anemiaIron deficiency anemia (in therapeutic phlebotomy)(in therapeutic phlebotomy) ALTERNATIVESALTERNATIVES  No real alternative to phlebotomy, however thereNo real alternative to phlebotomy, however there are various different sites on the body that couldare various different sites on the body that could be used.be used.  See Method.See Method.  Never attempt more than twice:Never attempt more than twice: •• Refer patient back.Refer patient back. PROCEDUREPROCEDURE Think Action & Rationale! WHAT are you doing? WHY are you doing it? At every step know: WASH HANDSWASH HANDS EQUIPMENT: Sterile Tray with:EQUIPMENT: Sterile Tray with:  Pair of glovesPair of gloves  TourniquetTourniquet  Alcohol wipesAlcohol wipes  GauzeGauze  VACUTAINER barrel and NeedleVACUTAINER barrel and Needle  Blood bottlesBlood bottles (color coded according to additive e.g.(color coded according to additive e.g. anticoagulant or preservative)anticoagulant or preservative) RULES OF ASEPSISRULES OF ASEPSIS STEP 2: CHECK PATIENT DETAILSSTEP 2: CHECK PATIENT DETAILS  Ask fullAsk full NameName,, DOBDOB,, GenderGender and compareand compare with blood request form!with blood request form!  Check blood form has beenCheck blood form has been signedsigned by theby the requesting doctorrequesting doctor  IfIf special requirementsspecial requirements, check patient has, check patient has complied, e.g. fasting!complied, e.g. fasting!  Have you had blood taken before?Have you had blood taken before? (preferred(preferred vein)vein) PutPut GlovesGloves on.on. Ensure patient is in a relaxed position.Ensure patient is in a relaxed position. FIND A SUITABLE VEINFIND A SUITABLE VEIN (Palpation: bouncy & large & superficial)(Palpation: bouncy & large & superficial)  90% used90% used –– AnteriorAnterior CubitalCubital FossaFossa,, –– MedianMedian CubitalCubital vein, Cephalic,vein, Cephalic, BasilicBasilic VeinVein  Back of handBack of hand-- Cephalic (Cephalic (housemanshousemans) vein) vein  Feet, Central Line, Peripheral Venous line,Feet, Central Line, Peripheral Venous line, Femoral stab (groin harder to disinfect)Femoral stab (groin harder to disinfect)  Attach VACUTAINER needle to barrel.Attach VACUTAINER needle to barrel.  Apply tourniquet 2 fingers aboveApply tourniquet 2 fingers above anterioranterior cubitalcubital fossafossa.. (increases pressure)(increases pressure) Inform patientInform patient ‘‘this may feel a little tightthis may feel a little tight’’..  Disinfect skin with alcohol wipes.Disinfect skin with alcohol wipes.  Remove cap from needle.Remove cap from needle.  Warn Patient of Sharp Scratch.Warn Patient of Sharp Scratch.  Stretch skin and insert needle atStretch skin and insert needle at 1515--30 degrees parallel30 degrees parallel into the veininto the vein (bevel edge(bevel edge ofof needleneedle facingfacing upup)) 15-30 degrees  Introduce VACUTAINER bottle intoIntroduce VACUTAINER bottle into the barrel.the barrel.  Allow blood to collect. It willAllow blood to collect. It will automatically stop filling when full.automatically stop filling when full.  NB: DifferentNB: Different colourcolour bottles contain differentbottles contain different additives and antiadditives and anti--coagulants etc!coagulants etc!  Amount drawn depends on indicationAmount drawn depends on indication (see request form)(see request form)  However normallyHowever normally 55--25 ml25 ml isis enough.enough.  FIRST Remove blood BOTTLEFIRST Remove blood BOTTLE  THEN remove TOURNIQUETTHEN remove TOURNIQUET  LASTLY, swiftly remove NEEDLELASTLY, swiftly remove NEEDLE  Safely dispose needle to sharps binSafely dispose needle to sharps bin immidiatelyimmidiately ––NEVER RESHEATH!!NEVER RESHEATH!!  Apply gauze to puncture site for 1Apply gauze to puncture site for 1 minute, with some pressure.minute, with some pressure.  Remove gloves and wash handsRemove gloves and wash hands MANAGEMENTMANAGEMENT  Invert blood bottle to ensure bloodInvert blood bottle to ensure blood mixes with the additives in specimenmixes with the additives in specimen bottlebottle Label blood bottle:Label blood bottle:  Patient NamePatient Name  Identification NumberIdentification Number  Date & TimeDate & Time ……etcetc  Document in patient record.Document in patient record.  Send to Pathology lab for analysis.Send to Pathology lab for analysis. WASH HANDSWASH HANDS OLD UKOLD UK / CURRENT CZ METHOD/ CURRENT CZ METHOD  MONOVETTE SARSTEDT VACUUM TUBESMONOVETTE SARSTEDT VACUUM TUBES  Pull syringe to create vacuum, then slot into needle.Pull syringe to create vacuum, then slot into needle.  When full, snap off handleWhen full, snap off handle To PreventTo Prevent HeamatomaHeamatoma!!  PuncturePuncture onlyonly thethe uppermostuppermost wallwall ofof thethe veinvein  EnsureEnsure needlneedlee fullyfully penetratespenetrates uppermostuppermost wallwall ofof thethe veinvein.. ((PartialPartial penetrationpenetration maymay allowallow bloodblood toto leakleak))  RemoveRemove tourniquettourniquet beforebefore removingremoving needleneedle (decreases pressure)(decreases pressure)  Use majorUse major superficialsuperficial veinsveins  ApplyApply pressurepressure toto thethe puncturepuncture sitesite Protect Yourself!Protect Yourself! (in addition to what has been mentioned)(in addition to what has been mentioned)  Change gloves between patients.Change gloves between patients.  Clean up spills with disinfectant.Clean up spills with disinfectant.  Do notDo not breakbreak,, oror rerecap needle.cap needle. ((avoidavoid accidentalaccidental needleneedle puncturepuncture oror splashingsplashing ofof contentscontents)) Protect Yourself!Protect Yourself! (in addition to what has been mentioned)(in addition to what has been mentioned)  In Event of being pricked with needle:In Event of being pricked with needle: •• RemoveRemove and dispose of gloves.and dispose of gloves. •• SqueezeSqueeze puncturepuncture sitesite toto promotepromote bleedingbleeding.. •• WashWash areaarea wellwell withwith soapsoap andand waterwater.. •• RecordRecord thethe patientpatient’’ss namename andand IDID numbernumber.. •• FollowFollow institutioninstitution’’ss guidelinesguidelines regardingregarding treatmenttreatment andand followfollow--upup.. NB PNB Prophylacticrophylactic zidovudinezidovudine followingfollowing bloodblood exposureexposure to HIV hasto HIV has shownshown effectivenesseffectiveness.. SUMMARYSUMMARY  TTourniquetourniquet  AAntiseptic wipentiseptic wipe  PPalpatealpate  IInsernsertt  ........ but be gentle!but be gentle!  DonDon’’t forget Safety and Communication.t forget Safety and Communication. VIDEOVIDEO THANKYOU FOR LISTENINGTHANKYOU FOR LISTENING http://www.youtube.com/user/vanitagoss#p/a/u/1/9http://www.youtube.com/user/vanitagoss#p/a/u/1/9 V_5Dgr9ozMV_5Dgr9ozM Overview:Overview: INTERPRETATION OFINTERPRETATION OF BLOOD RESULTSBLOOD RESULTS SHAN KESHRISHAN KESHRI Clinical Sessions 2010Clinical Sessions 2010 (Hematology)(Hematology) We will consider results ofWe will consider results of Full / Complete Blood CountFull / Complete Blood Count (FBC / CBC)(FBC / CBC)  HAEMATOLOGYHAEMATOLOGY  BIOCHEMISTRYBIOCHEMISTRY  LIPIDSLIPIDS  CARDIAC ENZYMESCARDIAC ENZYMES  OTHEROTHER ---------------------------------------------------------- 1 Unit Blood = just under 1 pint (450ml)1 Unit Blood = just under 1 pint (450ml)  Average Body contains 8Average Body contains 8--10 pints10 pints 11 MAIN HAEMATOLOGICAL11 MAIN HAEMATOLOGICAL VALUESVALUES (1) WBC (Leukocyte) COUNT(1) WBC (Leukocyte) COUNT  FUNCTION: Immune cells, fight infectionFUNCTION: Immune cells, fight infection Derived from Bone MarrowDerived from Bone Marrow  NORMAL :NORMAL : 4.34.3 -- 10.8 x 1010.8 x 10**99 /L/L  HIGH =HIGH = LeukocytosisLeukocytosis •• Infection?Infection? •• Malignancy? Leukemia?Malignancy? Leukemia?  LOW = LeucopeniaLOW = Leucopenia •• Bone MarrowBone Marrow probprob?? •• Chemotherapy treatment?Chemotherapy treatment?  28% Lymphocytes : Fight infection28% Lymphocytes : Fight infection  HIGH : Infection?, Leukemia?HIGH : Infection?, Leukemia?  LOW : Chemo?, Radiation?, Stress?LOW : Chemo?, Radiation?, Stress?  Granulocytes:Granulocytes: •• 3%3% EosinophilsEosinophils –– Allergic reactionsAllergic reactions  Low : Steroids?Low : Steroids? •• 65%65% NeutrophilsNeutrophils / 5%/ 5% MonocytesMonocytes –– Primary responsePrimary response  High : AcuteHigh : Acute inflaminflam?, Malignancy??, Malignancy?  Low : Chemo?, AI?, BMLow : Chemo?, AI?, BM probprob??  0.5%0.5% BasophilsBasophils (2) WBC DIFFERENTIAL COUNT(2) WBC DIFFERENTIAL COUNT  FUNCTION : O2 Transport. Derived from Bone marrow,FUNCTION : O2 Transport. Derived from Bone marrow, (large bones)(large bones)  NORMAL : 4.2NORMAL : 4.2 –– 5.9 x 10*9 /L5.9 x 10*9 /L  HIGHHIGH •• Low O2 (hypoxia) ?Low O2 (hypoxia) ? --> Inc. Erythropoietin> Inc. Erythropoietin (hormone that stimulates RBC production)(hormone that stimulates RBC production)  LOWLOW –– AnemiaAnemia •• Iron/Iron/ VitVit. B12 Deficiency? etc.. Refer to. B12 Deficiency? etc.. Refer to PathophysPathophys!! •• Bone Marrow diseaseBone Marrow disease  Most common blood cell / smaller than WBC , larger thanMost common blood cell / smaller than WBC , larger than platelets / Lifetime approx 120 days.platelets / Lifetime approx 120 days. (3) RBC(3) RBC (erythrocyte)(erythrocyte) COUNTCOUNT (4) HEMOGLOBIN ((4) HEMOGLOBIN (HbHb))  FUNCTION : Protein within RBC, O2 transport vehicle. GivesFUNCTION : Protein within RBC, O2 transport vehicle. Gives blood redblood red colourcolour..  NORMAL MALE : 13.5NORMAL MALE : 13.5 –– 16.916.9 g/dLg/dL (M av. 15.2)(M av. 15.2)  NORMAL FEMALE : 11.5NORMAL FEMALE : 11.5 –– 14.814.8 g/dLg/dL (F av. 13.2)(F av. 13.2) HEMOGLOBIN (HEMOGLOBIN (HbHb) cont.) cont.  LOW : AnemiaLOW : Anemia  Blood Loss?Blood Loss?  Nutritional (iron, b12,Nutritional (iron, b12, folatefolate) def. ?) def. ?  BMBM probprob??  Chemotherapy?Chemotherapy?  Kidney failure?Kidney failure?  Sickle cell anemia? /Sickle cell anemia? / ThallasemiaThallasemia (hereditary(hereditary lowlow HbHb))  HIGH :HIGH :  High altitudes?High altitudes?  Smoker?Smoker?  Dehydration?Dehydration? (5) HEMATOCRIT ((5) HEMATOCRIT (HctHct))  measured via RBC sedimentationmeasured via RBC sedimentation –– spin blood sospin blood so RBCRBC’’ss settlesettle  WHAT : % RBC volume relative to total blood volume.WHAT : % RBC volume relative to total blood volume.  NORMAL MALE : 45NORMAL MALE : 45 –– 52 % (M av. 49%)52 % (M av. 49%)  NORMAL FEMALE : 37NORMAL FEMALE : 37 –– 48 % (F av. 43%)48 % (F av. 43%) HEMATOCRIT (HEMATOCRIT (HctHct))  LOW :LOW :  Anemia?Anemia?  Blood Loss?Blood Loss?  Nutritional Def.?Nutritional Def.?  BMBM probprob??  Chemotherapy?Chemotherapy?  Sickle cell anemia?Sickle cell anemia?  HIGH :HIGH :  Erythropoietin abuse (athlete doping) ?Erythropoietin abuse (athlete doping) ?  High altitude ?High altitude ?  Smoker ?Smoker ?  Dehydration ?Dehydration ? (6) MEAN CORPUSCULAR(6) MEAN CORPUSCULAR VOLUME (MCV)VOLUME (MCV)  WHAT : Average vol. of RBCWHAT : Average vol. of RBC (calculated from(calculated from HctHct / RBC count)/ RBC count)  NORMAL: 80NORMAL: 80––100100 femtofemto--litreslitres (fraction of one millionth of a(fraction of one millionth of a litrelitre)) (7) MEAN CORPUSCULAR(7) MEAN CORPUSCULAR HEMOGLOBIN (MCH)HEMOGLOBIN (MCH)  WHAT : Average amount ofWHAT : Average amount of HbHb in RBCin RBC  NORMAL MALE : 45NORMAL MALE : 45 –– 52 % (M av. 49%)52 % (M av. 49%)  NORMAL FEMALE : 37NORMAL FEMALE : 37 –– 48 % (F av. 43%)48 % (F av. 43%) (8) MEAN CORPUSCULAR(8) MEAN CORPUSCULAR HEMOGLOBIN CONC (MCHC)HEMOGLOBIN CONC (MCHC)  WHAT : AverageWHAT : Average HbHb concconc in a given volume of RBCin a given volume of RBC  NORMAL : 32NORMAL : 32 –– 36 %36 % (9) RED CELL DISTRIBUTION(9) RED CELL DISTRIBUTION WIDTH (RDW)WIDTH (RDW)  WHAT : Measurement of variability of RBCWHAT : Measurement of variability of RBC size & shapesize & shape  NORMAL : 11NORMAL : 11 –– 1515  Higher valueHigher value –– More VariationMore Variation (10) PLATELET COUNT(10) PLATELET COUNT  FUNCTION : Role in clotting, Bleeding control.FUNCTION : Role in clotting, Bleeding control.  NORMAL 150NORMAL 150 –– 400 x 10*9 /L400 x 10*9 /L  LOW = ThrombocytopeniaLOW = Thrombocytopenia  Prolonged bleeding?Prolonged bleeding?  Drug toxicity?Drug toxicity?  HIGH =HIGH = ThrombocytosisThrombocytosis  Bone MarrowBone Marrow probprob?? (11) MEAN PLATELET(11) MEAN PLATELET VOLUMEVOLUME  WHAT : Average size of plateletsWHAT : Average size of platelets  PANCYTOPNEA : Low WBC, RBC &PANCYTOPNEA : Low WBC, RBC & PlateletsPlatelets •• Bone MarrowBone Marrow ProbsProbs OtherOther HaematologicalHaematological ref valuesref values  VitVit. B12 : 179. B12 : 179 –– 11621162  SerumSerum FolateFolate : 2.7: 2.7 –– 3434  FerritinFerritin : 10: 10 –– 204 :iron store204 :iron store  PT Time : 10PT Time : 10 –– 13 seconds :clotting?13 seconds :clotting?  Fibrinogen : 1.5Fibrinogen : 1.5 –– 4.5 g/L4.5 g/L  INR : 2INR : 2--4 :coagulation therapy4 :coagulation therapy  APTT Activated partialAPTT Activated partial thromboplastinthromboplastin time : 30time : 30--40s40s •• Test of intrinsicTest of intrinsic coagcoag. factor deficiency.. factor deficiency. SUMMARYSUMMARY 1.1. WBCWBC :: 4.34.3 -- 10.8 x 1010.8 x 10**99 /L/L 2.2. WBC DIFFERENTIAL :WBC DIFFERENTIAL : 28%28% LypLyp/ 3%/ 3% EosinophilsEosinophils/ 65%/ 65% NeutrophilsNeutrophils/ 5%/ 5% MonocytesMonocytes/ 0.5%/ 0.5% BasophilsBasophils 3.3. RBCRBC : 4.2: 4.2 –– 5.9 x 10*9 /L5.9 x 10*9 /L 4.4. HbHb:: M : 45M : 45 –– 52 %, F : 3752 %, F : 37 –– 48 %48 % 5.5. HctHct :: M : 45M : 45 –– 52 % F : 3752 % F : 37 –– 48 %48 % 6.6. MCVMCV : 80: 80––100100 femtofemto--litreslitres 7.7. MCH :MCH : M : 45M : 45 –– 52 % F : 3752 % F : 37 –– 48 %48 % 8.8. MCHCMCHC : 32: 32 –– 36 %36 % 9.9. RDWRDW : 11: 11 –– 1515 10.10. PLATELETSPLATELETS : 150: 150 –– 400 x 10*9 /L400 x 10*9 /L FURTHER READINGFURTHER READING  Thrombin TimeThrombin Time  APTTAPTT  Coagulation screening testsCoagulation screening tests  Platelet aggregation testsPlatelet aggregation tests  EuglobulinEuglobulin clotclot lysinglysing time (ELT)time (ELT)  Thrombotic diseasesThrombotic diseases  Diseases of Blood and Bone MarrowDiseases of Blood and Bone Marrow  AnaemiasAnaemias,, ThallassemiaThallassemia,, Splenomegaly,HaemophiliaSplenomegaly,Haemophilia andand coagulation disorderscoagulation disorders  History taking in relation to Blood disorders (presentingHistory taking in relation to Blood disorders (presenting symptoms)symptoms) Overview:Overview: INTERPRETATION OFINTERPRETATION OF BLOOD RESULTSBLOOD RESULTS SHAN KESHRI & AMIT KAUSHALSHAN KESHRI & AMIT KAUSHAL Clinical Sessions 2010Clinical Sessions 2010 (Biochemistry, Lipids, Enzymes & Other) BIOCHEMICAL VALUESBIOCHEMICAL VALUES BIOCHEMICAL VALUES  Sodium : 136Sodium : 136 –– 145145 mmolmmol/L/L  Potassium : 3.5Potassium : 3.5 –– 5.15.1 mmolmmol/L/L  Urea: MUrea: M –– 3.23.2 –– 7.4 / F7.4 / F –– 2.52.5 –– 6.76.7  CreatinineCreatinine : 53: 53 –– 115115 µµmol/Lmol/L  GFR:GFR:  HbA1c : 4.3HbA1c : 4.3 –– 6.1% : Insulin therapy6.1% : Insulin therapy  Glucose (random) : 4.0Glucose (random) : 4.0 –– 7.8mmol/L7.8mmol/L  Fasting Glucose : 3Fasting Glucose : 3--6mmol/L6mmol/L  Bilirubin : 0Bilirubin : 0--2020 µµmol/Lmol/L  ALT: 10ALT: 10--30 (IU/L)30 (IU/L)  ALP: 39ALP: 39--128 (IU/L)128 (IU/L)  Albumin : 35Albumin : 35--50 g/L50 g/L  Magnesium : 0.7Magnesium : 0.7--11 mmolmmol/L/L  Phosphate : 0.74Phosphate : 0.74 --1.521.52 mmolmmol/L/L  Calcium : 2.2Calcium : 2.2 -- 2.62.6 mmolmmol/L/L NaNa++ (136(136 –– 145145 mmolmmol/L)/L) •• Mostly ECFMostly ECF •• Controlled by RASControlled by RAS •• LowLow NaNa++ –– Signs and Symptoms: Seizures, Cardiac Failure,Signs and Symptoms: Seizures, Cardiac Failure, DehydrationDehydration –– Causes: Vomiting, Diuretics, AddisonCauses: Vomiting, Diuretics, Addison’’s Disease, Lows Disease, Low ADH, Renal FailureADH, Renal Failure –– Management:Management: Correct underlying cause, not theCorrect underlying cause, not the [Na[Na++ ] alone] alone –– Acute Situation: Saline infusion and FurosemideAcute Situation: Saline infusion and Furosemide •• HighHigh NaNa++ –– Signs and symptoms: Thirst, Hypertension,Signs and symptoms: Thirst, Hypertension, Dehydration, Fits, OliguriaDehydration, Fits, Oliguria –– Causes:Causes: HH220 loss0 loss (without Iron loss, eg. Vomiting &(without Iron loss, eg. Vomiting & Diarrhea )Diarrhea ) DiabetesDiabetes insipidusinsipidus (ADH intolerance)(ADH intolerance) –– Management:Management: HH220 administration0 administration KK++ 3.53.5 –– 5.15.1 mmolmmol/L/L •• Mostly ICFMostly ICF •• Exchanges with HExchanges with H++ acrossacross membmemb.. •• Insulin/Insulin/CatecholaminesCatecholamines stimulate Kstimulate K ++ uptake intouptake into cellscells •• HighHigh KK++ :: »» Signs and Symptoms: Cardiac arrhythmiasSigns and Symptoms: Cardiac arrhythmias (sudden death)(sudden death) »» ECG: WIDE QRS ComplexECG: WIDE QRS Complex »» Causes: Diuretics, AddisonCauses: Diuretics, Addison’’s Disease, Mets Disease, Met Acidosis, Burns, ACE InhibitorsAcidosis, Burns, ACE Inhibitors »» Management: Treat underlying causeManagement: Treat underlying cause »» Emergency Treatment: Insulin and GlucoseEmergency Treatment: Insulin and Glucose admin. (IV)admin. (IV) •• Low KLow K++:: »» S & S: Muscle weakness, crampsS & S: Muscle weakness, cramps »» ECG: Depressed ST SegmentECG: Depressed ST Segment »» Causes: Diuretics,Causes: Diuretics, ConnConn’’ss Syndrome,Syndrome, Alkalosis. High ACTH productionAlkalosis. High ACTH production »» Management: KManagement: K++ supplements, IV Ksupplements, IV K++ Do not give KDo not give K++ ifif oliguricoliguric Glucose: 4.0Glucose: 4.0 –– 7.87.8 mmolmmol/L/L •• Fasting: 3.0Fasting: 3.0--6.06.0 mmolmmol/L/L •• Post eating (Post eating (pranadialpranadial): <10): <10 mmolmmol/L/L •• High GlucoseHigh Glucose »» Causes: DM Type I & II, CushingCauses: DM Type I & II, Cushing’’s Syndrome,s Syndrome, PhaeochromocytomaPhaeochromocytoma,, »» Treatment: Insulin therapy (I) and Diet therapy (II)Treatment: Insulin therapy (I) and Diet therapy (II) »» Diagnosis:Diagnosis: oGTToGTT •• Low GlucoseLow Glucose »» Causes: ECauses: E--PLAIN (Exogenous drugs (insulin), PituitaryPLAIN (Exogenous drugs (insulin), Pituitary Insuff., Liver Failure, Addison's, Islet cell tumour, nonInsuff., Liver Failure, Addison's, Islet cell tumour, non-- pancreatic neoplasm)pancreatic neoplasm) »» Treatment: Oral Glucose/Long acting starch (toast)Treatment: Oral Glucose/Long acting starch (toast) »» Diagnosis: FingerDiagnosis: Finger--prick testprick test Bilirubin : 0Bilirubin : 0--2020 µµmol/Lmol/L PrePre--hepatichepatic:: HighHigh unconjugated bilirubinunconjugated bilirubin (hemolysis)(hemolysis) IntraIntra--hepatichepatic:: Hepatitis,Hepatitis, Cirrhosis, CarcinomaCirrhosis, Carcinoma PostPost--hepatichepatic:: HighHigh conjugated bilirubinconjugated bilirubin (biliary obstruction(biliary obstruction-- stones, pancreatitis)stones, pancreatitis) ALT: 10ALT: 10--30 (IU/L)30 (IU/L) ALP: 39ALP: 39--128 (IU/L)128 (IU/L) Increase = marker of a diseaseIncrease = marker of a disease •• High ALPHigh ALP;; •• Causes: Liver disease (bile duct block), Bone diseaseCauses: Liver disease (bile duct block), Bone disease (high activity e.g. Paget(high activity e.g. Paget’’s disease)s disease) •• High ALTHigh ALT;; •• Causes: Liver damage (hepatitis), InfectiousCauses: Liver damage (hepatitis), Infectious mononucleosis,mononucleosis, BiliraryBilirary duct obstructionduct obstruction AST:ALT > 2 = Alcoholic hepatitisAST:ALT > 2 = Alcoholic hepatitis AST:ALT < 1 = Viral hepatitisAST:ALT < 1 = Viral hepatitis Albumin : 35Albumin : 35--50 g/L50 g/L •• High AlbuminHigh Albumin;; »» Causes: DehydrationCauses: Dehydration »» S & S: WIKI itS & S: WIKI it…… •• Low AlbuminLow Albumin;; »» S & S:S & S: OedemaOedema »» Causes:Causes: NephroticNephrotic Syndrome, Liver disease,Syndrome, Liver disease, BurnsBurns Magnesium : 0.7Magnesium : 0.7--11 mmolmmol/L/L •• 65% in bone & 35% within cells65% in bone & 35% within cells •• High MgHigh Mg:: –– S & S: Neuromuscular depression and CNSS & S: Neuromuscular depression and CNS depressiondepression –– Dg: Renal failure ?Dg: Renal failure ? •• Low MgLow Mg:: –– Dg: Diarrhea ?Dg: Diarrhea ? KetoacidosisKetoacidosis ?? CaCa2+2+ : 2.2: 2.2 -- 2.62.6 mmolmmol/L/L •• Control of CaControl of Ca2+2+:: –– PTH,PTH, –– Vitamin D (Kidney, GIT, Skin)Vitamin D (Kidney, GIT, Skin) –– CalcitoninCalcitonin •• High CaHigh Ca2+2+:: –– S & S:S & S: ‘‘bones stones groansbones stones groans’’,, AbdAbd. pain, Constipation. pain, Constipation –– Dg: Primary PTHDg: Primary PTH--ism ?ism ? SarcoidosisSarcoidosis ?? –– Treatment: Diuretics, BiTreatment: Diuretics, Bi--phosphatesphosphates •• Low CaLow Ca2+2+:: –– S & S:S & S: TetaniTetani, Depression, Facial muscle twitch,, Depression, Facial muscle twitch, ChvostekChvostek signsign –– Dg: Chronic renal failure ? Thyroid surgery ? LowDg: Chronic renal failure ? Thyroid surgery ? Low Vitamin DVitamin D –– Treatment: Calcium admin.Treatment: Calcium admin. LIPID VALUESLIPID VALUES LIPID VALUES  Cholesterol : <5Cholesterol : <5 mmolmmol/L/L  Triglyceride : <2Triglyceride : <2 mmolmmol/L/L  HDL : >1HDL : >1 mmolmmol/L (good cholesterol)/L (good cholesterol)  LDL : <3LDL : <3 mmolmmol/L/L  HIGH LDL and LOW LDL = Increased risk of CHDHIGH LDL and LOW LDL = Increased risk of CHD  High cholesterol can lead to AtherosclerosisHigh cholesterol can lead to Atherosclerosis  Management: Lifestyle changes,Management: Lifestyle changes, StatinsStatins e.g. SIMVASTATINe.g. SIMVASTATIN CARDIAC ENZYMESCARDIAC ENZYMES CARDIAC ENZYMES  CKCK--MBMB  TroponinTroponin TT  MyoglobinMyoglobin  Markers of MI / Heart disease?Markers of MI / Heart disease? OTHER VALUESOTHER VALUES OTHER VALUES  CRPCRP  Markers of inflammation associated with acute phaseMarkers of inflammation associated with acute phase responseresponse  TSHTSH  Hyperthyroidism (Graves disease, Thyrotoxicosis)Hyperthyroidism (Graves disease, Thyrotoxicosis)  S & S: Sweating,S & S: Sweating, GoitresGoitres  Hypothyroidism (HashimotoHypothyroidism (Hashimoto’’s disease, Iodines disease, Iodine deficiencydeficiency  S & S: Constipation, Mental retardation in Kids,S & S: Constipation, Mental retardation in Kids, TirednessTiredness Graves Disease THANKYOU FOR LISTENING URINE COLLECTIONURINE COLLECTION SHAN KESHRISHAN KESHRI Clinical Sessions 2010Clinical Sessions 2010 Rapid & Cost effectiveRapid & Cost effective INDICATIONSINDICATIONS  Diagnose / Screen:Diagnose / Screen: –– Urinary Tract Infection?Urinary Tract Infection? –– Presenting urinary symptoms : urgency?, frequency? etcPresenting urinary symptoms : urgency?, frequency? etc –– Kidney Stones?Kidney Stones? –– Kidney disease? e.g.Kidney disease? e.g. proteinuriaproteinuria inin nephrosisnephrosis?? –– Hydration status of patient with fluid lossHydration status of patient with fluid loss –– Monitor disease progressions (DM :Monitor disease progressions (DM :glycosglycos && ketoketo--uriauria, HT), HT) –– Early detection of substances or abnormalities of body (Early detection of substances or abnormalities of body (endoendo, met), met) BEFORE BLOOD COMPONENTS AFFECTED!!BEFORE BLOOD COMPONENTS AFFECTED!! PROCEDUREPROCEDURE ‘‘Clean catch, MidClean catch, Mid--Stream SpecimenStream Specimen’’  Patient will do it themselves, so you mustPatient will do it themselves, so you must explain to them properly what to do!explain to them properly what to do! Clean CatchClean Catch  Wipe external urethral opening clean withWipe external urethral opening clean with cleansing wipe.cleansing wipe.  DONDON’’T USE ALCOHOLIC WIPET USE ALCOHOLIC WIPE –– theythey irritate!irritate!  