Study program: Life Sciences
List of Dissertation Topics
Admissions for academic year 2019/2020
with commencement of study in spring 2020
Field: Bio-omics
1. ADAR2 RNA editing in CNS
Supervisor: Liam Keegan, Ph.D.
2. Characterization of cyclin-dependent kinase 12 (CDK12) substrates and
their roles in regulation of transcription and tumorigenesis
Supervisor: Dalibor Blažek, Ph.D.
Consultant: assoc. prof. Zbyněk Zdráhal, Panagiotis Alexiou, Ph.D.
3. Dynamics of the Structure Maintenance of Chromosome (SMC) complexes
Supervisor: assoc. prof. Jan Paleček
4. Functions of cyclin-dependent kinase 11 (CDK11) in regulation of gene
expression
Supervisor: Dalibor Blažek, Ph.D.
Consultant: assoc. prof. Zbyněk Zdráhal, Panagiotis Alexiou, Ph.D.
5. Investigating the regulation of the RNA modifying enzyme ADAR1 and
how it regulates other biological pathways and diseases
Supervisor: prof. Mary O’Connell
Consultants: Liam Keegan, Ph.D.
6. Mass spectrometric imaging of biological tissues
Supervisor: prof. Jan Preisler
Consultant: Mgr. Markéta Machálková
7. Microenvironmental interactions and regulation of their crosstalk in
malignant B-cells by transcription fators
Supervisor: assoc. prof. Marek Mráz
8. Regulation of BCR signalling by DNA damage response and P53 protein
Supervisor: assoc. prof. Marek Mráz
9. Structure, function and evolution of plant telomere components
Supervisor: prof. Jiří Fajkus
10. The role of posttranscriptional RNA modifications in cell differentiation
Supervisor: assoc. prof. Štěpánka Vaňáčová
11. The role of protein-protein interactions in the dynamics of m6A RNA
modification
Supervisor: assoc. prof. Štěpánka Vaňáčová
12. Search for new regulators of intracellular trafficking in plants
Supervisor: Tomasz Nodzynski, Ph.D.
Consultant: Marta Zwiewka, Ph.D.
Field: Structural Biology
1. A structural basis for the cross-talk between histones and RNA
Polymerase II
Supervisor: assoc. prof. Richard Štefl
Consultants: Karel Kubíček, PhD., assoc. prof. Štěpánka Vaňáčová
2. Cracking the CTD code
Supervisor: assoc. prof. Richard Štefl
Consultants: Karel Kubíček, PhD., Pavel Plevka, Ph.D.
3. Integrative structural biology of 3’UTRs
Supervisor: Peter Lukavsky, Dr. rer. nat.
Consultants: Boris Tichý, Ph.D., assoc. prof. Zbyněk Zdráhal
4. Protein sensitivity of membrane curvature
Supervisor: assoc. prof. Robert Vácha
5. Regulation of protein-protein itneractions
Supervisor: assoc. prof. Robert Vácha
6. Structural and time-resolved studies of phage replication in bacterial
biofilm
Supervisor: Pavel Plevka, Ph.D.
7. Structural study of enterovirus replication in vivo
Supervisor: Pavel Plevka, Ph.D.
8. Structural studies of the TPLATE complex
Supervisor: Konstantinos Tripsianes, Ph.D.