Michaela Kunová Bosáková, Ph.D., 1 place
Regulation of primary cilia by cellular kinases


Assoc. prof. Lumír Krejčí, Ph.D., 1 – 2 places

Molecular mechanism of DSB repair and protection of stalled replication forks and their clinical
relevance

Pavel Krejčí, Ph.D., 2 places
Non-canonical signaling of human receptor tyrosine kinases


Mouse model for determination of precise spatiotemporal RTK/ERK signaling activity

Dr. Stjepan Uldrijan, 1 place
Regulation of signaling pathways affecting growth of malignant melanoma



Vladimír Rotrekl, Ph.D., 1 place
Modeling the cardiac progenitor depletion induced heart failure in patients suffering Duchenne musc
ular dystrophy using human induced pluripotent stem cells


Prof. David Šmajs, Ph.D. (2 places)
Single cell techniques in whole genome sequencing of uncultivable pathogenic treponemes

Sequence analysis of Treponema pallidum ssp. pallidum genomes isolated from clinical material


Jaeyoung Shing (1 place)

MAPK signalin molecular in cancer therapy


Research topic : The analysis of signalling complexes responsible for resistance mechanisms in
tumorigenesis.

Summary : RAS-RAF-MEK-MAPK pathway comprises a group of kinases which regulates the activities of
effector proteins in growth, proliferation and apoptosis. The extracellular signals from growth
factors, cytokines and other stimuli transmitted by surface receptors and upstream signaling
molecules are integrated by this cascade of kinases whose activity is regulated by the interaction
of oncoproteins and tumor suppressors. RAS-RAF-MEKMAPK pathway have been validated as effective in
therapy against a variety of cancers. The modality with combination of signaling molecular should
be considered based on cancer related gene profile of the individual patients. To do this, gene
expression-driven functional signatures were employed as cross-platform high resolution phenotypic
discriminators to link concordant cellular responses to siRNAmediated gene depletions and chemical
compound exposure on a library wide scale.

Requirements on applicants : - Master ́s degree or diploma in biology, biochemistry or in a related
discipline - Applying your broad skill set(molecular biology, biochemistry, microscopy, cell
biology) to drive the project further  - Practical knowledge in extraction techniques for
biomolecules (e.g. RNA, proteins)