WOMEN : Then spread labia of externalWOMEN : Then spread labia of external genetaliagenetalia, and wipe back to front., and wipe back to front. RIGHT LEFT MidMid--Stream CollectionStream Collection  Start urinating initial stream into the toiletStart urinating initial stream into the toilet (flush contaminants from outer urethra).(flush contaminants from outer urethra).  Stop, then restart urinating, approx 10Stop, then restart urinating, approx 10--1515 ml in the provided sterile specimenml in the provided sterile specimen container (till full),container (till full), akaaka Midstream.Midstream.  Remaining urine can be voided into toilet.Remaining urine can be voided into toilet.  Bottle returned to requesting physicianBottle returned to requesting physician (check labeling)(check labeling)  If immediate analysis not possible, sampleIf immediate analysis not possible, sample should be refrigerated.should be refrigerated. ManagementManagement ALTERNATIVESALTERNATIVES  Patient with urinary (Foley) catheter:Patient with urinary (Foley) catheter: analyseanalyse the urine inthe urine in the bagthe bag  Children not toilet trained : Attach collection bag toChildren not toilet trained : Attach collection bag to external genital region.external genital region.  Comatose/ confused patient : Urine collection by catheterComatose/ confused patient : Urine collection by catheter  SupraSupra--pubic transpubic trans--abdominal needle for aspiration ofabdominal needle for aspiration of urinary bladder (purest specimen)urinary bladder (purest specimen) NOTESNOTES  Female specimens may contain vaginal componentsFemale specimens may contain vaginal components e.g.e.g. trichomonadstrichomonads, yeast, RBC during menstruation, yeast, RBC during menstruation  Early morning sample preferred; before ingestion ofEarly morning sample preferred; before ingestion of any fluid is usually hypertonic and reflects ability ofany fluid is usually hypertonic and reflects ability of the kidney to concentrate urine during dehydrationthe kidney to concentrate urine during dehydration which occurs overnight.which occurs overnight.  If all fluid ingestion has been avoided since 6 p.m.If all fluid ingestion has been avoided since 6 p.m. the previous day, the specific gravity usually exceedsthe previous day, the specific gravity usually exceeds 1.022 in healthy individuals.1.022 in healthy individuals. URINALYSIS (UA)URINALYSIS (UA) SHAN KESHRISHAN KESHRI Clinical Sessions 2010Clinical Sessions 2010 MACROSCOPIC ANALYSISMACROSCOPIC ANALYSIS DIPSTICK ANALYSISDIPSTICK ANALYSIS THANKYOU FOR LISTENINGTHANKYOU FOR LISTENING  http://www.emedicinehealth.com/urinalysis/paghttp://www.emedicinehealth.com/urinalysis/pag e4_em.htme4_em.htm  ColourColour change of dipstick?change of dipstick?  http://en.wikipedia.org/wiki/Urinalysis#Medical_http://en.wikipedia.org/wiki/Urinalysis#Medical_ urinalysisurinalysis  http://library.med.utah.edu/WebPath/TUTORIALhttp://library.med.utah.edu/WebPath/TUTORIAL /URINE/URINE.html/URINE/URINE.html  http://www.emedicinehealth.com/urinalysis/page3_em.htmhttp://www.emedicinehealth.com/urinalysis/page3_em.htm  http://www.youtube.com/watch?v=_U1_TviVulshttp://www.youtube.com/watch?v=_U1_TviVuls really goodreally good vidvid  http://www.youtube.com/watch?v=8h3GWjeT2eo&feature=relatedhttp://www.youtube.com/watch?v=8h3GWjeT2eo&feature=related  http://www.patient.co.uk/doctor/Urinehttp://www.patient.co.uk/doctor/Urine--DipstickDipstick--Analysis.htmAnalysis.htm  http://archive.student.bmj.com/issues/09/02/education/68.phphttp://archive.student.bmj.com/issues/09/02/education/68.php  http://www.ucdmc.ucdavis.edu/cne/documents/competenhttp://www.ucdmc.ucdavis.edu/cne/documents/competen cies/poct/Urine%20Dipstick.pdfcies/poct/Urine%20Dipstick.pdf  OdourOdour, blood etc, blood etc Bhavin Doshi This presentation aims to present students with  an overview of cannulation, the knowledge and  skills required to undertake the procedure  safely and competently, how to recognise,  prevent and manage associated complications. Peripheral cannulation provides access for the purpose of IV hydration  or feeding and the administration of medications. A Cannula is a flexible tube, usually  containing a needle (stylet), which can be  inserted into a body cavity, duct, or vessel in  order to drain fluid or administer a  substance such as medications. A Catheter is a flexible tube that is inserted  into a body cavity in order to withdraw or  introduce fluids. Peripheral cannulation is a common  procedure with more than 24 million  cannulae of all designs sold in the U.K. Palpation of the vein should be performed before every cannulation to  determine veins from arteries (arteries pulsate and veins do not), and also to  locate valves. Palpation is achieved by placing one or two fingers over the vein and pressing  lightly; then releasing the pressure to assess the vein’s elasticity and rebound  filling. The ideal vein is bouncy, refills when depressed, is straight and free of  valves. Must choose a suitable vein for the intended purpose; (rate of flow, type of  infusion, duration of therapy, avoid joints since it will lead to mechanical  phlebitis or tissuing of cannula. And also restricts the patient’s movement. • Age of the patient – small and very fragile veins in young and elderly • Nutritional status – friable veins in those who are malnourished, deep  difficult veins in obese patients • Medical history – E.g. Amputations, lymphoedema, cerebrovascular  accident, mastectomy (the arm on the side of the unaffected breast should be  used), some surgical procedures or the presence of a haemodialysis shunt • Prescribed medications such as anticoagulants or long‐term corticosteroids,  which make the veins more fragile and prone to bruising • The physical condition of the patient, for example venous access is more  difficult if the patient is dehydrated, in shock or hypothermic • Skill of the practitioner • Use a tourniquet – apply 7‐8 cm above the chosen site, must be tight enough  to impede venous return but not affect atrial flow • Opening and closing the fist along with gravity both improve vasodilation • Gentle tapping or stroking may improve vasodilation – but can be painful • Apply heat – such as warm pack, or soaking limb in a bowl of warm water For prolonged courses of therapy, it is recommended, although not always practical, to  start distally and cannulate at proximal points since sites can be maintained for longer Cephalic vein – takes a large gauge cannula and provides a natural splint, but is at a joint Basilic vein – awkward for cannulation due to location, but is quite large Dorsal venous network – easily accessible, visualised and palpated – contraindicated in  older patients due to loss of turgor, so veins are not stable • Use “over the needle” type of cannula – where cannula is mounted on the  needle – available in various gauges (16–24g), lengths (25‐45mm),  compositions and designs. Also different materials have differing flow rates. • Smallest gauge should be used to minimise damage to the vessel intima and  ensure adequate blood flow around the cannula (reduce risk of phlebitis). • Cannula comprises of different components Some have wings to help fix it to the skin,  others have ports on top to enable the  administration of medications without  interfering with a continuous infusion. Safety  cannulae are liable to reduce the risk of  needlestick injury (have a safety button). • There should be adequate lighting and the room should be warm enough to  encourage vasodilation • Practitioner should be in a comfortable position (alter height of bed or chair) • Wear properly fitting gloves to protect from contamination by blood spillage • Anxiety in patient due to needle phobia or previous bad experience could present • Provision of clear and comprehensive information should alleviate anxiety • A careful explanation should be provided of the procedures and patient consent  must be gained (Verbal consent is usually acceptable) • Patient should be in a comfortable position. Placing arm on a pillow or rolled  towel provides support and a firm, flat surface Non‐pharmacological methods • Relaxation • Distraction – E.g. Coughing at time of insertion of needle Pharmacological methods • Local anaesthetics in the form of cream or gel or intradermal injection has  been advocated to reduce pain, and anxiety in children and selected adults • Local anaesthetic is also recommended if the cannula is larger than 18g, when  a sensitive site is used or at the patient’s request. • It is important to clean the skin properly – wash with soap and water to  remove visible dirt (removes transient flora) • Use anti septic solution ‐ E.g. Chlorhexidine (2%) or alcohol (70%) for 30‐60s • Allow skin to dry – ensures disinfection and avoids stinging from needle • Do not touch or repalpate the skin – avaoids recontamination • Hair removal is not neccessary – but can be trimmed with scissors or clippers • Stabilisation of the vein – apply traction with non‐dominant hand to the side of  the insertion site or below it, using thumb and forefinger • Stabilisation of vein should be maintained throughout the procedure until cannula  is sited • Needle enters skin with bevel side up, so sharpest side penetrates skin first • Angle needle enters varies depending on type of device used and the depth of the  vein in the subcutaneous tissue, from 10 to 45 degrees • Once entry into the vein is achieved, angle is reduced to prevent puncturing  posterior wall of the vein • When blood appears into chamber, it is known as “flashback”, indicating initial  entry into the vein is successful • Followed by a “giving way” sensation felt by the practitioner – overcoming of the  resistance of the vessel wall • Flashback may stop is posterior wall is pierced, or may slow if gauge of cannula is  small or patient is hypotensive • Cannula should be advanced gently and smoothly into the vein. The one‐handed  technique – the same hand that performs cannulation also withdraws the stylet  and advances the cannula into the vein • The one‐step technique – where the practitioner can slide the cannula off the  stylet in one movement once the cannula has entered the vein • The two‐handed technique – where the practitioner performs the cannulation  with one hand but releases the skin traction to advance the cannula off the stylet,  which can result in puncturing of the posterior wall of the vein • If cannulation is unsuccessful the stylet should never be reintroduced as this  could result in catheter fragmentation and embolism. The device should only be  used once. • Only two attempts should be made at cannulation before passing the patient  onto a more experienced practitioner Step 1: Use a BD Venflon and a cooked piece of penne pasta. Using a BD  Venflon is essential because the depth of its plastic casing means that the  pasta sits nicely at an accessible height for cannulation (other brands often  have deeper casings).  Step 2: Open the cannula, unfold its wings, and remove the plastic sheath  that covers the needle. Insert the sheath through the pasta to stent it. The  pasta simulates the skin, and the tapering end of the sheath creates a space  to cannulate, simulating the vein Step 3: Put the stented pasta into the cannula box ready for practice. In a  real scenario remember to wear gloves, clean the overlying skin, and locate  a sharps box before starting. Cannulation is easier if you first try to increase  venous filling. It helps to use a tourniquet; to lower the arm below the level  of the heart; to ask the patient to open and close their fist; and gently to tap  above the vein Step 4: Take a three point grip of the cannula, with your thumb on the white  cap, index finger on the coloured cap, and middle finger on the wing. In a  real scenario apply counter‐traction to the overlying skin with your other  hand to help anchor the vein during insertion Step 5: Approach at a 30° angle to go through the skin (the outer layer of  pasta) then reduce to a 15° angle to advance the needle inside the vein (the  space between sheath and pasta) until you see the first flashback (in a real  scenario). The flashback provides visual indication of venous entry. The first  flashback occurs as you enter the vein, and the second occurs as the needle  is withdrawn and blood moves to fill this space. There are three main  explanations for failed needle insertions—missing the vein; perforating the  posterior wall of the vein; and hitting a valve within the vein Step 6: Now change your grip, so the thumb and middle finger are on the  white cap to withdraw the needle about 5 mm to produce the second  flashback. Importantly the index finger provides counter‐traction on the  wing Step 7: With just the index finger remaining in place at the wing, advance the  cannula along the vein. In a real scenario this is the time to release the  tourniquet Step 8: Fully withdraw the needle. Remove the white cap and use it to cap  the cannula promptly. To prevent bleeding in a real scenario, occlude the  vein with your other hand at the tip of the inserted cannula while you  remove the needle until you cap the cannula. Step 9: When finished practising, remove the cannula, return the needle to  the cannula, and return this unit to its sheath for safe storage and further  practice • Flushing should be performed before and after each use of the cannula • If not used, the cannula should be flushed every 24 hours with 0.9% sodium  chloride, using a pulsated (push pause) flush to create turbulent flow and positive  pressure • Needleless injection caps are used to reduce significantly the incidence of  catheter occlusions. • Cannula can be secured using clean tape or a securement device, which have  been shown to reduce the risk of dislodgement and other complications such as  mechanical phlebitis. • A transparent dressing or low‐linting gauze should be applied and then a  bandage may be applied. Transparent dressings, particularly moisture‐permeable  dressings, should not be bandaged as visibility and moisture permeablity are  obscured • Date and time of insertion • The location of device • Type and gauge size of device • Signature of the practitioner inserting the device • Any other information that the practitioner feels is neccessary to ensure  continuity of care, such as problems with access and/or anxiety related to needles • Assessment of the site should be documented using relevant tools (Visual Infusion  Plebitis Score) – next slide • It is recommended that peripheral devices should be re‐sited every 72‐96 hours,  although some literature supports extending the dwell time up to 144 hours under  certain circumstances (E.g. Infusion of non‐irritant medications or fluids). • Removal of cannula should be conducted under aseptic conditions • Site should be inspected to ensure bleeding has stopped and should be covered  with a sterile dressing. • Cannula intergrity should be checked to ensure that the complete device has  been removed • Date, time and reason for removal of the cannula should be DOCUMENTED Complications need to be recognised and managed at the earliest possible stage,  as they can result in pain, patient anxiety, haematoma, inflammation,  infiltration or extravasation. • Haematoma formation • Inadvertent arterial puncture • Neural puncture If these occur, then they MUST BE DOCUMENTED and the patient must be  informed of who and when to contact if they develop numbness or tingling in the  limb • Phlebitis and infiltration are most common complications – management  depends on cause and also depends on extravated materials 1.Peripheral cannulation provides intravenous access for: a) Hydration b) Feeding c) Medications d) All of the above 2. Which of the following statements is correct? a ) Arteries and veins pulsate b) Arteries do not pulsate c) Veins do not pulsate d) Veins pulsate 3. Which of the following is not a form of phlebitis: a) Chemical b) Physical c) Infectious d) Mechanical 4. The ideal vein for cannulation should: a) Have a number of valves b) Refill when depressed c) Be rigid d) Be located over a joint 5.  How often should a cannula that is not in use be flushed? a) Every hour b) Twice a day c) Every other day d) Every 24 hours 6. The success of cannulation may be influenced by a patient’s a) Age b) Nutritional status c) Physical condition d) All of the above 7. What percentage of chlorhexidine solution should be used to clean the skin? a) 2 b) 5 c) 10 Department of Health (2007) High Impact Intervention No 2 Peripheral Intravenous Cannula Care Bundle. www.clean‐safe‐care.nhs.uk/toolfiles/16_SL_HII_2_v2.pdf (Last accessed  March 2nd 2010.) Dougherty L (1996) Intravenous cannulation. Nursing Standard. 11, 2, 47‐51 Dougherty L (2008) Peripheral cannulation. Nursing Standard. 22, 52, 49‐56 Dougherty L, Lamb J (Eds) Intravenous Therapy in Nursing Practice. Second edition.  Blackwell Publishing Oxford, 167‐196; 225‐270. Infusion Nurses society (2006) Infusion Nursing standards of practice. INS, Norwood MA Lavery I, Ingram P (2005) Venepuncture: best practice. Nursing Standard. 19, 49, 55‐56 Perucca R (2001) Obtaining vascular access. In Hankins J, Lonsway RAW, Hedrick C, Perdue  MB (Eds) Infusion Therapy in Clinical Practice. Second edition. WB Saunders, Philadelphia  PA, 375‐388 Royal College of Nursing (2005) RCN Standards for infusion Therapy. RCN, London Springhouse (2002) IV Therapy Made Incredibly Easy. Second edition. Lippincott Williams &  Wilkins, Philadelphia PA. http://archive.student.bmj.com/issues/08/06/education/244.php (Last accessed on March  6th 2010) Bhavin Doshi Direct administration of fluids into the vein of choice SC (subcutaneous) or IM (intramuscular) injections  are limited to 3 mL since  larger quantities lead to local problems Only limit on IV is the total body fluid content, since total fluid intake should be  35‐50 mL / kg body weight / day is acceptable (in 100kg man – 3.5 – 5L per day!!) IVs are given when we need to give a lot of fluid, or if we need to dilute a  medication a lot to reduce irritation Usually given over longer periods of time (15 minutes to several hours) in  contrast to SC and IM which give entire dose instantly IV administration allows fastest method of administration (bioavailability /  bioequivalence is high) because it goes directly into the blood, so may be used for  rapid onset of medication IVs are usually administered by  bags of fluid that come  premixed. The standard sizes  range from 50 mL to 1000 mL. The bag is hung from an IV pole,  and IV tubing is attached to the  bottom of the bag. The tubing has several  important parts: a) Drip chamber b) Roller clamp c) Side clamp d) Injection port • If it is too full, we cannot see the drops, so cannot count them • If it is not full enough, then this will allow air to get into the IV tubing and  therefore into the patient’s circulatory system, which can be very dangerous,  blocking a blood vessel (venous air embolism – VAE),or stopping the heart • Located just below the bag • Used to visualise the fluid dripping into  the tubing from the bag • This is where we measure the speed of  a manual IV setup – we look at the  chamber and count the number of drops  per minute • The drip chamber should always be  about half full. • This is what we use to control the rate at which the  IV fluid infuses • If we roll it one way, it squeezes the tubing more  tightly, making it more narrow and therefore slowing  the fluid flow through it • If we roll it the other way, it loosens its pinching of  the IV tubing, making the tubing less narrow,  increasing the fluid flow through it • All roller clamps on a set of IV tubing should be  closed before we attach a bag of IV fluid the top of  the tubing, ensuring no air gets into the tubing • Every medication is ordered at a specific infusion  rate (or flow rate) • This is used when we want to completely stop the  IV from flowing, without having to adjust the roller  clamp • It is useful for momentary breaks in the flow,  without having to reset the flow rate again by  readjusting the roller clamp all over again • It woks by completely pinching off the IV tubing when we slide the tube through the narrowest part  of the clamp • This is the place where medicine or fluids  other than those in the current IV bag can be  injected so that they will infuse into the  patient’s vein through the IV tubing • Here we can see 2 ports, one in the bag and  one below the drip chamber, there is also  usually one where the needle goes into the  patient’s vein • The injection port on the IV bag is used if  we want to mix some kind of medication  with the fluid in the bag (need to be  compatible) • If we want to inject medication or a second  kind of IV fluid that we’ve already attached,  then we will use one of the ports that are  located below the drip chamber • IV infusion works because of GRAVITY – pushes fluid down through tubing into  the vein • The higher the bag is hung, the greater the gravitational pressure on the IV  fluid to go downward through the tubing, if the bag is not high enough, there  will not be enough pressure to force fluid into the vein • All IV bags must be hung above the patient’s heart in order for there to be  enough pressure for the fluid to infuse – usually 3 feet above an adult patient’s  heart • Change in the movement of the patient will result in changes in the infusion  rate, so constant monitoring is required – usually every hour and after any major  change in position • Sometimes needle can be dislodged from the vein so that the fluid is infusing  into the tissue – infiltration – eventually IV will stop due to a higher pressure in  the tissue compared with the IV tube. Look for swelling, coolness and pain Can attach a peripheral line (to limb) – these can only be used for a short period,  usually 3 days due to risk of infection, so if it is required for longer then it is  standard procedure to move the injection site to a new location every 3 days A central line is an IV attached to a vein in the chest – usually through the chest  wall, or neck veins, but it is also possible to insert the cannula into a peripheral  vein and move the tip of the cannula slowly upward until it reaches a central vein • IV medication can be given continuously, or intermittently • A patient who requires continuous infusion has a constant IV setup • A patient who only requires intermittent IVs have a cannula setup to them  continuously, which is independent of the IV infusion equipment • The cannula has an injection port attached to it’s end called an infusion port  adapter (sometimes referred to as a heplock or saline lock/port) • Cannula should be flushed since it can become blocked by clotted blood – can  use 2mL saline or 2mL heparin (concentration of 100U/mL) every 6‐8 hours FOR MORE INFORMATION ON CANNULAS, SEE LECTURE ON INTRAVENOUS  CANNULATION • If patient is receiving continuous IV fluids  and/or medication and in addition must receive  a second kind of intermittent infusion, or if a  patients current IV infusion must be interrupted  in order to administer a second IV medication or  fluid that is more pressing, then we need to  hang a secondary IV for the patient • Secondary IV = IV Piggyback = IVPB = Second IV  bag hung next to first and enters patient through  first set of IV tubing through an injection port  below the drip chamber • Usually used for medications which have  smaller volumes than the primary IV (50 – 250  mL). Is also, usually given intermittently • Since we want the secondary infusion to infuse  faster, we hang it higher than the first bag • Sometimes we want to give an injection by intravenous administration, but  want to give a small volume all at once. This could be for a few reasons: could be  larger than 3mL; It will be better absorbed; avoid the first pass effect. •We can give the IV injection all at once by inserting a syringe into one of the  injection ports and this is called an IV push or Bolus •It can be given alongside a continuous infusion or can be given into a heplock which has previously been setup • If the volume of fluid we  wish to infuse is relatively  small (E.g. For an infant or  small child, then we need to  use a method where small  volumes can be controlled. •We use a volume‐controlled  burette ( allows measurement  of 120 mL in graduations of  1mL •Still has drip chamber, roller  clamp (on top so we can hang  an IV bag above it, to mix a  single dose) and injection port at the top • Most medications are mixed with IV fluids by injecting them directly into a  premixed IV fluid bag • Some drug manufacturers also produce special IV bags which contain a  medication vial port, which allows specially shaped vials of powdered  medication to be attached directly to the top of a special IV fluid bag • E.g. Powdered Vancomycin hydrochloride into 100 mL of 0.9% Sodium Chloride • It is becoming more and more common to for many IV setups in hospitals to be  implemented using machines which control the infusion rate on their own, only  requiring the practitioner to enter infusion rate in mL/hr. There are 3 common  kinds of electronic infusion devices: 1. Volumetric Pumps – force fluid into the vein under pressure and against  resistance, but DO NOT depend upon gravity. Rates need to be monitored  regularly. Some have an inbuilt alarm when rate is not being maintained. Also we  need to monitor regularly for infiltration 2. Syringe pumps ‐ these are used for infusion of a very small amount of fluid  over an extended period of time, but we need to control the speed that the  plunger is depressed. This is difficult to conduct manually, therefore syringe  pumps are very useful. Some medications cannot be diluted without losing  their efficacy, so these kinds of medications may be given using a syringe pump 3. Patient controlled analgesia – allows patient to choose when they can take  their IV medication, based on how they feel. The device includes a button  which the patient can press whenever they feel in need of pain relief, which  triggers the machine to dispense the pre‐programmed dose of medication, The  machine is also pre‐programmed to “time‐out” so that the patient cannot over‐ dose. Some machines record the frequency with which the patient presses the  button, so that the practitioner is able to monitor how often the patient is in  pain • There are many different types of IV fluids, and often these fluids are expressed  using abbreviations when they are written into the drug order form. • Any number that appear in an IV abbreviation indicate percentages. E.g. D5W is  5% dextrose in water and D2.5NS is 2.5% dextrose in 0.9% salt in water • Remember that percentages in IV fluids and other medications actually  represent number of grams in 100mL of diluent, so D2.5NS is 2.5g dextrose per  100mL normal saline, which is actually 2.5g dextrose and 0.9g salt per 100mL  water • Before fluid can be given via the IV route the infusion set must be primed. This  involves running the fluid to be infused through the set, to prevent an air  embolus. Asepsis should be maintained during the procedure to prevent any  internal or exposed areas being contaminated • There are various types of infusion sets available: • Large‐bore sets which have large internal diameter (reduced drops per mL  ratio) so that there can be fast flow rate • Smaller‐bore sets offer larger drops per mL value so can be used to  administer crystalloid and diluted drug infusions • Both types of devices are gravity dependent and flow is controlled by  means of the roller clamp •Only recommended sets may be used with electronic volumetric infusion  devices •All sets have a trocar and a luer lock connector •Packaging should be sterile, intact and within expiry date • Fluid to be infused • Administration set • Clean gloves / apron • Receptacle for any discarded fluid • Drip stand • Alcohol swab • Air inlet if using glass or rigid containers) • The correct patient should be identified , consent obtained and information and  reassurance given • The fluid to be infused should be checked against the prescription by two  practitioners – check date of prescription, expiry date of fluid and directions • Check infusion set contents for signs of contamination • Wash hands, don clean gloves and apron • Remove any packaging. Maintaining asepsis, snap the seal where the  administration set trocar is to enter the bag (invert the bag). If possible, hang  fluid on a drip stand • Close any flow controllers on the administration set. Expose the trocar without  touching and advance into the appropriate port • Gently squeeze the drip  chamber, allowing it to  partly fill with fluid • Partially release the flow  controller to allow fluid to fill and  move through the tubing. This  may require removing the  protective cap at the luer lock  connector to allow air to be  expelled • Expel any air by allowing the fluid to run through the set into a receptacle • Connect to patient’s intravascular device according to local policy and  DOCUMENT the procedure http://www.cwladis.com/math104/lecture6.php (Last accessed on March 7th 2010) Higgins, D. (2004) Priming an IV infusion set. Nursing Times Jamieson, E.M. (2002) Clinical Nursing Practices. Edinburgh: Churchill Livingstone Medical Devices Agency (2003) Infusion System Device Bulletin. MDA Device  Bulletin 2003: 02. London: MDA Quinn, C. (2000) Infusion devices, functions and management. Nursing Standard;  14: 26, 35‐41 RCN (2003) Standards for Infusion Therapy. London: RCN CommonCommon DrugsDrugs usedused toto treattreat commoncommon respiratorespiratoryry disdiseaeasesess (needs further explanations!)(needs further explanations!) SHAN KESHRISHAN KESHRI CLINICAL SESSIONS 2010CLINICAL SESSIONS 2010 Page references relate to OXFORD HANDBOOK OF CLINICAL MEDICINE, 7th Ed. PnemoniaPnemonia (p.152)(p.152)  AntibioticsAntibiotics –– infection?infection?  AnalgesicsAnalgesics –– ParacetamolParacetamol forfor pleuriticpleuritic chest painchest pain  IV Fluids (shock/dehydration)IV Fluids (shock/dehydration)  OxygenOxygen –– to maintain PaOto maintain PaO22 BronchioBronchio--ecstasisecstasis (p.158)(p.158)  AntibioticsAntibiotics -- infectioninfection  BronchodilatorsBronchodilators –– nebulisednebulised SalbutamolSalbutamol ((ββ --2 agonists)2 agonists)  CorticosteroidsCorticosteroids –– PrednisolonePrednisolone (anti(anti--inflammatory ofinflammatory of mucosa)mucosa)  Drain SputumDrain Sputum –– remove obstructionremove obstruction ABCDABCD Chronic AsthmaChronic Asthma (p.166)(p.166)  Check inhaler techniqueCheck inhaler technique  STEP 1: short actingSTEP 1: short acting ββ--2 agonist :2 agonist : SalbutamolSalbutamol (bronchodilator and smooth muscle relaxant)(bronchodilator and smooth muscle relaxant)  STEP 2: steroid:STEP 2: steroid: Beclometasone/FluticasoneBeclometasone/Fluticasone  STEP 3: long actingSTEP 3: long acting ββ--2 agonist :2 agonist : SalmeterolSalmeterol  STEP 4: increase dosesSTEP 4: increase doses  STEP 5: addSTEP 5: add PrednisolonePrednisolone corticosteroidcorticosteroid Chronic AsthmaChronic Asthma  CorticosteroidsCorticosteroids :: PrednisolonePrednisolone via spacervia spacer  AminophyllinneAminophyllinne (met. to(met. to TheophyllinneTheophyllinne)) : bronchodilator: bronchodilator  ββ --2 agonists2 agonists :: SalbutamolSalbutamol inhalerinhaler  AnticholinergicsAnticholinergics (prevent(prevent bronchoconstrictionbronchoconstriction)) :: IpratropiumIpratropium,, TiotropiumTiotropium CASACASA Acute Severe AsthmaAcute Severe Asthma (p.794)(p.794)  CorticosteroidCorticosteroid :: PrednisolonePrednisolone or Hydrocortisoneor Hydrocortisone  AminophyllineAminophylline  ββ--2 agonist2 agonist:: SalbutamolSalbutamol nebulisednebulised with oxygenwith oxygen  AnticholinergicAnticholinergic:: IpratropiumIpratropium CASACASA COPD (stable)COPD (stable) (p.169)(p.169)  AnticholinergicsAnticholinergics:: IpratropiumIpratropium  ββ--22 agonist :agonist : SalbutamolSalbutamol,, SalmeterolSalmeterol (long lasting)(long lasting)  Inhaled steroidInhaled steroid :: FluticasoneFluticasone  SymbicortSymbicort (combination of anti(combination of anti--inflammatoryinflammatory corticosteroid and long lastingcorticosteroid and long lasting ββ--22 agonistagonist  Diuretics for edemaDiuretics for edema  MucolyticsMucolytics  Flu and pneumococcal vaccinations (prophylaxisFlu and pneumococcal vaccinations (prophylaxis)) COPD (acute)COPD (acute) (p.796)(p.796)  OxygenOxygen  NebulisedNebulised bronchodilator:bronchodilator: salbutamolsalbutamol,, ipratropiumipratropium  AntibioticsAntibiotics: if infection, amoxicillin: if infection, amoxicillin  Steroid : hydrocortisone,Steroid : hydrocortisone, prednisoloneprednisolone  AminophyllinneAminophyllinne (decrease(decrease bronchobroncho--constriction)constriction) OO--NASANASA Pulmonary EmbolismPulmonary Embolism (p.174)(p.174)  InvestigateInvestigate thrombophilliathrombophillia??  Compression stockings (DVT) / EncourageCompression stockings (DVT) / Encourage mobilisationmobilisation: improve venous return: improve venous return  OralOral warfarinwarfarin (aim INR of 2(aim INR of 2--3)3) : prevent clots: prevent clots  Massive: Morphine for pain andMassive: Morphine for pain and antiemeticantiemetic  Anticoagulant LMW HeparinAnticoagulant LMW Heparin :: DalteparinDalteparin II--COMACOMA Pulmonary EdemaPulmonary Edema (p.787)(p.787)  Nitrate (Nitrate (vasodilationvasodilation): spray sublingual,): spray sublingual, IsosorbideIsosorbide dinitratedinitrate  Oxygen (aid breathing)Oxygen (aid breathing)  DiamorphineDiamorphine (chest pain relief)(chest pain relief)  Diuretic:Diuretic: FurosemideFurosemide NODDNODD Arterial Blood Gas Sampling ABG Nathan Golban Indications To assess. • Respiratory Status Assess oxygenation and ventillation • Acid Base Balance • Phlebotomy. Used if venous route is unavailable or inaccessible due to trauma or burns. Usually a femoral puncture, uncommon variation. Contraindications • Overlying infection or burn at insertion site. • Absent collateral circulation. • Arteriovenous shunt. Often radial or brachial. • Severe atherosclerosis • Raynauds disease. • Coagulopathy. Sites • Preferred radial or femoral arteries. • Less common. Dorsalis pedis and posterior tibial. • Avoid. Branches without collateral supply. Example is the brachial artery. Complications • Bleeding causing hematoma. • Arterial occlusion causing thrombus or dissection. • Infection causing arteritis or cellulitis. • Embolization • Last 3 uncommon. Normal Values • pH, 7.36 to 7.44. For acid base status of blood. • pCO2, 38 to 44 mmHg. Reflects ventillation. • pO2, 85 to 95 mmHg. Reflects oxygenation. • HCO3, 21 to 27 meq per litre. Key blood buffer. • Base excess, plus or minus 2 meq per litre • ABG quiz. http://www.vectors.cx/med/apps/abg.cgi Pathophysiology • Metabolic alkalosis • Metabolic acidosis • Respiratory alkalosis • Respiratory acidosis Initial Preparation • Wash hands • Gloves • Protective eye wear • Iodine swab. Povidone-iodine, betadine. Followed by alcohol swab • Arterial blood gas sampling kit • 2 x 2 cm gauze • Bag of ice. To store sample Allens Test • Indicates collateral circulation to hand. • Radial artery on non dominant hand. • Palpate radial artery. • Simultaneouslys palpate ulnar artery, or as close to that area as possible. • Patient makes a fist. Palpate both arteries for10 seconds. • Release ulnar artery and witness blood flow and pinking of the hand via collateral radial artery • Radial artery is now a candidate for testing. Set Up • Patient seated on stretcher • Rolled up towel under wrist. That hyperextends wrist, bringing artery closer to surface. • Clean area in a cicular motion with iodine. Allow to dry. • Wipe away iodine with alcohol. While drying, open sampling kit. Sampling Kit • 3 pieces 1. Orange air ball or cube. Used to expel excess air from the syringe. 2. Black cap for syringe, used for transport. 3. 3 cc, cubic centimetres heparinised syringe. With needle attached. Sampling Kit Use • Pull back slightly on plunger, so once needle is in artery, natural pulsations will fill the syringe. • Remove clear needle cap. Locate the bevel. Bevel is a slanted opening on one side of the needle tip. We want bevel facing upward, so you can see it. Syringe Use • 45 degrees, sharper angle. • Hold like a dart or pen. • Feeling pulse under non syringe finger is the only landmark for orientation. • Before piercing skin, roll finger back slightly from artery, so you dont stab yourself in the finger. • Flash of blood into hub of needle. Artery has been accessed. • Blood will pulse into syringe. 1.5 to 2.0 cc required. • Cover needle with gauze. Quickly remove needle. After Care • Physician applies pressure to gauze for 5 minutes. 10 minutes if patient is on anticoaggulant therapy. • Optional to ask patient to do this instead. Blood Care • Insert needle into orange air cube or ball. Want bevel covered, dont want needle to go through cube. • Push down on plunger to expell excess air. So it doesnt affect results. Key point because we are measuring air component levels in blood. • Remove cube and needle as one. • Attach black cap to syringe. • Roll test tube between hands, to ensure blood heparinisation. • Place in iced bag. Send to lab. • Needle and cube to sharps container. Video • http://www.youtube.com/watch?v=stxntv0 KkBE Intro to Procedures: The Arterial Blood Gas (Source: Internet) Information Obtained from an ABG: • Acid base status • Oxygenation – Dissolved O2 (pO2) – Saturation of hemoglobin • CO2 elimination • Levels of carboxyhemoglobin and methemoglobin Indications: • Assess the ventilatory status, oxygenation and acid base status • Assess the response to an intervention Contraindications: • Bleeding diathesis • AV fistula • Severe peripheral vascular disease, absence of an arterial pulse • Infection over site Why an ABG instead of Pulse oximetry? • Pulse oximetry uses light absorption at two wavelengths to determine hemoglobin saturation. • Pulse oximetry is non-invasive and provides immediate and continuous data. Why an ABG instead of Pulse oximetry? • Pulse oximetry does not assess ventilation (pCO2) or acid base status. • Pulse oximetry becomes unreliable when saturations fall below 70-80%. • Technical sources of error (ambient or fluorescent light, hypoperfusion, nail polish, skin pigmentation) • Pulse oximetry cannot interpret methemoglobin or carboxyhemoglobin. Which Artery to Choose? • The radial artery is superficial, has collaterals and is easily compressed. It should almost always be the first choice. • Other arteries (femoral, dorsalis pedis, brachial) can be used in emergencies. Preparing to perform the Procedure: • Make sure you and the patient are comfortable. • Assess the patency of the radial and ulnar arteries. Collection Problems: • Type of syringe – Plastic vs. glass • Use of heparin • Air bubbles • Specimen handling and transport Type of Syringe • Glass– Impermeable to gases – Expensive and impractical • Plastic– Somewhat permeable to gases – Disposable and inexpensive Heparin • Liquid – Dilutional effect if <2-3 ml of blood collected • Preloaded dry heparin powder – Eliminates dilution problem – Mixing becomes more important – May alter sodium or potassium levels The Kit Air bubbles • Gas equilibration between ambient air (pO2 ~ 150, pCO2~0) and arterial blood. • pO2 will begin to rise, pCO2 will fall • Effect is a function of duration of exposure and surface area of air bubble. • Effect is amplified by pneumatic tube transport. Transport • After specimen collected and air bubble removed, gently mix and invert syringe. • Because the wbcs are metabolically active, they will consume oxygen. • Plastic syringes are gas permeable. • Key: Minimize time from sample acquisition to analysis. Transport • Placing the AGB on ice may help minimize changes, depending on the type of syringe, pO2 and white blood cell count. • Its probably not as important if the specimen is delivered immediately. Performing the Procedure: • Put on gloves • Prepare the site – Drape the bed – Cleanse the radial area with a alcohol • Position the wrist (hyper-extended, using a rolled up towel if necessary) • Palpate the arterial pulse and visualize the course of the artery. Performing the Procedure: • If you are going to use local anesthetic, infiltrate the skin with 2% xylocaine. • Open the ABG kit • Line the needle up with the artery, bevel side up. • Enter the artery and allow the syringe to fill spontaneously. Performing the Procedure: • Withdraw the needle and hold pressure on the site. • Protect needle • Remove any air bubbles • Gently mix the specimen by rolling it between your palms • Place the specimen on ice and transport to lab immediately. PELVIC EXAMINATION SHAN KESHRI CLINICAL SESSIONS Anatomical bearings INDICATIONS  Vulva / Vaginal complaints  Pain, discharge, abnormal bleeding, itching, mass  Pregnancy suspected / proven  Exposure to STI (HPV is a factor in nearly all cases of cervical cancer!) SCREENING PRECANCEROUS LESIONS OF CERVIX - Method  Cervical Pap Smear  WHAT : Take specimen of cells of cervix for microscope examination  WHY : Identify cancerous changes (ep. cell abnormality) early in women at risk SCREENING PRECANCEROUS LESIONS OF CERVIX - Guidelines START :  3 years after onset of sexual activity  21 yrs age CONTINUE :  Annually until age 30  30yrs+, with 3 consecutive normal pap smears  then only need testing once per 3 years unless present with a risk factor e.g. STI, new sex partner STOP :  Total hysterectomy  Low Risk women aged 65-70 PROCEDURE  History  Patient preparation (lithotomy position)  External examination (vulva & glands)  Internal examination (cervix & vaginal walls)  Bi-Manual examination (vagina, cervix, uterus, adnexa (ovaries))  Recto-Vaginal examination (surrounding structures) HISTORY  LMP : Last Menstrual Period date?  History of abnormal pap smears?  Birth control usage?  Vulva and vaginal symptoms? (see ‘indications’)  Num. sexual partners?, Sex. Orientation?  STI concerns?  Discomfort in previous pelvic exams?  Post-menopausal?  Pregnant?  Hormone replacement therapy? WASH HANDS & GLOVE UP! EQUIPMENT  Speculum (check screw is working)  Water Soluble Lubricant  Light Source PATIENT PREPARATION  Make sure patient has emptied bladder before exam! Change to gown (privacy) – sit on exam table, with drape covering legs.  Offer to have a chaperone in room whilst you conduct examination!!!  COMMUNICATE:  Explain procedure to patient, alert them before you insert / retract / move anything! LITHOTOMY POSITION  Lay down on table  Guide feet into stirrups  Ask ‘slide buttocks to end of table’  Relax legs into abduction  Ensure she is draped for minimal exposure! EXTERNAL EXAMINATION (vulva & glands) How to Examine Bartholin Glands  Separate labia with non dominant hand  Place Index finger of dominant hand into introitus (entrance) +- lubricant How to Examine Bartholin Glands Examine for what?  Erythema  Swelling  Masses  Rashes  Tenderness, Discomfort, Irritation, Pain  Lesions  Trauma Pathologies Pathologies •Often assoc. with pregnancy INTERNAL (SPECULUM) EXAMINATION (cervix & vaginal walls) & Cervical pap smear Preparation  Wear clean gloves  Warm Speculum with warm water (check comfortable temp by touching it to thigh)  Apply water based lubricant to speculum Insert Speculum  Part labia minor & insert gently & slowly at slight downward angle (care with urethra)  Once past introitus (entrance of canal), insert into vagina using downward pressure to depth 4-5cm.  Speculum handle 2cm away from introitus  Only then, Open speculum Visualise Cervix  Smooth & firm & shiny Problem finding cervix?  Find vaginal fold to guide  Close speculum, back up 1-2 cm & reinsert back into vagina (using downward pressure) in direction of vaginal folds  Re-open slightly and search for cervix.  May need to repeat many times! Once found cervix:  Open speculum further, and lock in place by turning down the screw on thumb piece. Take Specimen Revise Pathology:  Remember, Cervical cancer arises from the transitional zone of cervix (most vulnerable)  Pre-pubertal: junction lies in endocervix  Post-pubertal: junction MOVES to exocervix, exposed to acid of vagina and undergoes sq. metaplasia.  Transitional zone is area between pre pubertal junction & post pubertal junction. Liquid Based Technique (endocervix)  Rotate broom shaped brush  Disconnect handle, and place brush in liquid based pap container. (maintain Sterile Conditions) Glass Slide Technique (endocervix)  Rotate wooden spatula  Then, Rotate Endo-Brush in internal cervical os  Transfer specimen to slide  Apply fixative to slide  Cotton bud can be used instead of endo-brush in pregnant women to minimise risk of bleeding and irritation. ExoCervix Specimen  Cotton tip swab: sample vaginal discharge and exocervix for wet mount or cerv. culture. (e.g. AMIES media)  Use swab to check pH (normal acidic = 4 / yellow pH paper)  Blue (alkaline) : infection DNA, Gonococal, Chlamydiae probes  Position cotton tip swab in cervical os for 30s  Place directly into medium provided & label  If needed, a biopsy can be taken for histological examination. Remove Speculum  Warn patient before  Unscrew lock and gently retract  Slowly close blades as you retract. Observe vaginal walls.  Blade should be completely closed when exiting introitus After effects  Warn there may be a small amount of bleeding Risks  No Medical Risks of pap smear BIMANUAL VAGINAL EXAMINATION (vagina, cervix, uterus, adnexa (ovaries))  Insert index and middle finger of dominant hand into vagina, to palpate vagina, cervix and uterus & adnexa. +- lubricant  Use non dominant hand to press on abdomen to push pelvic organs towards palpating dominant hand (which elevates them) Try to notice:  Size  Shape  Tenderness  Mobility  Position  Masses  Vaginal walls  with fingers  Cervix  with fingertips  Uterus  with fingertips and pressure on abdomen  Ovaries (adnexa)  e.g. fingers in right fornix and pressure externally on right iliac fossa  mobile ovaries (2x3cm)  Remove fingers  Check glove for discharge  Dispose  Wash Hands RECTO-VAGINAL EXAMINATION Indications  Assess retro-verted uterus  Screen for colorectal cancer (50yrs+)  Evaluate pelvic pathology  Insert index finger into vagina and middle finger into rectum. Apply pressure to palpate structures  Use non-dominant hand to press on abdomen to push pelvic organs towards palpating dominant hand Contra-Indications  Consider examination under anesthesia for difficult patients  Physical, mental disability  Abnormal anatomy  Physical immaturity  Menstruation : Glass slide technique contraindicated Liquid based still possible Video Links  Part 1:  http://video.google.com/videoplay?docid=- 3683431334751191546&ei=Ch-YS- i3Apa62wLzmdXZAg&q=pelvic+examination#  Part 2:  http://video.google.com/videoplay?docid=- 3683431334751191546#docid=-1686931554619562136 Further Reading  Different types of speculum e.g. Sims?  Details how to fixate the slides and perform wet mount  Pathology: Uterine tumors THANKS FOR LISTENING •Obstetrics’ & Gynaecology •Blood pressure investigations •Swab analysis By Arjun Bhusan Keshri & By Arjun Bhusan Keshri &  Saanta ChatzialiSaanta Chatziali What is Obstetrics? Study and management of normal and abnormal pregnancies Gynaecology? Describes the study of diseases of the female genital tract  and  reproductive  system  as  well  as  the  periods  of  childbirth and postnatal life Continuum between both subjects, therefore a Continuum between both subjects, therefore a  definitive division is somewhat arbitrarydefinitive division is somewhat arbitrary Common conditions seen in Obstetrics Common conditions seen in Obstetrics  Common conditions seen in  Gynaecology When to do the breast examination?When to do the breast examination?  First consultations of women over the age of 45  Presence of secretions of milk at times not associated  with pregnancy (galactorrhoea)  Breast lumps/nodules felt on palpation  Pain (chart)  Discoloration or change in the quality of the skin:   Redness suggests infection/inflammation  ‘Peau d'orange’ quality ‐ an "Orange Peel" like  texture that's caused by an uncommon,  aggressive inflammatory malignancy  Breast Pain ChartBreast Pain Chart  When pregnant, the amount of HCG hormone in When pregnant, the amount of HCG hormone in  the body rises rapidly in the early days & weeksthe body rises rapidly in the early days & weeks  A home pregnancy test can detect this in the A home pregnancy test can detect this in the  urine or blood (the chemical markers)urine or blood (the chemical markers)  However, the HCG hormone can only be detected However, the HCG hormone can only be detected  accurately after implantation (there is also a false accurately after implantation (there is also a false  result if the test is done too early)result if the test is done too early) Common test examplesCommon test examples  Error in application results if urine Error in application results if urine  flow is lowflow is low  Drugs interferenceDrugs interference  Not 100% accurate (professionals Not 100% accurate (professionals  estimate it to be 97% correct)estimate it to be 97% correct)  Will not necessarily work if test is Will not necessarily work if test is  taken too early taken too early   Wrap machine around Wrap machine around  wrist or forearmwrist or forearm  Push on/start buttonPush on/start button  Read displayRead display  Push off buttonPush off button  Take machine offTake machine off Evaluating Blood  Pressure Readings  Nasal SwabsNasal Swabs  Detection of nasal infections, especially presence Detection of nasal infections, especially presence  Staphylococcus Staphylococcus aureusaureus  Insert swab into the anterior Insert swab into the anterior narenare (nostril)(nostril)  Sweep upwards towards the top of the Sweep upwards towards the top of the narenare  Repeat the procedure with the same swab in the Repeat the procedure with the same swab in the  other other narenare  Place  swab in culture mediumPlace  swab in culture medium Throat SwabThroat Swab  Similar technique to the nasal swab collectionSimilar technique to the nasal swab collection  Rub the swab along the back of  the throat near the  tonsils. Ask the patient to resist gagging and closing  the mouth while the swab touches this area  Used particularly in Used particularly in strep throatstrep throat  nb do not used antiseptic mouthwash before the test SkinSkin SwabsSwabs  Rubbing (gently) across investigated area of skinRubbing (gently) across investigated area of skin  Send to culture labSend to culture lab You are now able to do the following: 1.1.Short  Overview  of  Obstetrics'  and  Gynaecology;  common Short  Overview  of  Obstetrics'  and  Gynaecology;  common  conditions and risk factors conditions and risk factors  2.2.Perform and interpret value of breast examination (quadrants, Perform and interpret value of breast examination (quadrants,  common sites for lesions)common sites for lesions) 3.3.Perform  and  interpret  pregnancy  test  (urine  hormone Perform  and  interpret  pregnancy  test  (urine  hormone  detection) detection)  4.4.Perform and interpret blood pressure measurement  (manually Perform and interpret blood pressure measurement  (manually  and electronic devices) and electronic devices)  5.5.Perform and value of taking sterile Nose, Throat, and Skin SwabsPerform and value of taking sterile Nose, Throat, and Skin Swabs Pooja Mithani Indications:  Where IV administration is not available.  Drugs with specific actions on muscles.  A longer half life is needed eg. Morphine for anaesthesia  Damage to the sciatic nerve. (Upper outer quadrant)  Injection fibrosis - causes inability to flex muscle drug is administered to.  Thrombocytopenia (low platelets) and coagulopathy (bleeding) can lead to hematomas.  Local sepsis  Arterial/IV injection  Infection  Check identity of patient and contents and expiry date of drugs  Insert needle into syringe, and fill with the required amount of drug. Tap syringe to bring any air bubbles to the top and push the air out.  Choose a suitable injection site and inspect for signs of inflammation, swelling, infections or lesions  5 main sites: ▪ Upper arm (deltoid) – vaccines ▪ Dorsogluteal (gluteus maximus) ▪ Ventrogluteal(gluteus medius) ▪ Vastus lateralis (quadriceps femoris) outer side of femur ▪ Rectus femoris (anterior quadriceps) – self administration or infants  Swab site with alcohol and let it dry (bactericidal and decreases pain)  Pull skin laterally and insert needle in one swift motion at 90°, aspirate to avoid an intravenous placement, if blood is drawn in, restart with new medication and slowly inject the drug.  Remove needle and apply a pressure gauze and observe for signs of an adverse reaction. Moving the skin may distract from the intended needle destination, therefore visualise and aim for the underlying muscle about to receive the injection. http://www.youtube.com/watch?v=nA8i9eYW0_M Pooja Mithani Indications  When drug is desired to have a slow, sustained absorption effect  Local anaesthesia  Administration of vaccines and medicines such as insulin and morphine  Avoid using the same site repetitively which can cause lumps or dents (lypodystrophies – loss or degeneration of fat) from forming.  Accidental IV, ID, IM injections  Check identity of patient and contents and expiry date of drugs  Insert needle into syringe, and fill with the required amount of drug. Tap syringe to bring any air bubbles to the top and push the air out.  Choose a suitable injection site and inspect for signs of inflammation, swelling, infections or lesions  4 main sites: ▪ Upper arm outer area ▪ Abdomen – above and below waist, except around navel ▪ Anterior thigh – midway of outer side ▪ Upper area of butt – behind hip bone  When repeated injections are needed use a hidden site to cover bruises – but the same area at the same time each day to reduce changes in the action of the insulin  Swab site with alcohol and let it dry (bactericidal and decreases pain)  Gently pinch skin to elevate subcutaneous fat and separate it from underlying muscle.  Insert the needle at a 30° angle and inject the drug – aspiration before injecting the drug is unnecessary as can increase the risk of local hematoma formation for heparin. http://www.youtube.com/watch?v=bxdYGXKz1iA Pooja Mithani Contraindications  Patient refusal – but many can be persuaded  Allergy – rare  DO NOT USE adrenaline containing LA on digits or penis – vasoconstriction can lead to ischaemia and necrosis.  Anticoagulated patients have a tendency to bleed if a vessel is punctured.  Infection at intended site may make it more painful and spread.  Broken needles  Acute systemic toxicity – CNS, CVS – when plasma conc., exceeds toxic limit.  LA block fast sodium channels in nerve axons preventing propagation of nerve impulse  Pain nerves are usually smaller and non myelinated fibres so are blocked faster than larger myelinated fibres (motor, proprioception, touch)  Injected subcutaneously  Onset of effect is 2 minutes, but duration varies depending on the drug.  LA solutions are alkaline pH 10/11 therefore are more painful  A less painful approach would be ID (instant anaesthesia)  Avoid intra vascular injection, so aspirate first. ABDOMINAL EXAMINATIONABDOMINAL EXAMINATION POSITIONINGPOSITIONING  PatientsPatients handshands remainremain on his/hers sideon his/hers side  Legs,Legs, straightstraight  HeadHead resting on pillowresting on pillow –– if neck is flexed, ABDif neck is flexed, ABD muscles will tense andmuscles will tense and therefore harder totherefore harder to palpate ABDpalpate ABD  INSPECTIONINSPECTION  AUSCULATIONAUSCULATION  PALPATIONPALPATION  PERCUSSIONPERCUSSION INSPECTIONINSPECTION INSPECTIONINSPECTION  ShapeShape  Skin AbnormalitiesSkin Abnormalities  MassesMasses  Scars (PreviousScars (Previous op'sop's -- laproscopylaproscopy))  Signs of TraumaSigns of Trauma  JaundiceJaundice  CaputCaput MedusaeMedusae (portal H(portal H--T)T)  AscitiesAscities (bulging flanks(bulging flanks)  SpiderSpider NaviNavi--Pregnant womenPregnant women  CushingsCushings (red(red--violet)violet) Hands + MouthHands + Mouth  ClubbingClubbing  PalmerPalmer ErythmeaErythmea  Mouth ulcerationMouth ulceration  Breath (Breath (foeterfoeter ex oreex ore) AUSCULTATIONAUSCULTATION  Use stethoscope to listen toUse stethoscope to listen to all areasall areas  Detection of Bowel sounds (Peristalsis/Silent?? = Ileus)  If no bowel sounds heardIf no bowel sounds heard –– continue tocontinue to auscultateauscultate up toup to 3mins in the different areas to3mins in the different areas to determine the absence of boweldetermine the absence of bowel soundssounds  Auscultate for BRUITS!!! Swishing (pathological) sounds over the arteries (eg. Abdominal Aorta) PALPATION ALWAYS ASK IF PAIN IS PRESENT BEFORE PALPATING!!!  Firstly:Firstly: Superficial palpationSuperficial palpation  Secondly:Secondly: Deep where no pain isDeep where no pain is present. (deep organs)present. (deep organs)  Assessing Muscle Tone: - Guarding = muscles contract when pressure is applied - Ridigity = inidicates peritoneal inflamation - Rebound = Releasing of pressure causing pain MURPHY'S SIGN  Indication:Indication: - pain in U.R.Quadrant  Determines:Determines: - cholecystitis (inflam. of gall bladder) - Courvoisier's law – palpable gall bladder, yet painless - cholangitis (inflam. Of bile ducts) METHODMETHOD  Ask patient to breathe out.  Gently place your hand below the costal margin on the right sideGently place your hand below the costal margin on the right side at theat the midmid--clavicularclavicular line (location of the gallbladder).line (location of the gallbladder).  Instruct to breathe in.  Normally, during inspiration, the abdominal contents are pushed downward as the diaphragm moves down.  If the patient stops breathing in (as the gallbladder comes in contact with the examiner's fingers) the patient feels pain with a 'catch' in breath.  Test is positive.Test is positive. BLUMBERG'S SIGNBLUMBERG'S SIGN  Determines:Determines: -- peritonitisperitonitis -- appendicitisappendicitis  ALWAYS START OPP. SIDE TOALWAYS START OPP. SIDE TO WHERE THE PAIN IS !!!!WHERE THE PAIN IS !!!!  ABD is compressed slowly andABD is compressed slowly and then rapidly released.then rapidly released.  Pain upon removal of pressurePain upon removal of pressure rather than application ofrather than application of pressure to the abdomenpressure to the abdomen  Pain present = positive.Pain present = positive. McBURNEY'SMcBURNEY'S POINTPOINT  From ASIS (anteriorFrom ASIS (anterior superior iliac spine) tosuperior iliac spine) to the umbilicus.the umbilicus.  Determines: - location of appendix (varies) - deep tenderness @ point = acute appendicitis NOTE:NOTE: McBURNEY'SMcBURNEY'S PUNCH SIGNPUNCH SIGN == Tenderness is presentedTenderness is presented when gently tapping the area of the back overlying the kidney prwhen gently tapping the area of the back overlying the kidney producingoducing pain in people with an infection around the kidney (pain in people with an infection around the kidney (perinephricperinephric abscess)abscess) oror pyelonephritispyelonephritis.. Carnett'sCarnett's signsign  Abd. pain remains unchanged or increases when the muscles of the abdominal wall are tensed.  Positive = Abd. wall is the source of the pain (e.g. due to rectus sheath hematoma).  Negative = pain decreases when the patient is asked to lift the head; this points to an intraabdominal cause of the pain Fluid wave test / Iceberg Sign  Test forTest for ascitesascites..  Have patient push theirHave patient push their hands down on the midlinehands down on the midline of the abdomen.of the abdomen.  Then you tap one flank,Then you tap one flank, while feeling on the otherwhile feeling on the other flank for the tap.flank for the tap.  > 1 litre of fluid allows the> 1 litre of fluid allows the tap to be felt on the othertap to be felt on the other side.side. SpleenSpleen Only palpable if enlarged;Only palpable if enlarged; splenomegalysplenomegaly –– indicated byindicated by Castell'sCastell's signsign (bulge of(bulge of U.LQuadrantU.LQuadrant).). Patient on his/her Right Side & palpate from behind. Liver  PALPATE:PALPATE: - from R.iliac fossa up towards and under the last rib whilst the patient is breathing in deeply.  ASSESSING:ASSESSING: Regulatrities Smoothness Tenderness  PERCUSSION:PERCUSSION: - Outline of liver (norm: 8-12 cms) - In Mid-Clavicular Line from 2nd rib downwards  Hollow ---> Dull ----> Hollow HEPATO-JUGULAR REFLUX  Pressing enlarged liver ---> Increases Jugular Filling ----> Hepatic congestion (R.Heart Failure) Head of PancreasHead of Pancreas  De Jardins Point: - MCL - 9th Costal Cartilage - Right Side  Indication: - Pancreatitis/Tumour @ head THANK YOU FOR YOURTHANK YOU FOR YOUR ATTENTIONATTENTION NASOGASTRIC (NASOGASTRIC (RylesRyles) TUBES) TUBES (NGT)(NGT) SHAN KESHRISHAN KESHRI CLINICAL SESSIONSCLINICAL SESSIONS WHATWHAT 20 Fr LEVIN TYPE Many holes prevent blocks! Markers INDICATIONSINDICATIONS  ININ –– Fine Bore tube 12Fr (less irritating)Fine Bore tube 12Fr (less irritating)  FeedingFeeding  e.g. anorexia nervosa toe.g. anorexia nervosa to stabalisestabalise body weightbody weight  e.g. esophageal cancer to maintain nutritional intakee.g. esophageal cancer to maintain nutritional intake  Swallowing difficultySwallowing difficulty ((dysphagiadysphagia))  Administer drugsAdminister drugs (inject into tube)(inject into tube)  Oral substancesOral substances e.g. charcoale.g. charcoal (poison antidote,(poison antidote, antiflatulentantiflatulent, lower blood lipid), lower blood lipid) INDICATIONSINDICATIONS OUTOUT –– Large Bore tubeLarge Bore tube  AspirationAspiration (suction) of stomach contents(suction) of stomach contents  Gastric secretionsGastric secretions  SwallowedSwallowed air / obstructionsair / obstructions / paralytic/ paralytic ileusileus  ExtractExtract samples of gastric liquidsamples of gastric liquid for examinationfor examination  Extract swallowedExtract swallowed toxin / poisontoxin / poison  Patient who has undergonePatient who has undergone pneumonectomypneumonectomy (risk of anesthesia related vomiting leading to aspiration of st(risk of anesthesia related vomiting leading to aspiration of stomach contents)omach contents) INDICATIONSINDICATIONS  IntraIntra--operativelyoperatively::  Inflate / Deflate stomach, to give easier access to upperInflate / Deflate stomach, to give easier access to upper abdomenabdomen Continuous FeedingContinuous Feeding  Gravity based systemGravity based system  Feeding solution placed above level of stomachFeeding solution placed above level of stomach Supervised feedingSupervised feeding  Tube is connected toTube is connected to electronic pumpelectronic pump  Controls and measures intake, & signals interruptions in feedingControls and measures intake, & signals interruptions in feeding.. Continuous DrainageContinuous Drainage  Gravity Based System:Gravity Based System:  Attach to collector bag. Placed below level of stomachAttach to collector bag. Placed below level of stomach CONTRACONTRA--INDICATIONSINDICATIONS  History of / currently has:History of / currently has:  Gastric bypass surgeryGastric bypass surgery  EsophagealEsophageal VaricesVarices  Alcoholism, Liver DiseaseAlcoholism, Liver Disease  Bleeding disordersBleeding disorders  Fractured noseFractured nose  Deviated septumDeviated septum  Nasal / Sinus surgery / TraumaNasal / Sinus surgery / Trauma  EtcEtc…… EQUIPMENTEQUIPMENT  Cup ofCup of water with strawwater with straw  patient sip during insertion of tubepatient sip during insertion of tube  NasoNaso--gastric Tubegastric Tube (NGT)(NGT)  LubricantLubricant  pH / Litmus paperpH / Litmus paper  Pen lightPen light  Vomiting basinVomiting basin  Measuring tapeMeasuring tape  SurgicalSurgical TapeTape  Mask and eye protectionMask and eye protection  Non Sterile DrapeNon Sterile Drape  Non sterile GlovesNon sterile Gloves  60ml Syringe60ml Syringe  Bottle of water for irrigationBottle of water for irrigation NON STERILE TECHNIQUENON STERILE TECHNIQUE  Classed as aClassed as a nonnon--sterile proceduresterile procedure because, as thebecause, as the NGT passes through the nose, it will pick up bacteria onNGT passes through the nose, it will pick up bacteria on the way down to the stomach anyway.the way down to the stomach anyway.  Place non sterile drape across patients chest.Place non sterile drape across patients chest.  Give patient the basin to holdGive patient the basin to hold  In case of nausea / vomitingIn case of nausea / vomiting ASSESSASSESS  Has patient had :Has patient had :  Nasal / Sinus Surgery?Nasal / Sinus Surgery?  Fractured nose?Fractured nose?  Deviated septum?Deviated septum?  Nasal TraumaNasal Trauma  Difficulty breathing through a particular nostrilDifficulty breathing through a particular nostril  (ask them to blow nose)(ask them to blow nose)  Check bothCheck both naresnares with pen lightwith pen light –– clear?clear?  Inform patient to take sips of water through the straw,Inform patient to take sips of water through the straw, during insertion of NGT, as this swallowing will help itduring insertion of NGT, as this swallowing will help it pass more easily!pass more easily!  Also explain it may cause discomfort.Also explain it may cause discomfort. PROCEDUREPROCEDURE Remember:Remember: Safety & Communication!Safety & Communication! PreparePrepare  Wash HandsWash Hands  Check identity of patient with request form / recordsCheck identity of patient with request form / records  Name / DOBName / DOB  Explain procedure to patientExplain procedure to patient  Sitting positionSitting position  Measure with the tube from theMeasure with the tube from the tip of the nosetip of the nose, to the, to the tip of their earlobetip of their earlobe andand down to thedown to the xyphoidxyphoid processprocess..  Tube is then marked at this level indicating how far theTube is then marked at this level indicating how far the tube must be inserted in order to reach the stomach.tube must be inserted in order to reach the stomach.  However, most tubes now have several standard depthHowever, most tubes now have several standard depth markingsmarkings  18" (46cm) / 22" (56cm) / 26" (66cm) / 30" (76cm) from distal18" (46cm) / 22" (56cm) / 26" (66cm) / 30" (76cm) from distal end;end;  Infant tubes have 1 cm depth markings.Infant tubes have 1 cm depth markings.  Prepare surgical tape ready to fix tube in place after insertionPrepare surgical tape ready to fix tube in place after insertion  Put Gloves onPut Gloves on..  Lubricate first 2Lubricate first 2--4 inches of NGT4 inches of NGT  Help it pass easilyHelp it pass easily Ready to insertReady to insert…… Give patient water and remind to take sips duringGive patient water and remind to take sips during insertion.insertion.  Insert steadily, untilInsert steadily, until nasonaso--pharynx (resistance)pharynx (resistance)  During insertion, the tube must point downDuring insertion, the tube must point down  Then, atThen, at nasonaso--pharynx, twist the NGT 180 degreespharynx, twist the NGT 180 degrees  MinimisesMinimises risk of the tube coiling at the back of the mouth!risk of the tube coiling at the back of the mouth! EE TT Careful not to go down the wrong hole!  When enteringWhen entering orooro--pharynx, greatest risk of gaggingpharynx, greatest risk of gagging (drink water!)(drink water!)  Once in esophagus, goes down easy.Once in esophagus, goes down easy.  When you reach the mark:When you reach the mark:  Secure tube with the surgical tapeSecure tube with the surgical tape  Attach Drainage / Feeding bagAttach Drainage / Feeding bag  Document Procedure in patient recordsDocument Procedure in patient records  IndicationIndication  Size of tube usedSize of tube used  Amount & nature of aspirateAmount & nature of aspirate 3 Ways to check correct position3 Ways to check correct position 1) Check pH of gastric contents1) Check pH of gastric contents 2) Chest X2) Chest X--Ray (CXR)Ray (CXR) 3) With Air bolus3) With Air bolus 1) Checking pH of gastric contents1) Checking pH of gastric contents  Pinch tube before connecting syringe to end of NGTPinch tube before connecting syringe to end of NGT  Connect 60ml SyringeConnect 60ml Syringe  Withdraw 5Withdraw 5--10ml of gastric contents10ml of gastric contents  Place a few drops of the contents on the pH / litmus paper.Place a few drops of the contents on the pH / litmus paper.  pH paper preferred!pH paper preferred!  pH <5.5 = Success!pH <5.5 = Success! (blue litmus strip turns red!)(blue litmus strip turns red!)  Return contents of syringe to patient via NGT.Return contents of syringe to patient via NGT. NB: pH PAPER PREFERRED!  Flush tube with water to prevent cloggingFlush tube with water to prevent clogging  Fill syringe with water, hold above stomach level and allowFill syringe with water, hold above stomach level and allow gravity to carry water to stomach.gravity to carry water to stomach.  Flush tube with 30ml Air, to remove fluid from the line.Flush tube with 30ml Air, to remove fluid from the line. 2) Chest X2) Chest X--Ray (CXR)Ray (CXR) •• Most ReliableMost Reliable CXRCXR  Measure length of tube outside of the body. (tip of noseMeasure length of tube outside of the body. (tip of nose till end). Record.till end). Record.  Send patient for CXR.Send patient for CXR.  Upon return from CXR, measure tube ensuring it has notUpon return from CXR, measure tube ensuring it has not moved.moved. 3) Using Air Bolus3) Using Air Bolus •• Becoming an outBecoming an out--dated methoddated method Less reliableLess reliable  Take 60ml SyringeTake 60ml Syringe  Pinch tube before connecting it to end of NGTPinch tube before connecting it to end of NGT  Instill approx 30ml air to stomach.Instill approx 30ml air to stomach.  At the same time, listen inAt the same time, listen in epiepi--gastric area withgastric area with stethoscope forstethoscope for ‘‘whooshwhoosh’’ & bubbling.& bubbling.  YES: Tip of NGT is in stomach = Success!YES: Tip of NGT is in stomach = Success! MAINTAINENCEMAINTAINENCE  Check positioning at least one a dayCheck positioning at least one a day  Checking the markChecking the mark OROR  Measure length of tube outside of bodyMeasure length of tube outside of body  Mouth, Lip, Nose Care every 2 hrsMouth, Lip, Nose Care every 2 hrs  Keep MoistKeep Moist  TissuesTissues  ToothbrushingToothbrushing COMPLICATIONS & SIDE EFFECTSCOMPLICATIONS & SIDE EFFECTS  Pain & DiscomfortPain & Discomfort  Nose bleedsNose bleeds  SinusitisSinusitis  Sore throatSore throat  VomitingVomiting  Erosion of nose where tube is attachedErosion of nose where tube is attached  Pulmonary aspirationPulmonary aspiration  Perforation of stomachPerforation of stomach  EsophagitisEsophagitis  Tracheal/ Duodenal intubationTracheal/ Duodenal intubation ALTERNATIVESALTERNATIVES  Longer Term Feeding:Longer Term Feeding:  PEG feedingPEG feeding ((percutaneouspercutaneous endoscopicendoscopic gastrostomygastrostomy))  More possible complications (infection, peritonitis etc)More possible complications (infection, peritonitis etc) FURTHER READINGFURTHER READING  Differences in procedure for childrenDifferences in procedure for children  NGT RemovalNGT Removal LINKSLINKS  http://http://www.youtube.com/watch?vwww.youtube.com/watch?v=WgfNa7dzSn0&feature==WgfNa7dzSn0&feature=player_embeddedplayer_embedded  http://en.wikipedia.org/wiki/Nasogastric_intubationhttp://en.wikipedia.org/wiki/Nasogastric_intubation  http://http://www.youtube.com/watch?vwww.youtube.com/watch?v=WgfNa7dzSn0&feature==WgfNa7dzSn0&feature=player_embeddedplayer_embedded  Part 1:Part 1:  http://http://www.youtube.com/watch?vwww.youtube.com/watch?v==TDXczuzHCeYTDXczuzHCeY  Part 2:Part 2:  http://www.youtube.com/watch?v=cTeEfULr0d0http://www.youtube.com/watch?v=cTeEfULr0d0  http://http://www.youtube.com/watch?vwww.youtube.com/watch?v=6oxCda6FKUY&feature=related=6oxCda6FKUY&feature=related First Aid Devangna Bhatia Equipment: ABC’s: D: Danger R: Response ------------------ A: Airways B: Breathing C: Circulation ------------------- D: Disability (acute problems) / defib if CPR E: Exposure (to more danger) What is First Aid and what are its aims? “Provision of initial care for an illness or injury.” 3 aims: Preserve life Prevent further harm - this covers both external factors, such as moving a patient away from any cause of harm, and applying first aid techniques to prevent worsening of the condition, such as applying pressure to stop a bleed becoming dangerous. Promote recovery - first aid also involves trying to start the recovery process from the illness or injury, and in some cases might involve completing a treatment, such as in the case of applying a plaster to a small wound. Before CPR – Primary Survey 1) Danger - Are you or the casualty in any danger? If you have not already done so, make the situation safe and then assess the casualty. 2) Response - If the casualty appears unconscious check this by shouting: ‘Can you hear me?’, ‘Open your eyes’ and gently shaking their shoulders. If there is no response: 1) Shout for help. If possible, leave the casualty in the position found and open the airway. 2) If this is not possible, turn the casualty onto their back and open the airway. If there is a response AND no further danger: 1) leave the casualty in the position found and summon help if needed. 2) Treat any condition found and monitor vital signs - level of response, pulse and breathing. 3) Continue monitoring the casualty either until help arrives or he recovers. 3) Airway - Open the airway by placing one hand on the casualty’s forehead and gently tilting the head back, then lift the chin using 2 fingers only. • This will move the casualty's tongue away from the back of the mouth. 4) Breathing: • Look to see if the chest is rising and falling. • Listen for breathing. no more than 10 seconds • Feel for breath against your cheek. 1) If the casualty is breathing normally , place them in the recovery position. 2) 2)Check for other lifethreatening conditions such as severe bleeding and treat as necessary. 1) If the casualty is not breathing normally or if you have any doubt whether breathing is normal begin CPR!! Recovery Position CPR – Cardiopulmonary Resuscitation • Physical interventions to create artificial circulation by chest compressions, and artificial respiration by the rescuer exhaling into the patient (or using a device to simulate this). • Its main purpose is to maintain a flow of oxygenated blood to the brain and the heart – both are vulnerable to damage from hypoxia. • Some brain cells start dying within less than 5 minutes of hypoxia! • CPR for adults: DEEP INHALATIONS AND EXHALATIONS! 30 compressions : 2 breaths for 2 minutes rate of 100/min ventilation: 8 – 10 breaths/min • CPR for children (1 year to puberty): SHALLOW BREATHS AND DON’T EMPTY YOUR LUNGS COMPLETELY! Start: 5 rescue breaths & 30 compressions then continue with 30 compressions: 2 breaths • CPR for babies (birth to 1 year): FILL YOUR CHEEKS WITH AIR AND USE THIS! Start: 5 rescue breaths & 30 compressions then continue with 30 compressions: 2 breaths • Agonal breathing : This is common in the first few minutes after a sudden cardiac arrest. It usually takes the form of sudden irregular gasps for breath. It should not be mistaken for normal breathing and if it is CPR should be started. CPR on adults CPR on children: 1yr - puberty CPR on infants: ALS – Advanced Life Support • Advanced life support, including intravenous drugs and defibrillation (the administration of an electric shock to the heart) is usually needed to restore a viable rhythm. This only works for certain heart rhythms: 1) ventricular fibrillation (VF) (uncoordinated contraction of the cardiac muscle of the heart ventricles, making them quiver rather than contract properly.) 2) pulse less ventricular tachycardia (fast heart rhythm, that originates in one of the ventricles.) • NOT useful in a 'flat line' asystolic patient, since the heart is already depolarised. CPR and injections of epinephrine/atropine will help. • CPR is generally continued, usually in the presence of advanced life support, until the patient regains a heart beat (called "return of spontaneous circulation" or "ROSC") or is declared dead. Defibrillation Consists of delivering a therapeutic dose of electrical energy to the affected heart, using a defibrillator. This depolarizes a critical mass of the heart muscle, terminates the arrhythmia, and allows normal sinus rhythm to be re-established by the sinoatrial node of the heart. CPR Videos • http://www.youtube.com/watch?v=5r7haVfZXek • http://www.youtube.com/watch?v=qSsHcdy4GnA ALS Video: • http://www.youtube.com/watch?v=zO3r50mIgr4 http://www.sja.org.uk/sja/first-aid- advice.aspx CENTRAL VENOUS CATHETERISATION Shilpa Nelapathla  Measurement of central venous pressure (CVP)  ( E.G. those with hypotension not responding to normal management, requiring  infusion of inotropes)  For long term administration of drugs for pain,  infection, cancer or to supply nutrition.  Venous access for IV fluids or antibiotics or a  peripheral site is unavailable/unaccessible  Haemodialysis     Patients undergoing thrombolytic or anticoagulative therapy  Bleeding disorders  Vasculitis  Distorted local anatomy   Overlying skin infections( dermatitis), burns    Uncooperative  patient • INFECTIOUS Sepsis (also septic arthritis, osteomyelitis) • VASCULAR  Air embolism, blood clot, hematoma, arterial puncture  • OTHERS PNEUMOTHORAX, hemothorax, arrhythmias , nerve injury  INTERNAL JUGULAR VEIN  SUBCLAVIAN VEIN  FEMORAL VEIN Length of catheters  15cm catheters for subclavian and internal jugular lines, and  60cm catheters for femoral line  Patient on a tilting bed, trolley or operating table  Standard multiple lumen kit  Guide wire  Sterile gloves   Sterile gown  Drapes   Disinfectant (Povidone‐iodine solution/ chlorhexidine)  Suturing needle  Scalpel  Local Anaesthetic (lidocaine)   Sterile saline flush  A= small syringe and  vial of  1% Lidocaine (L.A) B= guide needle C= IV syringe with catheter attached‐ D E= Disinfectant sponge   Guidewire: J‐shaped tip to reduce  risk of vessel perforation Dilator Triple lumen        catheter  SELDINGER TECHNIQUE  (most common) 1) Use guide needle to locate the vein 2) Wire threaded through needle  3) Remove needle 4) A dilator is passed over the guide wire 5) Dilator is removed and catheter is passed over wire and  wire is removed 6) Catheter secured in place Allows larger catheters to be placed in the vein after the passage of appropriate dilators along the wire and a small incision in the skin at the point of entry.  Obtain informed consent and explain risks and benefits of  procedure  Optimal patient positioning and cooperation,  make sure patient is  comfortable  Take your time  Sterile technique    Local anaesthetic should be used    Always have a hand on your wire  Aspirate while advancing as you withdraw the needle slowly  Withdraw  needle to the level of the skin before redirecting the angle  Don’t poke yourself with the needle  The tip of the catheter can lie in either the superior or inferior vena  cava (SVC or IVC) or into the right atrium (RA). 1. POSTIONING : TRENDELENBURG POSITION  Patient supine on  surface inclined 45 degrees, head at the lower end and legs flexed over  upper end.  ( This distends the central veins and prevents air embolism)  Head turned to opposite side of central venous line  Stand at the head of the patient  Ultrasound and landmarks can be  used  IJV is between the clavicular  and  sternal heads of the  sternocleidomastiod muscle  Point of needle insertion is  midway  between  sternal head of  SCM and mastoid process behind  ear     Disinfect area , apply L.A  and  fenestrated drape  Place three fingers on carotid artery   Place needle about 45 degrees to the skin, lateral to the  carotid artery  Direct needle in sagittal plane angled towards feet   Vein should be 1‐1.5 cm deep, avoid deep probing in the  neck   Seldinger technique used   http://www.youtube.com/watch?v=QHiuYc22pfE 1.Disinfection, L.A and sterile drape 2. Insert needle into IJV and aspirate 3. Hold tip of needle with one hand 4. Place wire through needle and remove needle 5. Insert catheter over wire then remove wire 6. Once catheter is in place , secure and apply dressing POSITIONING  Trendelenburg postion (10‐15 degrees)   Supine position, head and shoulders neutral  with arm slightly abducted  Stand beside the patient at the side PROCEDURE  Disinfect area and apply local anaesthetic   Cover procedure area with fenestrated sterile drape  Use seldinger technique  LOCATION AND ACCESS TO VEIN  Identify the midclavicular point and sternal notch  Insert needle into the skin  1cm below and lateral to the midclavicular point   Direction of needle should be parallel to skin   Advance posterior to the clavicle aiming for the sternal notch (Do not  pass the needle further than the sternal head of the clavicle) http://video.google.com/videoplay?docid=242132498694 8418582# POSITIONING   Supine patient   Extend the patient’s leg and abduct slightly at the hip PROCEDURE  Disinfect area and apply local anaesthetic   Cover procedure area with fenestrated sterile drape  Use seldinger technique  LOCALISATION AND ACCESS TO VEIN  Vein is medial to femoral artery  Identify the pulsation of the femoral artery 1‐2 cm below the inguinal  ligament.    Position needle at 45 degree angle and about 1cm medial to pulsation  Needle  inserted at skin about 2 cm below inguinal ligament  Aiming towards the umbilicus  (In adults, the vein  normally found 2‐4cm from the skin. In small children  reduce elevation on the needle to 10‐15° as the vein is more superficial) http://www.4shared.com/file/61538831/b1027127/Placement_of_a_Fe moral_Venous_.html 1) Aspirate blood from each port 2) Flush with saline / sterile water 3) Secure the catheter with sutures 4) Apply  sterile dressing  5) Dispose of used gloves, needles, syringe etc 6) Wash hands  7) Chest x‐ray for IJ and SC lines LOCATION BENEFITS RISKS INTERNAL JUGULAR VEIN •Bleeding can be seen  and controlled •Decreased risk of  pneumothorax  •Risk of Carotid artery  puncture •Pneumothorax SUBCLAVIAN VEIN •Most comfortable for  concious patients •Increased risk of  pneumothorax •Should not be done on  less than 2yrs  •Vein is non‐ compressible FEMORAL VEIN •Easy to locate  •Less  bad  complications •No risk of  pneumothorax •Preffered in  emergencies •Highest risk of  infection •Risk of DVT THANX FOR LISTENING! Main Points  What’s a suture?  Why do I need to know how to do one?  What instruments do I use for it? Can I tie a knot? What techniques shall I use? What types of sutures and materials do I know? Definitions  Suture: Is a medical device used to hold body tissues together after an injury or surgery. To stitch together, cut or torn edges of tissue with suture material.  Tensile Strength : The resistance of a material to a force tending to tear it apart, measured as the maximum tension the material can withstand without tearing Suture Characteristics Absorbable Sutures Natural Synthetic Polymers Collagen Surgical gut, plain Surgical gut, chromic Dexon (Polyglycolic Acid Suture) Vicryl (Polyglactic Acid Suture) PDS (Polydioxanone) Maxon (Polyglyconate) Suture Characteristics II  Absorbable Suture: A suture that degrades and loses its tensile strenght within 60 days under the skin  Natural Suture: Can be made of collagen from mammal intestines or from synthetic collagen (polymers)  Synthetic:New technology in surgical stitches We use this sutures in patients who cannot return for suture removal, or in internal body tissues Absorbable Sutures 1. Catgut Suture: Tensile strength is maintained for 7-10 days, absorption complete within 60 days. Used for ligating superficial blood vessels and for epidermal use 2. Dexon and Vicryl: Tensile strength is maintained for 14 days. Absorption completed in 56-70 days. Used in general soft tissues and vessel ligations 3. PDS (Polydioxanone): Polyester monofilament suture with tensile strength maximal for 14 days. Absorption completed within 6 months. Used for soft tissue approximation in pediatric, cardiovascular, gynecologic, ophtalmic, plastic and digestive situations. Monofilament vs Multifilament Mono is made of a single strand, more resistant to microorganisms, less resistant to passage through tissue, needs great care in handling and tying because it crushes easily Sutures Characteristics III Non-Absorbable Sutures Natural Synthetic Polymers Surgical Silk Surgical Cotton Surgical Steel Nylon Polyester fiber Novafil (Polybutester) Prolene (Polypropylene) Non-Absorbable Sutures  Silk: Many surgeons consider silk suture the standard of performance. Tensile strength decreases with moisture absorption and is lost by 1 year. The problem is the acute inflammatory reaction triggered by this material. Prolene: Monofilament suture, useful in contaminated and infected wounds. Widely used in plastic, cardiovascular, orthopedic surgery. Ideal for use in continuous suture closure. Fig.A - Correction of blepharoptosis Fig.B - Repair of a left indirect inguinal hernia Suture Material – Needle Holders Suture Specifications Needles • Curvature • Straight needle • Curved 2/8 of circle • Curved 3/8 of circle • Curved 4/8 of circle • Curved 5/8 of circle • Needle Tip 1. Taper 2. Conventional cutting needle 3. Reverse cutting needle Traumatic needles: With holes or eyes which are supplied to the hospital, separate from their suture thread. Suture must be threaded on site as is done when sewing at home Atraumatic needles: With sutures comprise an eyeless needle attached to specific length suture thread Suture Material - Needles Fig.C – Atraumatic Needle, Taper Fig.D – 3/8 circle needle, Cutting Fig.D – Traumatic Needle, Reverse Cutting Suture Size  Size O: Largest suture  Size 2-O  Size 3-O • Skin: Foot or Sole • Deep: Chest, Abdomen, Back, Scalp  Size 4-O • Skin: Scalp, Chest, Abdomen, Foot, Extremity • Deep: Scalp, Extremity, Foot  Size 5-O • Skin: Scalp, Brow, Oral, Chest, Abdomen, Hand • Deep: Brow, Nose, Lip, Face, Hand  Size 6-O • Skin: Ear, Lid, Brow, Nose, Lip, Face, Penis  Size 7-O: Smallest Suture • Skin: Eyelid, Lip, Face Suture Removal Timing Scalp: 6-8 days Face, Eyelid, Eyebrow, Nose, Lip: 3-5 days .Follow with papertape or steristrips Ear: 10-14 days Chest and abdomen: 8-10 days Back: 12-14 days Extremities: 12-14 days Hand: 10-14 days Foot and sole: 12-14 days Penis: 8-10 days Condition delaying Wound Healing: 14 to 21 days Chronic Corticosteroid use and Diabetes Mellitus Suture Technique Pic.E - Suture Kit http://www.softwarecasa.com/apprentice-doctor-how-to-stitch-up-wounds.html The aim of all these techniques is to approximate the wound edges without gaps and without tension. Staples are an expensive alternative and glue may not be widely available. Suturing is the most versatile, least expensive and most widely used technique. The choice of sutures and needles is determined by the location of the lesion, the thickness of the skin in that location, and the amount of tension exerted on the wound. List of Suture Techniques :: Interrupted Suture :: Continuous simple or Running Suture :: Vertical mattress :: Horizontal mattress :: Subcuticular Suture :: Purse string :: Retention/tension Simple Interrupted Suture  The most commonly used and versatile suture in cutaneous surgery (i.e repair lacerations)  This suture is placed by inserting the needle perpendicular to the epidermis, traversing the epidermis and the full thickness of the dermis, and exiting perpendicular to the epidermis on the opposite side of the wound http://www.youtube.com/watch?v=PoO RW7pQs2M Continuous/Running Suture  Is an uninterrupted series of simple interrupted sutures  Poor cosmetic result but less time/consuming  Is started by placing a simple interrupted stitch, which is tied but not cut. A series of simple sutures are placed in succession without tying or cutting the suture material after each pass. The line of stitches is completed by tying a knot after the last pass at the end of the suture line http://www.youtube.com/watch?v=H1FmNevH2QE&feature=related Vertical Matress Suture http://www.youtube.com/watch?v=qNcM6D9OK0s Is a variation of the simple interrupted suture. It consists of a simple interrupted stitch placed wide and deep into the wound edge and a second more superficial interrupted stitch placed closer to the wound edge and in the opposite direction. Perfect apposition and great to relieve tension from skin edges Horizontal Matress Suture  Is placed by entering the skin 5 mm to 1 cm from the wound edge.  The suture is passed deep in the dermis to the opposite side of the suture line and exits the skin equidistant from the wound edge.  The stitch is passed deep to the opposite side of the wound where it exits the skin and the knot is tied http://www.youtube.com/watch?v=Svcau54Svyg&feature=related Subcuticular (Intradermal) Sutures  Excellent cosmetic result  It is placed by taking horizontal bites through the papillary dermis on alternating sides of the wound. No suture marks are visible, and the suture may be left in place for several weeks  Useful in wounds with strong skin tension http://www.youtube.com/watch?v=-osbgWMXcFE Knot Tying  Essentially there are 3 basic techniques: 1. Instrumental tie - This is the most straightforward and the most commonly used technique - You must cross your hands to produce a square knot - Do not use instrument ties if the patient’s life depends on the security of the knot Knot Tying II 2. One handed knot Use the one handed technique to place deep seated knots and when one limb of the suture is immobilized by a needle or an instrument Hand tying has the advantage of tactile sensations lost when using instruments; if you place the first throw of the knot twice, it will slide into place, but will have enough friction to hold while the next throw is placed http://www.youtube.com/watch?v=b8JEuD0C3Pw&feature=related Knot Tying III 3. Two handed knot The two handed knot is the most secure. Both limbs of the suture are moved during its placement. A surgeon’s knot is easily formed using a two handed technique With practice, the feel of knot tying will begin to seem automatic. As with learning any motor skill, we develop “muscle memory”. Our brain teaches our hands how to tie the knots, and eventually our hands tie knots so well, we are no longer consciously completing each step Joao Marques de Oliveira Rectal Examination Nikos Lymberopoulos Anatomy I  The rectum is the curved lower, terminal segment of large bowel.  It is about 12 cms long and runs along the concavity of the sacrum.  Anterior to the lower 1/3 of the rectum lie different structures in men and women Anatomy II  In men, anterior to the lower 1/3 of the rectum lie the prostate, bladder base and seminal vesicles.  In women, anterior to the lower 1/3 of the rectum lies the vagina. At the tip of the examining finger it may be possible to feel cervix and even a retroverted Uterus  This is an intimate and sometimes uncomfortable examination which is most often done when disease (usually gastrointestinal or genitourinary disease) is suspected or already identified. It may also be done as part of a screening examination when there is no suspicion or expectation of disease but the examination is performed as part of a thorough screening process. It is important in all cases to explain the reasons for the examination and to get verbal consent. Indications for R.E.  Assessment of the prostate (particularly symptoms of outflow obstruction).  When there has been rectal bleeding (prior to proctoscopy, sigmoidoscopy and colonoscopy).  Constipation.  Change of bowel habit.  Problems with urinary or faecal continence.  In exceptional circumstances to detect uterus and cervix (when vaginal examination is not possible). Procedure  The finger is then moved through 180°, feeling the walls of the rectum. With the finger then rotated in the 12 o'clock position, helped usually by the examiner bending knees in a half crouched position and pronating the examining wrist, the anterior wall can be palpated. Rotation facilitates further examination of the opposing the walls of the rectum. In men, the prostate will be felt anteriorly. In women, the cervix and a retroverted uterus may be felt with the tip of the finger. It is important to feel the walls of the rectum throughout the 360°. Small rectal wall lesions may be missed if this is not done carefully. Examination of the Prostate Gland  Normal size is 3.5 cms wide, protruding about 1 cm into the lumen of the rectum.  Consistency: it is normally rubbery and firm with a smooth surface and a palpable sulcus between right and left lobes.  There should not be any tenderness.  There should be no nodularity. External Inspection  Skin disease.  Skin tags  Genital warts  Anal fissures  Anal fistula  External haemorrhoids  Rectal prolapse  Skin discolouration with Crohn's disease  External thrombosed piles Internal Inspection  Simple piles (but best examined at proctoscopy)  Rectal carcinoma  Rectal polyps  Tenderness  Diseases of the prostate gland  Malignant or inflammatory conditions of the peritoneum (felt anteriorly) Contraindications  Imperforate Anus  Unwilling patient  Immunosuppressed patient  Absence of anus following surgical excision  Stricture  Moderate to severe anal pain  Prolapsed thrombosed internal hemorroids OTOSCOPY &OTOSCOPY & OPTHALMOSCOPOPTHALMOSCOPYY SHAN KESHRISHAN KESHRI CLINICAL SESSIONSCLINICAL SESSIONS OTOSCOPYOTOSCOPY http://medweb.cf.ac.uk/otoscopy/index.htm ANATOMY OF EARANATOMY OF EAR EXTERNAL INNER MIDDLE Outer ear & canal until TM Cochlea, SC canals,vestibule TM + air filled area behind, including ossicles ANATOMY OF EXTERNAL EARANATOMY OF EXTERNAL EAR LAYERS OF TYMPANIC CAVITYLAYERS OF TYMPANIC CAVITY MUCOSA FIBROUS LAYER SKIN OF EXT. CANAL FIBROUS LAYER: Pars Tensa: circular and radial fibres Pars Flaccida: only circular fibres • Explain to patient what you are going to do. – May be some discomfort, but should be no pain. • Clean & Disinfect speculum, and wash hands between patients Safety & CommunicationSafety & Communication • Clinical examination of the ear should begin with a general examination of the external ear, and of the lymph nodes of the head. • Following this, we can use an otoscope to look inside the ear. To StartTo Start…… • In primary care we use otoscope aka auroscope – Clean speculum & functioning batteries (BRIGHT light is important!!) OTOSCOPE / AURISCOPEOTOSCOPE / AURISCOPE Removable Speculum On / Off Switch Battery Compartment & Handle Magnifying area w/ light source Speculum size should be the LARGEST THAT CAN FIT WITHOUT CAUSING PAIN • Hold close to eyepiece for more control – Pencil (or hammer grip) – Right hand right ear, left hand left ear • Pull pinna back and up to straighten ear canal – To make speculum insertion easier • Examine good ear first QUADRANTSQUADRANTS NORMAL TYMPANIC MEMBRANENORMAL TYMPANIC MEMBRANE WHAT TO LOOK FORWHAT TO LOOK FOR • External canal Wall – Skin (normal, inflammed?) – Debris? • Malleus HANDLE (or lateral process) • UMBO (malleus stria) • CONE OF LIGHT (triangle shape, with apex at umbo)) • Inspect Pars Tensa, starting in Posterior-Superior quadrant, clockwise • Inspect Pars Flaccida • Identify as many structures as you can HUC Ask YourselfAsk Yourself • Can I see all the external auditory canal? – stenosis, foreign body, edema, blood, debris • Can I see the TM, or the handle of malleus, or both? • Is the TM intact? – retraction, perforation, blood vessels, clues about middle ear problems • Is the TM correct colour and transparency? – Gold/blue/dull = fluid/blood in middle ear – White patches = tympanosclerosis (post-surgical?) – Pearly grey = Normal NORMAL TYMPANIC MEMBRANENORMAL TYMPANIC MEMBRANE • Thin • Semi-transparent • Pearly grey NORMAL TYMPANIC MEMBRANENORMAL TYMPANIC MEMBRANE • Most otoscopes have a small air vent connection that allows the doctor to puff air in to the canal. • Observing how much the eardrum moves with air pressure assesses its mobility, which varies depending on the pressure within the middle ear. INSUFFLATIONINSUFFLATION CanCan’’t work out whatt work out what’’s what?s what? • Look for the lateral process of malleus for orientation. • Even when most other part have been destroyed, this is usually still visible. • Normal secretion of outer meatus • Initially semi liquid and colourless, later oxidises to yellow-brown harder substance which can block passage of sound. WAX / CERUMENWAX / CERUMEN • Inflammation of middle ear (infection) • Upper half: – Prominent blood vessels, Bulging, malleus prominence obscured (fluid) • Lower half: – Dull ACUTE OTITIS MEDIAACUTE OTITIS MEDIA (w/ effusion)(w/ effusion) NORM • Inflammation of middle ear (infection) • Bulging TM, with Purulent fluid behind a tense TM • Risk of perforation – need to drain! ACUTE OTITIS MEDIAACUTE OTITIS MEDIA (w/no definition)(w/no definition) NORM • Incomplete healing of OM • Inflammatory process > Scar Tissue = Calcified plaques on TM TYMPANOTYMPANO--SCLEROSISSCLEROSIS NORM • Causes include Trauma to head, Spontaneous perforation, Loud sounds, Middle ear fluid build up, kissing ear (negative pressure) etc • Pressure related: circular • Trauma related: cake shaped CENTRAL PERFORATION OF TMCENTRAL PERFORATION OF TM • Acute Otitis Media with effusion • Secretory Otitis Media • Fluid behind eardrum • Resolution of Middle Ear Infection • Serous Otitis Media • Grommet / Tympanostomy tube • Otitis Externa OTHERS TO LOOK INTOOTHERS TO LOOK INTO • Glue Ear (children) • Myringotomy • Retracted ear drum • Cholesteatoma • Grommets • Tuning Fork tests – Rhines & Webers • Tympanometry (jerger classification) • Evoked Potentials • Vestibulo-ocular relfex (VOR) • Vestibulo-spinal reflec (VSR) • Audiometry • http://archive.student.bmj.com/back_issues/0795/7-otos.htm • http://s818.photobucket.com/albums/zz101/bainiangudu168/video%20otoscope/?action=view¤t= 002-2.flv FURTHER READINGFURTHER READING OPTHALMOSCOPYOPTHALMOSCOPY Examination of eye ANATOMY OF EYEANATOMY OF EYE Sclera Vascular Choroid Photosensitive Retina OPTHALMOSCOPEOPTHALMOSCOPE Lid Depress and rotate green button to turn on Change magnification Look through here FACES EXAMINER FACES PATIENTS EYE Magnification number OPTHALMOSCOPEOPTHALMOSCOPE • Examine Fundus – Interior surface of the eye, opposite the lens, includes retina, optic disc, macula and fovea. RETINARETINA • Innermost of 3 layers – Pars optica retina – photoreceptive – Pars ceca retina – not photoreceptive • Review 11 histological layers of retina • Macula Lutea : flattened oval area in centre of retina, slightly below optic disc. – In centre: Avascular fovea centralis : point of sharpest visual acuity; only cones, each with own nerve supply RETINA: VASC SUPPLYRETINA: VASC SUPPLY • Inner layers – Central retinal arteries (br. of opthalmic) • Occlusion > retinal infarction • Outer layers – No capillaries – Nourished by diffusion from vascular choroid layer, which is supplied by retinal arteries • Retinal Arteries: – BRIGHT red, BRIGHT relfex, NO PULSE, Paler with age, • Retinal Veins: – DARK red, NARROW reflex, SPONTANEOUS PULSE, 1.5x THICKER RETINA: NERVE SUPPLYRETINA: NERVE SUPPLY • No Sensory supply • Disorders of retina are painless!! METHODMETHOD • Slightly Dark room (dilated pupils – can apply eye drops to help) • Ask patient to keep looking straight ahead and focus into distance • Check ophthalmoscope works and lid is open by shining onto your hand • Hold ophthalmoscope touching your eye, 30cm from patient. Put spare hand on patients head • From lateral side (holding ophthalmoscope in right hand for right eye), look into the patients eye, through the pupil • Observe red reflex – reddish-orange reflection from the eye's retina – No? – cataract, retinoblastoma?? • Move closer to eyes, focusing better using the focusing dial • Identify the optic disc (white circle / origin of all the blood vessels) and see the fundus. • Notice: – Colour size borders of optic disc – Vessels (of all quadrants) – Macula • Slightly darkened pigmented area, 2 optic disc widths from the optic disc – Fovea • Ask patient to looked directly into light, and you may see it • Do this last NORMAL FUNDUSNORMAL FUNDUS • Completely transparent retina, with no intrinsic colour. • Uniform bright red coloration from the choroid layer vessels • Optic disc: sharply defined, yellow-orange – Younger people : pale pink optic disc • Central Vein lies lateral to artery, no crossing over • Uniform diameter of vessels • Normal spontaneous venous pulse • NO arterial pulse NORMAL FUNDUSNORMAL FUNDUS AGE RELATED CHANGESAGE RELATED CHANGES • Optic disc turns pale yellow (from pink) • Fundus turns dull, and non reflective • Drusen visible – tiny yellow or white accumulations of extracellular material that build up in Bruch's membrane • Thick vascular walls > less elastic • Meandering of venules – Sclerotic changes can compress vessels ABNORMAL CHANGESABNORMAL CHANGES • Loss of transparency of retina – edema? – white/yellow • Much more reading needed. FURTHER READINGFURTHER READING • Direct & indirect ophthalmoscope • Ophthalmic history taking • Tests or visual acuity (sharpness) : Snellens letter chart 20/20 / pictogram kids • Ocular motility : 9 possible degrees of gaze • Strabismus, paralysis of ocular muscles, gaze paresis • Binocular alignment: cover test • Eyelid and nasolacrimal duct examination • Conjunctiva examination • Cornea, and corneal sensitivity • Examination of anterior chamber • Lens examination : slit lamp, focused light • Confrontational field testing • Measure intraocular pressure • Admin of eye drops, ointment, eye bandages Urethral Catheterization Diogo Forjaz Clinical Sessions Masaryk University Urethral Catheterization Is a routine medical procedure that facilitates direct drainage of the urinary bladder. Catheters may be inserted as:  an in-and-out procedure for immediate drainage,  left in with a self-retaining device for short-term drainage (eg, during surgery)  left indwelling for long-term drainage for patients with chronic urinary retention. INDICATIONS DIAGNOSTIC THERAPY DIAGNOSTIC PURPOSES: • Determine the etiology of various genitourinary condictions • Collection of urine specimen for microbiology testing • Monitoring of urine output THERAPEUTIC PURPOSES: • Acute urinary retention (eg, blood clots) • Chronic urinary retention (eg, obstruction that causes hydronephrosis and damage of kidney) • Intermittent decompression for neurogenic bladder • Hygienic care of bedridden patients • Benign prostatic hyperplasia BUT ALSO:  On patients who are anesthesized or sedated for surgery or other medical care  On comatose patients  On some incontinent patients  Post orthopedic surgery that may limit a patient's movement  On patients who are unable due to paralysis or physical injury to use either standard toilet facilities or urinals.  Sometimes before Furosemide administration CONTRAINDICATIONS ABSOLUTE traumatic injury in the lower urinary tract Signs that increase suspicion for injury are:  hematuria  perineal hematoma  blood at the meatus  High riding prostate a rectal exam, genital exam and a retrograde urethrogram should be performed to rule out prior to placing a catheter into the bladder. injection of a radiopaque dye (contrast agent) into the urethral meatus in conjunction with x-ray imaging of the pelvic area. CONTRAINDICATIONS RELATIVE Urethral stricture Recent bladder or urethral surgery Combative or uncooperative pt. EQUIPMENT Sterile drapes and gloves Antiseptic solution (povidone-iodine) Cotton balls and forceps Catheter – FOLEY Sterile lubricant Syringe with saline for balloon inflation Drainage bag Viscous Lidocaine 2% Tape to secure the catheter to patient. http://www.youtube.com/watch?v=o0DoftBJ 1ew&feature=player_embedded http://www.youtube.com/watch?v=NLJ4vwa SOCE&feature=related The maximal recommended volume for urethral balloon inflation can be found on the inflation valve (usually, 10-30 mL). Catheter Types 1) Straight tip; 2) Coude tip; 3) 3-way catheter irrigation 1) Straight tip catheter – 2 lumens: urinary drainage Inflate the balloon at distant end of catheter 2) Coudé tip catheter – 2 lumens and final semirigid curved end to facilitate in prostatic enlargement pt. 3) 3 way catheter irrigation – addition lumen for drainage for post surgery bladder and prostatic patients, for hematuria and clots prevention. CATHETER MATERIALS  Latex Silicone If the pt. is allergy/hypersensivity Silver prevent colonization of bacteria, use in recurrent urinary infections pt. CATHETER SIZES UNIT IS FRENCH 1 F is equivalent to 0.33 mm Adults: Foley (straight tip) catheter (16-18F) Adult males with obstruction at the prostate Coudé tip (18 F) Adults with gross hematuria - Foley catheter (20-24F) or 3-way irrigation catheter (20-30F) Children - Foley; to determine size, divide child's age by 2 and then add 8 Infants younger than 6 months - Feeding tube (5F) with tape COMPLICATIONS  INFECTIONS (Urethritis, Cystitis, Pyelonephritis, Transient bacteremia)  PARAPHIMOSIS (caused by failure to reduce the foreskin after catheterization)  Urethral STRICTURES  Urethral PERFORATION  BLEEDING LONG TERM COMPLICATIONS: Bladder spasm – due to inflated balloon Blood infections – sepsis Bladder stones Bladder cancer THANK YOU FOR YOUR ATTENTION Gait, Arms, Legs and Spine Examination by David Utulu  A GALS screen is an examination used by doctors and  other healthcare professionals to detect locomotors  abnormalities and functional disability relating to  gait, arms, legs and the spine Locomotors Examination  G gait  A arms  L legs  S spine  To describe a rapid screening examination of the  musculoskeletal system ‐ termed the ‘GALS’ screen  To overview how abnormal joints are assessed during  the physical examination   GALS Screen – Gait, Arms, Legs, Spine  The GALS screen aims to find out the following:  Are any of the joints abnormal?  What is the nature of the joint abnormality?  What is the extent (distribution) of the joint  involvement?  Are any other features of diagnostic importance  present? The key questions  Have you any pain or stiffness in your muscles, joints  or back?  Can you dress yourself completely without any  difficulty? (dressing involves all joints)  Can you walk up and down stairs without any  difficulty? (assesses muscle wasting) Gait  observe patient walking, turning and walking back  look for:  smoothness and symmetry of leg, pelvis and arm  movements  normal stride length  ability to turn quickly  NB: Parkinson an patients have poor arm swing  and cannot turn quickly Arms  Ask patient to stand in the anatomical position  Check normal girdle muscle bulk and symmetry  Check that elbows are straight and in full extension  Attempt to place both hands behind the head, then push elbows  back (look for glen humeral joint disease)  Examine hands palms down, with fingers straight   Observe normal suspiration and probation (check for  musculoskeletal dysfunction)  Observe normal grip (reduced grip  arthritis)  Place tip of each finger on to the tip of the thumb to assess  normal dexterity and precision grip  Squeeze across 2nd to 5th metacarpal (metacarpal ‘squeeze’ test) ‐ discomfort suggests sinusitis Legs  Observe any knee or foot deformity   Assess flexion of hip and knee, whilst supporting the  knee  Passively internally rotate each hip, in flexion  Examine each knee for presence of fluid using ‘bulge’ sign and ‘patella tap’ sign  Squeeze across the metatarsals to detect any synovitis  Inspect soles of the feet for rashes and/or callosities  (common in rheumatoid arthritis) Spine  Check par spinal and shoulder girdle muscle bulk and symmetry  Look at straightness of spine (look for scoliosis)  Check levels of iliac crest (look for hip pathology)  Look for abnormal glutei muscle bulk (look for hip pathology)  Check for political swellings (behind the knee)  Check Achilles tendons (look for ethsopathy)  Press over mid‐point of each supraspinatus and squeeze  skinfold over trapezius ‐ tenderness suggests fibromyalgia.  Note normal spine curvatures when standing, then ask patient  to bend forward and assess lumbar and hip flexion – a straight  spine and loss of lumbar flexion suggests enclosing spondylitis  Try to place ear on the shoulder each side ‐ tests lateral cervical  flexion. Joint Abnormality Active Inflammation  Detailed examination of abnormal joints:  Inspection  Swelling, redness, deformity  palpation  Warmth, crepitus, tenderness  movement  Active, passive, against resistance  Function  loss of function Inflammation of joints  Arthritis’ refers to definite inflammation of a joint(s) i.e. swelling,  tenderness,  warmth and loss of function of affected joints.  ‘Arthralgia’ refers to pain within a joint(s) without demonstrable  inflammation by physical examination. Commonly occurs with SLE  complaining of pain.  The main signs of active inflammation include: swelling, warmth, erythema,  tenderness, and loss of function of the joint.   Site of swelling  Tissue involved  Indicative of…  articular soft tissue  joint synovium or effusion  inflammatory joint disease Inflammation of joints  periarticular soft tissue  subcutaneous tissue  inflammatory joint disease  non‐articular synovial  bursa/tendon sheath  inflammation of structure  bony areas  articular ends of bone  Osteoarthritis  Enthesopathy: pathology or lesions of enthesis (the site where  ligament or tendon inserts into bone) Examples include: plantar fasciitis, Achilles tendonitis.  Irreversible Joint Damage Joint deformity  malalignment of two articulating bones  Crepitus  audible and palpable sensation resulting from movement of one  roughened surface on another   classic feature of osteoarthritis e.g. patellofemoral crepitus on  flexing the knee  Loss of joint range or abnormal movement   Dislocation: articulating surfaces are displaced and no  longer incontact  Subluxation: partial dislocation   Valgus: lower limb deformity whereby distal part is  directed away from the midline e.g. hallux valgus Joint deformity  Varus: lower limb deformity whereby distal part is directed towards the  midline e.g. varus knee with medial compartment OA  Theses may be consequence of inflammation, degenerative arthritis or  trauma:  Identified by  Painful restriction of motion in absence of features of inflammation  e.g. knee ‘locking’ due to meniscal tear or bone fragment  Instability associated with abnormal movement or abnormal range of  movement  e.g. side‐to‐side movement of tibia on femur due to ruptured collateral  knee ligaments   A spinal abnormality such as ankylosing spondylitis is a loss of the lordosis of  cervical spine and lumbar spine. This pushes the head forwards, and means  that a patient with this condition will be unable to look up. Distribution of Joint Involvement  Determine number of joints involved:  polyarthritis > 4 joints involved  oligoarthritis 2‐4 joints involved  monoarthritis single affected joint  Note if involvement is symmetrical  Note the size of the involved joints  Is there axial involvement?   Bilateral and symmetrical involvement of large and  small joints is typical of rheumatoid arthritis  Lower limb asymmetrical oligoarthritis and axial involvement would be typical of reactive arthritis  Exclusive inflammation of the distal interphalangeal joints of the fingers is highly suggestive of psoriatic  arthritis  The distribution of the polyarthritis is helpful in the differential diagnosis:  Disease  Joints involved  Joints spared  Rheumatoid arthritis  PIP, MCP, wrist, elbow, shoulder, cervical spine, hip, knee, ankle, tarsal, MTP  DIP, thoracic spine  lumbar spine  Osteoarthritis  1st CMC, DIP, PIP, cervical spine, thoracolumbar spine, hip, knee, 1st MTP, toe  IP  MCP, wrist, elbow, shoulder, ankle, tarsal joints  Polyarticular gout  1st MTP, ankle, knee  Axial  Other Diagnostically Important Features  Rheumatoid nodules: collection of normal cells including  lymphocytes, and fibroblasts that surround a center of fibrinoid necrosis  Tophi: deposit of crystallised monosodium urate in people with  longstanding hyperuricemia  Psoriasis: the characteristic skin condition may be present on  various areas of the skin – commonly the elbows. In Psoriasis,  patients commonly have nail “pitting” and also onycholysis – separation or loosening of part or all of a nail from its bed.  Malar rash: red/purple scaly rash. NEUROLOGICAL EXAMINATION SHAN KESHRI CLINICAL SESSIONS HISTORY  Presenting symptoms:  Headache  Weakness  Visual disturbance  Special senses (hearing, smell, taste etc)  Dizziness  Speech disturbance  Dysphasia  Fits, faints, involuntary movements  Tremor  Skin sensation disturbance (sensory loss) HISTORY  Cognitive State  Mini Mental State Exam  Past Medical history  Meningitis, encephalitis, trauma, seizures  Drug History  Anticonvulsant, antipsychotic, antidepressant, drugs with SE  Social & Family History  Barthel Index Score Wash hands UPPER LIMB EXAMINATION  General Inspection  Posture, asymettery, abnormal movements (fasciculation's, tremor), muscle wasting UPPER LIMB EXAMINATION  Tone:  Ask patient to relax  Passively flex and extend limb, & also pronate and supinate  Look for SPASTICITY / RIDGIDITY UPPER LIMB EXAMINATION  Power:  Resist movements as appropriate to grade power.  Test each muscle group bilaterally.  Shoulder:  “Shrug shoulders, don’t let me push down”  “Push arms out the side against me, try to pull them back in”  Elbow:  “Hold forearms up, and pull me towards you”  Finger extension:  “Hold your hand out, don’t let me push it down”  “Now don’t let me push it up”  Offer two fingers and ask patient to squeeze  Ask to spread fingers and resist you pushing them back  . UPPER LIMB EXAMINATION  Tendon Reflexes:  Compare left and right  Distract patient e.g ask them to clasp hands tight  Assess reflex as NORMAL, ABSENT, BRISK, EXAGGERATED  Biceps: C5, C6  Triceps: C7  Supinator: C6 Biceps Reflex (C5,6) Triceps Reflex (C7) Supinator Reflex (C6) UPPER LIMB EXAMINATION  Co-ordination:  Finger Nose Test:  “Touch my finger, and then your nose as fast as you can”  Look for tremor or past pointing, or missing the targets  Test for dysdiadokokinesis:  (failure to perform rapidly alternating movements)  Ask patient to repeatedly pronate and supinate hands together  Test for pronator drift:  Patients eyes closed, arms outstretched palm up.  Tap down on palm and look for failure to maintain supination  . UPPER LIMB EXAMINATION  Sensation:  Light touch  Cotton wool- check dermatomes  Pin Prick  Temperature  Hot & cold probes LOWER LIMB EXAMINATION  General Inspection  Posture, asymettery, abnormal movements (fasciculation's, tremor), muscle wasting  Deformities, Pes cavus (champagne bottle below) LOWER LIMB EXAMINATION  Tone:  Ask patient to relax  Passively flex and extend at knees and hips and ankles, & also internally and externally rotate  Hold one hand on knee and rotate it  Hold hand on back of knee and raise it quickly  Heel should lift slightly  Test for clonus (involuntary contractions)  Plantar flex foot, the quickly dorsiflex.  . LOWER LIMB EXAMINATION  Power:  Resist movements as appropriate to grade power.  Test each muscle group bilaterally.  Hip:  “Keeping your leg straight, can you lift your leg off the bed – don’t let me push it down”  “Using your leg, push my hand into the bed”  “With my hands on outer thighs, push legs out to sides”  “With my hands on inner thighs, push legs together”  Knee:  “Bend knee and bring you heel to your bottom – don’t let me pull it away”  “Now kick out against me”  Ankle:  “Bend foot down, pushing my hand down”  “Cock up your foot, point toes to ceiling, pushing my hand up” LOWER LIMB EXAMINATION  Tendon Reflexes:  Compare left and right  Distract patient e.g ask them to clasp hands tight, clench teeth  Assess reflex as NORMAL, ABSENT, BRISK, EXAGGERATED  Knee: L3,4  Ankle: L5, S1  Extensor Plantar : L5, S1, S2  Stroke sole of foot  Positive Babinski : Dorsiflexion of great toe (Fanning)  Abnormal over rage of 6m (UMN Lesion)  . Patellar Knee Reflex (L3,4) Ankle Reflex (L5, S1) Extensor Plantar Reflex (L5, S1, S2) LOWER LIMB EXAMINATION  Co-ordination:  Heel to Shin test  Put heel to shin and run heel up and down  Both sides LOWER LIMB EXAMINATION  Sensation:  Light touch  Cotton wool- check dermatomes  Pin Prick  Temperature  Hot & cold probes LOWER LIMB EXAMINATION  Gait:  Ask patient to walk a few metres, turn and walk back  Note use of walking aids, symmetery, size of pace, arm swing  Ask patient to walk heel to toe (tightrope style)  This exxagerates instabilities  Ask patient to walk on tiptoes (S1 lesion), then on heels (L4,5 lesion / foot drop)  ROMBERGS TEST:  Ask patient to stand unaided, arms by sides, then close eyes.  Sway/loss of balance is positive  posterior column disease / sensory ataxia CRANIAL NERVE EXAMAINATION CN I: Olfactory  One nostril at a time  Put non-irritating stimulus near nostril  Peppermint, lavender, coffee  Detection of smell is more important than identification CN II: Optic  One eye at a time, Cover the other  Visual Acuity  Snellen Chart / pictogram  Visual fields:  Central  Face to face  Tell patient stare at your nose  Wiggle finger left and right, up and down  Ask patient as you move can they see it  Compare your field with patients  Peripheral  Face to face  Tell patient to cover one eye  You cover same side eye  http://www.youtube.com/watch?v=mtdBGOvj-No CN II: Optic CN III, IV, V Nystagmus? CN V  Sensory  Cotton bud – close eyes, ask patient say where is the touch felt  Forehead (opthalmic), cheek (maxillary), chin (mandibular)  Motor  Open mouth against resistance CN VII  Raise eyebrows, smile, puff cheeks  Muscles of facial expression! CN VIII  Eyes closed  Rub fingers near ear  Say which side!  Webers, rhines test – tuning fork CN IX  Gag reflex  Touch back of palate with spatula  Wretch CN X  Say “ahhhhhh” with mouth open and look with torch  Palate and uvula rise  Cough  Gag reflex CN XI  Turn head against resistance  Shrug shoulders against resistance CN XII  Tongue protrusion (deviates to side of lesion?) FURTHER READING • Mingazinni • Barres reflex • Speech & higher mental function – aphasia (Broca, wernickes) • UMN signs • LMN signs • Pyramidal signs • Lassegues sign (and reverse) Chest DrainsChest Drains DevangnaDevangna BhatiaBhatia Anatomy reviewAnatomy review How to remember the order  at the hilum: Right Lung: Bronchiole Artery Vein Left Lung: Artery Bronchiole Vein INDICATIONSINDICATIONS  PneumothoraxPneumothorax  Pleural effusion (accumulation of fluid in the pleuralPleural effusion (accumulation of fluid in the pleural space):space):  MalignantMalignant  ComplicatedComplicated parapneumonicparapneumonic  TraumaticTraumatic haemopneumothoraxhaemopneumothorax  ChylothoraxChylothorax: a collection of lymphatic fluid in the pleural: a collection of lymphatic fluid in the pleural spacespace  EmpyemaEmpyema: a: a pyogenicpyogenic infection of the pleural spaceinfection of the pleural space  HemothoraxHemothorax: accumulation of blood in the pleural space: accumulation of blood in the pleural space  Hydrothorax: accumulation of serous fluid in the pleuralHydrothorax: accumulation of serous fluid in the pleural spacespace  PostoperativePostoperative——Prevention of hydrothorax afterPrevention of hydrothorax after cardiothoracic surgerycardiothoracic surgery PneumothoraxPneumothorax Definition:Definition:  presence of air within the pleural spacepresence of air within the pleural space Classification:Classification:  Spontaneous (not caused by trauma)Spontaneous (not caused by trauma)  TraumaticTraumatic  IatrogenicIatrogenic Depending on the size:Depending on the size:  SmallSmall  LargeLarge presence of a visible rim of <2 cm or >2cm  between the lung margin and the chest wall Spontaneous (not caused by trauma)Spontaneous (not caused by trauma)  PrimaryPrimary (PSP)(PSP) -- occurring in persons without clinically oroccurring in persons without clinically or radiologicallyradiologically apparent lung diseaseapparent lung disease  DueDue subpleuralsubpleural bullaebullae  Familial (genetics)Familial (genetics)  Cigarette smoking increases the risk of PSPCigarette smoking increases the risk of PSP Clinical Signs:Clinical Signs:  90% of PSP occur while the patient is at90% of PSP occur while the patient is at restrest  Main symptoms areMain symptoms are chest painchest pain oror dyspnoeadyspnoea either alone or ineither alone or in combination. Chest pain is more prominent and can be alone incombination. Chest pain is more prominent and can be alone in 69%69%  Symptoms usually resolve within 24 hours, even if theSymptoms usually resolve within 24 hours, even if the pneumothoraxpneumothorax remains untreated and does not resolveremains untreated and does not resolve Spontaneous (not caused by trauma)Spontaneous (not caused by trauma)  Secondary (SSP)Secondary (SSP)-- in which lung disease is present andin which lung disease is present and apparentapparent  Diseases of the airways: COPD, cystic fibrosis, and statusDiseases of the airways: COPD, cystic fibrosis, and status asthmaticusasthmaticus  Interstitial lung diseases:Interstitial lung diseases: LangerhansLangerhans cellcell histiocytosishistiocytosis,, sarcoidosissarcoidosis,, lymphangioleiomyomatosislymphangioleiomyomatosis, tuberous sclerosis,, tuberous sclerosis, rheumatoid disease, idiopathic pulmonary fibrosis, and radiationrheumatoid disease, idiopathic pulmonary fibrosis, and radiation fibrosisfibrosis  Infectious diseases: Necrotizing gramInfectious diseases: Necrotizing gram--negative pneumonia,negative pneumonia, anaerobic pneumonia, staphylococcal pneumonia, AIDS withanaerobic pneumonia, staphylococcal pneumonia, AIDS with PP jirovecijiroveci pneumonia, andpneumonia, and Mycobacterium tuberculosisMycobacterium tuberculosis  Malignancies: Sarcoma, lung cancerMalignancies: Sarcoma, lung cancer  Pneumoconiosis:Pneumoconiosis: SilicoproteinosisSilicoproteinosis,, berylliosisberylliosis, and bauxite, and bauxite pneumoconiosispneumoconiosis Clinical Signs:Clinical Signs:  Occurs duringOccurs during acute exacerbationacute exacerbation. Should be. Should be suspected if the patient fails to respond to currentsuspected if the patient fails to respond to current treatment.treatment.  DyspnoeaDyspnoea is more prominent than PSPis more prominent than PSP  Chest painChest pain is less common but more severe thanis less common but more severe than in PSPin PSP  Symptoms of SSP donSymptoms of SSP don’’t resolve spontaneouslyt resolve spontaneously TraumaticTraumatic  Direct communication of the pleural spaceDirect communication of the pleural space with the atmospherewith the atmosphere  penetrating injurypenetrating injury  Disruption of the proximalDisruption of the proximal tracheobronchialtracheobronchial tree or visceral pleuratree or visceral pleura blunt chest traumablunt chest trauma PA chest film demonstrates a right upper lobe mass  abutting the pleural surface with associated metallic  bullet fragments. PneumothoraxPneumothorax: Signs: Signs  Maybe minimal in smallMaybe minimal in small pneumothoraxpneumothorax or in SSP.or in SSP.  Decreased movement of the chest wallDecreased movement of the chest wall  HyperresonantHyperresonant percussion note with diminished tactilepercussion note with diminished tactile focalfocal fremitusfremitus (palpable vibration) and resonance(palpable vibration) and resonance  Decreased or absent breath sounds on the affectedDecreased or absent breath sounds on the affected side.side.  HaemodynamicHaemodynamic instability (tachycardia, hypotension,instability (tachycardia, hypotension, and cyanosis) suggests tensionand cyanosis) suggests tension pneumothoraxpneumothorax.. PneumothoraxPneumothorax: Radiology: Radiology CT scan (which is very sensitive) should be obtainedCT scan (which is very sensitive) should be obtained if aif a pneumothoraxpneumothorax is suspected in case of :is suspected in case of :  CXR of patient in a supine position and does notCXR of patient in a supine position and does not demonstrate ademonstrate a pneumothoraxpneumothorax OROR  It can not be differentiated fromIt can not be differentiated from bullousbullous diseasedisease CONTRA-INDICATIONS • Coagulopathy • Small, stable pneumothorax (may spontaneously  resolve) • Empyema (collection of pus) caused by acid‐fast  organisms • Fluid accumulation in small cavities (loculated fluid accum.) COMPLICATIONSCOMPLICATIONS Minor complications:Minor complications:  subcutaneoussubcutaneous hematomahematoma oror seromaseroma  anxietyanxiety  shortness of breath (dyspnoea)shortness of breath (dyspnoea)  cough (after removing large volume of fluid)cough (after removing large volume of fluid) Others:Others:  HaemorrhageHaemorrhage  InfectionInfection  ReRe--expansion pulmonary oedema.expansion pulmonary oedema.  Chest tube cloggingChest tube clogging  Injury to the liver, spleen or diaphragm is possible if the tubeInjury to the liver, spleen or diaphragm is possible if the tube isis placed inferior to the pleural cavity.placed inferior to the pleural cavity.  Injuries to the thoracic aorta and heartInjuries to the thoracic aorta and heart EQUIPMENTEQUIPMENT Drapes An assistant Sterile gloves Suture kit Dressing pack Gauze pads Scalpel 1% or 2% lidocaine 2/0 silk suture on curved needle 10‐ml syringe 21‐gauge (green) needles 27‐gauge (orange) needles Cleaning agent (e.g., iodine or  chlorhexidine) Chest drain Chest drain bag (for pleural effusion) or  water‐tight bottle containing some normal  saline or sterile water (for pneumothorax) TECHNIQUETECHNIQUE –– in shortin short  Is drain really necessary?Is drain really necessary?  Consent patientConsent patient  Decide what size drain is neededDecide what size drain is needed  Review imagingReview imaging  Make sure the tray has everything you needMake sure the tray has everything you need  Sterile techniqueSterile technique  Have an assistantHave an assistant  Chest xChest x--ray after insertionray after insertion TECHNIQUETECHNIQUE -- detaileddetailed  Make sure it is the correct patient and them tell them what youMake sure it is the correct patient and them tell them what you are going to do.are going to do.  Wash your hands and put drapes on.Wash your hands and put drapes on.  Confirm the position of theConfirm the position of the pneumothoraxpneumothorax/effusion clinically and also with a/effusion clinically and also with a chest xchest x--ray.ray.  Sit the patient upright, legs over the side of bed, leaning overSit the patient upright, legs over the side of bed, leaning over a high table soa high table so the arms are up, the back is straight, and you have access to ththe arms are up, the back is straight, and you have access to the affected sidee affected side of the chest. In an unwell patient, you might have to perform thof the chest. In an unwell patient, you might have to perform this with theis with the patient sitting at a 45patient sitting at a 45°° angle.angle.  Prepare the underwater sealPrepare the underwater seal –– fill a bottle onefill a bottle one--third full with sterile water. Thethird full with sterile water. The end of the tube should be 2end of the tube should be 2––3 cm into the water.3 cm into the water.  Choose the chest drain; tailor it to the patient by looking at hChoose the chest drain; tailor it to the patient by looking at how much rib spaceow much rib space is available. Some chest physicians prefer larger drains, particis available. Some chest physicians prefer larger drains, particularly for effusionsularly for effusions andand empyemasempyemas –– as a guide, 24F is suitable for aas a guide, 24F is suitable for a pneumothoraxpneumothorax; use 28; use 28––32F32F for effusions andfor effusions and empyemasempyemas..  Put on your gloves and prepare your cart so that all of the itemPut on your gloves and prepare your cart so that all of the items are within easys are within easy reach.reach.  Clean the patient's skin withClean the patient's skin with chlorhexidinechlorhexidine or iodine and perform pleuralor iodine and perform pleural aspiration in the midaspiration in the mid--axillaryaxillary line at the 4thline at the 4th––5th5th intercostalintercostal space; aim above thespace; aim above the rib.rib.  When pleural fluid has been located, insert more localWhen pleural fluid has been located, insert more local anestheticanesthetic: Be generous: Be generous –– use up to 15 ml in the area around the aspiration site. Some pause up to 15 ml in the area around the aspiration site. Some patients mighttients might find this uncomfortable, so you can give a small dose offind this uncomfortable, so you can give a small dose of diamorphinediamorphine IV with 10IV with 10 mgmg metoclopramidemetoclopramide IV.IV.  Make a 1Make a 1––2 cm incision with the scalpel in line with the ribs, remaining2 cm incision with the scalpel in line with the ribs, remaining justjust above the lower rib. When you are through the skin and into theabove the lower rib. When you are through the skin and into the subcutaneoussubcutaneous fat, bluntfat, blunt--dissect down with forceps. Continue until you reach the pleura.dissect down with forceps. Continue until you reach the pleura. ThisThis can be painful, so have remaining localcan be painful, so have remaining local anestheticanesthetic available and inject intoavailable and inject into pleura if necessary.pleura if necessary.  Take the introducer out of the chest drain, so only the tubing rTake the introducer out of the chest drain, so only the tubing remains. After youemains. After you have blunthave blunt--dissected the pleura and fluid or air begins to escape, insert tdissected the pleura and fluid or air begins to escape, insert thehe drain into the hole. It should enter the pleural cavity easily,drain into the hole. It should enter the pleural cavity easily, but keep a fingerbut keep a finger over the end of the drain until it is connected to the bag or unover the end of the drain until it is connected to the bag or underwater seal.derwater seal.  Place a 1Place a 1--mattress suture on either side of the drain and pull taut. Placemattress suture on either side of the drain and pull taut. Place anotheranother suture in the middle of incision around the drain. Tie the two ssuture in the middle of incision around the drain. Tie the two side sutures, soide sutures, so the skin is pulled tight, then secure around the drain by coilinthe skin is pulled tight, then secure around the drain by coiling around severalg around several times. Leave the central suture free, to be tied when the draintimes. Leave the central suture free, to be tied when the drain is removed.is removed.  Place pads of gauze around drain and secure with dressing. SecurPlace pads of gauze around drain and secure with dressing. Secure the proximale the proximal part of the drain to the patient with tape.part of the drain to the patient with tape.  Ensure that the drain is draining/bubbling freely. Get a postEnsure that the drain is draining/bubbling freely. Get a post--procedure chest xprocedure chest x-- ray to review the position.ray to review the position.  http://http://www.youtube.com/watch?vwww.youtube.com/watch?v=tSXQ7GR35E4=tSXQ7GR35E4  http://http://en.wikipedia.org/wiki/Seldinger_techniqueen.wikipedia.org/wiki/Seldinger_technique SITE OFSITE OF INSERTIONINSERTION Pectoralis major Superior Line to the horizontal level of the nipple Latissimus dorsi Semi‐recumbent ‐ “Safe triangle” Triangle  bordered  by  the  anterior  border  of  the  latissimus dorsi, the lateral border of the pectoralis major muscle, a line superior to the horizontal level  of the nipple, and an apex below the axilla BE CAREFUL AS TO AVOID:BE CAREFUL AS TO AVOID:  Internal mammary arteryInternal mammary artery  IntraIntra--abdominal insertionabdominal insertion  Damage to muscleDamage to muscle  Damage to breast tissueDamage to breast tissue  UnsightlyUnsightly scarringscarring REMOVALREMOVAL Explain the procedure to the patient Remove dressing and stay sutures. Cover the site of tube entry with sterile gauge. While patient performs Valsalva manoeuvre,  remove the drain with a swift action and cover  the wound with the gauge. Place a dressing on  the gauze. Thank You!Thank You! ECG {Electrocardiogram} by David Utulu Introduction The Heart • The heart consists of four  chambers – The right atrium and right  ventricle: responsible for  delivery of deoxygenated  blood to lungs – The left atrium and left  ventricle: responsible for  delivery of oxygenated blood  to the body The Heart: Phases  There are two phases of the cardiac cycle  Systole: The ventricles are full of blood and begin to  contract.  The mitral and tricucuspid valves close  (between atria and ventricles).  Blood is ejected through  the pulmonic and aortic valves.  Diastole: Blood flows into the atria and through the open  mitral and tricuspid valves into the ventricles. ECG The ECG records the electrical signal of the heart as the  muscle cells depolarize (contract) and repolarize. Normally, the SA Node generates the initial electrical  impulse and begins the cascade of events that results in a  heart beat. Recall that cells resting have a negative charge with  respect to exterior and depolarization consists of positive  ions rushing into the cell Cell Depolarization • Flow of sodium ions into cell during activation Depol Repol. Restoration of ionic balance ECG Leads• In 1908, Willem Einthoven developed a system capable of  recording these small signals  and recorded the first ECG. • The leads were based on the  Einthoven triangle associated  with the limb leads. • Leads put heart in the middle  of a triangle ECG Leads  The basic values  The lead values Also note that by KVL: VI + VIII = VII ECG: Electric Signal • Assumptions – Model cardiac source as a dipole producing an electric  heart vector, p. – Model body as an infinite, homogeneous volume  conductor  • The leads will pick up the projection of the electric heart  vector, p, along the lead Propagating Activation  Wavefront • When the cells are at rest, they have a negative  transmembrane voltage – surrounding media is positive • When the cells depolarize, they switch to a positive  transmembrane voltage – surrounding media becomes  negative • This leads to a propagating electric vector (pointing from  negative to positive) Propagating Activation Wavefront • When the activation does not align directly with the lead  (or propagate directly toward and electrode), the signal is  proportional to component of the activation direction  along the lead direction. ECG Signal • Heart behaves as a syncytium: a  propagating wave that once  initiated continues to propagate  uniformly into the region that is  still at rest. • The depolarization wavefront defines a dividing line between  activated and resting cells.  • Elsewhere, the signal is zero • Will propagate along conduction  paths – sinus node – AV node – bundle branches – Purkinjie fibers ECG Signal • The excitation begins at the  sinus (SA) node and spreads  along the atrial walls • The resultant electric vector is  shown in yellow • Cannot propagate across the  boundary between atria and  ventricle • The projections on Leads I, II  and III are all positive Normal ECG Signal • P – atrial depolarization • QRS complex – ventricular  depolarization • T – ventricular  repolarization Augmented Leads • Three additional limb leads are also used: aVR, aVL, and  aVF • These are unipolar leads • Each lead uses the average of the average of the other  two leads as reference – VR = ΦR – (ΦL + ΦF)/2 Precordial Leads • Measure potentials close to the heart, V1‐ V6 • Unipolar leads ECG Information  • The 12 leads allow  tracing of electric vector  in all three planes of  interest • Not all the leads are  independent, but are  recorded for redundant  information ECG Diagnosis • The trajectory of the  electric vector resulting  from the propagating  activation wavefront can be  traced by the ECG and used  to diagnose cardiac  problems Electric Axis of the Heart This axis changes during cardiac cycle as shown  earlier – generally lies between +30º and ‐110º in the  frontal plane and +30º and ‐30º in the transverse  plane Clinically, it is generally taken where the QRS  complex has the largest positive deflection Note: Often use –aVR Deviation to R: increased activity in R vent. – obstruction in lung, pulmonary emboli, some heart  disease Deviation to L: increased activity in L vent. – hypertension, aortic stenosis, ischemic heart disease NORMAL SINUS RHYTHM Impuses originate at S-A node at normal rate SINUS TACHYCARDIA Impuses originate at S-A node at rapid rate All complexes normal, evenly spaced Rate > 100/min SINUS TACHYCARDIA Impuses originate at S-A node at rapid rate All complexes normal, rhythm is irregular Longest R-R interval exceeds shirtest > 0.16 s ATRIAL FLUTTER Impulses travel in circular course in atria – No interval between T and P Rapid flutter waves, ventricular response irregular ATRIAL FIBRILLATION Impuses have chaotic, random pathways in atria Baseline irregular, ventricular response irregular PREMATURE VENTRICULAR CONTRACTION A single impulse originates at right ventricle Time interval between normal R peaks is a multiple of R-R intervals VENTRICULAR TACHYCARDIA Impulse originate at ventricular pacemaker – odd/wide QRS complex - often due to myocardial infarction Wide ventricular complexes Rate> 120/min VENTRICULAR FIBRILLATION Chaotic ventricular depolarization – ineffective at pumping blood – death within minutes Rapid, wide, irregular ventricular complexes PACER RHYTHM Impulses originate at transvenous pacemaker Wide ventricular complexes preceded by pacemaker spike Rate is the pacer rhythm A-V BLOCK, FIRST DEGREE Atrio-ventricular conduction lengthened P-wave precedes each QRS-complex but PR-interval is > 0.2 s A-V BLOCK, SECOND DEGREE Sudden dropped QRS-complex Intermittently skipped ventricular beat RIGHT BUNDLE-BRANCH BLOCK QRS duration greater than 0.12 s Wide S wave in leads I, V5 and V6 RIGHT ATRIAL HYPERTROPHY Tall, peaked P wave in leads I and II LEFT ATRIAL HYPERTROPHY Wide, notched P wave in lead II Diphasic P wave in V1 LEFT VENTRICULAR HYPERTROPHY Large S wave in leads V1 and V2 Large R wave in leads V6 and V6 Myocardial Ischemia and Infarction • Oxygen depletion to heart can  cause an oxygen debt in the  muscle (ischemia) • If oxygen supply stops, the  heart muscle dies (infarction) • The infarct area is electrically  silent and represents an  inward facing electric  vector…can locate with ECG  The normal electrocardiogram (ECG) pattern consists  of a P wave, a QRS complex, and a T wave (A). The  portion of the ECG between the QRS complex and the  T wave is called the ST segment. In patients who have  an ST elevation most probably have myocardial  infarction (MI), the ST segment is elevated above the  baseline (B). In patients who have a non‐ST elevation  MI, the ST segment is not elevated, and instead other  patterns are seen (for example, ST depression) (C).  Thank you for your attention Pulmonary Function Tests Dave Utulu Objectives • Review basic pulmonary anatomy and physiology. • Understand the reasons pulmonary function tests (PFTs) are performed. • Understand the technique and basic interpretation of spirometry. • Know the difference between obstructive and restrictive lung disease. • Know how PFTs are clinically applied. Before you can proceed, you need to know a little about the lungs… What do the lungs do? • Primary function is gas exchange • Let oxygen move in • Let carbon dioxide move out How do the lungs do this? • First, air has to move to the region where gas exchange occurs. • For this, you need a normal ribcage and respiratory muscles that work properly (among other things). Conducting Airways • Air travels via laminar flow through the conducting airways comprised of the following: trachea, lobar bronchi, segmental bronchi, subsegmental bronchi, small bronchi, bronchioles, and terminal bronchioles. How do the lungs do this? (cont) • The airways then branch further to become transitional/respiratory bronchioles. • The transitional/respiratory zones are made up of respiratory bronchioles, alveolar ducts, and alveoli. How do the lungs do this? (cont) • Gas exchange takes place in the acinus. • This is defined as an anatomical unit of the lung made of structures supplied by a terminal bronchiole. From Netter Atlas of Human Anatomy, 1989 How does gas exchange occur? • Numerous capillaries are wrapped around alveoli. • Gas diffuses across this alveolar-capillary barrier. • This barrier is as thin as 0.3 μm in some places and has a surface area of 50-100 square meters! Gas Exchange What exactly are PFTs? • The term encompasses a wide variety of objective methods to assess lung function. (Remember that the primary function is gas exchange). • Examples include: – Spirometry – Lung volumes by helium dilution or body plethysmography – Blood gases – Exercise tests – Diffusing capacity – Bronchial challenge testing – Pulse oximetry Why do I care about PFTs? • Add to diagnosis of disease (pulmonary and cardiac) • May help guide management of a disease process • Can help monitor progression of disease and effectiveness of treatment • Aid in pre-operative assessment of certain patients Yes, PFTs are really wonderful but… • They do not act alone. • They act only to support or exclude a diagnosis. • A combination of a thorough history and physical exam, as well as supporting laboratory data and imaging will help establish a diagnosis. Where would I perform PFTs? • At home--peak expiratory flow meter/pulse ox • Doctor’s office • Formal PFT laboratory When would I order PFTs? • INDICATIONS FOR SPIROMETRY • Diagnostic • To evaluate symptoms, signs, or abnormal laboratory tests • -Symptoms: dyspnea, wheezing, orthopnea, cough, phlegm production, • chest pain • -Signs: diminished breath sounds, overinflation, expiratory slowing, • cyanosis, chest deformity, unexplained crackles • -Abnormal laboratory tests: hypoxemia, hypercapnia, polycythemia, • abnormal chest radiographs • To measure the effect of disease on pulmonary function • To screen individuals at risk of having pulmonary diseases • -Smokers • -Individuals in occupations with exposures to injurious substances • -Some routine physical examinations • To assess preoperative risk • To assess prognosis (lung transplant, etc.) • To assess health status before enrollment in strenuous physical activity • programs • Monitoring • To assess therapeutic interventions • -bronchodilator therapy • -Steroid treatment for asthma, interstitial lung disease, etc. • -Management of congestive heart failure • -Other (antibiotics in cystic fibrosis, etc.) • To describe the course of diseases affecting lung function • -Pulmonary diseases • Obstructive airways diseases • Interstitial lung diseases • -Cardiac diseases • Congestive heart failure • -Neuromuscular diseases • Guillain-Barre Syndrome • To monitor persons in occupations with exposure to injurious agents • To monitor for adverse reactions to drugs with known pulmonary toxicity (From ATS, 1994) When would I order PFTs (cont)? • Disability/Impairment Evaluations • To assess patients as part of a rehabilitation program • -Medical • -Industrial • -Vocational • To assess risks as part of an insurance evaluation • To assess individuals for legal reasons • -Social Security or other government compensation programs • -Personal injury lawsuits • -Others • Public Health • Epidemiologic surveys • -Comparison of health status of populations living in different • environments • -Validation of subjective complaints in occupational/environmental • settings • Derivation of reference equations (From ATS, 1994) Spirometry Spirometry is a medical test that measures the volume of air an individual inhales or exhales as a function of time. A Brief Aside on History • John Hutchinson (1811-1861)—inventor of the spirometer and originator of the term vital capacity (VC). • Original spirometer consisted of a calibrated bell turned upside down in water. • Observed that VC was directly related to height and inversely related to age. • Observations based on living and deceased subjects. A Brief Aside on History • Hutchinson thought it could apply to life insurance predictors. • Not really used much during his time. • Hutchinson moved to Australia and did not pursue any other work on spirometry. • Eventually ended up in Fiji and died (possibly of murder.) Silhouette of Hutchinson Performing Spirometry From Chest, 2002 Lung Volumes • Tidal Volume (TV): volume of air inhaled or exhaled with each breath during quiet breathing • Inspiratory Reserve Volume (IRV): maximum volume of air inhaled from the endinspiratory tidal position • Expiratory Reserve Volume (ERV): maximum volume of air that can be exhaled from resting end-expiratory tidal position Lung Volumes • Residual Volume (RV): – Volume of air remaining in lungs after maximium exhalation – Indirectly measured (FRC-ERV) not by spirometry Lung Capacities (cont.) • Functional Residual Capacity (FRC): – Sum of RV and ERV or the volume of air in the lungs at end-expiratory tidal position – Measured with multiplebreath closed-circuit helium dilution, multiple-breath open-circuit nitrogen washout, or body plethysmography (not by spirometry) What information does a spirometer yield? • A spirometer can be used to measure the following: – FVC and its derivatives (such as FEV1, FEF 25-75%) – Forced inspiratory vital capacity (FIVC) – Peak expiratory flow rate – Maximum voluntary ventilation (MVV) – Slow VC – IC, IRV, and ERV – Pre and post bronchodilator studies Forced Expiratory Vital Capacity • The volume exhaled after a subject inhales maximally then exhales as fast and hard as possible. • Approximates vital capacity during slow expiration, except may be lower (than true VC) patients with obstructive disease How is this done? Performance of FVC maneuver • Check spirometer calibration. • Explain test. • Prepare patient. – Ask about smoking, recent illness, medication use, etc. (adapted from ATS, 1994) Performance of FVC maneuver (continued) • Give instructions and demonstrate: – Show nose clip and mouthpiece. – Demonstrate position of head with chin slightly elevated and neck somewhat extended. – Inhale as much as possible, put mouthpiece in mouth (open circuit), exhale as hard and fast as possible. – Give simple instructions. (adapted from ATS, 1994) Performance of FVC maneuver (continued) • Patient performs the maneuver – Patient assumes the position – Puts nose clip on – Inhales maximally – Puts mouthpiece on mouth and closes lips around mouthpiece (open circuit) – Exhales as hard and fast and long as possible – Repeat instructions if necessary –be an effective coach – Repeat minimum of three times (check for reproducibility.) (adapted from ATS, 1994) Special Considerations in Pediatric Patients • Ability to perform spirometry dependent on developmental age of child, personality, and interest of the child. • Patients need a calm, relaxed environment and good coaching. Patience is key. • Even with the best of environments and coaching, a child may not be able to perform spirometry. (And that is OK.) Flow-Volume Curves and Spirograms • Two ways to record results of FVC maneuver: – Flow-volume curve---flow meter measures flow rate in L/s upon exhalation; flow plotted as function of volume – Classic spirogram---volume as a function of time Normal Flow-Volume Curve and Spirogram Spirometry Interpretation: So what constitutes normal? • Normal values vary and depend on: – Height – Age – Gender – Ethnicity Acceptable and Unacceptable Spirograms (from ATS, 1994) Measurements Obtained from the FVC Curve • FEV1---the volume exhaled during the first second of the FVC maneuver • FEF 25-75%---the mean expiratory flow during the middle half of the FVC maneuver; reflects flow through the small (<2 mm in diameter) airways • FEV1/FVC---the ratio of FEV1 to FVC X 100 (expressed as a percent); an important value because a reduction of this ratio from expected values is specific for obstructive rather than restrictive diseases Spirometry Interpretation: Obstructive vs. Restrictive Defect • Obstructive Disorders – Characterized by a limitation of expiratory airflow so that airways cannot empty as rapidly compared to normal (such as through narrowed airways from bronchospasm, inflammation, etc.) Examples: – Asthma – Emphysema – Cystic Fibrosis • Restrictive Disorders – Characterized by reduced lung volumes/decreased lung compliance Examples: – Interstitial Fibrosis – Scoliosis – Obesity – Lung Resection – Neuromuscular diseases – Cystic Fibrosis Normal vs. Obstructive vs. Restrictive (Hyatt, 2003) Spirometry Interpretation: Obstructive vs. Restrictive Defect • Obstructive Disorders – FVC nl or↓ – FEV1 ↓ – FEF25-75% ↓ – FEV1/FVC ↓ – TLC nl or ↑ • Restrictive Disorders – FVC ↓ – FEV1 ↓ – FEF 25-75% nl to ↓ – FEV1/FVC nl to ↑ – TLC ↓ Spirometry Interpretation: What do the numbers mean? • FVC • Interpretation of % predicted: – 80-120% Normal – 70-79% Mild reduction – 50%-69% Moderate reduction – <50% Severe reduction FEV1 Interpretation of % predicted: – >75% Normal – 60%-75% Mild obstruction – 50-59% Moderate obstruction – <49% Severe obstruction • <25 y.o. add 5% and >60 y.o. subtract 5 Spirometry Interpretation: What do the numbers mean? • FEF 25-75% • Interpretation of % predicted: – >79% Normal – 60-79%Mild obstruction – 40-59%Moderate obstruction – <40% Severe obstruction • FEV1/FVC • Interpretation of absolute value: – 80 or higher Normal – 79 or lower Abnormal What about lung volumes and obstructive and restrictive disease? (From Ruppel, 2003) Maximal Inspiratory Flow • Do FVC maneuver and then inhale as rapidly and as much as able. • This makes an inspiratory curve. • The expiratory and inspiratory flow volume curves put together make a flow volume loop. Flow-Volume Loops (Rudolph and Rudolph, 2003) How is a flow-volume loop helpful? • Helpful in evaluation of air flow limitation on inspiration and expiration • In addition to obstructive and restrictive patterns, flowvolume loops can show provide information on upper airway obstruction: – Fixed obstruction: constant airflow limitation on inspiration and expiration—such as in tumor, tracheal stenosis – Variable extrathoracic obstruction: limitation of inspiratory flow, flattened inspiratory loop—such as in vocal cord dysfunction – Variable intrathoracic obstruction: flattening of expiratory limb; as in malignancy or tracheomalacia Spirometry Pre and Post Bronchodilator • Obtain a flow-volume loop. • Administer a bronchodilator. • Obtain the flow-volume loop again a minimum of 15 minutes after administration of the bronchodilator. • Calculate percent change (FEV1 most commonly used---so % change FEV 1= [(FEV1 Post-FEV1 Pre)/FEV1 Pre] X 100). • Reversibility is with 12% or greater change. Case #1 Case #2 Case #3 Case #4 If you see a patient with cough and symptoms of breathing problems connected to airways and lungs,then this presentation will be very useful. Thanks a lot for your time... Goodluck everyone!!! Take home message... Points of Discussion:  Revising Anatomy Structures  What is intubation?  What is the purpose of intubation?  Is there more than one type of intubation?  How´s the correct technique?  What kind of instruments are used?  What are the main complications of intubation?  Laryngeal Masks Anatomy Mallampati Classification Definitions Endotracheal intubation is a procedure by which a tube is inserted through the mouth down into the trachea (the large airway from the mouth to the lungs). Before surgery, this is often done under deep sedation. In emergency situations, the patient is often unconscious at the time of this procedure. Main Goal / Purpose of Endotracheal Intubation  The endotracheal tube serves as an open passage through the upper airway.  The purpose of endotracheal intubation is to permit air to pass freely to and from the lungs in order to ventilate the lungs.  Endotracheal tubes can be connected to ventilator machines to provide artificial respiration. This can help when a patient is unconscious and by maintaining a patent airway, especially during surgery.  It is often used when patients are critically ill and cannot maintain adequate respiratory function to meet their needs. How do i decide to Intubate? – Indications - 1. Inadequate oxygenation (decreased arterial PO2, etc.) that is not corrected by supplemental oxygen supplied by mask 2. Inadequate ventilation (increased arterial PCO2) 3. Need to control and remove pulmonary secretions (bronchial toilet) 4. Need to provide airway protection in a patient with a depressed gag reflex (for example during a general anesthesia). Do not Intubate... – Contraindications - 1. Severe airway trauma or obstruction that does not permit safe passage of an endotracheal tube. 2. Cervical spine injury, in which the need for complete immobilization of the cervical spine makes endotracheal intubation difficult. Preparing the Procedure Essentials that must be present to ensure a safe intubation. They can be remembered by the mnemonic SALT  Suction. This is extremely important. Often patients will have material in the pharynx, making visualization of the vocal cords difficult.  Airway. the oral airway is a device that lifts the tongue off the posterior pharynx, often making it easier to mask ventilate a patient. The inability to ventilate a patient is bad. Also a source of O2 with a delivery mechanism (ambu-bag and mask) must be available.  LLaryngoscopearyngoscope. This lighted tool is vital to placing an endotracheal tube.  TTubeube. Endotracheal tubes come in many sizes. In the average adult a size 7.0 or 8.0 oral endotracheal tube will work just fine. Instruments used... 1. Self-refilling bag-valve combination (eg, Ambu bag) or bag-valve unit (Ayres bag), connector, tubing, and oxygen source. Assemble all items before attempting intubation. 2. Laryngoscope with curved (Macintosh type) and straight (Miller type) blades of a size appropriate for the patient. 3. Endotracheal tubes of several different sizes. Low-pressure, high-flow cuffed balloons are preferred. 5. Tincture of benzoin and precut tape. 6. Introducer (stylets or Magill forceps). 7. Suction apparatus (tonsil tip and catheter suction). 8. Syringe, 10-mL, to inflate the cuff. 9. Mucosal anesthetics (eg, 2% lidocaine) 10. Water-soluble sterile lubricant. 11. Gloves. Instruments used... (II) TECHNIQUE Topical Anesthesia: Anesthetize the mucosa of the oropharynx, and upper airway with lidocaine 2%, if time permits and the patient is awake. Direct Laryngoscopy: 1. Place the patient in the sniffing position. 2. Check the laryngoscope and blade for proper fit, and make sure that the light works. 3. Make sure that all materials are assembled and close at hand. MADgicWand™ Mucosal Atomization Device for atomizing topical solutions. With 5mL syringe a) Open the patient's mouth with the right hand, and remove any dentures. b) Grasp the laryngoscope in the left hand c) Spread the patient's lips, and insert the blade between the teeth, being careful not to break a tooth. d) Pass the blade to the right of the tongue, and advance the blade into the hypopharynx, pushing the tongue to the left. e) Lift the laryngoscope upward and forward, without changing the angle of the blade, to expose the vocal cords. Curved blade technique f) The anesthesiologist then takes the endotracheal tube, made of flexible plastic, in the right hand and starts inserting it through the mouth opening. g) The tube is inserted through the cords to the point that the cuff rests just below the cords h) Finally, the cuff is inflated to provide a minimal leak when the bag is squeezed Using a stethoscope , the anesthesiologist listens for breathing sounds to ensure correct placement of the tube Document the view of the larynx obtained during laryngoscopy using the following criteria: Grade I: full view of the cords Grade II: partial view of the cords Grade III: view of the epiglottis Grade IV: No view of the cords or epiglottis http://www.youtube.com/watch?v=eRkleyIJi9U Curved blade technique (II) Straight blade technique Follow the steps outlined for curved blade technique, but advance the blade down the hypopharynx, and lift the epiglottis with the tip of the blade to expose the vocal cords. The tip of the laryngoscope blade fits below the epiglottis, which is no longer visible with the blade in position. Complications 1. Tube malpositioning (esophageal intubation ) 2. Tube malfunction or physiologic responses to airway instrumentation 3. Trauma such as tooth damage, lip/tongue/mucosal laceration, sore throat, dislocated mandible 4. Mucosal inflammation and ulceration and excoriation of nose can occur while the tube is in place 5. Laryngeal malfunction and aspiration, glottic, subglottic or tracheal edema and stenosis, vocal cord granuloma or paralysis during extubation Physiologic responses to intubation include hypertension, tachycardia, intracranial hypertension, and laryngospasm Laryngeal Masks (LMA) The Laryngeal Mask Airway is an alternative airway device used for anesthesia and airway support.  They cause less pain and coughing than an endotracheal tube, and are much easier to insert It consists of an inflatable silicone mask and rubber connecting tube. It is inserted blindly into the pharynx, forming a low-pressure seal around the laryngeal inlet and permitting gentle positive pressure ventilation. All parts are latex-free Indications: When endotracheal intubation is not necessary or it’s difficult Contraindications: • Non-fasted patients • Morbidly obese patients • Obstructive or abnormal lesions of the oropharynx Short Procedure: 1. The cuff of the mask is deflated before insertion and lubricated. 2. The patient is sedated or fully anaesthetized if conscious, and their neck is extended and their mouth opened widely. 3. The apex of the mask, with its open end pointing downwards toward the tongue, is pushed backwards towards the uvula. 4. The cuff follows the natural bend of the oropharynx, and its long walls come to rest over the piriform fossa. 5. Once placed, the cuff around the mask is inflated with air to create a tight seal. Air entry is confirmed by listening for air entry into the lungs with a stethoscope Laryngeal Masks (II) Advantages vs. Disadvantages Advantages: •Allows rapid access •Does not require laryngoscope •Relaxants not needed •Provides airway for spontaneous or controlled ventilation •Tolerated at lighter anesthetic planes Disadvantages: • Does not fully protect against aspiration in the non-fasted patient • Requires re-sterilization THANK YOU! Administration Of Oxygen Therapy Richard Dolan Oxygen Therapy. • Oxygen therapy is the administration of oxygen as a medical intervention. For a variety of purposes in both acute and chronic patient care. • Oxygen is essential for cell metabolism, and in turn, tissue oxygenation is essential for all normal physiological functions. • Room air only contains 21% oxygen, and increasing the fraction of oxygen in the breathing gas increases the amount of oxygen in the blood. • It is often only required to raise the fraction of oxygen delivered to 30– 35% and this is done by use of a nasal cannula. Oxygen Therapy. • When 100% oxygen is needed, it may be delivered via a tight-fitting face mask, or by supplying 100% oxygen to an incubator in the case of infants. • Oxygen can be administered in other ways, including specific treatments at raised air pressure, such as hyperbaric oxygen therapy. Indications For Use. • Chronic conditions, patient with COPD, a common long term effect of smoking, patients need more oxygen to breathe during a temporary worsening of this condition or full time through day and night. • Acute conditions, oxygen used in emergency medicine, like in resusitations, major trauma, anaphylaxis, major haemorrage, shock and hypothermia. Delivery. • Various devices are used for administration of oxygen. • Most often, the oxygen will flow through a pressure regulator, used to control the high pressure of oxygen delivered from a cylinder, to a lower pressure. • This lower pressure is then controlled by a flowmeter, which may be preset or selectable, and this controls the flow in a measure such as litres per minute (lpm). • The typical flowmeter range for medical oxygen is between 0 and 15 lpm with some units able to obtain up to 25 liters per minute. Supplemental oxygen. • Majority of patients require only a supplementary level of oxygen in the room air they are breathing, rather than pure oxygen. • A nasal cannula (NC) is a thin tube with two small nozzles that protrude into the patient's nostrils. It can only comfortably provide oxygen at low flow rates, 0.25-6 litres per minute (LPM), delivering a concentration of 24-40%. (pic on previous slide). • Also, the face mask option, such as the simple face mask! • Often used at between 5 and 15 LPM, with a concentration of oxygen to the patient of between 28% and 50%. • Venturi masks, which can accurately deliver a a predetermined oxygen concentration to the trachea up to 40%. Supplemental oxygen. • In some cases, oxygen can be delivered using a partial re breathing mask, based on a simple mask but has a reservoir bag, which increases the provided oxygen rate to 40 – 70% oxygen at 5 – 15 lpm. High flow oxygen delivery. • In cases where the patient requires a flow of up to 100% oxygen, a number of devices are available, with the most common being the nonrebreather mask (or reservoir mask). • This is similar to the partial rebreathing mask except it has a series of one-way valves preventing exhaled air from returning to the bag. • There should be a minimum flow of 10 L/min. • The delivered FIO2 of this system is 60-80%, depending on the oxygen flow and breathing pattern. Positive pressure delivery. • Patients who are unable to breathe on their own will require positive pressure to move oxygen in to their lungs for gaseous exchange to take place. • Systems for delivering this vary in complexity (and cost), starting with a basic pocket mask, which can be used by a basically trained first aider to manually deliver artificial respiration with supplemental oxygen delivered through a port in the mask. • Many emergency medical service and first aid personnel, as well as hospitals, will use a bag-valve-mask (BVM), which is a maleable bag attached to a face mask, usually with a reservoir bag attached, which is manually manipulated by the healthcare professional to push oxygen (or air) in to the lungs. Hyperbaric oxygen therapy. • Therapeutic principle of HBOT lies in its ability to drastically increase partial pressure of oxygen in the tissues of the body. The oxygen partial pressures achievable using HBOT are much higher than those achievable while breathing pure oxygen at normobaric conditions (i.e. at normal atmospheric pressure); • Hyperbaric oxygen therapy (HBOT), is the medical use of oxygen at a level higher than atmospheric pressure. • The increased overall pressure is of therapeutic value when HBOT is used in the treatment of decompression sickness and air embolism. (Prevention of decompression syndrome is for the diver to make decompression stops on his way up to surface). Indications for HBOT. • Air or gas embolism. • Carbon monoxide poisoning. • Clostridal myositis and myonecrosis (gas gangrene) • Decompression sickness. • Intracranial abscess • Big blood loss (anemia). Oxygen Toxicity. As a drug delivery route • Oxygen therapy can also be used as part of a strategy for delivering drugs to a patient. • The usual example of this being through a nebulizer mask, which delivers nebulizable drugs such as salbutamol or epinephrine into the airways by creating a vapor-mist from the liquid form of the drug . Thanks For Listening Using a nebulizer and inhaler correctly. Richard Dolan Nebulizer. • A Nebulizer is a device used to administer medication to people in the form of a mist inhaled into the lungs. • Commonly used in treating cystic fibrosis, asthma, COPD and other respiratory diseases. • The common technical principal for all nebulizers, is to either use oxygen, compressed air or ultrasonic power, as means to break up medical solutions/suspensions into small aerosol droplets, for direct inhalation from the mouthpiece of the device. Use and attachments. • Nebulizers accept their medicine in the form of a liquid solution, which is often loaded into the device upon use. • Corticosteroids and Bronchodilators such as salbutamol are often used. • The reason these pharmaceuticals are inhaled instead of ingested is in order to target their effect to the respiratory tract, which speeds onset of action and reduces side effects, compared to other alternative intake routes. Nebulizer. • The most commonly used nebulizers are the Jet Nebulizers. • Jet nebulizers are connected by tubing to a compressor, that causes or oxygen to blast at high velocity through a liquid medicine to turn it into an aerosol. • Aerosol is then inhaled by the patient. Inhalers. • Instead of using nebulizers to deliver a medical liquid to the lungs in the form of aerosol droplets, its also possible to use inhalers for the same purpose. • It is mainly used in the treatment of asthma and COPD. • Pictured is the pressurised metered dose inhaler (MDI), the most common type of inhaler. Use • In MDI’s, medication is most commonly stored in solution in a pressurized canister that contains a propellant. • The MDI canister is attached to a plastic, hand-operated actuator. • On activation, the metered-dose inhaler releases a fixed dose of medication in aerosol form. Use • The correct procedure for using an MDI is to first fully exhale, place the mouth-piece of the device into the mouth, and having just started to inhale at a moderate rate, depress the canister to release the medicine. • The aerosolized medication is drawn into the lungs by continuing to inhale deeply before holding the breath for 10 seconds to allow the aerosol to settle onto the walls of the bronchial and other airways of the lung. Categories • Bronchodilator Inhalers: Short-Acting Beta-2 Adrenergic Bronchodilator Inhalers • Daily Inhalers: Long-Acting Adrenergic Bronchodilator Inhalers • Daily Inhalers: Anticholinergic Bronchodilators in COPD • Daily Inhalers: Corticosteroids • Combination Inhalers: Corticosteroid with LongActing Beta-2 Adrenergic Agonist